Zhishang Chemical

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Zhishang Chemical

P-Methoxyacetophenone CAS 100-06-1

Molecular Formula: C9H10O2

Formula Weight: 150.17

ZSpharmac: P-Methoxyacetophenone Raw Material Supplier

Product Name: P-Methoxyacetophenone
CAS No: 100-06-1
Purity: 99%

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Basic Info

Product Name:P-Methoxyacetophenone
Other Names:4′-Methoxyacetophenone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystals or Crystalline Powder
EINECS No.:202-815-9
Storage:Room Temperature
Provide:P-Methoxyacetophenone MSDS;
P-Methoxyacetophenone  COA

What is P-Methoxyacetophenone?

Methoxyacetophenone has a strong and long lasting hay aroma, coumarin-like fragrance, flower and hawthorn aroma. The look is crystalline. p-Methoxyacetophenone can be utilized in everyday chemical fragrance formulas. Since it is reasonably stable in alkaline tool, it is specifically appropriate for usage in soap and synthetic detergent scent solutions. The dose in scent solutions is within 5%.

P-Methoxyacetophenone Property

Melting point 

36-38 °C (lit.)

Boiling point 

152-154 °C/26 mmHg (lit.)



vapor pressure 

0.42Pa at 20℃

refractive index 

1.5470 (estimate)


>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature


H2O: soluble2.474g/L at 20°C


Crystals or Crystalline Powder




at 100.00 %. sweet hawthorn anisic powdery balsamic acacia

Odor Type


Water Solubility 



Applications of P-Methoxyacetophenone

p-Methoxyacetophenone is a food flavoring allowed by nationwide laws and is sensitive to light. Soluble in ethanol, somewhat soluble in water. It has a strong hawthorn fragrance and is an important resources for mimosa, hawthorn and various other scents. It is suitable for fragrances such as hawthorn blossom, acacia, mimosa, acacia, great smelling myrtle, orchid, brand-new trimming turf, clover and various other scents. It has high security in soap and is commonly made use of in premium cosmetics and cosmetics with herbal fragrance and woody scent. In soap scent; likewise used in the production of sun block, p-methoxyphenylacetic acid (puerarin intermediate), p-methoxystyrene and fluid crystal monomer.

Application 1. CN201210268091.8 connects to the preparation approach of 4-tert-butyl-4″-methoxydibenzoylmethane, which belongs to the field of fine chemical technology. It consists of the following steps: (1) Mix p-methoxyacetophenone and solvent evenly; (2) Mix p-tert-butyl methyl benzoate and solvent equally, and include 60%~ of the mass of p-methoxyacetophenone. 100% sodium methoxide or salt ethoxide, heat up to 40 ℃ ~ 100 ℃ and after that include p-methoxyacetophenone service dropwise until the mass ratio of p-methoxyacetophenone and p-tert-butyl methyl benzoate is 0.6 ~ 2.0, the dropwise enhancement is finished, and the insulation reaction proceeds; (3) After the reaction is total, the unrefined product is acquired, adjust the pH of the unrefined product to ≤ 5, liquify it after stirring, and wash it with water to different layers; (4) After the water-washed product is eliminated from the solvent, include methanol to liquify, after that decolorize with turned on carbon, repetitively add methanol, and fine-tune once again to acquire the product. The reaction molar yield of the development is high, the response conditions are light, and the reaction technique appropriates for commercial production.

Application 2. CN201810391635.7 divulges a preparation technique of avobenzone, in which a changed ZSM-5 zeolite solid acid stimulant is used to remove acetic acid, an unstable by-product, under reduced pressure without presenting a solvent. Get p-methoxyacetophenone; at the same time, usage p-toluenesulfonic acid as the driver instead of typical focused sulfuric acid to execute an esterification reaction to get p-tert-butyl benzoic acid methyl ester; after that p-methoxyacetophenone and p-tert-butyl Avobenzone is gotten from the reaction of methyl benzoate, developing a new sort of avobenzone prep work procedure.

Preparation of P-Methoxyacetophenone

Strong acid militarizes the preparation of p-methoxyacetophenone from anisole and acetyl chloride:
1) Prep job of vehicle driver MoSi (molar percentage 1:1): Dissolve 1gp123 in 12.4 ml n-propanol in an ice-water combined bath, consist of 3mmol tetraethyl orthosilicate, and afterwards include 3mmolMoCl, mix till totally dissolved, while mixing Under this trouble, consist of 45 mmol of ammonia drop by drop. Currently, the salt in the option begins to hydrolyze to produce a precipitate. Continue stirring the gotten slurry at area temperature degree for 24-hour, and after that setting it in an evaporating dish to be air-dried at 110 ° C and baked at 500 ° C for 5 hours (home heating up Program 1.5 ℃/ minutes), MoSi composite steel oxide stimulant can be gotten.

2) Prep work of p-methoxyacetophenone: Add 0.05 g of MoSi, 5ml of anisole, and 0.5 ml of acetyl chloride right into a 50ml round-bottomed flask, cozy in a constant temperature level oil bathroom at 80 ° C, mix magnetically at 400r/min, and respond. 10h.

P-Methoxyacetophenone Related Chemical Reactions

Add ethanol, sulfur and piperazine hexahydrate into the reaction pot and reflux for 4 hours, after that evaporate the ethanol. The acquired sulfide piperazine was reacted with p-methoxyacetophenone at 135-140 ° C for 20 hours, and then salt hydroxide was included and refluxed for 20 hours. After the response is completed, cool down to listed below 35 ° C and change the pH worth to 8-9 with hydrochloric acid. After separating the sulfur with a centrifuge, counteract it up until the pH value is 3-4, cool it, and dehydrate it by centrifugation. The resulting crude product is fine-tuned to get p-methoxyphenylacetic acid.
Use p-methoxyacetophenone as the beginning product, usage potassium borohydride to reduce it to p-methoxy-α-methylbenzyl alcohol, usage potassium hydrogen sulfate as the stimulant to react for a particular period of time under solvent-free conditions, and the reaction service travels through the tube The activator produces p-methoxystyrene without including stimulant.

About Products:
If you need P-Methoxyacetophenone, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced P-Methoxyacetophenone manufacturer and supplier, our company, ZSpharmac will provide P-Methoxyacetophenone raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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