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Para Methoxyacetophenone CAS 100-06-1

Molecular Formula: C9H10O2

Formula Weight: 150.17

ZSpharmac: Para Methoxyacetophenone Supplement

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Product Name: Para Methoxyacetophenone
CAS No: 100-06-1
Purity: 99%

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Basic Info

Product Name:Para Methoxyacetophenone
Other Names:4′-Methoxyacetophenone
CAS:100-06-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Flavors and Fragrances
Appearance:Clear Yellow to Yellow-Brown Solution
EINECS No.:201-164-8
Storage:2-8°C
Provide:Para Methoxyacetophenone MSDS;
Para Methoxyacetophenone COA

What is Para Methoxyacetophenone?

Para Methoxyacetophenone has a strong and persistent hay, coumarin-like aroma with floral and hawthorn notes. Appearance is crystalline. Para Methoxyacetophenone can be used in the formula of daily chemical essence. Because it is relatively stable in alkaline medium, it is especially suitable for use in the essence formula of soap and synthetic detergent, and the dosage in the essence formula is less than 5%.

Para Methoxyacetophenone Properties:

Melting point 36-38 °C (lit.)
Boiling point 152-154 °C/26 mmHg (lit.)
density 1.08
  
refractive index 1.5470 (estimate)
Fp >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility H2O: soluble2.474g/L at 20°C
form Crystals or Crystalline Powder
color White
Water Solubility insoluble

 

Para Methoxyacetophenone Uses

  1. Para Methoxyacetophenone appropriates for hawthorn, acacia, mimosa, locust, fragrant myrtle, orchid, brand-new mowing, clover and other fragrances, and is frequently used in organic, woodsy and other soap significances. However it is generally advisable to show anisaldehyde and also anisol. It can additionally be utilized as the collaborated aroma of fennel as well as bean, and also is extensively used in the formulation of different flavors. It can additionally be made use of in edible flavors such as lotion, tobacco candy, delicious chocolate, fresh fruit, nuts, vanilla beans and also various other tastes and also tobacco tastes.
  2. Para Methoxyacetophenone GB 2760– 1996 states as the permitted edible flavor. It is generally used to prepare tastes such as vanilla beans, nuts, butter and tobacco.
  3. Para Methoxyacetophenone is utilized to formulate fragrances, typically used in sophisticated cosmetics and soap fragrances, as well as can also be made use of in natural synthesis.
  4. Para Methoxyacetophenone has a strong aroma of hawthorn, as well as is a vital basic material for fragrances such as shyness as well as hawthorn. Frequently utilized in high-grade cosmetics and also soap essences, it has high stability in soaps, and also can additionally be utilized as fruit food significances. my nation’s GB2760-86 stipulates that the edible tastes are enabled to be made use of, as well as are generally used to prepare flavors such as vanilla beans, nuts, butter and cigarette. It is additionally made use of in sunscreens as well as organic synthesis, the manufacturing of p-methoxyphenylacetic acid as an intermediate for puerarin, and the manufacturing of fluid crystal monomers.

Synthesis of Para Methoxyacetophenone

Para Methoxyacetophenone (p-MOAP) was synthesized by Friedel-Crafts acylation using gallium phosphotungstate (GaPW12O40) and indium phosphotungstate (InPW12O40) as catalysts and anisole and acetic anhydride as raw materials.

Preparation of catalyst:

Prepare GaPW12O40 catalyst according to the method reported in the literature: Weigh a certain amount of H3PW12O40 and gallium nitrate, dissolve them in a certain amount of distilled water respectively, and add the gallium nitrate solution dropwise to the H3PW12O40 solution at room temperature; After aging at 80 °C for 1 h, the excess water was slowly evaporated to dryness and dried at 120 °C overnight to obtain the GaPW12O40 catalyst. The catalyst was calcined at 300 °C for 2 h before use.

Preparation of InPW12O40 catalyst: prepared by reacting H3PW12O40 with indium nitrate, the preparation method is the same as above.

Synthesis and purification of p-MOAP:

Add an appropriate amount of anisole and catalyst to a 100 mL three-neck round-bottomed flask, install a reflux device, stir magnetically, heat the oil bath to a certain temperature, slowly drop an appropriate amount of acetic anhydride with a constant pressure funnel, and react at a constant temperature for a certain period of time. Cool to room temperature. The product yield was calculated according to the quality of the reaction solution and the feeding amount of acetic anhydride. The above reaction solution and catalyst were separated, washed with alkali, washed with water, dried with anhydrous magnesium sulfate, and collected fractions at 152-154 °C (3.5 kPa) by vacuum distillation to obtain the p-MOAP product.

The optimal conditions for the synthesis of p-MOAP are as follows: the amount of pretreated GaPW12O40 catalyst at 300 ℃ is 0.1 g, the amount of acetic anhydride is 20 mmol, n (anisole): n (acetic anhydride) = 5, reaction temperature 90 ℃, reaction time In 30 min, the conversion of acetic anhydride reached 98.49%, the selectivity of p-MOAP reached 94.91% and the purity was high.

The GaPW12O40 catalyst is very prone to coking and carbon deposition during the reaction process, which seriously hinders the reuse of the catalyst, so its stability needs to be further improved.

Para Methoxyacetophenone was synthesized by acylation of anisole with acetic anhydride using iodine as a catalyst.

In the reaction flask, add the catalyst, anisole, and acetic anhydride, install a reflux condenser, and stir with a magnetic stirrer. Control a certain reaction temperature through a water bath or oil bath, and cool down after a constant temperature reaction for a certain period of time. A small sample was taken for quantitative analysis by gas chromatography. Water was added to the filtrate to hydrolyze the unreacted acetic anhydride, the layers were left to stand, the organic layer was washed with sodium hydroxide solution until nearly neutral, the organic layer obtained after separation was dried with anhydrous magnesium sulfate, firstly distilled at atmospheric pressure, and benzene was recovered. methyl ether and other light fractions, and then collect the fractions with a temperature of 152-154 °C/3.5 kPa under reduced pressure, which is the reaction product Para Methoxyacetophenone.

According to the mechanism of acylation reaction, the mechanism of iodine-catalyzed acylation reaction is speculated as follows:

The optimal reaction conditions are: anisole is 0.1 mol, the molar ratio of anisole to acetic anhydride is 1∶1.5, the optimal mass of catalyst is 1 g, the reaction time is 1.5 h, the reaction temperature is 100 ℃, and the product yield is reached 52.9%. The catalytic effects of different catalysts on the acylation of anisole with acetic anhydride were compared. The results show that the catalytic efficiency of iodine is much higher than that of heteropolyacids and zeolite molecular sieves, and it is an efficient catalyst for acylation.

Para Methoxyacetophenone was synthesized by acylation of anisole with acetic anhydride using heteropolyacid as catalyst.

Pretreatment of catalyst and preparation of supported heteropolyacid:

The heteropoly acid is dried to a certain temperature in a controllable oven, and dried at a constant temperature for 1.5 h. The loaded H3 [PW12O40] was prepared by the excess impregnation method. A certain amount of carrier was mixed and stirred with the aqueous solution of H3 [PW12O40] respectively, kept in a water bath at a constant temperature for 14 hours, then evaporated to dryness in a water bath, and then placed in a controllable oven and dried at 150 °C for 2 hours to obtain the load. H3[PW12O40].

Friedel-Crafts acylation of anisole with acetic anhydride:

In the reaction flask, add the catalyst, anisole and acetic anhydride, install a reflux condenser, and stir with a magnetic stirrer. Through a water bath or an oil bath, a certain reaction temperature is controlled, and the reaction is kept constant for a certain period of time and then cooled. Chloroform was added to precipitate the heteropolyacid, and the catalyst was filtered off. Add water to the filtrate to hydrolyze the unreacted acetic anhydride, stand for stratification, wash the organic layer to near neutrality with sodium hydroxide solution, dry the organic layer obtained after the separation with anhydrous magnesium sulfate, distill at atmospheric pressure first, and recover chloroform , anisole and other light fractions, and then collect under reduced pressure the fractions at 152~154 ℃ under the pressure of 3.5Kpa, which is the reaction product Para Methoxyacetophenone.

The optimal reaction conditions are: the catalyst needs to be pretreated, the temperature is 150 ℃, the molar ratio of anisole to acetic anhydride is 1:1.5, the optimal mass ratio of anisole to catalyst is 11, and the reaction time is 4h 9%。 , the reaction temperature of 100 ° C, the product yield reached 52.9%. Under the optimal conditions, the catalytic effects of different heteropolyacids and supported heteropolyacids on the acylation of p-anisole with acetic anhydride were investigated. As the strongest acid among heteropolyacids, phosphotungstic acid has the best catalytic activity.

Para Methoxyacetophenone Application

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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