Zhishang Chemical

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Zhishang Chemical

Oleanolic Acid CAS 508-02-1

Molecular Formula: C30H48O3

Formula Weight: 456.7

ZSpharmac: Oleanolic Acid Cosmetic Raw Material Suppliers

Product Name: Oleanolic Acid
CAS No: 508-02-1
Purity: 99%

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Basic Info

Product Name:Oleanolic Acid
Other Names:OleanolicAcid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Yellow Neat
EINECS No.:208-081-6
Provide:Oleanolic Acid MSDS;
Oleanolic Acid COA

What is Oleanolic Acid?

Oleanolic acid is a pentacyclic triterpenoid substance separated and drawn out from the whole plant of the gentianaceae plant Swertia genus or the fruit of Ligustrum lucidum. It exists in lots of species in the form of complimentary bodies and glycosides. Among these plants, it has come to be a typically utilized hepatoprotective drug in professional practice. It has a significant protective impact on intense and chronic liver damage in rats triggered by carbon tetrachloride. It can decrease raised ALT and AST, inflammation, death and interstitial inflammation. Minimize the response, protect against the development of fibrosis, promote the regrowth of liver cells, and accelerate the healing of necrotic cells. Electron microscopy showed that the bigger mitochondria and harsh endoplasmic reticulum were brought back after oleanolic acid therapy. Its succinate ester can decrease the task of computer mouse liver microsomal cytochrome P450 enzymes. Furthermore, oleanolic acid has the features of correcting healthy protein metabolic process disorders, anti-inflammatory, cardiotonic, diuretic, increasing white blood cells, reducing blood sugar, promoting immune function, and preventing the growth of S-180 tumor pressures.

Oleanolic Acid Property

Melting point >300 °C (lit.)
alpha D20 +83.3° (c = 0.6 in chloroform)
Boiling point 502.79°C (rough estimate)
density 1.0261 (rough estimate)
refractive index 1.4940 (estimate)
storage temp. 2-8°C
solubility Chloroform (Very Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form neat
pka2.52(at 25℃)
color light yellow


The Role of Oleanolic Acid

1. Oleanolic acid has anti-inflammatory, sedative, cardiotonic, diuretic, lowering blood lipids, decreasing blood sugar, protecting the liver and decreasing enzymes, enhancing resistance and preventing the advancement of S180 swelling stress. It is an energetic element in the innovation of medications to take care of liver condition and minimized blood sugar.
2. Oleanolic acid has a safety and security result on chromosome damages and quits speculative atherosclerosis. It is clinically utilized to treat contagious extreme jaundice liver disease and persistent viral liver disease. It has obvious effect on reducing alanine aminotransferase and decreasing jaundice.
3. Oleanolic acid has the result of preventing liver fibrosis. In rats with liver fibrosis treated with oleanolic acid, liver fibroplasia was serious and considerably decreased, and liver collagen internet material was reduced, recommending that it has the effect of protecting against and dealing with liver cirrhosis.
4. Minimize the tyrosine level psychological homogenate of rats with cirrhosis: Due to the fact that the tyrosine level in the mind homogenate is substantially lessened, it can inhibit the manufacturing of pseudo natural chemicals, so it is beneficial to the evasion and therapy of hepatic encephalopathy.
5. Oleanolic acid capsules more than the counter complementary medicines for liver illness and are utilized for the corresponding treatment of acute and persistent liver illness. It has a specific protective impact on liver damage, can reduce raised serum alanine aminotransferase, promote liver cell regeneration, and accelerate the repair work of lethal cells.

Biological Activity of Oleanolic Acid

1. Secure liver and detoxify
OA has energetic functional teams such as dual bonds, hydroxyl teams, and carboxyl teams that can conveniently integrate with poisonous materials in the body to attain detoxing functions.

2. Reduced blood glucose and lipids
With animal experiments, it was discovered that OA can lower blood glucose in regular mice and withstand the rise in blood sugar in computer mice caused by epinephrine or glucose. While OA decreases blood glucose, liver glycogen and serum insulin boost dramatically.

3. Immunosuppressive result
OA has a substantial promoting effect on the synthesis of prostaglandins, can advertise the boost in cyclic adenosine monophosphate degrees, and has a significant repressive result on the release of cycloguanosine and histamine, proving that OA has an immunosuppressive effect.

4. Anti-peroxidation
OA can feed on complimentary radicals, hinder the production of lipid peroxide malondialdehyde, enhance the security of the body’s lipids, and have a protective effect on the body.

OA is drawn out from natural plants. Along with its biological activities of safeguarding liver, cleansing, lowering blood glucose and lowering blood lipids, it likewise has anti-viral, immune-modulating, anti-peroxidation and various other effects without noticeable poisonous and adverse effects. It can also be used as an additive to replace prescription antibiotics. Used in feed industry.

Method for Preparing Oleanolic Acid From Red Dates

The red dates are cored and squashed to get raw material crumbs; the red dates are defective dried red dates;
Add a solvent to the raw product bits to get service A; the solvent is 80% -95% ethanol, preferably 90% ethanol; the mass ratio of the solvent to the raw product particles is 10-18: 1, Ideally 14: 1;

The solution A goes through microwave home heating and extraction; the microwave power is 70W-350W, ideally 140W-280W, more preferably 210W; the microwave heating time is 90 seconds-150 seconds, preferably 100 seconds-140 seconds, more ideally is 120 secs;

Filter the item after microwave home heating extraction to get remedy B;
After service B was concentrated and the solvent was eliminated, distilled water was contributed to obtain option C;
Include flocculant to service C to generate precipitation D; where, the flocculant is a 1% chitosan remedy, and the enhancement amount of the flocculant is 0.006 g/L;

Speed up D is liquified in outright ethanol, filteringed system to eliminate insoluble issue, and after that concentrated to get rid of outright ethanol to obtain oleanolic acid.

The creation likewise offers an oleanolic acid prepared by the approach of the development. The oleanolic acid described in the present invention is extracted from faulty dried out red days by the approach offered by the existing creation.

The here and now innovation embraces microwave-assisted extraction, which can simplify the process, make the procedure operation easy and inexpensive, enhance the removal price of oleanolic acid, keep the useful features of oleanolic acid, and embrace flocculation innovation for splitting up, which is easy to run; In addition, the present invention utilizes malfunctioning dried out red days as raw materials, which expands the detailed utilization technique of defective red dates; the oleanolic acid extract gotten by the present innovation has top quality, high purity, and is very easy to maintain. Therefore, the method for preparing oleanolic acid adopted in today innovation has easy-to-obtain basic materials, high product return, basic and efficient manufacturing procedure, low cost, and is suitable for industrial manufacturing.

About Products:
If you need the cosmetic raw material Oleanolic Acid, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company, as an experienced Oleanolic Acid manufacturer and supplier, ZSpharmac will provide Oleanolic Acid raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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