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Palmitoyl Hexapeptide-12 CAS 171263-26-6

Molecular Formula: C38H68N6O8

Formula Weight: 736.98

ZSpharmac: Palmitoyl Hexapeptide-12 Raw Material Supplier

Product Name: Palmitoyl Hexapeptide-12
CAS No: 171263-26-6
Purity: 99%

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Basic Info

Product Name:Palmitoyl Hexapeptide-12
Other Names:Palmitoyl Hexapeptide
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Liquid
EINECS No.:256-145-7
Storage:Room Temperature
Provide:Palmitoyl Hexapeptide-12 MSDS;
Palmitoyl Hexapeptide-12 COA

What is Palmitoyl Hexapeptide-12?

Because Fleming uncovered that bacteria generate penicillin, microbes have come to be an essential source of naturally energetic substances, supplying a rich resource for all-natural artificial chemicals. Early study on biosurfactants was seen in 1946. After 1965, research on the emulsification mechanism of hydrocarbons by microorganisms attracted individuals’s attention. Surfactant generated by microorganisms is just one of the vital mechanisms by which microbes improve oil healing. The use of bacteria to create surfactants has actually come to be a new topic in the field of biotechnology. Biosurfactants are metabolites with particular surface area activity secreted throughout the metabolic procedure of bacteria when they are cultured under certain conditions, such as glycolipids, polysaccharide proteolipids, lipopeptides, phospholipids and neutral lipid derivatives of fatty acids, etc. They are comparable in framework to basic surfactant particles, that is, the particles not only consist of non-polar hydrophobic teams composed of aliphatic hydrocarbon chains, yet also contain polar hydrophilic groups. In 1968, Arima et al. first found that Bacillus subtilis creates lipopeptide surfactants, which are crystalline and have the trade name surfactin. This sort of surfactant primarily contains: iturin Amongst them, surfactin has the strongest surface activity and is one of one of the most reliable biosurfactants reported until now.
Lipopeptide (lipopeptide, peptidolipid) is additionally called acylpeptide. The lipopeptide molecule is composed of hydrophilic peptide bonds as well as lipophilic aliphatic hydrocarbon chains. It has excellent surface area activity and also can boost the organic activity of hydrophobic hydrocarbons. availability, stimulates the biodegradation of hydrocarbons, as well as can remove heavy metals from contaminated soil as well as sediments when incorporated with some heavy metals. It is an important sort of biosurfactant; at the same time, it also has unique organic task as well as can enhance urine circulation. Kinase activity stops blood clotting. The majority of lipopeptides have antimicrobial results and are also known as prescription antibiotics. Due to its unique chemical composition and amphiphilic molecular framework, lipopeptide biosurfactants have crucial application leads in the fields of medication, microbial oil recovery, and environmental management. There are lots of lipopeptide biosurfactants found until now.

Palmitoyl Hexapeptide-12 Property

Boiling point 1024.8±65.0 °C(Predicted)
density 1.105±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature


Applications of Palmitoyl Hexapeptide-12

The surface area task of biosurfactants amounts that of chemically synthesized surfactants, but it has the advantage of being biodegradable and for that reason does not create ecological damage. Biosurfactants have wide application potential customers in a selection of areas as well as can be used in industries such as food, cosmetics, medicine, and microbial oil healing.
Oil Removal
Microbial enhanced oil recovery (microbialenhancedoilrecoverMEOR) innovation is a vital application field of biosurfactants. In oil area exploitation, about 70% of the petroleum remains in the storage tank after one removal. Boosted oil recuperation can increase the oil recovery rate to 80% -85%. Utilizing biosurfactants to displace oil will not cause pollution to the atmosphere. Palmitoyl Hexapeptide-12, produced by Bacillus licheniformis NK-X3, does not end up being non-active at a high temperature of 120 ° C at a pH of 4 to 12 as well as a calcium ion mass concentration of 4000 mg/L. These characteristics are beneficial to making use of this item in petroleum. Utilized in increased mining as well as transportation.

Antiviral Effect
The inactivation effectiveness of surfactin for lipid-enveloped infections is greater than that of non-lipid-enveloped viruses, particularly herpes viruses and retroviruses. Its system of action is that it can interact with phospholipids (Phospholipids) on the cell membrane to create ion networks, chelating monovalent and also divalent cations, therefore preventing the activity of numerous enzymes such as CyclicAMPphosphodiesterase and cytoplasmic PLA2; surfactin can likewise interact with The virus lipid membrane (Viruslipid membrane) engages to destroy the virus lipid membrane and also capsid, thereby revealing antiviral, antitumor, antimycoplasma, antifungal and a particular degree of anti-bacterial task. The antibiotic Iturin has a broad range of repressive results on plant pathogenic germs. It can be utilized as an organic control agent to change some chemical pesticides as well as can properly hinder the harm of pathogenic germs to tomatoes. Different stress of Bacillus subtilis can likewise generate bacilli antimycin analogs, which additionally have solid antifungal activity. The lipopeptide antibiotic created by Bacillus subtilis B2 strain is made use of to stop as well as manage Chinese cabbage soft rot and rapeseed sclerotinia, as well as has a good control impact.

Deterioration of Recurring Pesticides
Adding Palmitoyl Hexapeptide-12 surfactant or surfactant-producing germs to pesticide-contaminated dirt can dramatically break down harmful active ingredients. The deterioration price of endosulfan pesticide can be boosted by 30% to 45%.

For the Control of Plant Pathogenic Germs
The antibiotic Iturin has a broad range of inhibitory results on plant pathogenic bacteria. The yield of Iturin obtained by solid society fermentation of soybean residue is 10 times that of fluid culture. This culture fluid can effectively hinder Rhizoctonia in tomatoes. Experiments have actually shown that Iturin can be made use of as an organic control agent to replace chemical pesticides, enabling organic wastes in the food market to be converted by germs right into natural wastes with biopesticide effects, properly realizing the recycling of natural wastes. Various strains of Bacillus subtilis can additionally create bacilli antimycin analogs, which additionally have solid antifungal activity.

Get Rid of Heavy Metal Ions From Infected Dirt
Palmitoyl Hexapeptide-12 can selectively eliminate heavy metal ions such as Pb, Zn, Cu and also Cd from soil. Among them, Cu is the easiest to eliminate, as well as NaOH or Na2CO3 has an essential impact on the removal of Cu. The reason why heavy metal ions can be eliminated is that they have a negative charge as well as can bind to positively charged metal cations. The lipopeptide lichenysin created by Bacillus licheniformis can chelate cations, as well as lichenysin is a more secure cation chelator than surfactin. The number proportion of the Lichenysin-Ca2+ complex is 2:1, that is, one Ca2+ can bind 2 lichenin particles, and also the binding ratio of Surfactin is 1:1.

Foaming Performance
Surfactin can form stable foam in aqueous service. The frothing volume almost remains unchanged when the Surfacin focus raises from 0.05 to 0.2 mg/ml. The foam formed is much more consistent as well as delicate than BSA (bovine serum albumin). Moreover, the lathering of Surfactin generates a collaborating impact after including BSA. The lipid and also peptide structures of lipopeptide surfactants have an impact on foaming residential or commercial properties. The foaming performance is best when the carbon chain number is 14 carbon atoms. When the carbon number increases to over 15, the foam volume lowers greatly. C13 has great emulsifying efficiency while the various other 2 have great lathering performance. When the number of carbon atoms is the same, Surfactin can generate more delicate foam while Iturin can generate foam with much better stability, suggesting that the peptide framework has an important influence on lathering performance.

Preparation and Production of Palmitoyl Hexapeptide-12

Stress testing: capillary method, Wilhelmian hanging plate approach, ring approach, bubble pressure method and hanging decrease method, bead axis balance analysis approach as well as colorimetric technique.
Culture conditions: In an iron ion-enriched tool, the production of Surfactin will certainly be greatly boosted; when the Mn2+ focus in the sugar medium is 0.01 mmol/L, the mass focus of Surfactin can reach 2.6 g/L, which is typically 0.33 g/L. 8 times of L.
Nutrient substrate: In a culture medium making use of ammonium nitrate as a nitrogen source, when the ammonium is consumed, bacteria will make use of nitrate as a nitrogen resource under anaerobic conditions; additionally, waste fluid from potato processing is utilized to make It is possible to produce Surfacin by cultivating Bacillus subtilis with carbon resource.
Production process: The traditional manufacturing process is to make use of fermentation containers to cultivate microorganisms to generate surfactants. Somebody has actually researched the expediency of using wheat bran as raw material to make a stuffed column activator to allow Bacillus subtilis to produce surfactants, suggesting that the stuffed column reactor can be utilized in the business area as a solid-phase response system for the manufacturing of biosurfactants.

Palmitoyl Hexapeptide-12 Review

The surface area task of biosurfactants can be evaluated by the surface area stress in between air and also water and also the interfacial stress between the oil/water interface, or by the instability of the emulsion (emulsification splitting capacity) and also the hydrophilic-lipophilic value. (HLB); or expressed by the effectiveness of biosurfactants – important micelle concentration (CMC). The lipopeptide biosurfactant fermentation broth generated by Daqing Huali Energy Biotechnology Co., Ltd. has a surface area tension of 26.3 Mn/ml and also an essential micelle concentration of 23.4 mg/L after being put in the container. Zhang Cuizhu et al. evaluated a pressure of Bacillus licheniformis NK-X3 from the wastewater of Dagang Refinery and also generated a Palmitoyl Hexapeptide-12 with a pH series of 4-12 as well as a high calcium ion focus of 4000 mg/L and also a high salt concentration of 15%. It still preserves its initial surface task under high temperature, as well as its exceptional attribute is that it does not shut down at heats of 120 ° C. This item can reduce the surface stress of water from 76.6 to 35.5 Mn/ml, its emulsification task value is 1.50, the critical micelle focus worth is 30.0 mg/L, as well as the thickness reduction price of high colloidal asphaltene oil is as high as 50%. Over, the solubilization and also desorption effects are considerable, which can make oil and also water liquify right into each other to create oil-in-water emulsion beads, so that high wax material oil can be properly emulsified and also distributed.

About Products:
If you need Palmitoyl Hexapeptide-12, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
Our company, as an experienced Palmitoyl Hexapeptide-12 manufacturer and supplier, ZSpharmac will provide Palmitoyl Hexapeptide-12 raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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