Zhishang Chemical

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Zhishang Chemical

Oleanolic Acid Sigma CAS 508-02-1

Molecular Formula: C30H48O3

Formula Weight: 456.7

ZSpharmac: Oleanolic Acid Sigma Supplement

Product Name: Oleanolic Acid Sigma
CAS No: 508-02-1
Purity: 99%

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Basic Info

Product Name:Oleanolic Acid Sigma
Other Names:Oleanolic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:light Yellow Neat
EINECS No.:208-081-6
Provide:Oleanolic Acid Sigma MSDS;
Oleanolic Acid Sigma COA

What is Oleanolic Acid Sigma?

Oleanolic Acid Sigma In Spain, Italy as well as Argentina, oleanole forests occupy substantial areas.The mesocarp contains 25-40% olean oil, which is abundant in vitamins and is quickly digested by the organism. The oil is used medicinally to avoid arteriosclerosis. Today, it is mostly expanded in grown or wild state.

Oleanolic Acid Sigma is a type of pentacyclic triterpenoids which is separated as well as drawn out from the fruit of the entire plant of the gentian plant, the category of the category Syringa or Ligustrum lucidum. It exists in a variety of free types and glycosides. In plants, it has come to be a generally utilized hepatoprotective drug in medical technique. It has obvious protective result on acute and persistent liver damages in rats caused by carbon tetrachloride, and also can minimize the elevated ALT and AST, as well as trigger inflammation, necrosis as well as interstitial inflammatory reaction. Relieve, prevent the development of fibrosis, promote the regeneration of liver cells, and also speed up the recovery of lethal tissue. Electron microscopy revealed that the enlarged mitochondria as well as rough endoplasmic reticulum recovered after treatment with Oleanolic Acid Sigma. Its succinate can decrease the task of mouse liver microsomal cytochrome P450 enzyme. Additionally, Oleanolic Acid Sigma has the features of dealing with healthy protein metabolism problems, anti-inflammatory, cardiotonic, diuretic, enhancing leukocyte, lowering blood sugar level, advertising immune function, and hindering the development of S-180 tumor line.

Oleanolic Acid Sigma Property

Melting point >300 °C (lit.)
alpha D20 +83.3° (c = 0.6 in chloroform)
Boiling point 502.79°C (rough estimate)
density 1.0261 (rough estimate)
refractive index 1.4940 (estimate)
storage temp. 2-8°C
solubility Chloroform (Very Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form neat
pka2.52(at 25℃)
color light yellow


Oleanolic Acid Sigma Uses

  1. Oleanolic Acid Sigma has the functions of securing liver and also lowering enzymes, advertising regeneration of hepatocytes, anti-inflammatory, cardiotonic, diuretic, and anti-tumor. It is medically used for the treatment of infectious severe jaundice hepatitis, which has noticeable impact of decreasing alanine aminotransferase and also jaundice, boosting the signs and symptoms, signs as well as liver function of clients with viral as well as chronic persistent liver disease; it can likewise be used for psoriasis, rheumatic joints Swelling, nephritis, edema, ascites due to cirrhosis, severe and also chronic liver disease, belly discomfort as well as turbidity, metrorrhagia, contusions, carbuncle swollen, weak waist and knees, uneasy fetal activity blood clot.
  2. Oleanolic Acid Sigma is suitable for various types of hepatitis. It can promote the regrowth of liver cells, speed up the repair of damaged liver cells, and also has cardiotonic, diuretic as well as anti-inflammatory impacts.
  3. Oleanolic Acid Sigma is a natural triterpenoid widely discovered in food and medical plants.
  4. Oleanolic Acid Sigma A triterpenoid isolated from medicinal plants. Antitumor as well as hepatoprotective representative. It was utilized as a recommendation substance in the quantification by high performance slim layer chromatography (HPTLC) in the roots of Cinnamomum sinensis.

Preparation Method of Oleanolic Acid Sigma

1. Extraction method
At present, the separation and purification methods of Oleanolic Acid Sigma commonly used in this field mainly include: organic solvent extraction method, precipitation method, column chromatography step elution method, macroporous adsorption resin method, high-speed countercurrent chromatography, etc. Microwave extraction is to use the difference in the ability of substances with different structures to absorb microwaves in the microwave field, so that some regions in the substance or some components in the extraction system are selectively heated, so that the extracted material is separated from the substance or system. , into the extractant with small dielectric constant and relatively poor microwave absorption ability. The advantages of this method are that it has high selectivity to the extract, high extraction rate, fast extraction speed, less solvent consumption, safety, energy saving, and simple equipment. Simulated moving bed chromatography technology is to introduce the design idea of ​​simulated moving bed into liquid preparative chromatography, which not only maintains the advantages of low consumption, high separation purity, and variable temperature operation of liquid preparative chromatography, but also overcomes the usual liquid preparative chromatography. The disadvantage of not being able to operate continuously makes it have the characteristics of strong separation ability, small size of equipment, low investment cost, and it is especially beneficial to the separation of materials with high heat sensitivity and difficult separation.

CN201510083053.9 provides a method capable of effectively extracting and separating oleanolic acid in Prunella vulgaris. The method for extracting oleanolic acid from Prunella vulgaris of the present invention comprises the following steps:

(1) pulverize the dried Prunella vulgaris, pass through a 20-60 mesh sieve, place it in a microwave synthesis extractor for extraction, add ethanol solution to reflux for extraction; filter out the extract, concentrate under reduced pressure to recover the solvent to obtain extract A;

(2) adding petroleum ether to the extract A for leaching, then dissolving with an ethanol solution, filtering, and entering the filtrate into simulated moving bed chromatography for separation to obtain component B rich in Oleanolic Acid Sigma;

(3) The solvent is recovered and dried under reduced pressure to obtain oleanolic acid with a purity of more than 95%.

The Oleanolic Acid Sigma extraction method of the present invention adopts the technology of combining microwave-assisted extraction and simulated moving bed chromatography to separate and purify, and determines the relevant process parameters. The steps are simple, the product purity is high, the extraction and separation time is short, and the production efficiency is obtained. improve.

2. Preparation of oleanolic acid polyvesicular liposomes
At present, the related preparations of oleanolic acid in clinical practice are mainly Oleanolic Acid Sigma tablets, but oleanolic acid is a fat-soluble drug, which has the disadvantages of low dissolution rate in the gastrointestinal tract, poor absorption, and obvious first-pass effect in the liver, making it a Bioavailability is greatly reduced, therefore, research and development of new formulations of Oleanolic Acid Sigma is necessary. CN201510401465.2 provides an oleanolic acid multivesicular liposome with high bioavailability, a preparation method and application thereof. Include the following steps:

1), take by weighing soybean lecithin, cholesterol, glyceryl trioleate, oleanolic acid, stearic acid and be dissolved in organic solvent, dissolve and form oil phase;

2), add a specified amount of oil phase to the inner water phase, and shear and disperse with an emulsifying machine to form colostrum;

3), take the colostrum of the specified amount and join in the outer water phase, vortex oscillation forms double milk;

4), the double emulsion is rapidly transferred to a round-bottomed flask, and the organic solvent is removed by rotary evaporation to obtain oleanolic acid polyvesicular liposomes.

In the present invention, oleanolic acid is loaded in the lipid layer of multivesicular liposomes to prepare oleanolic acid multivesicular liposomes (OA-MVLs), in order to improve bioavailability, achieve slow release of drugs, and reduce the number of administrations , the purpose of improving patient compliance.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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