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Paeonol CAS 552-41-0

Molecular Formula: C9H10O3

Formula Weight: 166.17

ZSpharmac: Paeonol Supplement

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Product Name: Paeonol
CAS No: 552-41-0
Purity: 99%

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Basic Info

Product Name:Paeonol
Other Names:Paeonol 99%
CAS:552-41-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Beige Crystalline Powder
EINECS No.:209-012-2
Storage:2-8°C
Provide:Paeonol MSDS;
Paeonol COA

What is Paeonol?

Paeonol, as the major medical element of Paeonol, has actually obtained more and more interest in the last few years, and also the research outcomes of its physicochemical homes, medicinal impacts and detection and removal have actually been fruitful.

Paeonol is white or yellow-colored lustrous needle-like crystal, anemic needle-like crystal (ethanol), melting point 49 ℃ -51 ℃, special scent, somewhat spicy, conveniently soluble in ethanol as well as methanol, E (1% 1cm) at 274nm wavelength is 862. Using this home, it can be identified by ultraviolet spectrophotometer.

Paeonol Property

Melting point 48-50 °C(lit.)
Boiling point 154 °C / 20mmHg
density 1.3102
refractive index 1.5452 (estimate)
Fp >230 °F
storage temp. 2-8°C
solubility Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
pka9.79±0.10(Predicted)
form Crystalline Powder
color White to beige

 

Paeonol Uses

  1. An energetic ingredient isolated from Danpi. Its pharmacological impacts include anti-aggregation, anti-inflammatory, anti-ischemia-reperfusion injury as well as anti-lipid peroxidation.
  2. Paeonol is used as an anti-rheumatic drug with anti-inflammatory and analgesic results.
  3. Paeonol has sedative, hypnotic, anti-bacterial, anti-inflammatory, antioxidant, and also hypotensive impacts. In cosmetics: Paeonol can prevent the production of intracellular O2-free radicals, bleach the skin, restore and also fade the pigment deposited in the skin, remove silt spots, minimize inflammation, minimize swelling and pain, anti-allergic, anti-virus and other results. It has far better therapy and health care results on coloring, muscle mass pain, itchy skin, psoriasis, shingles, and also dermatitis. On top of that, it has better results in toothpaste, gargle, tooth powder, and tooth pain water.

Pharmacological Effects of Paeonol

Paeonol has a particular possible value in the growth and also application of practical wellness products, yet there is still an absence of methodical and extensive toxicological safety examination information. In this study, the effects of paeonol on the acute toxicity of nematodes as well as signs such as electric motor actions, feeding behavior as well as reproductive capability were discovered, and the toxicological security analysis information were provided for the growth as well as usage of paeonol-related useful health items. The activity habits of nematodes is an index showing the fundamental features of their body systems, with straightforward operation, high level of sensitivity, easy monitoring, inexpensive and brief cycle. Feeding habits can mirror whether the feeding of nematodes is impacted by exogenous drugs, as well as the adjustments in reproductive capacity mirror the effects of exogenous drugs on the reproductive as well as physiological features of nematodes.

Experiments showed that paeonol with focus of 100 as well as 200 mg/L treated nematodes for 24 hr had no severe poisonous effects; paeonol might boost the nematode’s head moving and body flexing exercise capacity, as well as improve the activity of the body, 100 mg/L Paeonol has the best impact. Paeonol has no impact on the energy consumption of nematodes. It can be ruled out that paeonol may impact physical functions by decreasing the swallowing regularity of nematodes, thereby reducing the energy constraint path of food intake. No result on reproductive ability indicates that the nematodes remained in a healthy and balanced state during their action. Paeonol has no harmful impact on nematodes, and also can considerably boost the workout ability of nematodes. It has particular possible application worth in the development and also application of practical wellness items.

Determination of Paeonol Content

( 1) Take about 5 mg of this item, add 1 ml of ethanol to liquify, include 0.5 ml of agarazine sulfonic acid test remedy, shake well, add 1 decrease of sodium bicarbonate examination option, as well as progressively become orange-red.
( 2) Take this product and also liquify it in ethanol to make a service including concerning 5μg per 1ml. According to the spectrophotometry (Appendix IV A of Chinese Pharmacopoeia 2000 Version), the maximum absorption is at the wavelengths of 314nm and also 274nm, and also the There is marginal absorption at the wavelengths of 295 nm and also 244 nm.
( 3) In the chromatogram taped under the web content resolution item, the retention time of the major height of the test substance should be consistent with the retention time of the recommendation material optimal of paeonol.

The clarity as well as color of ethanol service take 1.0 g of this product, include 10ml of ethanol to liquify, the remedy must be clear as well as anemic; if it is turbid, compare it without any. It has to not be thicker; if the shade is developed, it needs to not be darker than the basic colorimetric service of brown-red No. 2 or orange-red No. 2 (Chinese Pharmacopoeia 2000 Version, Part II, Appendix IX A, Technique 1).
For chloride, take 0.5 g of this item, add 30ml of water, warmth to dissolve, cool down, include 10ml of weaken nitric acid, filter, take the filtrate, check according to the law (Chinese Pharmacopoeia 2000 Version Part II Appendix VIII A), and basic sodium chloride solution 5.0 ml Compared to the prepared control option, it needs to not be a lot more concentrated (0.01%).
Take 1g of this item for sulfate, include 25ml of water, shake for 10 mins, filter, take the filtrate, and check according to the regulation (Appendix VIII B, Component II of the Chinese Pharmacopoeia 2000 Version). More focused (0.03%).
Pertinent materials were examined according to high performance fluid chromatography (Appendix V D of Chinese Pharmacopoeia 2000 Edition). Use octadecylsilane adhered silica gel as filler; methanol/FONT >( 50:50) as mobile stage; discovery wavelength is 275nm. The number of academic plates need to not be less than 2000 according to the paeonol height. Take this product, add methanol to make a remedy having 2mg per 1ml, as the test service; precisely measure an ideal amount, add methanol to make a remedy including 0.02 mg per 1ml, as a control service. Take 20 μl of the control remedy and infuse it right into the liquid chromatograph to change the detection sensitivity to ensure that the top elevation of the main part chromatographic height is 10% to 30% of the full scale; To twice the retention time of the major element optimal. If there are impurity tops in the chromatogram of the examination solution, the amount of the areas of the contamination peaks will not be above the main top location of the control service.

loss on drying out
Take this item, put it in a phosphorus pentoxide desiccator and dry it under minimized stress to constant weight, as well as the weight management ought to not exceed 1.0% (Chinese Pharmacopoeia 2000 Version, Part II, Appendix VIII L).

Residue on ignition
Not more than 0.1% (Chinese Pharmacopoeia 2000 edition of the 2nd appendix VII N).

heavy metal
Take the residue left under the product of deposit on ignition, and check it according to the legislation (Appendix VIII H, Second Approach of Chinese Pharmacopoeia, 2000 Edition), and also the heavy metal material must not go beyond 10 components per million.

According to gas chromatography (Chinese Pharmacopoeia 2000 edition of the two appendix VI E) resolution.

Chromatographic conditions and also system viability test Polyethylene glycol (PEG) -20 M was used as the stationary stage, and the layer focus was 10%; the column temperature was 200 ° C. The number of theoretical plates should not be less than 2000 calculated according to the paeonol peak, as well as the resolution in between the paeonol peak and also the internal conventional compound peak must meet the needs.

Decision of modification variable Take a proper quantity of biphenyl, add petroleum ether (60 ~ 90 ℃) to make an option containing 0.5 mg per 1ml, as the internal basic remedy. In addition, regarding 50 mg of paeonol reference compound was taken, accurately evaluated, and also placed in a stoppered conelike flask; 50 ml of interior common service was added exactly, trembled, and 2 μl was infused right into the gas chromatograph, and the adjustment element was determined according to the peak location.

Assay

Take 50 mg of this product, properly evaluate it, and also place it in a stoppered conical flask; properly include 50 ml of the internal typical remedy, tremble well, soak up 2 μl, infuse it right into a gas chromatograph, procedure as well as determine.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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