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N,N-Dimethylformamide CAS 68-12-2

Molecular Formula: C3H7NO

Formula Weight: 73.09

ZSpharmac: N,N-Dimethylformamide Supplement

Product Name: N,N-Dimethylformamide
CAS No: 68-12-2
Purity: 99%

Basic Info

Product Name:N,N-Dimethylformamide
Other Names:N,N-Dimethylformamidez
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Colorless Transparent Liquid
EINECS No.:200-679-5
Storage:Store at +5°C to +30°C.
Provide:N,N-Dimethylformamide MSDS;
N,N-Dimethylformamide COA

What is N,N-Dimethylformamide?

N,N-Dimethylformamide is abbreviated as DMF. It is a compound generated by the substitution of the hydroxyl group of formic acid by a N,N-Dimethylformamide group, and the molecular formula is HCON(CH3)2. It is a colorless, transparent, high-boiling liquid with a light amine odor and a relative density of 0.9445 (25°C). Melting point -61 ℃. Boiling point 152.8 ℃. Flash point 57.78 ℃. Vapor density 2.51. Vapor pressure 0.49kpa (3.7mmHg25 ℃). The auto-ignition point is 445°C. The explosion limit of vapor and air mixture is 2.2 to 15.2%. In case of open flame and high heat, it may cause combustion and explosion. It can react violently with concentrated sulfuric acid and fuming nitric acid and even explode. It is miscible with water and most organic solvents. It is a common solvent for chemical reactions. Pure N,N-Dimethylformamide is odorless, but industrial-grade or spoiled N,N-Dimethylformamide has a fishy smell because it contains N,N-Dimethylformamide impurities. N,N-Dimethylformamide is produced using formic acid and dimethylamine. It is very stable in air and when heated to boiling. When the temperature is higher than 350 ℃, it will lose water and generate carbon monoxide and dimethylamine. N,N-dimethylformamide is a good aprotic polar solvent, which can dissolve most organic and inorganic substances, and is miscible with water, alcohols, ethers, aldehydes, ketones, esters, halogenated hydrocarbons and aromatic hydrocarbons, etc. . The positively charged end of the N,N-dimethylformamide molecule is surrounded by methyl groups, forming a steric hindrance, so that negative ions cannot approach, but only positive ions are associated. The naked anion is much more active than the solvated anion. Many ionic reactions are more easily carried out in N,N-N,N-Dimethylformamide than in general protic solvents, for example, the reaction of carboxylates with halogenated hydrocarbons in N,N-N,N-Dimethylformamide at room temperature , can generate high-yield esters, especially suitable for the synthesis of sterically hindered esters.

N,N-Dimethylformamide Properties:

Melting point -61 °C (lit.)
alpha 0.94 º
Boiling point 153 °C (lit.)
density 0.944 g/mL (lit.)
vapor density 2.5 (vs air)
vapor pressure 2.7 mm Hg ( 20 °C)
refractive index n20/D 1.430(lit.)
Fp 136 °F
storage temp. Store at +5°C to +30°C.
solubility water: miscible
form Powder
color APHA: ≤15
OdorFaint, ammonia-like odor detectable at 100 ppm
Relative polarity0.386
PH7 (200g/l, H2O, 20℃)
Odor Threshold1.8ppm
explosive limit2.2-16%(V)
Water Solubility soluble


N,N-Dimethylformamide Uses

  1. N,N-Dimethylformamide is additionally used as an extractant, as a basic material for medications as well as pesticides.
    as well as can be made use of for damp rotating of artificial fibers such as polyacrylonitrile fibers, as well as synthesis of polyurethane; It is utilized for plastic film making; it can additionally be utilized as a paint stripper for getting rid of paint; it can also dissolve some low-solubility pigments, to ensure that the pigments have the attributes of dyes.
  2. N,N-Dimethylformamide is utilized for aromatic extraction and also separation and also healing of butadiene from C4 portions as well as isoprene from C5 portions, and can likewise be made use of as a reliable reagent for the splitting up of non-hydrocarbon components from paraffin.In the pesticide sector, it can be used to produce ciprofloxacin; in the pharmaceutical industry, it can be made use of to manufacture iodine, doxycycline, cortisone, vitamin B6, iodine, quercetin, pyrantel, N-formylsarcomin, Tumorine, Methoxyfen mustard, Bian nitrogen mustard, cyclohexyl nitrosourea, furoflurouracil, hemostatic acid, bepartame, megestrol, bilevitamin, chlorpheniramine, and so on. DMF has a catalytic impact in the reactions of hydrogenation, dehydrogenation, dehydration and dehydrohalogenation, to ensure that the response temperature level is decreased and also the product pureness is boosted.
  3. N,N-Dimethylformamide non-aqueous titration solvent. Solvent for vinyl and acetylene. Photometric determination. Gas chromatographic stationary liquid (maximum temperature 50℃, solvent is methanol), can separate and analyze C2-C5 hydrocarbons, and can separate normal, isobutene and cis, trans-2-butene. Pesticide residue analysis. 

The Preparation Method of N,N-Dimethylformamide

report one,
The preparation method of high-purity N,N-dimethylformamide is characterized in that, the extraction step comprises:

a. Take the waste liquid N,N-dimethylformamide, add sulfuric acid solution with a volume concentration of 30% to it, and control the pH value within the range of 6 to 8; and mix it with the waste liquid N,N-dimethylformamide Impurities such as organic bases in the amide react to precipitate the reactants from the solution.

b. Preheat the N,N-dimethylformamide obtained by the above quenching and tempering to 120°C, the vacuum of the flash tank is 30mmhg, and flash evaporation to remove low-boiling impurities and water.

c. The N,N-dimethylformamide obtained by the above distillation is preheated to 70°C, and the air heated to 90°C is introduced to remove residual methylene chloride, methyl tert-butyl ether, water, free amine.

d. The N,N-dimethylformamide decompressed rectification after the removal of metal ions is processed, the rectified distillate is tested qualified and then canned, and stored with nitrogen to obtain a medicinal product with a purity of ≥99.9% (wt) Grade N,N-dimethylformamide.

report two,
A preparation method of chromatographic grade N,N-dimethylformamide, the steps are as follows:

(1) with raw material N, N-dimethylformamide (content is about 99.5%) through the calcium hydride adsorption column that particle diameter is 5mm~10mm, the amount of column packing is 4/5 of the column length, and the flow rate is about 50mL/ min, N,N-dimethylformamide raw material is fully contacted with calcium hydride to adsorb impurities such as moisture in it, and the effluent to be adsorbed is qualified for inspection (that is, each index of the effluent is close to the technical index requirements of the chromatographic grade, and the specific technical index requirements are See Table 1.) and enter the next step;

(2) The adsorption effluent in the step (1) is pumped into a still, and 5% of alumina (weight ratio) is added to the still, and pre-burned at 500-600° C. for about 1 hour. Under the pressure of 5~10mmHg, vacuum distillation is carried out to further dehydrate and dry N,N-dimethylformamide, remove a small amount of amine impurities, and discard the front distillate;

(3) Collect the finished product after passing the test of the distillate in step (2), filter it with a 0.45 μm NYL microporous membrane, and store it in a nitrogen-filled reagent bottle to obtain chromatographic grade N,N-dimethylformamide.

report three.
After the methanol is gasified, the reaction temperature is 220 °C on a composite catalyst with copper as the main body (the amount of methanol is 1 wt%), and the pressure is normal pressure, and the catalytic dehydrogenation generates methyl formate, which is then mixed with dimethyl formate. The amine undergoes amination reaction to obtain crude N,N-dimethylformamide and methanol, and the crude product is purified to obtain high-purity N,N-dimethylformamide.

report four.
20 g of hydroxyapatite was weighed and immersed in a solution of 48.6 mmol·L-1 of hydrated ruthenium trichloride, stirred at room temperature for 20 h, dried at 130 °C, and reduced under a hydrogen atmosphere at 350 °C for 3 h to obtain 2wt% Ru-HAP; The 2wt% Ru-HAP was immersed in a certain volume of 0.1M cerium nitrate aqueous solution, left standing overnight, and vacuum dried at 200°C to obtain a 1wt% CeO2-2wt% Ru-HAP composite catalyst. The 14-25 mesh catalyst was taken from the forming screen and filled into the reaction tube, and the 15 mm bed was filled. Under the pressure of 4.0 MPa, the space velocity of dimethylamine was 200 h-1, and the flow rate of raw material CO was 5 mL·min-1. The reaction was carried out at 200° C., the reaction was sampled for 2 h and the chromatographic analysis showed that the yield of DMF (N,N-dimethylformamide) was 75%.

Method for Recovering N,N-Dimethylformamide

report one,
Method for recuperating N,N-dimethylformamide from alprazolam intermediate refining mommy liquor Particular actions are as follows: In the 500L activator, add the refined mom liquor 200kg (including N,N-dimethylformamide 140kg, water 50kg, unrefined product regarding 6kg, impurity about 4kg) of alprazolam intermediate benzodiazepine thione, add 50kg The water of mixing, there is light yellow alprazolam intermediate to separate out; Filter,
50kg of dichloromethane was added to the waste liquid for extraction, and the lower organic layer was separated. Extract 3 times, combine the organic layers, about 280kg. 100kg of the separated water layer is waste water, which is treated by the sewage treatment plant.
To the dichloromethane extract containing N,N-dimethylformamide, add 25kg of anhydrous sodium sulfate, stir and dry at normal temperature and pressure for 6 hours; filter to obtain 270kg of the dried extract.
Fractionation of the extract was carried out, firstly at normal pressure and slowly fractionation, and 123 kg of dichloromethane, a recyclable extractant with a boiling point below 40°C, was collected, and the recovery rate was 82%; then the temperature was raised to 50°C, and the collected content was 98%. The above N,N-dimethylformamide was 119 kg, and the recovery rate was 85%.
report two,
The obtained batch of N,N-dimethylformamide waste water solvent, the concentration of N,N-dimethylformamide in it was determined to be 40%, and the single solvent octanoic acid was used as the extraction agent, which entered from the lower part of the rotary disk extraction tower, The feed flow rate was fixed at 10ml/min, the waste solvent entered from the upper part of the extraction column, and the flow rate was set at 20ml/min. Set the rotating speed of the sieve plate rotating disk extraction tower to 40 r/min and the extraction temperature to 25 °C, and obtain the extraction phase at the top of the extraction tower. The obtained extraction phase is subjected to rectification operation, entering from the middle of the rectification column, the operating pressure is controlled to be 0.75 atm, and the reflux ratio is set to 0.5. Under these operating conditions, an overhead fraction was collected at an overhead temperature of 140.8°C. Then, the obtained fractions are further refined through a dehydration column and a decolorization column, and finally a high-purity N,N-dimethylformamide product is obtained. It has been determined that the purity of N,N-dimethylformamide in the product is 99.94%, and the moisture content is 376ppm, and the quality fully meets the requirements of spinning organic solvent recycling.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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