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Zhishang Chemical

Nonivamide CAS 2444-46-4

Molecular Formula: C17H27NO3

Formula Weight: 293.4

ZSpharmac: Nonivamide Supplement

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Product Name: Nonivamide
CAS No: 2444-46-4
Purity: 99%

Basic Info

Product Name:Nonivamide
Other Names:N-Vanillylnonanamide
CAS:2444-46-4
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Active Pharmaceutical Ingredients
Appearance:White to Off-White Powder
EINECS No.:262-390-0
Storage:Sealed in Dry,2-8℃
Provide:Nonivamide MSDS;
SigmaAldrich COA

What is Nonivamide?

Nonivamide, likewise called Nonivamide, capsaicin, is the energetic ingredient of capsicum plant red pepper, its main zesty component is capsaicin, and the chemical name of capsaicin is 8-methyl-6-decene vanillylamine. Capsaicin normally coexists with other capsaicinoids in capsicum, primarily consisting of dihydrocapsaicin (DC), nordihydrocapsaicin (NDC), high capsaicin (HC) and also homodihydrocapsaicin (HDC). It is bothersome to creatures consisting of humans as well as can create a burning sensation in the skin. Capsaicin and some relevant substances, additionally known as capsaicinoids, might be secondary metabolites generated by peppers to prevent grazing by herbivores and also parasitical fungi.

Nonivamide Properties:

Melting point 54°C
Boiling point 200-210 °C(Press: 0.05 Torr)
density 1,1 g/cm3
FEMA 2787 | NONANOYL 4-HYDROXY-3-METHOXYBENZYLAMIDE
Fp 190°C
storage temp. Sealed in dry,2-8°C
solubility methanol: 100 mg/mL, clear to slightly hazy
pka9.76±0.20(Predicted)
form powder
color white to off-white
JECFA Number1599
BRN 2144300
Stability:Stable. Incompatible with strong oxidizing agents.

Nonivamide Uses

  1. Nonivamide for Biochemical Research
  2. Nonivamide rodent repellent, rodent-proof cable material, used as rodent-proof additive for cable plastic sheath to prevent animal bites, and can be used in cable and optical cable industries. Biological antifouling agent, which has been used in ship antifouling coatings, is applied to the parts of ships and offshore structures in contact with seawater to prevent the adhesion of marine organisms such as algae, shellfish, mollusks, etc., and can prevent the accumulation of aquatic organisms on the hull. For the purpose of replacing organotin antifouling coatings. In the field of medication, it can be utilized for non-addictive analgesia, preventing germs and also fungi, promoting blood flow, as well as also can be made right into lotions, tinctures, creams, areas, etc. Eliminating agent, using the strong tear and also sneezing result of artificial capsaicin, is used to manufacture tear gas as well as various other eliminating gadgets as well as personal defense items.
  3. Nonivamide synthesizes capsaicin analogs with similar biological activities.

Physiological function of Nonivamide

1 Reduce tiredness
Nonivamide can especially bind to delicate receptors in the human body, release signal particles to act upon the transport networks of special cations, and then release certain energetic substances to lower tiredness.
2 hypoglycemic and also lipid-lowering
Nonivamide’s hypoglycemic and lipid-lowering impacts are mostly accomplished by acting upon lipid-related cytokines, acting upon intestinal tract vegetation as well as regulating bacteria. Insulin plays an essential duty in controling fat material, as well as several types of monocytes in adipocytokines can influence insulin by activating inflammation. The intestinal flora is carefully related to the intake, metabolic rate and storage space of glycolipids by the body. Amongst them, capsaicin can act upon the intestinal tract vegetation to change its framework and also diversity, so as to accomplish the function of reducing blood sugar level and also lipids. Capsaicin minimizes the body’s intake of food by boosting the focus of anorectic hormones as well as decreasing the concentration of dietary hormones, to ensure that the body’s power consumption is lower than the energy usage.
3 Secure the stomach
Gastritis is a swelling of the gastric mucosa caused by numerous factors, which has a serious adverse impact on the digestion system. Nonetheless, existing research study has actually revealed that little doses of capsaicin not only do not trigger damage to the tummy, yet can additionally repair damage to the gastric mucosa.

Biosynthesis of Nonivamide

It was found that the biosynthesis of Nonivamide is mainly via the phenylalanine to vanillylamine pathway and the branched-chain fatty acid pathway from valine to 8-methyl-6-decenoyl CoA. Capsaicin synthase (CS) is considered to be the key enzyme in capsaicin synthesis. At present, several candidate enzymes related genes of capsaicin biosynthesis pathway have been cloned, including pAMT, BCAT, KAS I, Fat A, AT3 and so on.

1. The synthesis site of Nonivamide Using isotope tracer technology and high-density electron scanning microscope observation, it was found that capsaicinoids are formed in the cytoplasm of the epidermal gland cells of the capsicum placenta, and transported through the ovary septum to the gland cells of the placenta and pulp epidermis to accumulate. . Microscopic observation of the placenta of the fruit of pepper and sweet pepper at post-flowering 55 days showed that the annual pepper (C. annuum) inbred lines ’59’, ‘612’ and the Chinese pepper (C. chinense) ‘Shabushaulaa’ Glandular cells in the epidermis of the placental septum of the inbred line ‘740’ (both capsaicin) contained numerous “vesicular” structures, while the sweet pepper (C. annuum var. grossum) inbred line ‘170’ (no capsaicin) ) does not contain such structures.

2. Nonivamide-phenylpropane synthesis pathway Phenylalanine lyase (PAL) widely exists in various plants and a few microorganisms, plays an important role in the synthesis of plant secondary metabolites, and participates in the biosynthesis of proteins, flavonoids, lignin and other compounds. PAL is an essential enzyme in the metabolic rate of phenylpropane and also the initial enzyme in the phenylpropane path in capsaicin biosynthesis. Research studies have revealed that the content of capsaicin in pepper fruit is positively associated with the activity of buddy, that is, when the level of PAL is higher, the web content of capsaicin increases. Cinnamate hydrolase (C4H) is the second crucial enzyme in the phenylpropane pathway that militarizes the conversion of cinnamic acid to p-coumaric acid. Aminotransferase (AMT) is a catalytic enzyme in the final step of capsaicin biosynthesis in the phenylpropane branch, which catalyzes the synthesis of vanillylamine from vanillin.

3. Branched-chain fatty acid synthesis pathway of Nonivamide Branched-chain amino acid transferase (BCAT) catalyzes valine to α-ketoisovalerate, and KAS is an important component of fatty acid synthase. Through transcriptome analysis and comparison, it was found that there were significant differences in the expression of these two homologous genes during placental development in pepper and tomato fruit. BCAT and KAS were rarely expressed in tomato, and similar results were obtained in the potato genome. This suggests that changes in BCAT and KAS expression enable capsaicin synthesis. Acyl transporter ACL is an acidic protein with small molecular weight and conserved serine residues. It carries an acyl chain to complete enzymatic reactions such as condensation, reduction, anddehydrogenation. Studies have found that fatty acid synthesis Three candidate genes of enzymes, KAS, ACL and FAT, their expression levels were positively correlated with the pungency of pepper fruit flavor, and were located in the epidermal cells of the placenta.

4. Nonivamide synthase (CS). Capsaicin synthase catalyzes the last step of capsaicin synthesis, specifically, the synthesis of capsaicin from vanillylamine in the phenylpropane path and also 8-methyl-6-decenoyl CoA in the branched-chain fatty acid path. Immunolocalization studies confirmed that the CS gene was specifically located in the placenta tissue of pepper fruits; in addition, Western blot analysis showed that during fruit development, CS levels and capsaicin accumulation were significantly increased. By comparing the expression of capsaicinoid biosynthesis genes in pungent and non-spicy pepper placentas, it was found that the absence of CS gene expression was the main reason for the production of non-spicy peppers.

5. Nonivamide
Capsaicinoids include capsaicinate, dihydrocapsaicinate, nordihydrocapsaicinate, etc., which are compounds of fatty acid and vanillyl alcohol. Capsaicinate and capsaicin have similar biological functions and chemical structures. It was found that the production of capsaicinoid in the ‘CH-19’ variety (C. annuum) was due to the insertion of a t-nucleotide at 1 291 bp of the pAMT gene, forming a new stop codon, preventing pAMT translation. Park et al. (2015) reported a low-spicy variety ‘S3212’ (Capsicum frutescens L.) containing a large amount of capsaicinoids, and a 12 bp deletion mutation was found in the pAMT gene exon 7, which proved that the fetal The synthesis of capsaicinoids in locus tissue is associated with mutations in the pAMT gene.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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