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Paeoniflorin CAS 23180-57-6

Molecular Formula: C23H28O11

Formula Weight: 480.47

ZSpharmac: Paeoniflorin Supplier

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Product Name: Paeoniflorin
CAS No: 23180-57-6
Purity: 99%

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Basic Info

Product Name:Paeoniflorin
Other Names:Paeoniflorin Extract
CAS:23180-57-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:245-476-2
Storage:2-8°C
Provide:Paeoniflorin MSDS;
Paeoniflorin COA

What is Paeoniflorin?

Peony is the dried root of the perennial herb Paeoniaceae (Paeoniaceae). It is bitter, sour, and slightly cold. It returns to the liver and spleen meridian. For headache, dizziness, rib pain, abdominal pain, spasm and pain in limbs, blood deficiency and chlorosis, irregular menstruation, spontaneous sweating, and night sweating.
Paeoniflorin is the main functional component of peony, an important physiologically active substance, with anti-inflammatory effects, immune system effects, liver protection effects, analgesic effects, etc.

Paeoniflorin Property

Melting point approximate 124℃ (dec.)
Boiling point 498.51°C (rough estimate)
density 1.3044 (rough estimate)
refractive index 1.5376 (estimate)
storage temp. 2-8°C
solubility Methanol (Slightly, Sonicated), Pyridine (Slightly)
pka11.52±0.70(Predicted)
form powder
color white

 

Paeoniflorin Uses

Paeoniflorin is made use of in typical Chinese medication for its antispasmodic as well as analgesic buildings. Anti-myocardial anemia, anticoagulation as well as inhibition of platelet aggregation; antispasmodic effect; analgesic and sedative effects; anti-inflammatory as well as anti-ulcer impacts; Professional application: for the therapy of coronary cardiovascular disease; for senile illness, boosting fitness and immune function, anti-inflammatory cough, expectorant as well as bronchial asthma, etc, especially as a complementary drug in the therapy of senior persistent respiratory illness.

Preparation of Paeoniflorin

1. Investigation on static adsorption performance of macroporous resin

Weigh 1kg Radix Paeoniae Alba decoction pieces, extract twice with 8L of 70% ethanol under reflux, each time for 2h, filter, combine the filtrates, concentrate under reduced pressure until there is no alcohol smell, adjust the medicinal solution so that each 1ml medicinal solution is equivalent to 0.5g crude drug, and set aside.

Weigh 1.00g of the dry weight of each type of resin, place them in ten 50ml conical flasks with stoppers, add 10ml of Radix Paeoniae Alba extract (0.5g crude drug/ml), shake in a constant temperature shaking box at 35°C for 6h, The vibrating speed was 180prm, and the adsorbed Radix Paeoniae Alba extract was vacuum filtered, and the filtrate was properly diluted, and the contents of Paeony Radix and Radix Paeoniae Alba were determined by HPLC with reference to the method of the 2010 edition of Pharmacopoeia. The adsorbed resin was washed with water for 3 times, after vacuum drying, 10ml of 95% ethanol was added, and the same was shaken in a constant temperature shaking box at 35°C for 6h at a shaking speed of 180prm to perform desorption. The content of paeoniflorin and paeoniflorin was determined by HPLC after the desorption solution was properly diluted. The adsorbed resin was washed with water for 3 times, after vacuum drying, 10ml of 95% ethanol was added, and the same was shaken in a constant temperature shaking box at 35°C for 6h at a shaking speed of 180prm to perform desorption. The content of paeoniflorin and paeoniflorin was determined by HPLC after the desorption solution was properly diluted.

2. Preparation of Radix Paeoniae Alba Extract

Weigh 40kg of Radix Paeoniae Alba, soak overnight in 70% ethanol, reflux extraction twice, each time for 2 hours, filter, combine the filtrate, and rotary evaporate until there is no alcohol smell, adjust the liquid so that every 1ml of liquid is equivalent to 0.5g of crude drug, spare. Weigh 120kg (wet weight) of LX38 resin, put it into a stainless steel column (300×2300cm), the column volume is 60L, load the sample, after adsorption for 1h, first remove impurities with 300L of water, 300L of 10% ethanol, and then use 360L of 50% ethanol Elute paeoniflorin and paeoniflorin, and finally regenerate the resin with 95% ethanol at a flow rate of 150‑200L/h. Concentrate and evaporate the 50% ethanol part to obtain 2.52kg, wherein the purity of paeoniflorin is 24%, and that of paeoniflorin is 16 %.

3. Preparation of monomer components by medium pressure silica gel column

Take 8 g of the Radix Paeoniae Alba extract obtained in Example 2, dissolve it in methanol, add 8 g of 200-300 mesh silica gel to mix the sample, use a medium-pressure column system to separate, use silica gel H to pack the column (150×35 mm i.d.), and elute with ethyl acetate 1000ml, flow rate 50mL/min, then elute with ethyl acetate:methanol=95:5, detect with ultraviolet 230nm, collect paeoniflorin fraction and paeoniflorin fraction successively, concentrate under reduced pressure, dry, obtain paeoniflorin 2.8g, Paeonin 1.2g, the purity is 95.4% and 92.2% respectively.

Advances in Research on the Neuroprotective Mechanism of Paeoniflorin

About Products:
If you need Paeoniflorin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Paeoniflorin manufacturer and supplier, ZSpharmac will provide Paeoniflorin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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