Zhishang Chemical

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Zhishang Chemical

Orotic Acid CAS 65-86-1

Molecular Formula: C5H4N2O4

Formula Weight: 156.1

ZSpharmac: Orotic Acid Supplier

Product Name: Orotic Acid
CAS No: 65-86-1
Purity: 99%

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Basic Info

Product Name:Orotic Acid
Other Names:Orotic Acid, 99%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:200-619-8
Storage:Sealed in dry,Room Temperature
Provide:Orotic Acid MSDS;
Orotic Acid COA

What is Orotic Acid?

Orotic acid is a substance naturally produced by the human intestinal flora. This acid is also known as vitamin B13 or pyrimidine acid. It’s not actually a vitamin, but fell into that category after being added to the diets of laboratory animals in the 1960s. Adding it to food can promote heart health and show some vitamin-like benefits.

Orotic Acid Property

Melting point ≥300 °C
Boiling point 280.29°C (rough estimate)
density 1.6814 (rough estimate)
refractive index 1.4800 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility DMSO : 32 mg/mL (205.00 mM; Need ultrasonic and warming)
pkapK1:1.8(+1);pK2:9.55(0) (25°C)
form Crystalline Powder
color White
Water Solubility Slightly soluble


Orotic Acid Uses

  1. Orotic acid is mainly used in daily cosmetics and medicine, nucleic acid, biological research, and in medicine for the preparation of jaundice liver medicine, heart disease medicine, etc.
  2. Orotic acid is a nutritional medicine, also known as vitamin B13. This product and 5-aminoimidazole-4-carboxamide form a salt at 90 ° C, and then obtain amino-imidamide orotate (C9H10N6O5·2H2O, [2574-78-9]). Both of these drugs are liver protection drugs.
  3. Orotic acid is a vitamin drug. It is suitable for hyperuricemia, hypercholesterolemia, chronic hepatitis, and liver cirrhosis. It can also be used as an anti-anemia and nutritional tonic. Large doses can induce fatty liver. Patients with acute hepatitis, leukemia, and malignant tumors should not use it.

Orotic Acid Uremia

Orotic aciduria is a pyrimidine metabolic disorder caused by hereditary orotate phosphoribosyltransferase and orotidine phosphate decarboxylase defects. It is a rare autosomal recessive genetic disease. The child was born with no abnormalities, but gradually appeared to be physically and mentally retarded from 2 to 6 months after birth. Accompanied by pale complexion, blue sclera, strabismus, hypotonia and splenomegaly, peripheral blood showed megaloblastic anemia and low leukocytes. Bone marrow examination: both erythroid and granulocyte lines have megaloblastic changes. The amount of orotic acid in urine increases up to 400-1400mg/24h (the normal value for adults is about 1-4mg/24h), and the urine becomes obviously turbid after a little cold, with needle-like crystals inside; crystallized urine can sometimes cause urinary tract obstruction . Daily treatment with large doses of uracil (150mg/kg) can rapidly relieve anemia and orotic aciduria; the decrease of orotic acid content in urine suggests that the synthesis of orotic acid is regulated by a negative feedback mechanism in the process of pyrimidine biosynthesis .
The above two enzymes are simultaneously lacking in most patients’ liver cells, leukocytes and cultured fibroblasts. However, there have been reports of decarboxylase deficiency alone, and the clinical manifestations of such patients are no different from those with simultaneous deficiency of transferase and decarboxylase. Recent data suggest simultaneous deficiency of orotate phosphoribosyltransferase and orotidine phosphate decarboxylase because they share a common subunit and are controlled by a single gene. At present, various methods are available to measure enzyme activity to assist in diagnosis and prenatal diagnosis.

Preparation of Orotic acid

About Products:
If you need Orotic acid, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Orotic acid manufacturer and supplier, ZSpharmac will provide Orotic acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Orotic Acid Quotation