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Zhishang Chemical

PALMITOYL TETRAPEPTIDE-3 CAS 1228558-05-1

Molecular Formula: C24H44N6O9

Formula Weight: 560.65

ZSpharmac: PALMITOYL TETRAPEPTIDE-3 Supplement

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Product Name: PALMITOYL TETRAPEPTIDE-3
CAS No: 1228558-05-1
Purity: 99%

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Basic Info

Product Name:PALMITOYL TETRAPEPTIDE-3
Other Names:Pal-GQPR ;PalMitoyl Tetrapeptide-3
CAS:1228558-05-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Viscous Liquid
EINECS No.:0
Storage:Under Inert Gas (Nitrogen or Argon) at 2–8 °C
Provide:PALMITOYL TETRAPEPTIDE-3 MSDS;
PALMITOYL TETRAPEPTIDE-3 COA

What is PALMITOYL TETRAPEPTIDE-3?

Palmitoyl tetrapeptide-3 is a signal peptide, which can promote the synthesis of matrix healthy proteins, specifically collagen, and might also promote the synthesis of numerous proteins such as elastin, hyaluronic acid, glycosaminoglycans and fibronectin. create.

A true appeal peptide requires to have the adhering to attributes at the same time:
( 1) Specific amino acid series and also molecular weight, presently usual cosmetic peptides are 2-10 amino acid condensates;
( 2) The system is clear, and also it clearly acts on a tiny receptor in the skin;
( 3) The quantity of addition is tiny;
( 4) The majority of the sources are chemical synthesis. This type of small particle oligopeptide has the features of non-toxicity, high organic activity, particular biochemical physical system, homology and simple absorption.

The palmitoyl collection of peptides are the best among them. Palmitoyl peptides belong to signify peptides, which can advertise the synthesis of matrix proteins, specifically collagen, as well as might also promote the manufacturing of numerous healthy proteins such as elastin, hyaluronic acid, glycosaminoglycans and also fibronectin. Palmitoyl peptides promote collagen synthesis by raising the task of stromal cells, increasing skin elasticity as well as looking younger. Similar to standard anti-wrinkle resources, such as vitamin C, vitamin A by-products, but the capacity to promote collagen manufacturing is far much better than vitamin C and also vitamin A retinol. Palmitoyl tetrapeptide-3, a polypeptide cosmetic basic material, is contributed to eye lotions as well as skin firming items by several aesthetic manufacturers.

Application of Palmitoyl Tetrapeptide-3

Palmitoyl tetrapeptide-3 has significant anti-eyelid puffiness, eliminates eye bags, anti-inflammatory, enhances the skin’s tolerance to the external environment, and increases the defense against pollution. About four weeks after use, the bags under the eyes are significantly reduced, the fine lines and crow’s feet around the eyes are reduced, and the skin is firm and plump. Examples of its application are as follows:

1) Prepare an age-reducing skin care product for cell gene regeneration and repair, which is composed of the following raw materials by weight: human placenta extract 8-20%, magnesium ascorbyl phosphate 4-10%, acetyl hexapeptide ~81~ 3%, palmitoyl oligopeptide 1~3%, palmitoyl tetrapeptide ~31~3% tocopherol 1~3%, sea celery extract 0.05~2%, sodium hyaluronic acid 0.05-3%, xanthan gum 3-5%, bis(hydroxymethyl)imidazolidinyl urea 0.30%, allantoin 0.20%, tetrasodium EDTA 0.10%, sodium metabisulfite 0.03%, butanediol 11.00%, and the balance is deionized water. Due to the use of an appropriate ratio of peptide firming factors (acetyl hexapeptide~8, palmitoyl oligopeptide, palmitoyl tetrapeptide~3), combined with human placenta extract and sea celery extract, it can tighten the skin and increase skin elasticity , Anti-wrinkle, anti-aging effect.

2) Prepare a skin care product for repairing cells, which is composed of the following raw materials by weight: 10-15 parts of human placenta extract, 4-10 parts of N-hexanoyl-phytosphingosine, and 4 parts of cetyl ethylhexanoate ~6 parts, palmitoyl oligopeptide 4~6 parts, palmitoyl tetrapeptide-34~6 parts tocopherol 4~6 parts, sea celery extract 0.05~2 parts, sodium hyaluronic acid 0.05~3 parts, xanthogen 3~5 parts of glue, 0.30 parts of bis(hydroxymethyl) imidazolidinyl urea, 0.20 parts of allantoin, 0.10 parts of EDTA tetrasodium, 0.03 parts of sodium metabisulfite, 11.00 parts of 1,2-pentanediol, sage 10 parts of leaf extract, the balance is deionized water. Due to the proper proportion of repairing factors (cetyl ethyl caproate, palmitoyl oligopeptide, palmitoyl tetrapeptide-3), combined with human placenta extract, medicinal sage leaf extract has firm skin, increased Skin elasticity, anti-wrinkle, anti-aging effect.

3) Prepare a facial mask essence that increases skin elasticity and can also improve skin roughness. It is composed of the following raw materials by weight percentage: 12-25% of propolis, 5-8% of snail secretion filtrate, and 2-5% of sea buckthorn seed oil , Sandalwood Oil 0.5~1%, Magnesium Ascorbyl Phosphate 5~8%, Arbutin 1~3%, Ylang Ylang Essential Oil 1~3%, Rosemary Essential Oil 1.5~2.0%, Matricaria Flower Extract 1~3% , Sargassum extract 5~10%, Centella asiatica extract 3~5%, Palmitoyl tetrapeptide-3-1~3%, Phytosphingosine 1~3%, Tocopherol 1~3%, Hyaluronic acid Sodium Acid 0.05~3%, Acetyl Hexapeptide-3-0.2%~0.3%, Allantoin 0.15~0.2%, Bisabolol 0.15~0.20%, Sodium Pyrosulfite 0.01~0.03%, VC-1~3% And isopropyl myristate 8.0%~9.0%, the balance is deionized water. The present invention can effectively lift and tighten the skin, promote the metabolism and respiration of the skin, and can obtain a soft, smooth, elastic and beautiful touch of the skin.

4) An anti-aging cosmetic cream is prepared, which is composed of the following raw materials by weight: 1-4 parts of avocado stem cell extract, 0.05-2 parts of celery total flavonoids, 0.5-1.5 parts of plant extract, 3 parts of magnesium ascorbyl phosphate ~9 parts, acetyl hexapeptide-8-1-3 parts, palmitoyl oligopeptide 1-3 parts, palmitoyl tetrapeptide-3-1-2 parts, tocopherol 1-2 parts, sodium hyaluronate 0.05- 2.55 parts, xanthan gum 2-4 parts, bisimidazolidinyl urea 0.2-0.3 parts, allantoin 0.1-0.2 parts, tetrasodium EDTA 0.02-0.08 parts, sodium metabisulfite 0.02-0.03 parts, butanediol 8-14 parts Parts, deionized water to 100 parts, can effectively slow down the aging caused by natural or unnatural factors and reduce skin symptoms such as pigmentation, tanning, and it is safe and non-irritating.

5) Preparation of a complex for eliminating eye bags and dark circles, the complex is composed of the following components by weight percentage: palmitoyl tetrapeptide-3-0.025%-0.035%, dipeptide-2-0.08 %-0.12%, Acetyl Tetrapeptide-5-0.1%-0.2%, Methyl Hesperidin Chalcone 4%-6%, Sodium Hyaluronate 0.2%-0.4%, Glycerin 4%-6%, 1, 2-Hexanediol 0.3%-0.5%, the balance is pure water. The compound prepared by the invention can be prepared into eye essence, eye cream, eye mask and other cosmetic and skin care products, and has the effect of diluting eye bags and dark circles.

Palmitoyl Tetrapeptide-3 Clinical Trials

Palmitoyl Tetrapeptide-3 has been medically shown to hinder the body’s manufacturing of interleukin (IL6), a chemical carrier that triggers inflammation, the initial step in the aging waterfall. Inflammation is immune feature, a safety action to cells damage or damage. This is the body’s method of isolating damaging materials and also damaged cells. Under regular situations, the secretion of IL6 is very tiny and also its secretion is strictly regulated. However, with age, this governing system becomes faulty and considerable degrees of IL6 appear in plasma also in the lack of inflammatory stimulation. This leads to high degrees of inflammatory healthy proteins in the cells and also loss of healing capacity. At concentrations over 10 ppm, Palmitoyl Tetrapeptide-3 considerably decreases the secretion of the cytokine IL6. This reduction is progressive as well as depends upon the concentration of the peptide: baseline secretion can be prevented by approximately 40%. Palmitoyl Tetrapeptide-3 minimized IL6 levels by as much as 86% after cells were exposed to UV radiation, even though IL6 had actually been raised regarding 20-fold by UV. These results suggest that Palmitoyl Tetrapeptide-3 has the ability to influence baseline levels of IL6 in addition to modulate the results of UV-stimulated IL6 overproduction. Palmitoyl Tetrapeptide-3 is marketed by Sederma as a molecule that brings back the equilibrium of cytokines that are characteristic of younger skin. Palmitoyl Tetrapeptide-3 minimized IL6 levels by up to 86% after cells were exposed to UV radiation, even though IL6 had been enhanced regarding 20-fold by UV. These results suggest that Palmitoyl Tetrapeptide-3 has the ability to influence baseline levels of IL6 as well as modulate the effects of UV-stimulated IL6 overflow. Palmitoyl Tetrapeptide-3 is marketed by Sederma as a particle that restores the equilibrium of cytokines that are characteristic of youthful skin. Palmitoyl Tetrapeptide-3 minimized IL6 levels by as much as 86% after cells were subjected to UV radiation, even though IL6 had been enhanced regarding 20-fold by UV. These results suggest that Palmitoyl Tetrapeptide-3 has the ability to impact baseline levels of IL6 as well as modulate the impacts of UV-stimulated IL6 overproduction. Palmitoyl Tetrapeptide-3 is marketed by Sederma as a molecule that recovers the equilibrium of cytokines that are characteristic of youthful skin.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get PALMITOYL TETRAPEPTIDE-3 Quotation