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P-Anisaldehyde CAS 123-11-5

Molecular Formula: C8H8O2

Formula Weight: 136.15

ZSpharmac: P-Anisaldehyde Supplier Manufacturers

Product Name: P-Anisaldehyde
CAS No: 123-11-5
Purity: 99%

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Basic Info

Product Name:P-Anisaldehyde
Other Names:Natural P-Anisaldehyde
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless to Yellow Liquid
EINECS No.:204-602-6
Storage:Store Below +30°C.
Provide:P-Anisaldehyde MSDS;
P-Anisaldehyde COA

What is P-Anisaldehyde?

P-Anisaldehyde (Anisaldehyde), also called anisaldehyde, 4-methoxybenzaldehyde, p-anisaldehyde, anisaldehyde, is a colorless to light yellow fluid at room temperature level, with a hawthorn-like odor. Density 1.123 g/cm3( 20 ° C). Melting point 2 ° C. Boiling point 249.5 ° C. Refractive index 1.5731.Insoluble in water (solubility in water is 0.3%), a little soluble in propylene glycol, glycerin, quickly soluble in ethanol, ether, acetone, chloroform, as well as a lot more. Solvent. It can be volatilized with water vapor. It exists in fennel oil, cumin oil, dill oil, acacia blossom, and also vanilla essence in nature, and also is managed oxidative dividing as well as likewise removal.

P-Anisaldehyde Property

Melting point 

-1 °C

Boiling point 

248 °C(lit.)



vapor density 

4.7 (vs air)

vapor pressure 

<1 hPa (20 °C)

refractive index 

n20/D 1.573(lit.)


228 °F

storage temp. 

Store below +30°C.






Clear colorless to yellow


sweetish odor


7 (2g/l, H2O, 20℃)

explosive limit


Odor Type


Water Solubility 

Miscible with acetone, alcohol, ether, chloroform and benzene. Immiscible with water.


P-Anisaldehyde Uses

P-Anisaldehyde has a long-lasting hawthorn scent. It can be utilized as the main scent in hawthorn flower, sunflower as well as lavender essence; it can be used as scent agent in lily of the valley significance; it can be made use of as modifier in osmanthus significance, as well as it can likewise be used in everyday significance and also food essence. This product is an edible flavor that is momentarily permitted to be made use of according to my country’s GB2760-86. It is generally made use of to prepare flavors such as vanilla, flavors, apricot, cream, fennel, sugar, cherry, chocolate, walnut, raspberry, strawberry, and mint. It functions well with vital oils such as tangerine. As a superb brightener for cyanide-free galvanizing DE additive, it can boost anodic polarization in a large existing range, obtain a brilliant layer, and create positive conditions for environmental protection. The pharmaceutical industry is utilized to produce antimicrobial drugs such as amoxicillin, and also is an intermediate of antihistamine drugs.

Preparation of P-Anisaldehyde

Dissolving P-Anisaldehyde in a natural solvent, under the action of a driver composition, undertakes a methylation reaction with dimethyl carbonate, as well as the resulting reaction solution is filtered and also distilled to acquire p-methoxybenzaldehyde;

Wherein, the catalyst structure consists of a very first stimulant as well as a 2nd stimulant, where the initial stimulant is a stage transfer stimulant, and also the 2nd catalyst is selected from a basic driver, an acidic driver or an organic enzyme catalyst;

The molar ratio of P-Anisaldehyde: dimethyl carbonate: very first driver: 2nd driver is (0.5-1): 1.24: (0.05-0.1): (0.2-0.75);

The stage transfer catalyst is tetramethylammonium chloride, tetramethylammonium bromide or tetrabutylammonium bromide;.

Ideally, the second stimulant is chosen from sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, salt methylate, organic amines, highly fundamental anion exchange resins, bimetallic oxides, clay, molecular sieves, composite oxides, Supported alkali steel oxides, focused sulfuric acid, sulfonic acid, strongly acidic cation exchange resin, zirconium sulfate, tin sulfate, zirconium oxide or zirconium tungstate.

The artificial route of the P-Anisaldehyde in the technical system of the present development is:


The artificial path of P-Anisaldehyde.

Amongst them, PTC is a phase transfer stimulant.

In the technical system of the present development, to start with, p-hydroxybenzaldehyde is put in a four-necked flask with a stirrer as well as a reflux device, and also an organic solvent as well as a driver composition are included.

Wherein, the organic solvent is not especially minimal, as well as it can be picked from generally used reagents in the art, such as DMSO, xylene, chlorobenzene, acetonitrile, pyridine, DMF and so on. Yet as preferably, in some personifications of today invention, the inventor has actually studied the impact of response solvent on response return, and also its outcome shows, utilize DMF as the solvent in the synthetic technique of the present innovation than various other organic solvents, can acquire The reason for the greater return may be that solid polar solvents are a lot more conducive to the reaction, and in this reaction, DMF has a far better solvation impact than natural solvents such as DMSO, which is a lot more for the response.

In the methylation reaction of the technical service of today development, the inventors made use of a phase transfer stimulant. Stage transfer catalysts are utilized to catalyze such a two-phase reaction. The response process mainly consists of the transfer of reactants from one phase to the various other and the chemical reaction between the moved compound as well as the material to be moved. The stage transfer driver of today creation includes: tetramethylammonium chloride, tetramethylammonium bromide or tetrabutylammonium bromide.

Ideally, in the prep work technique of p-methoxybenzaldehyde of today innovation, the phase transfer stimulant is tetramethylammonium chloride. When tetramethylammonium chloride is used as a stage transfer driver, it can create very good results no matter from the response return or the item purity. Moreover, in some personifications of today invention, the developers researched the certain enhancement ratio of tetramethylammonium chloride to make the effect extra exceptional. Extra preferably, when n( TMAC): n( PHB)= 0.0973, the response yield and product purity are optimum.

Along with those phase transfer stimulant, the driver in the synthesis technique of the technical remedy of today invention additionally includes a 2nd driver. The 2nd catalyst is primarily utilized to provide a certain atmosphere.

Additionally, in some embodiments of the here and now creation, the developers also studied the impact of the type and also quantity of the second driver on the return as well as item pureness of the synthesis method of the present creation. The outcomes reveal that when the 2nd stimulant is selected from sodium carbonate, potassium carbonate, salt hydroxide or potassium hydroxide, no matter in terms of reaction yield or item pureness, excellent results can be produced. Extra ideally, when the molar proportion of the second catalyst: p-hydroxybenzaldehyde = 0.56:0.75, the reaction return and product purity are optimal.

After that, under typical stress as well as a temperature level of 60-70 ° C., stir as well as go down dimethyl carbonate, raise the temperature to 120-150 ° C., reflux for 3-5 hours, as well as finish the reaction.

In the synthesis approach of the present creation, the molar ratio of the raw material p-hydroxybenzaldehyde: dimethyl carbonate: the very first stimulant: the 2nd driver is (0.5-1): 1.24: (0.05-0.1): (0.2-0.75). When the molar ratio of different basic materials is within the above variety, better response return as well as item pureness can be gotten.

Preferably, the molar ratio of p-hydroxybenzaldehyde: dimethyl carbonate: very first catalyst: 2nd catalyst is (0.7-0.8): 1.24: (0.07-1): (0.5-0.6).

Ideally, the molar ratio of p-hydroxybenzaldehyde: dimethyl carbonate: initial driver: 2nd stimulant is 0.75: 1.24: 0.073: 0.56.

The reaction vessel of today creation can use a four-necked flask outfitted with a stirrer as well as a reflux device. The amount of the organic solvent added in the response can be 3.65-7.30 times the molar amount of P-Anisaldehyde.

Preferably, the temperature of the methylation reaction in the here and now creation is 130 ° C., and also the reaction time is 5 hrs.

Ultimately, the resulting response remedy was filteringed system and also distilled to acquire p-methoxybenzaldehyde.

Wherein, the filtering is to recuperate insoluble compounds such as catalysts, which can be accomplished using conventional filtering techniques and tools in the art, such as suction filtering using a Buchner funnel.

The distillation is to boil down off the solvent and dimethyl carbonate at air pressure initially, and then to boil down under reduced stress, as well as accumulate portions at 500 Pa and also 140-150 ° C. This procedure can be carried out making use of conventional techniques and also devices in the art, such as a rotating evaporator and so on.

Afterwards, the recovered solvent can be separated by correction to separate DMF as well as spin-off methanol, and the phase transfer driver that has not participated in the reaction at the end of the bottle can be recrystallized and recovered by utilizing the by-product methanol, so regarding accomplish repeated recycling.

Specific Implementation of P-Anisaldehyde

The invention reveals a preparation technique of P-Anisaldehyde, as well as those competent in the art can refer to the material of this short article and properly improve the procedure specifications to understand it. Specifically, it must be pointed out that all comparable replacements and also alterations are evident to those experienced in the art, and also they are all thought about to be included in the present innovation.

In order to make it possible for those knowledgeable in the art to better recognize the technical remedies of today creation, the here and now invention will certainly be more explained thoroughly below combined with details instances.

In the instances, various response basic materials and reagents utilized were purchased from analytically pure products of Sinopharm Chemical Reagent Co., Ltd., however not restricted to the products of this business.

Example 1

Take 0.05 mol of P-Anisaldehyde and location it in a 250ml four-necked flask with a stirrer and also reflux tool, include 20g of DMF, 0.005 mol of tetramethylammonium chloride, and 0.0375 mol of potassium carbonate; After the dropwise enhancement of 0.124 mol dimethyl carbonate, the temperature was elevated to 120 ° C as well as refluxed for 3 hours to complete the reaction. After the reaction is finished, filter the response solution to recuperate potassium carbonate, recuperate the solvent by atmospheric distillation, as well as gather the 500 , 140-150 ° C fraction by vacuum cleaner distillation at the end of the bottle to obtain the item p-methoxybenzaldehyde. DMF as well as spin-off methanol are separated by correction, and the tetramethylammonium chloride that has not joined the reaction at the end of the bottle is recouped by recrystallization making use of spin-off methanol.

Via evaluation and also calculation, the response yield is 88%, and the product pureness is 98.84%.

About Products:
If you need P-Anisaldehyde as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced P-Anisaldehyde manufacturer and supplier, ZSpharmac will provide P-Anisaldehyde raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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