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Zhishang Chemical

Palmitoyl Pentapeptide CAS 214047-00-4

Molecular Formula: C39H75N7O10

Formula Weight: 802.05

ZSpharmac: Palmitoyl Pentapeptide Supplement

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Product Name: Palmitoyl Pentapeptide
CAS No: 214047-00-4
Purity: 99%

Basic Info

Product Name:Palmitoyl Pentapeptide
Other Names:Palmitoyl Pentapeptide-3
CAS:214047-00-4
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:606-757-9
Storage:2-8°C(protect from light)
Provide:Palmitoyl Pentapeptide MSDS;
Palmitoyl Pentapeptide COA

What is Palmitoyl Pentapeptide?

Palmitoyl Pentapeptide is a tiny molecule healthy protein, additionally referred to as polypeptide or peptide. It is made up of amino acids with a particular series connected by amide bonds. Peptides play essential functions in the growth, growth and metabolic process of microorganisms.Peptides play vital roles in natural skin aging and also skin care processes, such as cell proliferation, cell movement, inflammation, angiogenesis, coloring, and also protein synthesis and law.

Palmitoyl Pentapeptide Properties:

Boiling point 1120.1±65.0 °C(Predicted)
density 1.147
storage temp. 2-8°C(protect from light)
pka2.98±0.10(Predicted)

 

Palmitoyl Pentapeptide Uses

Palmitoyl Pentapeptide has just 13 amino acids with little molecular weight as well as is conveniently soaked up. Among its substantial impacts is that it can promote the expansion of collagen as well as indirectly fix the micro-damage of the human dental mucosa. The anti-aging effect of Palmitoyl Pentapeptide can avoid and enhance gum tissue economic downturn. On top of that, Palmitoyl Pentapeptide can advertise the expansion of hyaluronic acid as well as elastic fibers, and can effectively turn on the synthesis of hyaluronic acid, which is really crucial for preserving oral moisture and also alleviating completely dry mouth.

Preparation of Palmitoyl Pentapeptide

1. Preparation of Fmoc-Ser(tBu)-WangResin 1.71g WangResin was put into the reaction column, washed once with DMF, and drained; use an appropriate amount of dry dichloromethane to swell at room temperature, stir with N2 for 30min until the resin is fully swollen, and drain the liquid ; DMF washed once and drained; re-evaporated DMF washed once and drained. 3.07g Fmoc-Gly-OH, 1.30g HOBt, 1.49ml DIC in DMF/DCM (1:1) solution 5ml were added. After the reaction for 5 min, 0.10 g of DMAP was added, and the reaction was continued for 4 h. After the reaction, the reaction solution was drained, washed three times with DMF and drained, and a little resin was taken out for substitution detection. Subsequently, 200 ml of blocking reagent (AC2O/pyridine (7:6, V:V)) was added, reacted for 8-16 h, washed twice with DMF; washed twice with anhydrous methanol (10 min/time), and dried under vacuum to constant weight. The substitution degree of Fmoc-Ser(tBu)-WangResin was measured to be 0.71 mmol/g.

2. Preparation of Matrixyl-WangResin 1) In the Fmoc-Ser(tBu)-WangResin reaction column, add DCM to swell for 20-30min, and remove it. Add DBLK solution (piperidine/DMF (V/V)=1:4) for deprotection twice (5+10min), add DMF to wash for 1min between the two deprotection, and remove. After two times of deprotection and extraction, use DMF, methanol, DCM, DMF to wash once each, pick a little resin with a glass rod, indene test, it shows dark purple red, indicating that Fmoc has been removed, and it is ready to be fed. 2) During the deprotection process, weigh 0.93g of Fmoc-Lys(Boc)-OH and 0.81g of HOBt into a beaker, add 2ml of refined DMF to dissolve, and after complete dissolution, put the beaker into an ice bath to cool for 2 minutes, and then Add 0.93ml DIC and activate it in the solution for 8min. If white flocculent foam appears, it indicates that the activation is complete. Use a Buchner funnel to filter out the small white solid particles in the activation solution. Pour the obtained clear filtrate into the reaction column, and then add DMF. In the reaction column, adjust N2 so that the resin is evenly blown up, cover the drying tube, and keep no wall hanging during the reaction process. If wall hanging occurs, use a little refined DMF to flush the resin on the wall to in the reaction solution. The reaction was carried out at room temperature for 2 hours, and after passing the indene test, the reaction solution could be removed to continue connecting the next amino acid.

3. Cleavage of Matrixyl-WangResin Put 0.10 g of MatrixylWangResin dried to constant weight in a glass flask, and add TFA-anisole-anisole-EDT (volume ratio 95:5:3:2) under stirring in an ice bath. 4ml, reacted for 30min, gradually raised to room temperature, and reacted at room temperature for 2h. Filter, wash the resin with a little TFA, pour the filtrate into 40ml of anhydrous ice ether to precipitate a white solid, centrifuge at 4000rpm for 4min, discard the supernatant, repeat twice, and vacuum dry to obtain 46.6mg of crude peptide.

4. Analysis and identification of Matrixyl crude peptide The crude Matrixyl was analyzed by RPHPLC. The HPLC-ESI-MS analysis of Matrixyl after purification showed that its m/z 402.3{[M+H]2+}, the molecular weight of Matrixyl was 802.05, and the theoretical value was the same as that of Matrixyl. The actual value matches.

Exploring The Secret - Anti-Aging God Five Peptides

Beauty Holy Product – Palmitoyl Pentapeptide
Palmitoyl Pentapeptide was first used by the dermatology medical community to act directly on the dermis with anti-aging ingredients such as vitamin A, promote collagen proliferation, and achieve the purpose of skin firming. Together with other moisturizing ingredients, it can accelerate skin firming.

Palmitoyl Pentapeptide is a kind of peptide, belonging to the signal peptide. Those who have studied biology will not be unfamiliar with peptides. Peptides, a small molecular protein in the human body, are hydrolyzed and converted into extremely small molecular weight substances composed of several amino acids. The properties are stable and easily absorbed by the human body. Palmitoyl Pentapeptide refers to a peptide composed of five amino acids connected by a peptide chain. Compared with the traditional hydrolyzed protein peptides, the five peptides in skin care products have a more tidy peptide sequence, so they can have a specific anti-aging function.

As a member of the signaling peptides, Palmitoyl Pentapeptide can promote the synthesis of matrix proteins, especially collagen, by increasing the activity of stromal cells, and can also improve the formation of elastin, hyaluronic acid, glycosaminoglycans and fibronectin. It can make the skin elastic and achieve the purpose of anti-aging. For example, Olay’s ProX Apple Muscle Essence is added with anti-aging god five peptides, which increases the collagen inside the skin and makes it plump and orderly. At the same time, compared with other anti-aging substances, peptides, as protein fragments, can easily pass through the stratum corneum gap and enter the dermis, exerting due effects, and the application rate is higher.

However, even if the application rate is very high, peptides have a certain period of action (mostly four weeks), so peptide skin care products should be adhered to for a long time in daily use. What’s more, the combination of peptides and other functional ingredients can increase its ability to penetrate the skin and maximize its anti-aging effects. For example, ProX apple muscle essence combines Palmitoyl Pentapeptide, dipeptide and cellular B3 (nicotinamide) factor to achieve the effect of restoring apple muscle.

1. Firms the skin

Palmitoyl Pentapeptide is originally a small molecule protein in the human body. It can be quickly converted into nutrients needed by cells for the areas that need to be modified for fine lines and wrinkles. Wrinkles are removed, and the skin regains its youthful, smooth and delicate state.

2. Remove red blood

It can effectively inhibit the erosion of pathogenic bacteria such as Pseudomonas aeruginosa and Bacillus acnes on the facial skin; reduce facial redness and telangiectasia, improve redness, effectively resist skin inflammation, and reduce allergic discomfort.

3. Bright eyes

Improve eye lymphatic microcirculation, skin elasticity and anti-edema function, promote the proliferation of collagen and hyaluronic acid, improve skin moisture content and elasticity, and relieve eye bags and dark circles.

4. Deep hydration

Promotes the growth of skin collagen and reminds the skin to enhance moisture retention, giving the skin the ability to resist daily stress stimuli and challenges, especially suitable for improving fragile, tired and dull skin and rejuvenating its vitality.

5. Fight against wrinkles

With similar nerve conduction inhibitory function, it can relax the expression lines caused by nervous tension, slow down facial wrinkles and cell aging, and long-term use can increase the resilience of cells, rejuvenate the skin, and improve static lines.

Today, the initial research on the anti-aging object Palmitoyl Pentapeptide has made it the main ingredient in anti-aging skin care products, and the follow-up research is also very exciting. Through this article, I also hope to increase most people’s understanding of pentapeptide, an anti-aging substance, which can be regarded as a small exploration.

Palmitoyl Pentapeptide is the darling of cosmetic engineers. Mainstream international brands are mainly used for lifting and tightening and eye care. It has extremely high hydrophilicity, promotes the production of hyaluronic acid, increases the moisture content of the skin, and makes it silky, supple and tender. Full of elasticity. The dense keratin of the skin blocks the penetration of skin care factors into the dermis of the skin, and most skin care products only stay on the surface of the skin. The bioactive Palmitoyl Pentapeptide can enter the dermis, promote collagen proliferation, increase skin moisture content, increase skin thickness and reduce fine lines.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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