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Palmitoyl Tripeptide-5 CAS 623172-56-5

Molecular Formula: C37H67F6N5O9

Formula Weight: 839.9463992

ZSpharmac: Palmitoyl Tripeptide-5 Supplement

Product Name: Palmitoyl Tripeptide-5
CAS No: 623172-56-5
Purity: 99%

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Basic Info

Product Name:Palmitoyl Tripeptide-5
Other Names:Palmitoyl Tripeptide-5/pal-KVK
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Viscous Liquid
EINECS No.:200-798-2
Storage:Under Inert Gas (Nitrogen or Argon) at 2–8 °C
Provide:Palmitoyl Tripeptide-5 MSDS;
Palmitoyl Tripeptide-5 COA

What is Palmitoyl Tripeptide-5?

Palmitoyl tripeptide-5 is the earliest and most widely used cosmetic peptide in the peptide series. What consumers call tripeptide or collagen peptide Siped® COLL-O2 is palmitoyl tripeptide-5, because of its excellent performance in promoting the synthesis of collagen and elastin in the dermis, and the collagen peptide Siped® COLL-02 can grow through tissue Factor (TGF-β) stimulates skin collagen synthesis to achieve the anti-wrinkle purpose of smoothing and firming. Dr. Powell Kruder of Germany said: “Peptides can make people younger and healthier, and peptides have brought great changes to the world of cosmetics.” Peptides are the basic materials that make up all cells in the human body, and peptides are the form of life. It is precisely because of the special physiological activity of small molecular peptides that it can substantially improve skin problems in essence, and it has a good effect in cosmetics. Olay (OLAY), Avon (Avon), Estee Lauder (Estee Lau-der), Lancome (LANCOME), L’Oreal (L’Oreal), Chanel (Chanel), Dior (Dior), SK-II, etc., can be said to have set off peptide beauty Skincare craze. According to statistics, the sales of peptide beauty and skin care products in the international market in 2011 have exceeded 16 billion US dollars, and are still increasing at an annual rate of 30% to 40%.

Palmitoyl tripeptide-5 is one of one of the most typically made use of aesthetic little particle peptide, we call it the collagen peptide Siped ® COLL-O2; it has the residential properties of promoting the synthesis of collagen and elastin in the dermis. A suitable ingredient for fixing creases. Including palmitoyl tripeptide-5 to cosmetics can assist the skin renew collagen, boost facial elasticity, and also substantially lower facial wrinkles. It additionally has the buildings of boosting cell task, enhancing skin wetness content, improving skin luster as well as boosting skin tone. In China, such small-molecule cosmetic peptides are still in the primary and imitative stages, yet small-molecule peptides with 3 and also 4 amino acids essentially utilize solid-phase synthesis, and the elegance industry can likewise borrow the synthesis modern technology of medicinal peptides.

Palmitoyl Tripeptide-5 Anti-Aging Properties

Syn-Coll or palmitoyl tripeptide-3/ 5 (palmitoyl-lysyl-valyl-lysine bis-trifluoroacetate) is an artificial signaling oligopeptide that has actually been The growth aspect TGFβ advertises collagen formation. The peptide’s device of action resembles thrombopoietin I (TSPI) activity. TSPI is expressed in dermal cells, particularly during wound healing. This protein binds to latent TGFβ as well as induces a conformational change that enhances collagen production as a downstream result. A research revealed that treatment of wounds in TSPI-null mice with the peptide KRFK rescued TSP1-dependent activation of TGFβ in facial cells. Syn-Coll, a derivative of this series, has been conjugated to a fat moiety to boost permeability. In facial fibroblasts, the pharmacological action of the associated peptide KFK is to increase collagen synthesis and also downregulate MMP-1 expression through TGFβ. A regulated trial in 60 volunteers revealed that when made use of two times a day for 84 days, Syn-Coll decreased skin roughness greater than a sugar pill and also Pal-KTTKS lotion.

The Mechanism of Action of Palmitoyl Tripeptide-5

Palmitoyl tripeptide-5, its cosmetic effect is comparable to that of collagen injection. It can promote the synthesis of collagen and glucosamine in human fibroblasts, strengthen connective tissue, increase skin firmness, and promote cell activity; when added to cosmetics, it can supplement collagen for the skin, improve its elasticity, and significantly reduce facial wrinkles; It can increase skin moisture content, restore smoothness and firmness, improve skin tone, enhance luster and transparency; in addition, it also has the effect of plumping lips.

which are also called dermal growth-promoting factors. Collagen is a representative component of the extracellular matrix (ECM). Tissue growth factor (TGF-β) is a key component of collagen synthesis. A molecule that activates tissue growth factor is ideal for accelerating collagen production and wrinkle repair. Collagen peptide COLL-02 produces collagen by mimicking the body’s own mechanism through tissue growth factor (TGF-β). Due to its special mechanism of action, palmitoyl tripeptide-5 is widely used by well-known foreign brands as an important ingredient in anti-wrinkle formulations, mainly used in face, eye and neck care products.

Why is Palmitoyl Tripeptide-5 Communication Important?

Palmitoyl Tripeptide-5 has the capability to communicate with skin cells and also promote collagen manufacturing. Youthful, firm skin is difficult without collagen, and the older the skin, the much less collagen it generates.
Palmitoyl Tripeptide-5 informs skin cells to naturally boost collagen production, which is why it’s very reliable.
Since Palmitoyl Tripeptide-5 raises collagen production from the inside out, you may see much better results sooner than using a lotion or product that contains collagen from animal tissue without Tripeptide-5.
Palmitoyl Tripeptide-5 helps every cell preserve its health and wellness and also informs it how to do it right by telling it exactly how to do it.
We use palmitoyl tripeptide 5 in our Botox substitute lotion due to the fact that our team believe that positioning skin cells in a regular stimulation cycle (like a morning and also night skincare routine) enables the body to operate a lot more efficiently. Our Botox Option Lotion enhances this efficiency because we integrate Tripeptide-5 with All-natural Collagen, Natural Elastin, Panthenol and Aloe Vera. This is an effective mix that slows the price at which you shed collagen and also elastin cells, naturally increases skin collagen and elastin production from the inside out, and assists shield your skin from harsh environmental variables Effect.

Palmitoyl Tripeptide - 5 Applications

1. Usage

1) Syn®-COll is a deep penetrating bioactive ingredient that can be used to eliminate various types of wrinkles and repair existing stretch marks.

2) As a breakthrough anti-wrinkle product, Syn®-COll can be used in almost any skin anti-wrinkle product for various aspects of wrinkle removal.

2. Recommended concentration

The recommended concentration of palmitoyl tripeptide is 1% to 3%. Syn®-COll is a clear, transparent liquid readily soluble in any aqueous solution.

Nutritious Anti-Wrinkle Ingredients of Palmitoyl Tripeptide-5

Palmitoyl Tripeptide-5 (PalmitoylTripeptide-5) belongs to the signal peptide, which is one of the most widely utilized cosmetic small molecule peptide, and also its cosmetic effect approaches that of infused collagen.

Research studies have revealed that these peptides promote the synthesis of collagen (types I, II as well as IV) and the production of extracellular matrix healthy proteins by increasing the activity of stromal cells, reinforce connective cells, promote cell activity, and also make the skin look better. Young and also durable. Lots of famous foreign cosmetic brands (such as Estee Lauder, Chanel, Avon, etc) use palmitoyl tripeptide-5 as a nutritional anti-wrinkle raw material, since it has the capacity to promote the synthesis of collagen and also elastin in the dermis, and it is a type of increased collagen. Suitable ingredient for healthy protein manufacturing as well as wrinkle repair work. Adding it to cosmetics can assist restore collagen, enhance facial elasticity, and also dramatically decrease face creases. It also has the homes of enhancing cell activity, boosting skin dampness web content, enhancing skin luster as well as improving complexion. On top of that, it additionally has the impact of plumping lips.

On top of that, there are numerous type of tripeptides, such as collagen II (BiopeptideCL), venom-like serum protein-like peptide (Syn-Ake), copper peptide (CopperPeptide), etc, which are also called facial growth-promoting aspects.

In China, such small-molecule cosmetic peptides are still in the main as well as imitative phases, however small-molecule peptides with 3 and also 4 amino acids basically use solid-phase synthesis, and also the elegance sector can likewise borrow the synthesis innovation of medicinal peptides.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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