Nicotinamide Adenine Dinucleotide CAS 53-84-9

Molecular Formula: C21H27N7O14P2

Formula Weight: 663.43

ZSpharmac: Nicotinamide Adenine Dinucleotide Supplier

Product Name: Nicotinamide Adenine Dinucleotide

CAS No: 53-84-9

Purity: 99%

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Basic Info

Product Name:	Nicotinamide Adenine Dinucleotide
Other Names:	β-Nicotinamide Adenine Dinucleotide
CAS:	53-84-9
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White Powder
EINECS No.:	200-184-4
Storage:	-20°C
Provide:	Nicotinamide Adenine Dinucleotide MSDS； Nicotinamide Adenine Dinucleotide COA

What is Nicotinamide Adenine Dinucleotide?

Nicotinamide adenine dinucleotide (shortened as NAD), furthermore called pyridine diphosphate (abbreviated as DPN), or co-dehydrogenase I or coenzyme I. In animals, there are 2 states of oxidized (NAD+) as well as lowered (NADH). The oxidized (NAD+) has an optimal ultraviolet absorption range at 260nm. Through numerous deaminases, it accepts a hydrogen atom from the substratum and One electron, comes to be the decreased kind (NADH), which has a maximum absorption at 340nm.
β-nicotinamide adenine dinucleotide is utilized as a coenzyme in redox reactions, as a factor of the ADP ribose moiety in ADP ribosylation responses, and also as a leader of the 2nd carrier particle, cyclic ADP ribose.β-nicotinamide adenine dinucleotide additionally works as a substratum for microbial DNA ligases and also a group of enzymes called sirtuins, which utilize NAD+ to get rid of acetyl teams from healthy proteins.

Nicotinamide Adenine Dinucleotide Property

Melting point	140-142 °C (decomp)
alpha	D20 -31.5° (c = 1.2 in water)
storage temp.	-20°C
solubility	H₂O: 50 mg/mL
form	Powder
color	White
Odor	Odorless
PH	~3.0 (50mg/mL in water)
Water Solubility	Soluble in water at 50mg/ml

Nicotinamide Adenine Dinucleotide Uses

Nicotinamide adenine dinucleotide is a crucial coenzyme in organisms, utilized in biochemical research study, scientific diagnosis, clinical medicine as well as medication research study.
Nicotinamide adenine dinucleotide is a coenzyme drug. Scientifically, it is mainly made use of for adjuvant therapy of coronary cardiovascular disease, which can enhance upper body rigidity, angina pectoris and other signs. Damaging reactions occasionally dry mouth, wooziness, queasiness and more.
Nicotinamide adenine dinucleotide is associated with the energy metabolism and material metabolism in the body, which is beneficial to the repair work and also revival of cells. For the treatment of coronary heart problem, myocarditis, leukopenia as well as various other illness.
Nicotinamide adenine dinucleotide is a coenzyme that transfers protons (a lot more specifically, hydrogen ions) that happen in many metabolic reactions in cells. NADH or even more properly NADH+H+ is its reduced form. It can be minimized to carry as much as two protons (written as NADH+H+). NAD+ is the coenzyme of dehydrogenases, such as alcohol dehydrogenase (ADH), used to oxidize ethanol. It plays an irreplaceable duty in glycolysis, gluconeogenesis, tricarboxylic acid cycle and respiratory system chain. The intermediate item will certainly pass the hydrogen off to NAD, making it NADH+H+. NADH+H+ will serve as a provider of hydrogen to synthesize ATP with chemical osmotic coupling in the respiratory chain. In regards to light absorption, NADH+H+ has an absorption top at 260nm and also 340nm, while NAD+ has just one absorption peak at 260nm, which is an important credit to differentiate both. This is likewise the physical basis for gauging metabolic price in several metabolic experiments. The absorption coefficient of NAD at 260nm is 1.78 * 104L/(mol * centimeters), while the absorption coefficient of NADH at 340nm is 6.2 * 10 ³ L/(mol * centimeters).

Nicotinamide Adenine Dinucleotide Production Method

Preparation of Nicotinamide Adenine Dinucleotide from Yeast
Wall breaking, extraction, separation Add freshly squeezed yeast with stirring, add the same amount of boiling water, heat to 95 ° C for 5 minutes, quickly add ice cubes twice the weight of the yeast, filter, wash the filter cake with water twice, combine the filtrate and washing liquid, Add strong basic quaternary ammonium type I anion exchange resin 201×7 (717), stir for 16 hours, filter, and collect the filtrate.
Freshly squeezed yeast [boiling water, ice cubes] → extract [201×7 resin] → filtrate
Adsorption and elution The filtrate is adjusted to pH=2-2.5 with concentrated hydrochloric acid, adsorbed by weakly acidic acrylic cation exchange resin 122 column, washed with pyrogen-free water until the effluent is clear, and then eluted with 0.3mol/L ammonium hydroxide solution , when the effluent was light brown, and the absorbance measured by a 340nm spectrophotometer was greater than 0.05, the collection was started, and the effluent was stopped when it was light yellow to obtain an eluent.
Filtrate [pH2-2.5]→adsorbate→eluent neutralization and adsorption Add strong acidic styrene-based cation exchange resin 001×7 (732) to the eluent, stir to measure pH=5-7, filter, filter Wash the cake with pyrogen-free water, combine the washing liquid and filtrate, add dilute ammonia water to adjust the pH value to 7 (about 15%), and then use strong basic quaternary ammonium type I anion exchange resin 201×7 (717) 50-60 mesh column Carry out adsorption and wash with pyrogen-free water until the effluent is clear and colorless.
Eluent [001×7 resin, ammonia water, 201×7 resin]→[pH7] adsorbate
Elution, adsorption, elution Connect the 766-type activated carbon 60-80 mesh column and the 201×7 resin column in series, elute with 0.1mol/L potassium chloride solution, and the eluent immediately flows through the activated carbon column for adsorption. Remove the two columns in series, wash with pyrogen-free water of pH 9, then wash with 4% ethanol of pH 8, and finally wash with pyrogen-free water until neutral. The volume ratio is acetone:ethyl acetate:water:concentrated ammonia water=4:1 The mixture of :5:0.02 was eluted. When the eluent was mixed with 3 times acetone to produce white turbidity, the eluate was collected.
Adsorbate [201×7 resin column, potassium chloride, 766 type activated carbon] → eluent [activated carbon column] adsorbate [pyrogen-free water, ethanol] → [wash to neutral] adsorbate [acetone, ethyl acetate, water, concentrated ammonia water] → eluate precipitate, dry eluate, add 30%-40% nitric acid to adjust pH=2-2.5 under stirring, filter, freeze overnight, filter, wash with 95% cold acetone, vacuum dry, Get the finished product.
Eluent [nitric acid] → [pH2-2.5, 0°C] precipitation [acetone] → [dry] COI finished product.

Function of Nicotinamide Adenine Dinucleotide (NAD+)

NAD+ is known to be involved in many metabolic processes of life, some of its main roles include:

Improves Mental Status: Nicotinamide adenine dinucleotide (NAD+) helps improve focus, memory, alertness and mental clarity.

The role of NAD+ in cellular respiration: NAD+ is an important enzyme that produces adenosine triphosphate (ATP), and ATP is the most important part of cellular respiration. Every cell in the body needs thousands of ATPs, and NAD+ helps cells get this energy they need.

Adenine dinucleotide (NAD+) is used to treat Alzheimer’s and Parkinson’s diseases: NAD+ is used to treat Alzheimer’s, Parkinson’s and depression patients and can effectively improve the health status.

For skin care and health care: As the most active coenzyme in the metabolic process, and has the ability to repair damaged cells, NAD+ becomes the most effective antioxidant. NAD+ ranks #1 in the anti-aging element category. It helps reduce the signs of aging, is an important element in skin care, and provides energy and longevity to aging cells.

Improve endurance: As an endurance enhancer, NAD+ can help complete various sports training tasks and improve sports performance. It doubles cell production and provides instant energy for physical activity.

NAD+ dietary supplements/health products: There are many dietary supplements/health products on the market that contain NAD+, which helps repair damaged DNA and cells by promoting growth hormone and other beneficial ingredients.

NAD+ for Chronic Fatigue Syndrome (CFS): Chronic Fatigue Syndrome is a mental state with extreme fatigue, and NAD+ helps relieve tension and stress in CFS patients.

Others: Others use NAD to treat high blood pressure, high cholesterol, adjust jet lag, ward off the effects of alcohol on the liver, reduce aging, and prevent the side effects of anti-AIDS drugs.

Nicotinamide adenine dinucleotide (NAD+) dosage

Talk to your doctor before taking any dose of NAD+. The usual dosage is:

· Daily requirement = 5-10 mg of nicotinamide adenine dinucleotide (NAD+).

· There is no accurate scientific evidence for the intake of NAD+, but the intake of NAD+ sometimes depends on factors such as age, previous health history, or allergies to any drugs.

Nicotinamide adenine dinucleotide (NAD+) precautions and side effects

Before using any kind of NAD+-containing medication, you should consider the following precautions to prevent side effects from occurring.

Short-term use is recommended: NAD+ dietary supplements/health products should be taken with water every morning for short-term use, preferably for about 1-2 months.

During Pregnancy: To be on the safe side, avoid NAD+ use during pregnancy and breastfeeding without consulting any healthcare professional.

Mood swings: Long-term use of NAD+ is not recommended as it may cause issues such as anxiety, insomnia, overstimulation, and fatigue.

Research data shows that NAD+ activity and content in the body begin to gradually decrease after the age of 30, and may decrease by 50% by the age of 50. However, no matter which age group you belong to, in addition to supplementing dietary supplements/health products, you can supplement and increase NAD+ levels through food and experience youth again, delay aging and prolong life.

About Products:
If you need Nicotinamide Adenine Dinucleotide this cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced Nicotinamide Adenine Dinucleotide manufacturer and supplier, ZSpharmac will provide Nicotinamide Adenine Dinucleotide raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.