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Orotic Acid CAS 65-86-1

Molecular Formula: C5H4N2O4

Formula Weight: 156.1

ZSpharmac: Orotic Acid Cosmetic Raw Material Suppliers

Product Name: Orotic Acid
CAS No: 65-86-1
Purity: 99%

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Basic Info

Product Name:Orotic Acid
Other Names:4-Pyrimidinecarboxylic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:200-619-8
Storage:Room Temperature
Provide:Orotic Acid MSDS;
Orotic Acid COA

What is Orotic Acid?

Orotic acid is a material normally generated by human digestive tract vegetation. This acid is likewise called vitamin B13 or pyrimidine acid. It is not actually a vitamin, however was put in this classification after being contributed to laboratory animal diet plans in the 1960s. Included in food, it promotes heart wellness and also shows some vitamin-like advantages.

Orotic Acid Property

Melting point ≥300 °C
Boiling point 280.29°C (rough estimate)
density 1.6814 (rough estimate)
refractive index 1.4800 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility DMSO : 32 mg/mL (205.00 mM; Need ultrasonic and warming)
pkapK1:1.8(+1);pK2:9.55(0) (25°C)
form Crystalline Powder
color White
Water Solubility Slightly soluble


Orotic Acid Uses

  1. Orotic acid is a vitamin medicine. Ideal for hyperuricemia, hypercholesterolemia, persistent liver disease, as well as cirrhosis. It can similarly be taken advantage of as an anti-anemia along with dietary restorative. Massive does can produce fatty liver. It needs to not be utilized by people with extreme liver condition, leukemia, in addition to malignant swellings.
  2. Orotic acid is a dietary medication, likewise referred to as vitamin B13. This product creates a salt with 5-aminoimidazole-4-carboxamide at 90 ° C to obtain aminoimidazole orotate (C9H10N6O5 · 2H2O, [2574-78-9] Both medicines are hepatoprotective medicines.
  3. Orotic acid is primarily made use of in day-to-day cosmetics in addition to medicine, nucleic acid, as well as also natural research study. It is additionally taken advantage of in medication to prepare gallbladder and additionally liver medications, heart trouble medicines, and so on.

Research Reports Related to Orotic Acid

Terahertz time domain name spectroscopy (THz-TDS) technology was utilized to measure the space temperature characteristic absorption spectrum of orotic acid in between 10 as well as 120 cm-1; based on density useful concept, the optical settings of the solitary particle as well as system cell regular framework of orotic acid were gauged. Execute simulation estimations. The research results show that orotic acid has 3 noticeable characteristic absorption peaks in the band range of 10 to 120 cm-1. Except for the absorption top at 95.5 cm-1, which comes from intramolecular and intermolecular communications, the other 2 characteristic absorption heights are The tops primarily stem from intermolecular communication patterns. The interaction in between orotic acid molecules limits its intramolecular vibration strength to a certain level. This study will certainly contribute to the surveillance of orotic acid in industrial production and also the analysis of its clinical pharmacological homes.

Wang Yuming and also others from the Institution of Food Science as well as Engineering of Ocean University of China examined the system of orotic acid-induced fatty liver in rats. Methods: Rats were divided into two groups. The control group was fed AIN93 typical feed, and the model group’s feed was supplemented with 1% orotic acid. After feeding for 10 days, the rat serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C) components, as well as liver TC, TG as well as phospholipid web content. At the same time, the activities and mRNA expression levels of fatty acid synthase (FAS), carnitine palmitoyl transferase (CPT), microsomal triglyceride transfer protein (MTP), and sterol regulative component binding protein (SREBP- 1c) and also peroxisome proliferator-activated receptor (PPARα) mRNA expression. Outcomes: Orotic acid can dramatically boost the product TG concentration as well as liver TC and also TG contents in rats. After adding orotic acid, FAS activity and also mRNA levels in rat liver were substantially boosted, while CPT and also MPT tasks as well as mRNA degrees were significantly lowered. At the same time, the expression of SREBP-1cmRNA, which is a transcriptional regulatory authority, boosted by 3.13 times, while the expression of PPARα mRNA was not substantial. Range. Conclusion: The fatty liver generated by 1% orotic acid in rats is connected to the hyperlipid synthesis caused by the raised expression of SREBP-1c, and also is related to the inhibition of fatty acid oxidation and decomposition and the reduction of MTP activity and also gene expression.

Preparation of Orotic Acid

About Products:
If you need the cosmetic raw material Orotic Acid, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Orotic Acid manufacturer and supplier, our company, ZSpharmac, will provide Orotic Acid raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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