Zhishang Chemical

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Zhishang Chemical

Palmitoyl Hexapeptide-12 CAS 171263-26-6

Molecular Formula: C38H68N6O8

Formula Weight: 736.98

ZSpharmac: Palmitoyl Hexapeptide-12 Supplier

Product Name: Palmitoyl Hexapeptide-12
CAS No: 171263-26-6
Purity: 99%

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Basic Info

Product Name:Palmitoyl Hexapeptide-12
Other Names:lipopeptide
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Viscous Liquid
EINECS No.:256-145-7
Storage:Sealed in Dry,Room Temperature
Provide:Palmitoyl Hexapeptide-12 MSDS;
Palmitoyl Hexapeptide-12 COA

What is Palmitoyl Hexapeptide-12?

Given that Fleming discovered that microorganisms create penicillin, microbes have actually come to be an essential resource of naturally active materials, giving abundant sources for natural artificial chemicals. The very early research study on biosurfactants was seen in 1946. After 1965, the study on the emulsification mechanism of hydrocarbons by microbes attracted people’s interest. Surfactants created by microbes are among the vital mechanisms for bacteria to boost oil recovery. Making use of microorganisms to create surfactants has actually become a new topic in the field of biotechnology. Biosurfactants are metabolites with particular surface task produced by bacteria during their metabolic process when cultured under particular conditions, such as glycolipids, polysaccharide protein lipids, Palmitoyl Hexapeptide-12, phospholipids and fat neutral lipid derivatives things etc. They are comparable in structure to general surfactant molecules, that is, there are not only non-polar hydrophobic groups made up of aliphatic hydrocarbon chains in the particles, yet also polar hydrophilic teams. In 1968, Arima and others found for the first time that Bacillus subtilis created lipopeptide surfactants in the form of crystals. The trade name was surfactin. This type of surfactant generally had: iturin (Iturins), Bacilomycin (Bacilomycin), Fengycin (Fengycin) and also Surfacin (Surfacin), among which surfactin has the greatest surface area activity as well as is among the best biosurfactants reported up until now. Palmitoyl Hexapeptide-12 (lipopeptide, peptidolipid) is likewise called acylpeptide. The lipopeptide particle is made up of a hydrophilic peptide bond and also a lipophilic aliphatic hydrocarbon chain. It has excellent surface area task as well as can enhance hydrophobic hydrocarbons. bioavailability, promote the biodegradation of hydrocarbons, combined with some heavy metals can get rid of heavy metals in contaminated soil and also debris, is a crucial course of biosurfactants; at the same time, it additionally has special organic task, can Enhance the task of urokinase to prevent blood clotting. A Lot Of Palmitoyl Hexapeptide-12 has antimicrobial results, additionally referred to as prescription antibiotics. Due to its special chemical composition as well as amphiphilic molecular structure, lipopeptide biosurfactants have essential application potential customers in the fields of medication, microbial oil healing, as well as ecological administration. There are loads of lipopeptide biosurfactants discovered so far.

Palmitoyl Hexapeptide-12 Property

Boiling point 1024.8±65.0 °C(Predicted)
density 1.105±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature


Application of Palmitoyl Hexapeptide-12

The surface activity of biosurfactants is equivalent to that of chemically synthesized surfactants, but has the advantage of being biodegradable and thus does not cause environmental hazards. Biosurfactants have broad application prospects in various fields, and can be used in industries such as food, cosmetics, medicine, and microbial oil recovery.
oil extraction
Microbial enhanced oil recovery (microbialenhancedoilrecoverMEOR) technology is an important application field of biosurfactants. In oilfield exploitation, after one exploitation, about 70% of the crude oil remains in the oil reservoir. Enhanced oil recovery can increase oil recovery to 80%-85%. Using biosurfactant to flood oil will not pollute the environment. A Palmitoyl Hexapeptide-12 biosurfactant produced by Bacillus licheniformis NK-X3, under the conditions of pH 4-12 and calcium ion mass concentration 4000mg/L, will not be inactivated at 120°C. These characteristics are It is beneficial for the product to be used in increasing recovery and transportation of crude oil.

Antiviral effect
The inactivation efficiency of surfactin for lipid-enveloped viruses is higher than that for non-lipid-enveloped viruses, especially for herpes viruses and retroviruses. Its mechanism of action is that it can interact with phospholipids on the cell membrane to form ion channels, chelate monovalent and divalent cations, thereby inhibiting the activity of various enzymes such as CyclicAMPphosphodiesterase and cytoplasmic PLA2; surfactin can also interact with Virus lipid membrane (Viruslipidmembrane) interacts to destroy the viral lipid membrane and capsid, thus exhibiting antiviral, antitumor, antimycoplasma, antifungal and to a certain extent antibacterial activities. Antibiotic Iturin has a broad-spectrum inhibitory effect on plant pathogenic bacteria, can be used as a biological control agent to replace some chemical insecticides, and can effectively inhibit the damage of pathogenic bacteria to tomatoes. Different strains of Bacillus subtilis can also produce bacillus antimycin analogs, which also have strong antifungal activity. The Palmitoyl Hexapeptide-12 antibiotic produced by Bacillus subtilis B2 strain is used for the prevention and treatment of Chinese cabbage soft rot and rape sclerotinia, and has a good control effect.

Degradation of residual pesticides
Adding lipopeptide biosurfactants or surfactant-producing bacteria to pesticide-contaminated soil can significantly degrade harmful components. The degradation rate of endosulfan insecticide can be increased by 30% to 45%.

For the control of plant pathogens
Antibiotic Iturin has a broad-spectrum inhibitory effect on plant pathogenic bacteria. The yield of Iturin obtained by solid culture and fermentation of soybean residue is 10 times that of liquid culture, and this culture solution can effectively inhibit Rhizoctonia of tomato. Experiments have shown that Iturin can be used as a biological control agent to replace chemical pesticides, so that organic waste in the food industry can be converted into organic waste with biopesticide effects by bacteria, effectively realizing the recycling of organic waste. Different strains of Bacillus subtilis can also produce bacillus antimycin analogs, which also have strong antifungal activity.

Remove heavy metal ions from contaminated soil
Palmitoyl Hexapeptide-12 biosurfactant can selectively remove heavy metal ions such as Pb, Zn, Cu and Cd in soil. Among them, Cu is most easily removed, and NaOH or Na2CO3 has an important influence on the removal of Cu. The reason for the ability to remove heavy metal ions is that they are negatively charged and can bind positively charged metal cations. The lipopeptide lichenin produced by Bacillus licheniformis can chelate cations, and lichenin is a more stable cation chelating agent than actin, and the number ratio of Lichenysin-Ca2+ complexes is 2:1, that is, one Ca2+ can bind Two lichenin molecules, and the binding ratio of Surfactin is 1:1.

Foaming properties
Surfactin can form a stable foam in aqueous solution, and the foaming volume of Surfacin concentration increases from 0.05 to 0.2 mg/ml almost unchanged, and the foam formed is more uniform and delicate than BSA (bovine serum albumin). Moreover, the foaming of Surfactin after adding BSA produces a synergistic effect. The lipid-based and peptide-based structures of lipopeptide surfactants have an effect on foaming properties. The foaming performance is the best when the carbon chain number is 14 carbon atoms. The foam volume decreases sharply when the carbon number increases above 15, C13 has good emulsifying performance while the other two have good foaming performance. When the carbon number is the same, Surfactin can produce finer foam and Iturin can produce more stable foam, indicating that the peptide structure has an important influence on the foaming performance.

Preparation and Production of Palmitoyl Hexapeptide-12

Strain screening: capillary method, Wilhelmy hanging method, ring method, bubble pressure method and hanging drop method, drop axis symmetry analysis method and colorimetric method.
Culture conditions: In the medium rich in iron ions, the yield of Surfactin will be greatly improved; when the concentration of Mn2+ in the glucose medium is 0.01mmol/L, the mass concentration of Surfactin can reach 2.6g/L, which is generally 0.33g/L 8 times of L.
Nutrient substrate: In the culture medium using ammonium nitrate as a nitrogen source, when the ammonium is consumed, the microorganisms will use nitrate as a nitrogen source under anaerobic conditions; It is feasible to culture Bacillus subtilis with carbon source to produce Surfacin.
Production process: The traditional production process is to use fermentation tanks to cultivate bacteria to produce surfactants. Someone has studied the feasibility of using wheat bran as a raw material to make a packed column reactor to make Bacillus subtilis produce surfactants, indicating that the packed column reactor can be used in the commercial field as a solid-phase reaction system for the production of biosurfactants.

About Products:
If you need Palmitoyl Hexapeptide-12, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Palmitoyl Hexapeptide-12 manufacturer and supplier, ZSpharmac will provide Palmitoyl Hexapeptide-12 raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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