Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical

P-Anisic Acid CAS 100-09-4

Molecular Formula: C8H8O3

Formula Weight: 152.15

ZSpharmac: P-Anisic Acid Supplier

Product Name: P-Anisic Acid
CAS No: 100-09-4
Purity: 99%

Navigation Bar

Basic Info

Product Name:P-Anisic Acid
Other Names:4-Methoxybenzoic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Slightly Gray-Beige Powder
EINECS No.:202-818-5
Storage:Store Below +30°C.
Provide:P-Anisic Acid MSDS;
P-Anisic Acid COA

What is P-Anisic Acid?

Anise is native to the south and southwest of Guangxi in my country, and only the western part of Fangcheng County and Debao County each account for a quarter of the country’s output.
Anise is an evergreen tree, up to 20 meters high; the bark is gray to reddish brown. Simple leaves alternate, leathery, lanceolate to oblong, 5-12 cm long, 1.5-5 cm wide, apex short or short acuminate, base narrowly cuneate, glossy and transparent oil spots above, sparse below Puberulent; petioles stout, about 1 cm long. Flowers open in spring, solitary leaf axils, perianth fleshy; sepals 3, yellow-green; petals 6-9, arranged in 2-3 whorls, pale pink or dark red, broadly oval or oblong; stamens 11-20 2-3 rounds; 8-9 carpels, separated, style short, base thick, stigma small. The aggregated fruits are arranged in a star shape, 2.5-3.5 cm in diameter, and the mature carpels are reddish-brown. Seeds oblate, brown, shiny. The flowering period is twice a year. The spring fruit harvest period is from January to February, and the autumn fruit period is from August to September.

P-Anisic Acid, also called p-anisic acid, 4-anisic acid, anisic acid, is an anemic needle-like crystal at area temperature level, soluble in ethanol, ether, chloroform, slightly soluble in hot water, insoluble in cold water. The intermediate p-methoxybenzoyl chloride of amiodarone is gotten by chlorination of thionyl chloride. It can be made use of as a pharmaceutical intermediate of lanacetam, as well as can likewise be utilized in seasonings and also preservatives.

P-Anisic Acid Property

Melting point 

182-185 °C(lit.)

Boiling point 

275 °C



vapor pressure 

0.001Pa at 25℃

refractive index 



185 °C

storage temp. 

Store below +30°C.


H2O: soluble2500 parts




4.50(at 25℃)


White to slightly gray-beige


3-4 (0.3g/l, H2O, 20℃)

Water Solubility 

Soluble in water at 20°C 0.3g/L. Soluble in alcohol, ethyl acetate and ether.



P-Anisic Acid Uses

  1. P-Anisic Acid is used for flavoring of food essence as well as toothpaste, tooth powder and also alcohol, candy, beverage as well as cigarette, and also a percentage is utilized in day-to-day essence.
  2. In medicine, P-Anisic Acid has the effects of appealing as well as minimizing qi, heating the kidneys and eliminating cold. Fennel oil is the main raw material for the synthesis of the unfavorable hormonal agent hexestrol in medicine.
  3. P-Anisic Acid is made use of to model the metabolic rate of the anti-anxiety actions drug Aniracetam and is also a tyrosinase inhibitor.
  4. P-Anisic Acid is a compound with disinfectant properties utilized as a preservative in cosmetics. p-Anisic acid has skin softening residential or commercial properties as well as is a compound with disinfectant buildings. It is normally originated from fennel as well as is utilized as a chemical in cosmetics to aid take care of your skin.

Synthetic Route of P-Anisic Acid

Theoretically, it is very suitable for the reaction in the continuous pipeline reactor: the dissolved alkaline aqueous solution of p-hydroxybenzoic acid and dimethyl sulfate enter the first-level pipeline reactor from two ports at the same time, and flow and mix in the first-level pipeline. The methylation reaction is carried out at the same time, and the complete reaction can be achieved before flowing out of the primary pipeline, and then the solution and the liquid caustic enter the heated secondary pipeline reactor at the same time, and the saponification reaction is carried out in the secondary reactor, and the solution after the reaction is completed. Collected in an acidification kettle, acidified and separated to obtain P-Anisic Acid. The traditional process is divided into multi-step reaction, the operation control is cumbersome, the materials in the kettle are not easy to mix, the reaction rate is slow, and the transfer process is easily polluted by the outside world. In order to fully react, the raw materials of dimethyl sulfate far exceed the theoretical amount. This process utilizes multiple pipeline reactors and adopts continuous pipeline reactors. The raw materials can be reacted in a small amount and continuously, and the process is easy to control. At the same time, the ratio of raw materials can be optimized to achieve full reaction, which greatly shortens the reaction time and reduces the production capacity. The whole reaction process is in a sealed environment from the entry of raw materials to the output of finished products, and there is no external pollution in the process, which is conducive to improving the quality of finished products; in addition, from the perspective of safety, due to the trace reaction, the process is simple and easy to control, which greatly improves the safety factor.


Preparation of P-Anisic Acid

Put 7.2g (0.04mol) P-Anisic Acid, 24mL (0.4mol) ethanol and 1g p-toluenesulfonic acid in a 100mL conical flask, install a reflux condenser, start magnetic stirring, heat in a water bath, and react under reflux for 2.5h. Slightly cool, change the distillation device, and evaporate the excess ethanol on the water bath (recovery). Cool, pour the reactant into ice water, gradually separate out large pieces of milky white solid, grind the solid into fine suction filtration, fully soak, wash with water, Na2CO3 solution and water respectively, drain and dry to obtain 75g milky white solid, the yield is 91.0%. The solid was dissolved in an appropriate amount of ether for further purification. The ether layer was fully washed with Na2CO3 solution, then washed with water until neutral, Na2SO4 was dried overnight, Na2SO4 was filtered off, the ether was evaporated on a water bath, and the residue was cooled to slowly precipitate p-methoxycinnamon. Acid ethyl ester white crystal, the above Na2CO3 solution can be neutralized by hydrochloric acid to precipitate a small amount of P-Anisic Acid, which can be recovered and reused after washing with water and drying.

About Products:
If you need P-Anisic Acid, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company, as an experienced P-Anisic Acid manufacturer and supplier, ZSpharmac will provide P-Anisic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get P-Anisic Acid Quotation