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Zhishang Chemical

Oxytocin 10 CAS 50-56-6

Molecular Formula: C43H66N12O12S2

Formula Weight: 1007.19

ZSpharmac: Oxytocin 10 Supplement

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Product Name: Oxytocin 10
CAS No: 50-56-6
Purity: 99%

Basic Info

Product Name:Oxytocin 10
Other Names:Oxytocin
CAS:50-56-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:White lyophilized Powder
EINECS No.:200-048-4
Storage:2-8°C
Provide:Oxytocin 10 MSDS;
Oxytocin 10 COA

What is Oxytocin 10?

Oxytocin 10, additionally referred to as oxytocin, is a uterine contraction medication that can be removed or chemically synthesized from the posterior pituitary gland of animals., reinforce its tightening, the struggling womb is most conscious Oxytocin 10 (raised estrogen secretion), the premature uterus is less competent to this product, the womb is much less receptive to oxytocin in the early or second trimester, and also slowly enhances in the late pregnancy, peaked prior to distribution. A small dosage can reinforce the balanced tightening of the smooth muscular tissue at the end of the womb, make it stronger and also faster, the contraction frequency resembles that of all-natural childbirth, and preserve polarity and also symmetry, so it is medically utilized for induction as well as induction of labor. Big dosages create tonic tightening of uterine muscular tissues, medically utilized to compress capillary in between muscle mass fibers, prevent postpartum hemorrhage and also postpartum involution, and also advertise lactation, make mammary ducts contract, and advertise milk discharge from the breast, but can not enhance milk secretion., can just advertise milk discharge. It must be kept in mind that when it is utilized for induction of labor or labor induction, the dose and drip price must be strictly managed to stay clear of creating tonic uterine contractions, causing fetal asphyxia or uterine tear. It is restricted to use when there is disproportion between the head as well as hips, unusual fetal placement or various other irregular birth canal. Oxytocin preparations isolated as well as extracted from bovine and also porcine pituitary sometimes trigger allergies, and fast intravenous mixture can cause light vasodilation and high blood pressure decline. The fastest dripping rate does not surpass 40 to 60 declines per minute. Slightly bigger doses are also used for postpartum hemorrhage, afterbirth, etc. In recent years, it has been found that this product has an excellent impact on lung hemoptysis, and also has an excellent effect on gastrointestinal feature leisure after vagus nerve resection or abdominal surgery.
It is ineffective when taken by mouth as well as is conveniently ruined by digestive juices, however can be soaked up by the dental mucosa. Intravenous mixture of 0.01 IU can trigger physical tightening of the uterus (with rhythm, polarity as well as symmetry) within 1 to 3 minutes, with short retention time and half-life A big dosage of only 2.5 to 3 minutes makes the uterine muscular tissue restorative. It has a collaborating impact with prostaglandins.
Oxytocin 10 is often made use of in mix with ergot preparations to treat postpartum hemorrhage; inescapable losing the unborn baby; mostly used for late maternity induction and lengthened labor caused by uterine atony throughout labor; for oxytocin sensitivity examination; for oxytocin excitement examination; to assist postpartum milk Discharging; hemoptysis; postoperative gastrointestinal mobility sluggish.

Oxytocin 10 Properties:

Melting point 192-194°C
alpha D22 -26.2° (c = 0.53)
density 1.1086 (rough estimate)
refractive index 1.6700 (estimate)
storage temp. 2-8°C
solubility Very soluble in water. It dissolves in dilute solutions of acetic acid and of ethanol (96 per cent).
form lyophilized powder
pkapKa ~6.1(free amino group on Cys) (Occasionally);~10(free phenol on Tyr) (Occasionally)
color White
Water Solubility Soluble in water.

 

Oxytocin 10 Uses

  1. Oxytocin 10 is absorbed from the oral mucosa and selectively acts on uterine smooth muscle to induce uterine contractions. Applicable to induction and delayed labor. The effect is the same as that of intravenous infusion of oxytocin.
  2. Oxytocin 10 uterine contraction medicine. It is used for uterine bleeding caused by labor induction, labor induction, postpartum and abortion due to weak uterine contractions. Nasal drops can promote breast discharge. Adverse reactions and contraindications: Obvious cephalopelvic asymmetry, umbilical cord presentation or prolapse, complete placenta previa, narrow pelvis, and excessive uterine contractions are contraindicated during childbirth. Placental abruption, heart disease, enlarged uterus, pregnant women over 35 years old, history of cesarean section, history of myomectomy and breech delivery should be used with caution. Severe hypertension and even cerebral vascular rupture can occur when Oxytocin 10 is used for caudal block. It cannot be injected in the same solution as norepinephrine. Incompatibility with hydrolyzed protein.

Oxytocin 10 Production Method

Method 1. Extraction method (the method currently used in my country has low purity but low cost) for the extraction of oxytocin 10 solution. Take 100 g of dry powder of the posterior leaf and 30 g of quartz powder into a ball mill, add distilled water, and extract four times with the same method. The quantity of distilled water added was 1.4 L two times as well as 1.3 L twice. Each extraction was performed for 45 min, centrifuged, the liquid was gathered, and the residue was removed again. The 4 essences were incorporated to acquire oxytocin service. Back fallen leave completely dry powder [water, sphere mill] → oxytocin removal fluid chromatographic splitting up Add 1500g of pre-treated artificial zeolite, add 20L of 0.25% acetic acid solution, put it right into the exchange column after stirring, wait on the acetic acid remedy to drop to above the surface of the zeolite When it is 2-3cm, the drawing out option is added, and the white turbid solution is accumulated at a proper circulation price (primarily including oxytocin, since its pI7.7, as well as vasopressin pI10.9, which is easy to end up being a favorable ion and be adsorbed). When the liquid level of the remove goes down to the surface of the zeolite, include distilled water instantly, and also remain to accumulate the turbid fluid until it goes out. The turbid solution was adapted to pH 3.5 with glacial acetic acid, swiftly heated up to 95 ° C in a water bathroom for 3 minutes, swiftly cooled down and also refrigerated over night. Oxytocin extract [HAc, man-made zeolite column] → turbid fluid [HAc, heating] → splitting up liquid adsorption, elution The next day, the refrigerated fluid was filtered, and also 10% bentonite slurry was included in the filtrate under stirring (include 3ml per 100ml ), mixed for 1 h, adsorbed, and centrifuged. The supernatant was contacted sulfosalicylic acid test option, and also the adsorption was full if no rainfall took place. If it is not complete, the adsorption is performed once more, and also the two bentonite slurry speeds up are incorporated. The bentonite was eluted four times with 1% acetic acid (1.6 L, 1.4 L, 1.2 L, and 0.8 L specifically). When the eluent was heated to 80 ° C, chlorobutanol was added, and then the temperature level was increased to 95 ° C., quick-cooled to 25 ℃, filteringed system or centrifuged, combined 4 filtrates, and also tested the titer and also vasopressin restriction. Chilled solution [purification] → filtrate [bentonite slurry] → adsorbate [1%HAc] → eluent Preparation of oxytocin injection Water down the determined qualified oxytocin solution to 5U/ml or 10U/ml, infiltrated a No. 4 or No. 5 vertical melting channel, potted, and also disinfected by flowing vapor at 100 ° C for thirty minutes to acquire the completed product. Oxytocin solution (qualified for determination) [filtered, potted, disinfected] → oxytocin 10 shot. Regrowth of man-made zeolite The man-made zeolite was cleaned twice with distilled water, after that 1.5 L of water (calculated according to 500g of zeolite) and 150g of sodium chloride were included and mixed for 2h, washed to get rid of vasopressin, and after that washed with distilled water till there was no chloride ion. Add an ideal amount of water, change the pH to 9 with sodium hydroxide, mix for half a hr, pour off the supernatant, wash with pure water, change the pH to 5.5-6 with sulfuric acid, clean with water up until almost neutral, filter completely dry, and cook at 105 ° C Dry extra. Include suitable amount of water before usage, change with glacial acetic acid, mix and soak. The preparation of 10% bentonite slurry was mixed in a ratio of bentonite mass to water quantity ratio of 1:10, ground for about 1 hr, and also the pH was gotten used to 3.5 with acetic acid during grinding, and positioned in a fridge for later use.
Technique 2. Chemical synthesis approach Initially, 7-peptide amide (paragraph 3-9) was manufactured from benzyloxycarbonylleucine-p-nitrophenyl ester, and then benzyloxycarbonyl-S-benzylcysteine · tyrosylazide was synthesized (paragraph 1-2), the 3rd action is to synthesize oxytocin 10.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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