Zhishang Chemical

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Molecular Formula:  

Formula Weight:  0

ZSpharmac: OLIGOPEPTIDE-3 Raw Material Supplier

Product Name: OLIGOPEPTIDE-3
CAS No:  
Purity: 99%

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Basic Info

Other Names:bFGF
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White  Liquid


bFGF, also known as oligopeptide-3, is a cationic polypeptide that stimulates cell growth. It consists of 155 amino acids and shares 55% of its amino acid sequence with aFGF. bFGF has a molecular weight ranging from 16 to 18.5 kDa. The molecule contains 4 cysteine amino acids which play a role in its three-dimensional structure. Interestingly, when serine is substituted for cysteine in the molecular structure of recombinant bFGF, its biological activity remains unaffected. Furthermore, the single-chain polypeptide can be easily produced in E. coli.

Application of Oligopeptide-3 in Beauty

1. The use of bFGF has shown positive effects on skin care and repair by improving the cell growth environment, increasing the synthesis of elastic fibers and collagen, and enhancing skin elasticity and smoothness.

2. bFGF also has anti-wrinkle and anti-aging properties as it promotes the growth of fibroblasts, facilitates the replacement of aging cells with new ones, and helps reduce wrinkles and signs of aging.

3. In addition, bFGF can aid in whitening and freckle removal by renewing senescent cells, reducing melanin content, and decreasing skin pigmentation.

4. When it comes to sun protection and post-sun repair, bFGF is beneficial in repairing damaged cells and minimizing skin damage caused by UV radiation.

5. Furthermore, bFGF has anti-acne and scar removal effects by stimulating skin granulation tissue formation, promoting granulation tissue epithelialization, and regulating collagen degradation and renewal to accelerate wound healing and reduce scar formation.


Applications of Oligopeptide-3

CN201810529928.7 describes a composition and a method for preparing the composition. The composition consists of the following percentages of raw materials by mass: water 70-90%, raw material 1-10%, second raw material 1-10%, third raw material 1-10%. The raw materials include water, oligopeptide-1, oligopeptide-3, mannitol, albumin, and heparin sodium; the second raw materials include water, hyaluronic acid, and oligopeptide-3; the third raw materials include water, hyaluronic acid, oligopeptide-5, and hexapeptide. This composition is easy to prepare and can repair damaged skin, increase skin moisture, maintain skin hydration, reduce wrinkles, and delay skin aging.

CN201811471622 presents a multi-effect repair peptide essence composition and its preparation method. The composition includes deionized water, glycerol, propylene glycol, sodium hyaluronate, allantoin, EDTA-2Na, methylparaben, oat beta-glucan, hydrolyzed oat protein, oligopeptide-3, oligopeptide-1, oligopeptide-5, ceramide 3, Portulaca oleracea extract, and oxyethanol. It enhances moisturization, cuticle softening, absorption promotion, anti-allergic, and antioxidant effects. It is effective in treating skin diseases and repairing skin, and is easy to prepare.

CN201810260596 discloses a repair freeze-dried powder with multiple polypeptides. The powder contains mannitol, disodium hydrogen phosphate, oligopeptide-1, oligopeptide-2, oligopeptide-3, oligopeptide-4, oligopeptide-5, glutathione, acetyl hexapeptide-8, copper tripeptide-1, and acetyl tetrapeptide-5. This repair powder promotes skin repair and growth, addresses various skin issues, and improves skin problems effectively and safely.

CN201810579548 reveals a method for preparing an exosome cosmetic preparation derived from human mesenchymal stem cells. The preparation includes mesenchymal stem cell exosomes, mannitol, oligopeptide-32, tetrapeptide-4, palmitoyl tripeptide-1, and palmitoyl pentapeptide-4. The exosome beauty preparation can rejuvenate skin cells and regulate the skin’s immune status, ultimately achieving skin rejuvenation.

Related Research on Oligopeptide-3

Structure-activity relationship studies are important for identifying potential bioactive peptides from food sources. In this study, we focused on egg white peptides and their ability to be completely absorbed in the small intestine. It is well-known that bioactive peptides must be able to overcome digestive enzyme degradation and epithelial absorption barriers in order to exert their biological effects in the body.

We utilized the Caco-2 cell monolayer membrane and everted rat intestinal sac models to investigate the degradation and absorption of egg white protein-derived peptides. Mass spectrometry was used to identify the structures of both degraded and absorbed peptides, with a focus on peptides derived from ovalbumin and ovotransferrin. Our results showed that egg white peptides could be completely absorbed by both models, with a higher number of peptides being absorbed by the Caco-2 cell monolayer membrane compared to the everted rat intestinal sac model. Specifically, four egg white-derived oligopeptides were identified as being completely absorbed by both models.

Further studies were conducted on the ACE inhibitory peptide TNGIIR, derived from egg white. We found that TNGIIR was partially degraded by gastrointestinal enzymes, but could still be completely absorbed by the Caco-2 cell monolayer membrane. The absorption mechanism of TNGIIR appeared to be regulated by tight junctions, as evidenced by the effects of cytochalasin D on absorption rates.

Overall, our study highlights the potential of egg white peptides as bioactive compounds that can be absorbed in the small intestine, offering promising opportunities for the development of functional foods and nutraceuticals.

Contact Us

About Products:
If you need Oligopeptide-3, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Oligopeptide-3 manufacturer and supplier, our company, ZSpharmac, will provide Oligopeptide-3 raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get OLIGOPEPTIDE-3 Quotation