Osthole CAS 484-12-8

Molecular Formula: C15H16O3

Formula Weight: 244.29

ZSpharmac: Osthole Supplier

Product Name: Osthole

CAS No: 484-12-8

Purity: 99%

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Basic Info

Product Name:	Osthole
Other Names:	Osthol
CAS:	484-12-8
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White Powder
EINECS No.:	1532714-185-1
Storage:	Sealed in Dry,2-8°C
Provide:	Osthole MSDS； Osthole COA

What is Osthole?

Osthole is a substance removed from the fruit of the yearly herbaceous plant Cnidium chinensis in the Umbelliferae household. Its look is yellow-green to white crystalline powder, insoluble in water as well as in addition amazing oil ether, along with easily soluble in acetone, methanol, ethanol, as well as also chloroform, chloroform, ethyl acetate, soluble in steaming oil ether, has antispasmodic, reducing blood pressure, antiarrhythmic, enhancing immune feature along with broad-spectrum anti-bacterial effects. Medically, it is typically utilized to take care of male impotence, scrotum wet itching, women genital inflammation, cool womb inability to conceive, rheumatic arthralgia, scabies as well as dermatitis, in addition to trichomonal vaginitis. Osthole can also be utilized as an area pesticide as well as also fungicide, mostly with contact action as well as supplemented by belly poisoning. The clinical liquid enters the insect body with body surface absorption, acts upon the nerves of the pest, as well as produces non-functional muscle contraction of the bloodsucker. It at some point passes away of exhaustion, and also has excellent phone call killing effect on various parasites such as cabbage caterpillar, tea looper, cotton bollworm, beetroot armyworm and also numerous aphids.

Osthole Property

Melting point	83-84°C
Boiling point	347.2°C (rough estimate)
density	1.1263 (rough estimate)
refractive index	1.5570 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	methanol: soluble10mg/mL, clear, colorless
form	powder
color	white
Odor	at 100.00 %. dry musty herbal
Odor Type	dry
Water Solubility	12mg/L(25 ºC)

Osthole Role

Osthole is the major pharmacological active component of Cnidium chinensis, an all-natural coumarin element. A multitude of speculative results have actually revealed that osthole has various medicinal impacts and also has been used in clinical study.

Osthole has a specific result on degenerative illness of the central nervous system, such as Alzheimer’s illness (senile dementia), Parkinson, and so on; it has a main sedative result and also promotes discovering and also memory;

In terms of endocrine system, it has anti-postmenopausal weakening of bones result as well as hormone-like result; in regards to body immune system, it has anti-inflammatory and anti-allergic responses (anti-allergic); boosts particular immune function;

Osthole likewise has anti-arrhythmia, anti-aging, anti-tumor, analgesic, regional anesthesia, insecticide (mainly call result, supplemented by tummy poisoning effect), broad-spectrum antibacterial effect, etc.

In vitro examinations have actually shown that osthole can inhibit the task of Trichophyton mentagrophytes and also fungi, and takes on skin dermatitis and other diseases;

The hygroscopicity examination of osthole shows that it has excellent hygroscopicity and also hydrating residential or commercial properties, as well as has a care effect on the skin.

Extraction Method of Osthole

The extraction methods of osthole primarily include solvent removal, acid-base method, ultrasonic removal, supercritical carbon dioxide removal and more. A lot of the purification techniques are silica gel column chromatography, macroporous resin approach, high-speed countercurrent chromatography modern technology and also recrystallization modern technology to separate osthole, yet all of them have the trouble of high separation price.

CN101948459B divulges a method for removing osthole from the Chinese medicine Fructus Cnidii, which is characterized because the removal approach comprises the adhering to actions:

1) Using 50-85% ethanol to penetrate Cnidium mongolica medical material to obtain Cnidium percolation remedy;
2) Ethanol is evaporated from the percolation fluid of Fructus Cnidii to acquire the water liquid of Fructus Cnidii;
3) Put the water of Cnidium Fructus Cnidii in a standing state, and also filter to get the unrefined osthole remove;
4) liquifying the unrefined essence with ethanol with a focus above 90% to acquire an unrefined osthole extract service, and also filtering the unrefined osthole essence service to eliminate impurities;

5) Concentrating the crude osthole essence remedy at a temperature level lower than 60 ° C to acquire a concentrated solution of the unrefined osthole essence;
6) Area the osthole crude remove concentrate in a 40-80 ° C water bath, stop home heating, and cool down the osthole crude essence concentrate with the water temperature level to speed up crystals;

7) Strain the crystals, dissolve the crystals with ethanol with a concentration above 90%, repeat the operation of step 6) for 3 to 6 times, and also get pure Cnidium chinensis crystals.

Osthole is a Botanical Insecticide

Osthole is a course of all-natural coumarin substances firstly drawn out as well as isolated from Umbelliferae. The completely dry and fully grown fruit Cnidinia (Fructuscnidii) of Umbelliferae Cnidii is relatively high in content, therefore the name. Appropriate studies have actually shown that osthole is likewise existing in numerous various other plants, mainly consisting of Umbelliferae such as Angelica, Gudang, as well as Cnidium, as well as Rutaceae such as Citrus, Sparkling wine, Citrus, and also Rutacea., In addition, it is additionally distributed in a few species of Asteraceae and also Fabaceae.
Osthole has one more name called methoxyparscreol or parshole (osthole, Ost), its chemical name is 7-methoxy-8-prenyl coumarin, as well as its core structure consists of benzene ring and also pyrene Composition of the ketone ring. As a member of coumarins, osthole has not only the core framework of coumarin, however likewise an isopentene framework, as well as the isopentene framework substance plays an essential role in condition resistance as plant protection.
Osthole is an herb insecticide. Its setting of action is generally call activity, supplemented by tummy poisoning. died of exhaustion. The interior activity as well as toxicity test reveals that it has high activity against cabbage caterpillar (LD50 is 6.2258 mg/kg). The field effectiveness examination shows that it has good control result on cruciferous vegetable cabbage caterpillar and also tea tree geometrid. The dose for preventing and regulating cruciferous vegetable cabbage caterpillar is 4.8 ~ 7.2 g/h of active ingredient (converted into 0.4% osthole emulsifiable oil, the business quantity is 80 ~ 120mL per mu); the dose for managing tea tree worm is 6 ~ 7.2 g/h (converted into 0.4% osthole emulsifiable oil, use 100 ~ 120mL per mu of land). Usually, the amount of medicine solution per mu is 50 ~ 75kg, as well as it is sprayed uniformly; the period of result is about 7 days. It is risk-free to plants within the dosage range, and also no phytotoxicity has been seen.

About Products:
If you need Osthole as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Osthole manufacturer and supplier, ZSpharmac will provide Osthole raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.