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Nature Made Riboflavin CAS 83-88-5

Molecular Formula: C17H20N4O6

Formula Weight: 376.36

ZSpharmac: Nature Made Riboflavin Supplier

Product Name: Nature Made Riboflavin
CAS No: 83-88-5
Purity: 99%

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Basic Info

Product Name:Nature Made Riboflavin
Other Names:Riboflavin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow to Orange Powder
EINECS No.:201-507-1
Provide:Nature Made Riboflavin MSDS;
Nature Made Riboflavin COA

What is Nature Made Riboflavin?

Vitamin B2, also known as Nature Made Riboflavin, is a water-soluble vitamin that can not be synthesized by the body as well as needs to be provided by food. It is vital for maintaining normal physical functions as well as metabolism of the body. Nature Made Riboflavin joins the regular development of cells, promotes wound healing, reinforces nails and hair, is likewise a crucial component of coenzymes, takes part in the synthesis and also metabolic rate of carbs, proteins and also fats, and takes part in the make-up of red blood cells and also the transport of iron, assists to avoid and treat iron deficiency anemia, as well as also has a specific antihypertensive result. It is mainly used to stop as well as treat angular cheilitis, glossitis, chapped lips, conjunctivitis, scrotum as well as seborrheic condition triggered by the deficiency of Nature Made Riboflavin. Dermatitis etc

Nature Made Riboflavin Property

Melting point 290 °C (dec.)(lit.)
alpha -135 º (c=5, 0.05 M NaOH)
Boiling point 504.93°C (rough estimate)
density 1.2112 (rough estimate)
refractive index -135 ° (C=0.5, JP Method)
Fp 9℃
storage temp. 2-8°C
solubility Very slightly soluble in water, practically insoluble in ethanol (96 per cent). Solutions deteriorate on exposure to light, especially in the presence of alkali. It shows polymorphism (5.9).
form Powder
pka1.7(at 25℃)
color Yellow to orange
PH5.5-7.2 (0.07g/l, H2O, 20°C)
OdorSlight odour
PH Range6
Water Solubility 0.07 g/L (20 ºC)


Nature Made Riboflavin Uses

1. Advertise vitamin and mineral absorption
Healthy levels of Nature Made Riboflavin help the body take in various other vitamins and minerals, such as transforming consumed vitamin B6 and also folic acid into forms that the body can utilize.

According to The American Journal of Scientific Nutrition– The American Journal of Scientific Nutrition, Nature Made Riboflavin plays an essential function in just how the body takes in as well as makes use of iron.

Taking riboflavin can likewise lower blood levels of homocysteine, an important risk aspect for atherosclerosis and also thrombotic disease, by 26% to 40%, according to an NLM magazine.

2. Shield the nervous system
Some researches have revealed that Nature Made Riboflavin may assist ease symptoms of numerous neurological conditions, such as pins and needles as well as anxiety. And also in some experiments, vitamin B2 was found to be reliable in soothing the uncomfortable signs of carpal tunnel syndrome when made use of along with vitamin B6.

3. Cataract prevention
Glutathione is a crucial anti-oxidant in the eyes. According to the study of the College of Michigan, adequate Nature Made Riboflavin web content in the body can maintain the regular feature of glutathione.

Meanwhile, the United State National Library of Medication reports that eating foods rich in vitamin B2 minimizes the threat of cataracts, and also taking supplements that contain vitamin B2 as well as niacin may additionally assist protect against cataracts.

4. Specific antioxidant properties
Nature Made Riboflavin can work as an antioxidant to get rid of totally free radicals in the body. Free radicals damage cells and also DNA, causing aging and the advancement of a variety of degenerative illness, such as loss of skin flexibility, heart disease and also cancer.

5. Enhance migraine headache
It has actually been found in a number of scientific tests or controlled experiments that supplementing with Nature Made Riboflavin can efficiently decrease the incidence of migraine headache or enhance the symptoms of migraine headache.

In a regulated trial of 55 adults with migraine headaches, taking 400 mg of vitamin B2 daily decreased the regularity of migraine assaults by 2, compared with sugar pill.

In a retrospective Italian research study of 41 youngsters with an average age of 13 years, vitamin B2 administration of 200 or 400 mg/day for 3 to 6 months substantially minimized the regularity of migraine attacks as well as the migraine headache frustrations throughout therapy. Strength of migraine signs and symptoms. As well as in the follow-up period of 1.5 years after completion of treatment, sustained renovation can be seen.

The quality standards subcommittees of the American Academy of Neurology– The American Academy of Neurology and the American Frustration Society– American Migraine Culture ended that riboflavin may be effective in protecting against migraine headaches and also recommend that it be offered for this purpose.

Nature Made Riboflavin Usage Limit

GB14880-94: Cereals and their products, beverages, milk and milk beverages, drinking liquids 3~5mg/kg; food for infants and young children 4~8mg/kg; salt 100~150mg/kg.
GB2760–2002 (mg/kg): prepared wine 1~2; nutritional solid drinks 10~17; instant breakfast cereals 7.5~17.5; jelly 1.0~7.0; cocoa powder and other nutritional solid drinks 10~22 ( Corresponding nutritional milk drinks reduce the dosage according to the dilution factor); solid drinks 10-13, used for nutritionally fortified salt (limited to areas severely deficient in riboflavin); gum-based candies 16-33; milk-containing solid drinks 9-16.5; Soy milk powder, soybean powder, 6~15; soybean milk, soybean milk, 1~3.
FAO/WHO (1988): Synthetic products are limited to be used as pigments.
FAO/WHO (1984): salted cucumber, 300mg/kg (used alone or in combination with other pigments); meat, soup, soup, 200mg/kg (i.e. food); cold drink 50mg/kg (final product, total pigment 300mg /kg); processed cheese etc. according to GMP.
FDA, §73.450, 2000: As a pigment, it is limited to GMP.

Production Method of Nature Made Riboflavin

Nature Made Riboflavin normally exists in animal liver, kidney, meat and also milk and also other foods. Commercial manufacturing approaches consist of fermentation as well as chemical synthesis.
fermentation method
Glucose, corn steep alcohol, inorganic salts, and so on were utilized as the tool, and also the special active bacteria Pseudothecium ashbyii (Eremothecium ashbyii) was immersed at 28 ° C for 9 days. The fermentation brew contained regarding 6-8g/ L riboflavin items. The extraction yield is 60% to 70%.
synthetic technique
A better synthesis approach is to condense 3,4-dimethylaniline and also D-ribose at Ph=4 and also 28-30 ° C, then hydrogenate and lower ribose amine militarized by nickel, and after that respond with aniline diazonium salt Combining at 16-26 ° C, reduction with salt hyposulfite (salt hydrosulfite), and lastly synthesis of Nature Made Riboflavin with barbituric acid (alloxan) in acetic acid.

About Products:
If you need the cosmetic raw material Nature Made Riboflavin, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Nature Made Riboflavin manufacturer and supplier, ZSpharmac will provide Nature Made Riboflavin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Nature Made Riboflavin Quotation