Octyl p-methoxycinnamate is a commonly used sunscreen, anti-aging and UV absorber. According to relevant studies, octyl p-methoxycinnamate has mutagenic effects, teratogenic effects and developmental toxicity on humans, and has potential chronic health effects.
In the “Washington State Children’s Product Safety Act” announced by Washington State, octyl p-methoxycinnamate is listed as Chemical High Concern to Children (Children’s High Concern Substance, CHCC for short). The bill requires that children’s products (including parts and raw materials) placed in Washington state must be declared if they contain more than 5 mg/kg of octyl p-methoxycinnamate.
Octyl P-Methoxycinnamate Properties:
Melting point
<-25℃
Boiling point
198-200°C
density
1.009
refractive index
1.543-1.547
Fp
193°C
storage temp.
2-8°C
solubility
Chloroform (Slightly), Methanol (Slightly)
form
Liquid
color
Clear colorless to yellow
Water Solubility
<0.1 g/100 mL at 27 ºC
Octyl P-Methoxycinnamate Uses
Octyl p-methoxycinnamate is made use of to formulate skin care cosmetics such as sunscreen (lotion, cream, liquid), which can successfully absorb ultraviolet rays in the sun, prevent human skin from sunburn, sunburn, and ink, and is additionally the therapy of photodermatitis medication. In industry, it can be made use of as an anti-aging agent as well as ultraviolet absorber for plastics and also inks.
Octyl p-methoxycinnamate is used as oil-soluble liquid UV-B absorber and can be compounded with various sunscreens.
Octyl p-methoxycinnamate is mainly used for cosmetic UV absorption.
Octyl p-Methoxycinnamate Detection Method
CN201711085814.X reported a detection method for octyl p-methoxycinnamate in textiles, comprising the following steps:
The first step, sampling from the textile: use stainless steel scissors to cut the sample into small rectangular pieces with a diagonal length not greater than 5mm.
In the second step, 1.0 g of the chopped sample was weighed and placed in a 40 mL container (reaction tube in this example), then 10 mL of methanol was added to the container, and the container was placed in an ultrasonic cleaner for ultrasonic extraction for 30 min. Ultrasonic frequency is 50kHz, ultrasonic temperature is 25 ℃, obtains extract;
In the third step, the extract obtained in the second step is filtered to obtain the liquid to be tested. Specifically, 1 mL of the extract is filtered with a 0.45 μm organic filter membrane into a sample bottle;
In the fourth step, the liquid to be tested obtained in the third step is analyzed by an ultra-high performance liquid chromatography tandem mass spectrometer (UPLC-MSMS). Wherein, the model of the ultra-high performance liquid chromatography tandem mass spectrometer is WatersAcquityHClass+XevoTQD, and the chromatographic column model is WatersBEHC18 column, and the specification of the chromatographic column is 50mm×2.1mm×1.7μm (column length is 50mm, and the particle size of the filler is 50mm×2.1mm×1.7μm). is 1.7 μm, and the inner diameter of the column is 2.1 mm).
The test conditions of the ultra-high performance liquid chromatography tandem mass spectrometer are: the injection volume is 5 μl; the flow rate is 0.2 mL/min; the elution process adopts the gradient elution procedure; the acquisition mode is the positive ion MRM mode; the capillary voltage is 0.5KV; the desolvation gas flow rate is 900L/h; the desolvation gas temperature is 400°C; the parent ion is 291.1, the cone voltage is 15V, the quantitative product ion is 179.1, and the collision energy is 8V; the qualitative product ion is 161.1, and the collision energy is 15V; quantitative transition 291.1→179.1, qualitative transition 291.1→161.1.
Specifically, the gradient elution procedure is shown in Table 1:
Table 1: Gradient elution procedure.
The flow rate of gradient elution was 0.2 mL/min.
By adopting the method of the invention, octyl p-methoxycinnamate and impurities can be efficiently separated, and the qualitative and quantitative analysis of octyl p-methoxycinnamate can be carried out quickly and accurately.
Application of Octyl P-Methoxycinnamate
Application 1
Application 2
Application three
Application 1
CN201910955854.8 discloses a pediatric trauma spray and a preparation method thereof. The pediatric trauma spray is composed of 5-chloro-7-(3-hydroxy-propoxy)-3-nitromethyl-3H-benzo[c][1,2]oxaborol -1-ol, borneol, octyl p-methoxycinnamate, isopropanol, methyl ethyl ketone, Tween 80, disodium edetate, and purified water, in the form of a solution with excellent promoting Traumatic wounds, especially hemorrhagic wound healing function.
Application 2
CN201210507572.X discloses an emulsifier-free sunscreen. The sunscreen agent of the present invention is composed of octocrylene, octyl p-methoxycinnamate, avobenzone, and original film powder to form a UV protection basic system, and is matched with isododecane/polydimethylsiloxane/ethylene A new type of sunscreen formula is prepared according to the proportion of inactive ingredients such as polydimethylsiloxane cross-linking compound, grapefruit essential oil, benzyl alcohol, silica silylate, silver koji oil, argan oil and other inactive ingredients. The UV protection base system can be added to other cosmetic formulation carriers to provide UV energy resistance. The sunscreen does not add emulsifier, and has little skin irritation. It can not only effectively block the damage of ultraviolet rays to the skin, but also has waterproof effect. It has good compatibility with foundation and other facial skin care products, and has a silky texture. Refreshing, non-greasy, natural makeup. Sunscreen products with SPF30~SPF50 are more suitable for Asian people and have broad market prospects.
Application three
CN201510735753.1 discloses a preparation method of sunscreen containing microcapsules with after-sun repair function, firstly using maltodextrin, gum arabic, hydroxyethyl cellulose, coconut oil, sea buckthorn oil, jojoba wax, squalane, vitamin E. The alcohol extract of witch hazel, the alcohol extract of Portulaca oleracea, paeoniflorin, the alcohol extract of green tea, L-cysteine and Span 80 are used as raw materials to prepare microcapsules with after-sun repair function; then the microcapsules are With coconut oil, lanolin, ethanol, zinc oxide, titanium dioxide, octyl p-methoxycinnamate, butylmethoxydibenzoylmethane, isooctyl 2-cyano-3,3-diphenylacrylate, vitamin E , deionized water, xanthan gum and Span 20 were used together as raw materials to prepare the sunscreen. The invention uses the microcapsule technology to encapsulate the post-sun repair ingredients and add them into the sunscreen, so that the sunscreen can exert the dual functions of sun protection and post-sun repair, and effectively avoid the bad interaction phenomenon caused by the coexistence of the two.
Octinoxate’s manufacturing and also use as a component in sunscreens and also cosmetics might result in its release into the environment with numerous waste streams. If launched right into air, an estimated vapor stress of 2.3X10-5 mm Hg at 25 ° C shows that octoate salts will certainly exist in both vapor as well as particle stages in the environment. The gas-phase octoate weakens in the atmosphere by reacting with photochemically created hydroxyl radicals; the half-life of this reaction in air is approximated to be 7.2 hrs. Gas-phase octoate will certainly likewise be weakened in the environment by response with ozone; the half-life of this response in air is estimated to be 20 hrs. The particulate stage octoate will be eliminated from the atmosphere by wet or dry deposition. Octinoxate absorbs light at wavelengths more than 310 nm and also might consequently be prone to direct photolysis by sunlight. Based on an estimated Koc of 8,600, octinoxate is expected to have no mobility if launched right into dirt. Based on the approximated Henry’s Legislation constant of 8.5X10-6 atm-cu m/mole, volatilization from wet soil surface areas is anticipated to be a vital destiny process. However, adsorption to soil is anticipated to attenuate volatilization. Based upon its vapour stress, Octinoxate is not expected to evaporate from dry soil surface areas. Utilizing OECD Standard 301 F (Prepared Biodegradability: Stress Breathometry Test), the unadapted activated sludge inoculum deteriorated 78% over a 28-day exposure period. If launched to the approximated Koc, octinoxate is expected to adsorb right into put on hold solids and debris. Based on the estimated Henry’s Legislation constant for this compound, volatilization from the water surface area is anticipated to be a crucial fate process. The approximated volatilization half-lives for the design river and also version lake are 7.6 days and also 60 days, specifically. Nevertheless, volatile columns at the water surface area are expected to be damaged by adsorption to suspended solids and sediments in the water. When adsorption is considered, the volatilization half-life of the design fish pond has to do with 6 years. The BCF values determined in rainbow trout (Oncorhynchus mykiss) were 174 and 433, respectively, suggesting a high bioconcentration capacity in water microorganisms. Hydrolysis half-life is more than one year at pH 5-9 as well as 20 ° C. Direct photolysis half-life in aqueous service is 1-9 days. Work direct exposure to octinoxate may occur with skin contact with the compound in work environments where octinoxate is produced or used. The general populace might be subjected to octoate via skin contact with this substance in consumer products such as cosmetics and sun blocks.
Company Profile and Corporate Culture
Company Profile：
ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .
The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .
The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.
Corporate Culture：
OUR MISSION Help China Chemicals to benefit the happiness of human life OUR VISSION Become the most trusted chemical supplier in the world OUR BUSINESS PHILOSOPHY Striver – oriented, enrich employees, customer first, deep service, seek development OUR VALUES Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight
About Us
The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.
“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.
Service
Pre-Sales Service
* Prompt reply and 24 hours online, professional team to provide best price and high quality product.
* Sample testing support.
* Every batch of products will be tested to ensureits quality.
*The packing also can be according the customers` requirment.
*Any inquiries will be replied within 24 hours.
*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.
After-Sales Service
*The fact of logistics information monitoring.
* Any questions about the product can be consulted at any time.
*Product has any problem can return.
FAQ
Do you accept sample order?
We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.
HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
What’s your MOQ?
Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Do you supply product report?
Yes. We’ll give you product analysis report before shipping.
Is there a discount?
Different quantity has different discount.
Shipping
1. ≤50kg, Express delivery recommended, usually called as DDU service;
2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;
3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;
4. For high value products, please select air shipping and express delivery for safe.
