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Neohesperidin CAS 13241-33-3

Molecular Formula: C28H34O15

Formula Weight: 610.56

ZSpharmac: Neohesperidin Cosmetic Raw Material Suppliers

Product Name: Neohesperidin
CAS No: 13241-33-3
Purity: 99%

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Basic Info

Product Name:Neohesperidin
Other Names:Neohesperidin 95% HPLC
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Neat
EINECS No.:236-216-9
Storage:Sealed in Dry,2-8°C
Provide:Neohesperidin MSDS;
Neohesperidin COA

What is Neohesperidin?

Neohesperidin, whose English name is Neohesperidin, is a white strong powder under regular temperature level and also stress. It is slightly soluble in water, easily soluble in hot water and also warm ethanol, however insoluble in ether. Neohesperidin is a brand-new all-natural dietary sugar drawn out from Citrus aurantium. Its hydrogenated neohesperidin dihydrochalcone is 1500-2000 times sweeter than sucrose and is widely made use of in Sweeteners (flavoring representatives) for juices, fruit glass of wines, beverages, cakes and pharmaceutical solutions.

Neohesperidin Property

Melting point 239-243°C
Boiling point 933.7±65.0 °C(Predicted)
density 1.65±0.1 g/cm3(Predicted)
vapor pressure 0Pa at 20℃
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Pyridine (Slightly)
form neat
color White to Off-White
Water Solubility 3.98mg/L at 20℃


Application of Neohesperidin

Neohesperidin has the result of treating the fragility of blood vessels and extreme protein permeability in plasma. It was when called the vitamin that preserves capillary permeability or vitamin P. This substance has a bitter taste as well as is an all-natural non-nutritive sweetener. Compared with sucrose, its sweet taste is 500-700 times that of sucrose. It has the characteristics of high sweetness, reduced calorie worth, non-toxicity and also safety and security, as well as can be utilized in Food, pharmaceutical as well as daily chemical sectors.

Neohesperidin Biological Activity

Neohesperidin is an antioxidant with an IC50 of 22.31 μg/ ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) free radical scavenging assay. Neohesperidin (50 mg/kg) dramatically hindered HCl/ethanol-induced gastric damage by 55.0%. In pyloric ligated rats, neohesperidin (50 mg/kg) dramatically reduced stomach secretion and also stomach acid output, and raised pH. Treatment with this substance considerably decreased fasting blood glucose, blood sugar and glycosylated lotion healthy protein (GSP) in mice, it considerably boosted oral glucose tolerance and insulin level of sensitivity, and also reduced insulin resistance in diabetic person mice. On top of that, the compound can dramatically decrease serum triglycerides, overall cholesterol, leptin degrees as well as liver index in computer mice.

Preparation of Neohesperidin

Neohesperidin DC does not happen in nature. It is chemically produced from neohesperidin (without DC at the end), extracted from bitter oranges or by chemical conversion of naringin in grapefruit. The procedure contains five steps:

1. Dissolve neohesperidin and potassium hydroxide in water.
2. Include hydrogen gas to the blend under high pressure in the presence of steel. This steel (usually palladium) works as a touchdown website for neohesperidin, potassium hydroxide, as well as hydrogen to incorporate into neohesperidin dihydrochalcone (i.e., neohesperidin DC). No steel is carried; it’s just a stimulant.
3. Usage sulfuric acid to counteract strongly alkaline mixes.
4. Heat the mixture to develop crystals. These crystals are not pure; they contain bits as well as microbes. Consequently, they are liquified in hot water, filtered, and after that heated to create purer neohesperidin DC crystals. This is called recrystallization and is repeated till the crystals consist of at least 96% neohesperidin DC.
5. The hence removed as well as purified neohesperidin DC crystals are then dried out, ground and packaged.

About Products:
If you need the cosmetic raw material Neohesperidin, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Neohesperidin manufacturer and supplier, our company, ZSpharmac, will provide Neohesperidin raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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