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Zhishang Chemical

Para Cymene CAS 99-87-6

Molecular Formula: C10H14

Formula Weight: 134.22

ZSpharmac: Para Cymene Supplier

Product Name: Para Cymene
CAS No: 99-87-6
Purity: 99%

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Basic Info

Product Name:Para Cymene
Other Names:P-Cymene
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Liquid
EINECS No.:202-796-7
Provide:Para Cymene MSDS;
Para Cymene COA

What is Para Cymene?

Para-cymene is transformed from D-limonene, and after transformation, it will become a more stable para-cymene with a more stable chemical structure. Because it contains a benzene ring, the antibacterial and anti-inflammatory effects of Para Cymene are more obvious and powerful. The molecular structure of Para Cymene is like a sun umbrella on the ground, which is bigger and better protected than the small umbrella of terpinene. It has a good bactericidal, anti-viral and immune-stimulating effect, just like the sun umbrella that protects health in monoterpenes. However, cymene is more irritating than limonene, and direct application will cause the skin to become hot and red. Essential oils containing more cymene are recommended to be diluted and applied to avoid burning the skin. Preservation of essential oils containing Para Cymene components requires attention to isolation from the air to avoid oxidation, otherwise Para Cymene will continue to be oxidized into phenols that are more irritating to the skin.

Para Cymene Property

Melting point 

-68 °C

Boiling point 

176-178 °C(lit.)


0.86 g/mL at 25 °C(lit.)

vapor density 

4.62 (vs air)

vapor pressure 

1.5 mm Hg ( 20 °C)

refractive index 

n20/D 1.490(lit.)


117 °F

storage temp. 







Mild, pleasant; aromatic, solvent-type.

Odor Threshold


explosive limit


Water Solubility 




Para-Cymene Application

p-Cymene (commonly known as Para-Cymene) is a very important chemical product and a wide range of organic synthesis intermediates, it can be used in soft drinks, iced food, candy, chewing gum, seasoning; also can be used to synthesize many A polycyclic musk-type spice such as cymbal musk, sandalwood musk, tuna musk, etc., drugs, herbicides, fungicides, etc.; terephthalic acid made from it can be used to make synthetic resins, synthetic fibers and plasticizers ; Para-Cymene obtains p-cresol and co-product acetone through oxidation and acid hydrolysis, and p-cresol is an important raw material for synthetic pesticides, medicines, synthetic materials, spices and other fine chemical products. Its application examples are as follows:

1. Synthetic Tuna Musk. Tonalide is a synthetic musk with tetralin structure. It has excellent fragrance quality, elegant fragrance, long-lasting fragrance, acid and alkali resistance, no discoloration under natural light, strong diffusion power, and no stimulation to human skin. It has good compatibility with other fragrances and is an ideal fragrance raw material.It is widely made use of in the fields of cosmetics, fragrance, tobacco, essence and also medicine, and also has actually turned into one of the most encouraging artificial musk items. Synthesis technique Para-Cymene is used as raw material, under the catalysis of mixed Lewis acid, it is cyclized with olefin, and after that undertakes Friedel-Crafts acylation response in ether solvent, and the complete return of nearly 85% is acquired. musk. The selectivity and yield of cyclization were boosted by improving the stimulant composition, as well as the conditions of Friedel-Crafts reaction were enhanced by evaluating solvents. Compared with the prior art, the approach has the features of light conditions, straightforward operation, high pureness and also yield of the obtained product, and so on.

2. The approach for preparing hexamethyltetralin, hexamethyltetralin is 1,1,3,4,4,6-hexamethyl-1,2,3,4-tetralin, referred to as HMT, is an artificial It is a vital intermediate of musk scent. Tuna musk is a kind of musk scent. It has a strong musk scent, long-lasting scent, solid scent diffusion capacity, acid as well as alkali resistance, great light security, as well as no injury to human skin. Stimulating and well coordinated with various other fragrances, it is a perfect synthetic musk product with fantastic potential for advancement, and also has been extensively made use of in fragrances, cosmetics as well as cleaning agent fragrance solutions. The preparation technique is as complies with: an acidic area temperature ionic fluid is used as a driver, a cyclic hydrocarbon is made use of as a solvent, and also Para-Cymene and also olefins are utilized as raw materials, and an alkylation response is accomplished in the visibility of a hydrogen transfer reagent; the acidic space temperature ionic liquid driver is a steel halide substance consisting of Prepared by the response of alkyl pyridine amine halides, alkyl-containing amine hydrohalides or alkyl-containing imidazole amine halides. The above process is easy, has high product selectivity, and relatively significant yield. The ionic liquid driver utilized in the reaction is simple to separate from the response fluid, and can be reused. The process does not create 3 industrial wastes. It is an environment-friendly as well as environmentally friendly craft.

Invention of Para-Cymene

In order to solve the shortcomings of the existing technology that the reaction scale is small, industrialized continuous production cannot be produced, and the processing process is complicated, the present invention provides a method and device for continuous production of Para-Cymene, which have continuous production, simple operation, and no waste , no solvent and other reagents are needed, and the catalyst is simple and recyclable.

The invention provides the following technical scheme: a method for continuous production of Para-Cymene, in which 0.1kg to 50.0kg of Pd/C catalyst is loaded into the reactor, and the inert load is fed at a rate of 0.01L/min to 5.00L/min. Gas such as nitrogen, turn on the heating device, when the temperature of the reactor reaches 150 ℃ ~ 400 ℃, turn on the metering pump, and continuously feed the industrial dipentene raw material at a speed equivalent to the space velocity of 0.5h-1 ~ 5.0h-1, After preheating, gasification, and contact reaction with the catalyst, as the reaction progresses, the reaction product continuously enters the condenser connected to the bottom of the reactor, and after being condensed, it is directly collected by the condenser to the product storage tank. The product obtained is a Para-Cymene product. Wherein, the space velocity refers to a parameter that expresses the feed rate without being affected by the size of the reactor. The palladium content of the above Pd/C catalyst is between 0.1%wt and 10.0%wt.

The device for implementing the method described in the present invention, that is: a method device for implementing the continuous production of Para-Cymene from industrial dipentene, mainly consists of a raw material storage tank, a metering pump, a preheater, a gasification It is composed of a reactor, a reactor, a condenser, a product storage tank and a heating device. A metering pump capable of continuous constant flow feeding is provided between the preheater and the raw material storage tank, and the inlet of the metering pump is connected with the outlet of the raw material storage tank. The outlet of the metering pump is connected to the inlet of the preheater, then the outlet of the preheater is connected to the inlet of the vaporizer, the outlet of the vaporizer is connected to the inlet on the top of the reactor, the outlet at the bottom of the reactor is connected to the inlet of the condenser, and the outlet of the condenser is connected to the product The inlet of the storage tank is connected, and the preheater, gasifier, reactor and heating device are connected. A nozzle with an inner diameter of 0.05 mm to 1.00 mm is installed in the vaporizer. The reactor is a tube-and-tube reactor, the tubes are loaded with reaction catalysts, the reactor is provided with a temperature sensor, and the tube-and-tube reactor is provided with a jacket. The reactor is a tube-and-tube multi-tube reaction bed, and the reactor jacket can control the temperature. The feed port of the reactor is located at the top of the reactor. After the raw material is preheated and atomized and gasified by the nozzle, it enters the reaction bed from the top of the reactor. The feed port of the reactor is at the bottom of the reactor, and the reaction product directly enters the condensation After being condensed, it is directly collected into the product storage tank. The heating device includes an expander, a magnetic pump, a cold oil tank and a hot oil furnace. A magnetic pump is installed between the cold oil tank and the hot oil furnace. The magnetic pump is connected to the preheater, gasifier and reactor. One end of the hot oil furnace is connected to the expansion The other end is connected with the preheater, gasifier and reactor, and forms a closed heating circuit with the magnetic pump.

The raw material industrial dipentene used in the present invention is a type of monocyclic terpene with a six-membered ring structure, and this type of monocyclic terpene can be converted into Para-Cymene after catalytic dehydrogenation. The industrial dipentene referred to in the present invention is a mixture of a class of monocyclic monoterpenes with the same molecular weight and similar structure, and usually has many isomers, such as: limonene, α-terpinene, α-phellandrene , β-phellandrene, γ-terpinene, terpinene, etc.

Preparation of Para-Cymene

1. Using toluene as raw material to synthesize Para-Cymene

So far, most of the industry has adopted this synthetic route to produce cumene, which is realized by the Frield-Craft s alkylation reaction of toluene and propylene (or isopropanol), usually using AlCl3 as a catalyst . Due to the weak ortho- and para-positioning effect of the methyl group in the toluene molecule and the reversibility of the reaction and the relative thermodynamic stability of the m-alkylbenzene compared with the ortho- and p-alkylbenzenes, the reaction product contains p-isopropyl In addition to a small amount of o-isopropyl toluene and a small amount of (steric hindrance effect), it also contains a considerable amount of m-isopropyl toluene. In fact, the ratio of meta-position and para-isopropyl toluene is about 60: 40, and the reaction formula as the picture shows.

Industrially, the mixed product thus obtained is further oxidized and acidolyzed to produce cresol, and the cresol obtained by this method is also m- and p-mixed cresol (o-isopropyl toluene is difficult to be oxidized).

2. Synthesis of Para-Cymene from turpentine

The selectivity of Para-Cymene synthesized from toluene is poor, and the synthesis method with high selectivity has relatively harsh conditions. Therefore, researchers have been looking for a synthesis route with abundant raw materials and simple methods. The preparation of Para-Cymene from turpentine oil is the focus and focus of research in recent years. Turpentine is an abundant renewable resource whose main component is pinene. In the production process of synthesizing camphor and terpineol with turpentine as raw materials, a large amount of by-product industrial dipentene will be produced, and its main components are several monocyclic terpenes with p-diene structure. Pinene and monocyclic terpene have the same or similar carbon frame structure as p-cymene. Pinene can be isomerized into monocyclic terpene through hydrogen transfer reaction, and monocyclic terpene can be converted into Para-Cymene. The preparation of Para-Cymene by using pinene and monocyclic terpene as starting materials is described separately below.

1) Using monocyclic terpene compounds as raw materials

The most studied is to prepare Para-Cymene by catalytic dehydrogenation of T-limonene as raw material. This was studied as early as the 1920s, using palladium-based catalytic systems. Studies have shown that T-limonene is disproportionated into p-alkane and p-cymene. In the 1950s, sodium metal was used as a catalyst, and sodium benzyl was used as a cocatalyst to catalyze the dehydrogenation of monocyclic terpenes such as T-limonene to produce Para-Cymene. Taking T-limonene as an example, the reaction process is shown in the figure.

2) Using bicyclic terpene compounds as raw materials

Mainly T-pinene (T-pinene) is used as the starting material, T-pinene is firstly ring-opened and isomerized into monocyclic terpene compounds, and then Para-Cymene is prepared through catalytic dehydrogenation. The acid-catalyzed ring-opening isomerization of T-pinene was studied. Under acidic conditions, the π bond in the double bond of T-pinene is broken, and a stable tertiary carbocation is formed first, and the formed tertiary carbocation is due to tension, and further For isomerization rearrangement, if an organic acid is used as a catalyst in a low polar solvent, process a mainly occurs; if an inorganic acid is used as a catalyst in a polar solvent, process b occurs, as shown in the figure. The next dehydrogenation reaction uses copper formate-nickel formate (Cu: Ni=1:1) and W-5 type Raney-Ni catalyst.

About Products:
If you need Para-Cymene, the cosmetic raw material, please contact our service personnel directly, and we will provide you with high-quality products at the best price.
As an experienced Para-Cymene manufacturer and supplier, ZSpharmac will provide Para-Cymene raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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