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Zhishang Chemical

Neossance Squalane CAS 111-01-3

Molecular Formula: C30H62

Formula Weight: 422.81

ZSpharmac: Neossance Squalane Supplement

Product Name: Neossance Squalane
CAS No: 111-01-3
Purity: 99%

Basic Info

Product Name:Neossance Squalane
Other Names:Squalane
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Liquid
EINECS No.:203-825-6
Provide:Neossance Squalane MSDS;
Neossance Squalane COA

What is Neossance Squalane?

Neossance Squalane is an important element of human sebum. The sebum secreted by the sweat glands of human skin has about 10% squalene as well as 2.4% Neossance Squalane. The body transforms squalene right into Neossance Squalane. Neossance Squalane can supply oxygen and also nutrients to cells, as well as can promote cell metabolism, develop a sebum film on the external layer of the skin, stop moisture loss, and isolate germs, dust and also ultraviolet damages. Nonetheless, the secretion of Neossance Squalane in ladies will go down greatly from the age of 25, and the skin will certainly be dehydrated, slack, dull, and also aging. Therefore, it is really important to supplement the skin with squalane! The cosmetic impacts of squalene as well as Neossance Squalane are almost the very same, yet the molecular structure of squalene is unpredictable as well as easily oxidized, so it is normally wrapped in pills as well as appropriate for dental administration; while Neossance Squalane is a steady pure oil, Neossance Squalane for exterior usage.

Neossance Squalane has great leaks in the structure as well as can go into the inside of the skin, renew cell lipids, and also nourish the skin. After rubbing the skin with Neossance Squalane, the skin will become soft, moisturized as well as elastic, which is the result of the infiltration of squalane into the skin. Neossance Squalane will create a breathable and water-permeable safety film externally of the skin. The advantage is that it is not hefty, however it is moderately hydrating. In specifically dry and also cold seasons, so Neossance Squalane is made use of, the water-locking capability is insufficient, and also it needs to be utilized along with various other items.

Neossance Squalane Properties:

Melting point -38 °C (lit.)
Boiling point 176 °C/0.05 mmHg (lit.)
density 0.81 g/mL at 25 °C (lit.)
refractive index n20/D 1.452(lit.)
Fp 424 °F
storage temp. 2-8°C
solubility chloroform: soluble100mg/mL, clear
form neat
color Clear Colourless
Water Solubility Not miscible or difficult to mix in water.


Neossance Squalane Efficacy and Action

Neossance Squalane, comparable to squalene, an essential part of human sebum, quickly incorporates into the skin, creates a protective film on the skin surface area, as well as works as a barrier. Neossance Squalane is dispersed in the major organs of the human body, as well as it is particularly high in sebum, with approximately 12% squalene in the sebum of healthy females. However, one of the most flourishing duration of Neossance Squalane secretion is between the ages of 15 as well as 18, and also it goes down dramatically around the age of 25. The oxygen material of the cells also progressively decreases, and the supporting force for the skin lowers, which impacts the manufacturing of wrinkles as well as the skin. It doesn’t look so watery anymore.
The surface of the stratum corneum of the skin has a layer of sebum produced from the sweat glands of the skin, lipids created by keratinocytes, as well as sweat secreted from the sweat glands as well as dirt, microorganisms, bacteria, and so on in the air. sebum movie. The PH value of the sebum membrane layer must be preserved at 4.5-6.5 in a weakly acidic state to keep the skin healthy.
The sebum membrane has crucial physiological functions on the skin and also the entire body, mostly in the adhering to elements:
A. Barrier feature, the sebum film is the most vital layer of skin dampness retention, which can efficiently lock wetness, protect against the short-term evaporation of skin moisture, as well as protect against a large amount of exterior dampness and also specific compounds from penetrating into the skin. The outcome is the dampness material of the skin. maintain it typical.
B. Moisturize the skin. The sebum movie is formed by emulsification of sebum as well as water. Its lipid component efficiently moisturizes the skin, maintains the skin lubed as well as nourished, and also makes the skin flexible, smooth as well as glossy; the water in the sebum film can make the skin Keep the skin moisturised to avoid dryness.
C. The sebum movie is the immune layer on the surface of the skin, which has an anti-infective effect. Some free fats in the sebum movie can prevent the development of some pathogenic microorganisms and have a self-purifying impact on the skin.

Neossance Squalane is a hydrogenated product of squalene, which perfectly inherits the advantages of squalene. It is skin-friendly, moisturizing, anti-oxidant, and has similar sebum components, making it easier to integrate into the skin and form a protective film on the skin surface. The character is also more stable than squalene, which is not only easy to preserve, but also can get along with other ingredients. Therefore, such an easy-to-use and versatile squalane has become a new aristocrat in skin care products.

Yes, related. To be precise, squalene is associated with sharks.
Squalene was first discovered by Japanese scientists from shark liver oil. Although many animals, including humans, have squalene, sharks are still the animals found to contain the most squalene.
Sharks have a huge liver, which accounts for almost 25% of its entire body weight, and more than 70% of the liver is squalene, which can help it improve its tolerance to hypoxia in the deep ocean where oxygen is scarce.
When the benefits of squalene were discovered, people began to mine sharks in large numbers. However, the life of 3000 sharks can be exchanged for 1 ton of squalene, which is too extravagant to calculate!
It was later found that squalene can also be extracted from vegetable oils such as olive oil, amaranth oil, and palm oil. In particular, crude olive oil has the highest content of squalene, and olive oil has become the main source of plant-derived squalene.
Hydrogenation of squalene can yield squalane with high purity, which is simple and efficient. Although squalane can also be made from other substances through complex synthetic methods, the cost is still high and the quality is difficult to control.
Many people feel that hunting sharks for squalene is too cruel and refuse to use squalane products. Now, even in Japan, most skin care brands are gradually turning to plant-derived squalene to produce squalane, and everyone can use it with peace of mind.

1. Neossance Squalane is a kind of lipid closest to human sebum, with strong affinity, it can be integrated with human’s own sebum membrane, forming a natural barrier on the skin surface. This ingredient is a gift from God for people with insufficient oil secretion (dry skin). For many sensitive skins, Neossance Squalane is colorless, odorless, stable, refreshing, and skin-friendly to absorb quickly. It can help repair the skin barrier and relieve sensitive symptoms.

2. Neossance Squalane can also inhibit the peroxidation of skin lipids. It has anti-oxidant function and therefore has anti-aging effects. The anti-aging effect is manifested in that it can promote the proliferation of skin basal cells.Neossance Squalane can be used during the day to assist in sun protection!

3.Penetrates into the skin; has low polarity and moderate spread, and is pure, colorless, and odorless; also inhibits mold growth. (There is no essential difference between squalene and Neossance Squalane in terms of skin care effects, except that olefins are converted into alkanes by the hydrogenation process of adding hydrogen.)
Neossance Squalane not only has moisturizing effect, but also repairs skin barrier, anti-aging and anti-oxidation, promotes metabolism, antibacterial and antibacterial. No matter what kind of skin type you have, as long as you add the right amount of moisture and oil to your skin, and let Neossance Squalane help lock in moisture, you can achieve the best water-oil balance for your skin.

Neossance Squalane Preparation

Rathane is a three-mushroom compound with thirty carbon atoms. At present, its preparation method has two kinds of semi-synthesis and total synthesis. The semi-synthetic method is the industrial production of cartonene, for example, by extracting cartonene from the livers of deep-sea-caught cartilage and then re-hydrogenating it. The total synthesis methods are: (1) Japanese Kuraray method; (2) oxidative coupling method of dehydronerolidol; (3) dimerization of dehydronerolidol followed by dehydration and hydrogenation; (4) from orange Carrageenene is prepared from anthocyanin and then hydrogenated; (5) Caratonene is prepared from farnesene and then hydrogenated.

1. Semi-synthetic method:

The horned soft-shelled turtle (Panthelidae) lives in the deep seas of Spain, Angola, Taiwan and the Philippines. In the past, cartonene was industrially produced by hydrogenation of cartonene obtained from turtle liver oil. This horned squid can only be caught in special fish farms in the deep sea of ​​about 1,000 meters. It is very difficult to suppress its catch to meet the needs of caratane production.

2. Kuraray full synthesis method:

Japan Kuraray Co., Ltd. is a company specializing in the development of isoprene series of fine chemical products. In 1970, the company developed the technology for the total synthesis of cartonane from isoprene. In 1976, Kuraray Co., Ltd. built a production plant for mushroomene compounds in Niigata Prefecture’s Nakajo-Dei Natural Gas-to-Acetylene Plant. In 1977, the company began to sell carotene, which is synthesized from isoprene and synthesized from linalool. In the same year, the company also plans to build 1,000 tons/year hornbecene and 500 tons/year isophytol plant. According to recent Japanese data reports, the annual production capacity of the isoprene fully-synthesized serratane plant of Japan Kuraray Company is only a few hundred tons.

Synthesis process steps:

①Addition of isoprene and hydrogen chloride to obtain methylbutene chloride.

②Methylbutene chloride is condensed with acetone to obtain methylheptenone, and the catalyst is quaternary ammonium salt or phosphorus salt-sodium hydroxide solution.

③ methylheptenone is alkylated to obtain dehydrolinalool, and the catalyst is alkali-liquid ammonia.

④ Dehydrolinalool is hydrogenated to obtain linalool.

⑤ Linalool is condensed with ethyl phenol acetate to obtain geranyl acetone, and the catalyst is isopropyl aluminum-triethylamine

⑥Geranyl acetone is coupled with diacetylene to obtain diacetylene glycol, the catalyst is potassium hydroxide-liquid ammonia, and the reaction temperature is 15 ℃.

7. Diacetylenic diol is hydrogenated to obtain saturated diol, which is carried out in three steps. First, the unsaturated triple bond and part of the double bond of diacetylenic diol are hydrogenated by using Raney nickel catalyst. The solvent is hexane, and the reaction temperature is 100 ° C. , hydrogen partial pressure 15-20 kilograms/cm 2; Secondly, reclaim saturated diol with rectification; Finally: adopt Ni/Si-Al catalyst, make saturated diol hydrogenation.

⑧ Dehydration and hydrogenation of saturated diol to obtain squalane. Dehydration catalyst can use sulfuric acid, phosphoric acid, Lewis acid (zinc chloride, aluminum chloride), alumina, silica-alumina and solid phosphoric acid, etc.; hydrogenation catalyst can use Pd/c, Raney nickel, etc.

At present, Kuraray Company of Japan has built the world’s first isoprene fully synthetic serratane plant. The Kuraray total synthesis method has the following advantages: (1) not only can produce cartonane, but also can co-produce other mushroom ene compounds; (2) use N-methyl pyrrolidone to selectively absorb butadiyne (natural gas cracking to produce acetylene) (3) continuous synthesis of methyl heptene ketone; (4) the product has high purity and stable quality.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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