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Naturium Azelaic Acid CAS 123-99-9

Molecular Formula: C9H16O4

Formula Weight: 188.22

ZSpharmac: Naturium Azelaic Acid Raw Material Supplier

Product Name: Naturium Azelaic Acid
CAS No: 123-99-9
Purity: 99%

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Basic Info

Product Name:Naturium Azelaic Acid
Other Names:Azelaic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Microcrystalline Powder
EINECS No.:204-669-1
Storage:Store Below +30°C.
Provide:Naturium Azelaic Acid MSDS;
Naturium Azelaic Acid COA

What is Naturium Azelaic Acid?

Azelaic acid is a medication commonly used to prevent and treat skin conditions such as acne, chloasma, and hyperpigmentation. It is also utilized as an important intermediate in organic synthesis. In industries like plastics, rubber, and aviation fuels, azelaic acid is used to synthesize plasticizers, lubricants, and electrolytic capacitors. The primary method of production involves the use of unsaturated fatty acids like oleic acid and triglycerides found in oils such as castor oil and cottonseed oil to create azelaic acid.

Naturium Azelaic Acid Property

Melting point 98 °C
Boiling point 286 °C100 mm Hg(lit.)
density 1,029 g/cm3
vapor density 6.5 (vs air)
vapor pressure <1 mm Hg ( 20 °C)
refractive index 1.4303
Fp 215 °C
storage temp. Store below +30°C.
solubility 2.4g/l
form Slightly Crystalline Powder or Flakes
pka4.53, 5.33(at 25℃)
color White to slightly yellow
PH3.5 (1g/l, H2O)
Water Solubility 2.4 g/L (20 ºC)


Effects of Naturium Azelaic Acid on Skin

Naturium Azelaic Acid possesses a broad-spectrum antibacterial effect, inhibiting common acne-causing bacteria such as Propionibacterium and Staphylococcus epidermidis. By reducing bacterial levels, it can effectively improve skin conditions associated with acne and other bacterial infections.

Additionally, Azelaic acid exhibits antioxidant properties that can combat free radicals and minimize oxidative stress damage to the skin. This helps prevent premature aging, diminish fine lines, wrinkles, and pigmentation, resulting in a more youthful and smoother complexion.

Furthermore, this ingredient promotes skin cell metabolism, accelerating the turnover of the stratum corneum. This leads to improved skin tone, reduced hyperpigmentation, and a decrease in acne and blackheads caused by the accumulation of dead skin cells. The skin will appear smoother, refined, and cleaner.

Azelaic acid also regulates sebum production, making it particularly beneficial for oily skin and acne-prone individuals. It helps control shine and reduces the formation of acne.

Lastly, Naturium Azelaic Acid has the ability to lighten pigmentation issues such as dark spots, freckles, and sun spots. This results in a more even, brighter, and clearer complexion.

How and How Often to Use Naturium Azelaic Acid

Proper application technique and frequency are crucial for maximizing the benefits of azelaic acid. Here are some tips to help you use it effectively:

1. Start with clean skin: It’s important to cleanse your skin thoroughly before applying azelaic acid. Use a gentle cleanser to wash your face and pat it dry with a soft towel.

2. Use a small amount: Only a small amount of azelaic acid is needed for each application. Apply it sparingly to the targeted area using your fingertips or a cotton pad to avoid using too much.

3. Massage gently: Gently massage the azelaic acid into your skin using circular motions to help it absorb better. Avoid applying it near the eyes and mouth, as these areas are more sensitive.

4. Use sunscreen: Azelaic acid can increase your skin’s sensitivity to UV rays, so make sure to apply sunscreen during the day to protect your skin from sun damage.

5. Adjust frequency: The frequency of azelaic acid use should be based on your skin type and the product’s instructions. Start by using it 2-3 times a week and gradually increase to daily use if your skin tolerates it well. If you experience any irritation or dryness, reduce the frequency or consult a professional.

Remember to always follow the product instructions and consult a dermatologist if you have any concerns about using azelaic acid. It has numerous benefits for the skin, such as antibacterial and antioxidant properties, regulation of sebum production, and lightening of pigmentation. By using it correctly and adjusting the frequency as needed, you can achieve the best results for your skin.

Naturium Azelaic Acid Preparation

A method for preparing azelaic acid catalyzed by solid acid involves several key steps. First, unsaturated fatty acids or mixed fatty acids obtained from the hydrolysis of animal and vegetable oils are mixed with a solid acid catalyst and cetyltrimethylammonium chloride. The mixture is then heated to 50~70°C and exposed to a mixed gas containing ozone at a concentration of 2~10g/L.

Next, a hydrogen peroxide solution with a weight percentage of 20~40% is added in batches while controlling the reaction temperature to not exceed 70°C. After all the raw materials are added, the temperature is raised to 95°C to 110°C and the reaction is allowed to proceed for 5 to 12 hours.

Once the reaction is complete, the mixture is separated using a separatory funnel to obtain a solid acid catalyst layer, an oil layer, and a water layer. The water layer is then refrigerated at 3°C to crystallize white azelaic acid, which is filtered and dried. The oil layer is extracted with boiling water, cooled, and crystallized at 3°C to obtain azelaic acid, which is also filtered.

The obtained azelaic acid is then purified by recrystallization with hot water. The solid acid catalyst is used in a dosage of 5-20% of the weight of unsaturated fatty acids or mixed fatty acids, while the hydrogen peroxide solution is used in a dosage of 5-20% of the weight of fatty acids. The cetyltrimethylammonium chloride is used in a dosage of 1% to 5% of the weight of unsaturated fatty acids or mixed fatty acids.

About Products:
If you need the cosmetic raw material Azelaic acid, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Azelaic acid, our company, ZSpharmac will provide Azelaic acid raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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