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Zhishang Chemical

Para-Cresol CAS 106-44-5

Molecular Formula: C7H8O

Formula Weight: 108.14

ZSpharmac: Para-Cresol Supplier

Product Name: Para-Cresol
CAS No: 106-44-5
Purity: 99%

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Basic Info

Product Name:Para-Cresol
Other Names:P-Cresol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Crystalline Solid or Liquid
EINECS No.:203-398-6
Storage:Store Below +30°C.
Provide:Para-Cresol MSDS;
Para-Cresol COA

What is Para-Cresol?

p-cresol, colorless or light yellow liquid or crystal, somewhat soluble in water, soluble in ethanol, ether as well as alkali solution. Cresol is a basic term for the mixture of 3 isomers of p-cresol, m-cresol and also o-cresol, mostly derived from byproducts of chemical synthesis or coking, oil shale completely dry purification and city gas. Although using cresol mix is rare, its monomers are commonly utilized natural chemical intermediates. P-cresol can be used in industrial sectors such as chemicals, dyes, and plastics, and also can likewise be used as intestinal tract repellents, disinfectants, as well as regional anti-corrosion agents in medication. m-cresol can be made use of in analytical reagents as well as natural synthesis, and also is a vital basic material for the synthesis of antioxidants, chemicals, vitamin E, cosmetics and medicines; at the same time, it likewise has essential applications in artificial resins, shade film developers, adhesives, etc. At present, the demand for high-purity cresol monomer is boosting everyday in the house as well as abroad, yet the manufacturing capacity wants, resulting in a lack of supply.

Para-Cresol Property

Melting point 

32-34 °C(lit.)

Boiling point 

202 °C(lit.)


1.034 g/mL at 25 °C(lit.)

vapor density 

3.72 (vs air)

vapor pressure 

1 mm Hg ( 20 °C)

refractive index 

nD20 1.5395


193 °F

storage temp. 

Store below +30°C.




10.17(at 25℃)


Crystalline Solid or Liquid

Specific Gravity

1.0341 (20/4℃)


Colorless to light yellow, may darken on exposure to light


at 0.10 % in dipropylene glycol. phenolic narcissus animal mimosa

Odor Type


Odor Threshold


explosive limit


Water Solubility 

20 g/L (20 ºC)

Para-Cresol Uses

  1. Para-Cresol is an intermediate of the fungicide tolclofos-methyl, the insecticide flucyvalerate and etofenproxil, along with additionally the antioxidant additive 2,6-di-tert-butyl-4-methylphenol in addition to p-hydroxybenzene Intermediates of formaldehyde.
  2. Para-Cresol is the raw item for the manufacture of anti-aging representative 264 (2,6-di-tert-butyl-p-cresol) and also rubber anti-aging representative. In the plastics sector, phenolic materials and plasticizers can be created. Used as an anti-bacterial in medication. On top of that, it can additionally be utilized as a raw material for dyes along with chemicals.

Para-Cresol Separation Method

Complexation (enhancement) separation method
The complexation (addition) splitting up technique describes adding an unique substance to the m-Cresol or Para-Cresol mix, and also the special compound can create a solid facility with one of the monomers in m-cresol or p-cresol, Or it can undertake addition response with chosen target substances to create molecular compounds, so regarding accomplish the function of splitting up. In research in your home and also abroad, the major optional complicateds are urea, tert-butanol and piperazine.

Piperazine or benzidine addition crystallization approach
On the basis of summing up a series of records, Bao Tiezhu et al. used a technique comparable to the urea complexation technique to separate cresol blends to get p-cresol, wherein the mass fraction of p-cresol in the mixed phenol should be above 30%. The concept is that the balance constants of piperazine (or piperazine hexahydrate) as well as different cresols are different, and piperazine is generally utilized as a complexing agent to selectively separate p-cresol in cresol isomers (complicated crystal The molar proportion of piperazine to p-cresol is 1:2). In ether solvents, piperazine as well as p-cresol can create a complicated precipitate, and the product can be mixed with 1-3 times the quantity of n-butyl ether

Essence and also rectify to get purified Para-Cresol. Making use of the mixed phenol containing 70% -80% p-cresol as basic material, the return of p-cresol generated by this process is over 92%. If there is phenol in the raw material, then the phenol will certainly also be complexed with piperazine, as well as the phenol in the crystallized item can be separated by rectification. The reaction formula is shown in the figure.

p-cresol can additionally be thawed with benzidine at 140 ° C to develop an adduct with a material proportion of 2:1, the formation problem is 110 ° C, centrifuged at 95 ° C, the adduct is cleaned with benzene, and the pureness is 98% by vacuum distillation p-cresol, return 90%. From the filtrate, m-cresol with a pureness of 99% can be obtained with a return of 92%.

Splitting up by alkylation describes the tert-butylation reaction between methane as well as Para-Cresol with isobutene under acid catalysis to create alkylated by-products, and also the created alkylated by-products have a huge boiling point difference, as well as the gotten derivatives are further The monomer is divided by physical and chemical approaches such as correction, recrystallization, solvent extraction, and dehydrocarbonation.

The alkylation response is a normal Friedel-Crafts response, in which an electrophilic alternative reaction happens on the benzene ring to form a carbocation, and an acidic stimulant is made use of for tert-butylation of cresol at a relatively reduced temperature level (60-70 ° C). Utilizing the distinction in physical homes of the major and byproducts, high-purity meta-cresol by-products and p-cresol derivatives are divided by conventional rectification, and also the main by-product of p-cresol, 2,6-di-tert-butyl p-cresol, is directly offered as an anti-oxidant. The derivatives of m-cresol are de-tert-butylated at greater temperature (150-200 ° C )as well as in the existence of acid to acquire m-cresol monomer.

The extraction method is to utilize the distinction in solubility and also circulation coefficient of cresol isomers in the two-phase system of natural phase such as benzene and aqueous NaOH option to transfer the cresol isomers from one solvent to another after duplicated removals. While doing so, the cresol isomers are extracted to achieve the objective of separation.

melt formation
Thaw formation is frequently used to divide isomers, normally consisting of 2 processes of crystallization and also sweating [24. There is a distinction of 24.6 ° C in the melting points of p/m-cresol, which can be divided by thaw condensation.

Adsorption separation method
The adsorption separation method is an approach to uniquely separate the cresol isomers by utilizing the different adsorption capabilities of the adsorbent Para-Cresol isomers. The primary procedure is adsorption-desorption-separation.

Other separation methods
A Japanese license reports a microbial technique for the splitting up of cresols. Making use of certain single-cell microorganisms, p-cresol in combined cresols can be converted into p-hydroxybenzoic acid, while m-cresol will not be oxidized. It can be separated by ordinary approaches in the later stage. m-cresol can be acquired. IMBERT et al. discovered that using HFAU zeolite [n(Si)/ n(A1)=3.9-100] as a catalyst, under the conditions of 653 K and also 0.01 MPa, the isomerization reaction of m-cresol was brought on by the strong acid site facility, as well as Para -Cresol as well as a percentage of various other spin-offs consist of o-cresol, phenol and xylenol, and high-purity p-cresol is precisely obtained via the isomerization conversion reaction of m-cresol, yet the result is not obvious as well as the conversion price is low.

Para-Cresol Production Method

Its prep work strategies are as complies with.
( 1) Toluene sulfonation alkali combination technique
Toluene is used as resources, sulfuric acid is used as sulfonating agent, sulfonation response is carried out at 110-130 ° C to produce intermediate toluenesulfonic acid, after neutralization, alkali-fusion response is completed with liquified salt hydroxide at 340-365 ° C to acquire Sodium cresol is acidified to get unrefined cresol, and later on distilled to separate o-cresol and also phenol to acquire m-cresol along with p-mixed cresol with p-cresol as the message. The temperature degree modification, the type of sulfonating agent as well as the ratio of toluene to sulfonating representative figure out the cosmetics of isomers in cresol. Nanjing Jinyan Chemical Corporation can generate high-purity p-cresol by sulfonation antacids mix technique Frequently made use of sulfonating representatives are fuming sulfuric acid in addition to chlorosulfonic acid.

The prep work of p-cresol by toluene sulfonation is the earliest developed technique. This technique has a fairly fully grown procedure, nevertheless it needs to eat a huge quantity of acid along with antacids, as well as additionally the trouble of tools rust is major. Presently, this approach is still the main approach for developing p-cresol.
The mama alcohol after extracting m-cresol from m-cresol combination can be recrystallized by oxalic acid enhancement technique. For example, warm urea and also filteringed system toluene remedy to 95-100 ° C, include oxalic acid under mixing for 2-3 hours, after that cool at area temperature for about 16 hours, as well as also vacuum cleaner filter to get white crystals, p-cresol oxalic acid facility. The complicated is rotted with warm water, along with the top oil layer is firstly distilled right into toluene along with water under routine stress, and then the fraction at 93-104 ° C is lowered at a hoover degree of 0.094 MPa to get p-cresol with a purity of 95%.

( 2) p-toluidine diazo hydrolysis approach.
P-toluidine as well as sulfuric acid produce p-toluidine sulfate, diazotize with salt nitrite at 0-5 ° C, after that cozy as well as hydrolyze the diazonium salt in damage sulfuric acid, different the oily product with hefty vapor, as well as likewise separate the oil layer Include it to 1% salt hydroxide, afterwards decolorize and also filter, include focused sulfuric acid to pH = 1, after that separate the water layer, include zinc powder and additionally sulfuric acid, counteract it with sodium carbonate to neutral, and split the oily material. Cleaned with water, and also after that distilled under lessened pressure to obtain the finished item.

( 3) Separated from kerosene

About Products:
If you need Para-Cresol, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Para-Cresol manufacturer and supplier, ZSpharmac will provide Para-Cresol raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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