Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Search
Close this search box.

Palmitoyl Tripeptide-8 CAS 936544-53-5

Molecular Formula: C37H61N9O4

Formula Weight: 695.94

ZSpharmac: Genivida Genistein Supplement

Facebook
Twitter
LinkedIn
Pinterest
WhatsApp
Email
Product Name: Palmitoyl Tripeptide-8
CAS No: 936544-53-5
Purity: 99%

Navigation Bar

Basic Info

Product Name:Palmitoyl Tripeptide-8
Other Names:Palmitoyl Tripeptide-8;Neutrazen
CAS:936544-53-5
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Grey Powder
EINECS No.:0
Storage:-20°C
Provide:Palmitoyl Tripeptide-8 MSDS;
Palmitoyl Tripeptide-8 COA

What is Palmitoyl Tripeptide-8?

Palmitoyl tripeptide-8 (Palmitoyl-Lysyl-Valyl-Lysine, Pal-Lys-Val-Lys-OH), also referred to as “tripeptide” or “collagen peptide COLL-O2”, is the earliest and also most commonly used cosmetic item. peptides. Palmitoyl tripeptide-8 belongs to the signaling class of peptides, which can advertise the synthesis of collagen (type I, II as well as IV) as well as the production of extracellular matrix healthy proteins by enhancing the task of stromal cells, making the skin look more youthful and extra attractive. Resilient. Including it to cosmetics can aid renew collagen, enhance facial flexibility, as well as substantially decrease face wrinkles. It likewise has the buildings of enhancing cell task, boosting skin dampness material, enhancing skin radiance as well as enhancing complexion. Boost the skin’s water web content and secure wetness, make the skin feel soft and smooth, and brighten the complexion from the inside out, no longer boring.

The synthesis methods of palmitoyl tripeptide-8 consist of traditional solid-phase peptide synthesis and also liquid-phase peptide synthesis. Because of its short series, the solid-phase synthesis of amino acids uses a big quantity of amino acids, and the cost is high, as well as it is challenging to accomplish massive preparation; liquid-phase synthesis method The quantity of amino acid is tiny, the return is high, and also it can be prepared in huge quantities. However, the existing fluid phase synthesis method is complicated in process, uses a huge quantity of natural solvents, has high price and is not eco-friendly.

Palmitoyl Tripeptide-8 Property

density 1.20±0.1 g/cm3(Predicted)
pka13.34±0.46(Predicted)

 

Palmitoyl Tripeptide-8 Uses

Palmitoyl tripeptide-8 is the earliest and also most widely made use of cosmetic peptide. Palmitoyl tripeptide-8 comes from the signaling class of peptides, which can promote the synthesis of collagen (kind I, II and also IV) as well as the production of extracellular matrix proteins by enhancing the activity of stromal cells, making the skin appearance more youthful and a lot more lovely. Resistant. Including it to cosmetics can assist renew collagen, improve face flexibility, and substantially reduce facial wrinkles. It additionally has the residential properties of improving cell task, improving skin dampness web content, boosting skin glow and also enhancing complexion.

Palmitoyl tripeptide - 8 Applications

Palmitoyl tripeptide-5 can inhibit the activity of tyrosinase, down-regulate the mRNA levels of microphthalmia-related transcription factor (MITF) and tyrosinase, thereby inhibiting the production of melanin in melanocytes, and it can be considered as a whitening additive Used in the field of cosmetics. Clinical trials have shown that skin care products containing palmitoyl tripeptide-8 significantly reduce skin sagging, reduce and change age lines, compared with placebo and reference substances. Significantly higher activity compared to 10 ppm palmitoyl pentapeptide-4. This ingredient was included in the list of names of cosmetic raw materials used in my country in 2015 and can be legally added.

Preparation of Palmitoyl Tripeptide-8

(1 ), the prep job of palmitoyl chloride (Pal-Cl).

In a 250mL single-neck round-bottom flask, include 20.52 g palmitic acid, include 60mL thionyl chloride to liquify, reflux at 80 ° C for 5 hrs, cool to location temperature level, as well as also revolve dry the solvent to obtain the white oily target item palmitoyl chloride (21.6 g, 98%). 1HNMR( CDCl3,300 MHz) δ0.86 -0.90( t,3 H),1.26 -1.34( m,24 H),1.66 -1.75( m,2 H),2.86 -2.90( t,2 H).

( 2) Prep Work of Pal-Lys( Cbz)- OH.

500mL single-neck round base flask, weigh 21g Na2CO3 as well as dissolve it in 120mL water, consist of 60mL of tetrahydrofuran, after that add 11g of Nε-Cbz-L-lysine to dissolve, at room temperature, include 60mL of tetrahydrofuran treatment consisting of 11.2 g of palmitoyl chloride dropwise, and likewise the addition is complete After that, the feedback was blended for 16h. After the reaction, the pH of the system was gotten used to 3-4 with 1M HCl, removed with dichloromethane, dried over anhydrous sodium sulfate, filteringed system, as well as the filtrate was spin-dried to get the white strong target product Pal-Lys( Cbz)- OH (19.3 g, 93%). 1HNMR( DMSO-d6,300 MHz) δ0.83 -0.87( m,3 H),1.23 -1.69( m,34 H),2.94 -3.00( m,2 H),4.10 -4.17( m,1 H),4.57( s, 1H), 5.00( s, 2H), 7.23-7.39( m, 5H), 7.99-8.01( d, 1H), 12.43( s, 1H).

( 3) Preparation Work of Pal-Lys( Cbz)- ONHS triggered ester.

In a 500mL single-neck round-bottomed flask, liquify 19.3 g Pal-Lys( Cbz)- OH in 300mL dichloromethane, add 6.4 g N-hydroxysuccinimide (NHS), 0.91 g DMAP as well as 10.7 g EDCl under ice restroom troubles, along with coating adding Later on, it was slowly gone back to space temperature level as well as blended for 18 h. After the action, the pH of the system was adjusted to 3-4 with 1M HCl, extracted with dichloromethane, dried over anhydrous sodium sulfate, filteringed system, as well as the filtrate was spin-dried to acquire the white strong target product Pal-Lys( Cbz)- ONHS (19.4 g, 85%). 1HNMR( DMSO-d6,300 MHz) δ0.82 -0.87( m,3 H),1.23 -1.29( m,26 H),1.40 -1.50( m,4 H),1.71 -1.86( m,2 H),2.10 -2.15( m, 2H), 2.79( s, 4H), 2.95-2.99( m, 2H), 4.54-4.61( m, 1H), 5.00( s, 2H), 7.24-7.39( m, 5H), 8.42-8.44( d, 1H).

( 4) Preparation Job of Pal-Lys( Cbz)- Val-OH.

500mL single-neck round bottom flask, consider 11.7 g Na2CO3 as well as liquify it in 120mL water, include 3.9 g L-valine to liquify, under nitrogen feel, under ice restroom conditions, decline 120mL of tetrahydrofuran treatment including 17g Pal-Lys( Cbz)- ONHS, dropwise add After final thought, it was gradually gone back to location temperature level, and likewise the response was mixed for 20h. After the reaction, the pH of the system was adapted to 3-4 with 1M HCl, eliminated with ethyl acetate, dried out over anhydrous salt sulfate, filteringed system, in addition to the filtrate was spin-dried to get the white solid target thing Pal-Lys( Cbz)- Val-OH (16.5 g, 97%). 1HNMR( DMSO-d6,300 MHz) δ0.82 -0.87( m,9 H),1.22 -1.46( m,32 H),1.98 -2.12( m,3 H),2.93 -2.97( m,2 H),4.09 -4.17( m,1 H),4.30 -4.40( m,1 H),4.99( s,2 H),7.23 -7.39( m,5 H),7.84 -7.91( m,1 H),7.97 -8.01( m,1 H),12.55( s,1 H).

( 5) Preparation of Pal-Lys( Cbz)- Val-ONHS activated ester.

In a 500mL single-neck round-bottom flask, liquify 17.5 g Pal-Lys( Cbz)- Val-OH in 200mL dichloromethane, include 4.9 g N-hydroxysuccinimide (NHS), 0.69 g DMAP and additionally 8.17 g EDCl under ice restroom problems, After the enhancement, it was progressively gone back to space temperature level and stirred for 18h. After the response, the pH of the system was adjusted to 3-4 with 1M HCl, drawn out with dichloromethane, dried out over anhydrous sodium sulfate, filteringed system, and additionally the filtrate was spin-dried to acquire the white solid target item Pal-Lys( Cbz)- Val-ONHS (18.2 g, 90%). 1HNMR( DMSO-d6,300 MHz) δ0.82 -1.02( m,9 H),1.22 -1.57( m,32 H),1.98 -2.21( m,3 H),2.80( s,4 H),2.91 -2.97( m, 2H), 4.31-4.63( m, 2H), 4.99( s, 2H), 7.22-7.39( m, 5H), 7.88-7.95( m, 1H), 8.41-8.51( m, 1H).

( 6) Prep Work of Pal-Lys( Cbz)- Val-Lys( Cbz)- OH.

500mL single-neck round-bottom flask, review 11.7 g Na2CO3 and likewise liquify it in 120mL water, include 60mL tetrahydrofuran, after that include 9.3 g Nε-Cbz-L-Lysine to dissolve, at area temperature, drop right into 60mL having 19.7 g Pal-Lys( Cbz)- Val -ONHS solution in tetrahydrofuran, after the dropwise addition, the action was blended for 16h. After the response, the pH of the system was adjusted to 3-4 with 1M HCl, removed with dichloromethane, dried out over anhydrous salt sulfate, filteringed system, and also the filtrate was spin-dried to acquire the white strong target thing Pal-Lys( Cbz)- Val-Lys( Cbz )- OH (23.56 g, 97%). 1HNMR( DMSO-d6,300 MHz) δ0.78 -0.85( m,9 H),1.22 -1.59( m,38 H),1.96 -2.09( m,3 H),2.91 -2.99( m,4 H),4.12 -4.32( m,3 H),4.99( s,4 H),7.21 -7.38( m,10 H),7.60 -8.16( m,3 H),12.49( s,1 H).

( 7) Prep Work of Pal-Lys-Val-Lys-OH (palmitoyl tripeptide-8).

In a 2000mL single-neck round base flask, 23.56 g Pal-Lys( Cbz)- Val-Lys( Cbz)- OH was liquified in 1500mL methanol, and 4.7 g 5% wet Pd/C( Pal-Lys( Cbz)- Val-Lys( Cbz) was included The mass proportion of )- OH to Pd/C was 5:1), nitrogen was changed three times, and also hydrogen was transformed 3 times. Finally, the hydrogen ambience was preserved, along with the reaction was mixed at space temperature as well as normal stress for 24-hour. After the response, Pd/C was filtered off, the methanol was spin-dried, and afterwards recrystallized from ethanol to obtain the target product palmitoyl tripeptide-8 (13.1 g, 80%) as a white powder. 1HNMR( CD3OD,300 MHz) δ0.87 -0.98( m,9 H),1.29 -1.86( m,40 H),2.12 -2.31( m,3 H),2.80 -2.88( m,4 H),4.12 -4.46( m, 3H).

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Palmitoyl Tripeptide-8 Quotation