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Nature Made Lutein CAS 127-40-2

Molecular Formula: C40H56O2

Formula Weight: 568.87

ZSpharmac: Nature Made Lutein Supplier

Product Name: Nature Made Lutein
CAS No: 127-40-2
Purity: 99%

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Basic Info

Product Name:Nature Made Lutein
Other Names:Xanthophyll
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Red to Very Dark Red Solid
EINECS No.:204-840-0
Provide:Nature Made Lutein MSDS;
Nature Made Lutein COA

What is Nature Made Lutein?

Nature Made Lutein, a promising star in the field of botanical substances, is gaining popularity today. Lutein is not only an antioxidant that suppresses the risk of cancer and heart disease, but also plays an important role in protecting the eyes. Lutein is an important carotenoid present in the eye. According to a recent report in “Ophthalmology”, foods containing lutein can prevent cataracts and protect eyes from age-related macular degeneration.

Nature Made Lutein Property

Melting point 195 °C
alpha 18Cd +165° (c = 0.7 in benzene)
Boiling point 572.66°C (rough estimate)
density 0.9944 (rough estimate)
refractive index n20/D1.361-1.363
Fp 269.1±27.5 °C
storage temp. -20°C
solubility Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly, Heated, Sonicated)
form Solid
color Red to Very Dark Red


The Role of Nature Made Lutein

1. Antioxidant effect

Our eyes are subjected to harmful compounds called energetic oxygen free radicals in every day life. These free radicals, such as superoxide anion, hydroperoxide complimentary radical, hydroxyl totally free radical, and so on, lug really unsteady unpaired electrons. They are like a team of energetic however extremely defiant intermediate school youths straying in our retinal tissue, and savagely taking electrons on the surface of regular tissue cells to create redox responses as well as harm our retinal tissue cells.

And Also Nature Made Lutein can take the lead in “feeding” electrons to these cost-free radicals before they take cell electrons, soothe their agitated hearts, and support these energetic oxygen cost-free radicals. So as to attain the effect of shielding retinal cells as well as anti-oxidation.

2. Anti-blue light impact

Given That Nature Made Lutein is initially yellowish, it can absorb light with a wavelength of around 460nm, and this spectrum is simply in the series of blue light. When our eyeballs are exposed to too much blue light, a great deal of responsive oxygen types will be produced in the retina, triggering oxidation responses and also speeding up the damages of retinal cells. Therefore, correct supplements of lutein amounts using a set of anti-blue light glasses for the eyes.

3. Boost cell signaling

Lots of researches have discovered that Nature Made Lutein has the feature of boosting visual top quality and enhancing the cognition of the brain’s visual cortex. This may be due to the fact that lutein can be utilized as an electrolyte to restore the link location in between cells, as well as increase the charging as well as releasing speed of retinal as well as optic nerve cells, thus including a speed-up “ENTHUSIAST” to retinal cells and also brain visual cortex cells. At the same time, lutein also has a certain anti-inflammatory result as well as advertises the repair work of omental cells after the inflammatory feedback.

As a result of the above series of features of Nature Made Lutein, it has a really active function in avoiding and also delaying some fundus retinal conditions such as age-related macular deterioration (AMD), diabetic retinopathy, high myopia fundus lesions, and retinopathy of prematurity., In addition, researches have located that the incidence and development of nuclear cataract will be significantly lowered in the elderly with high plasma lutein web content.

"Golden Guarantee for Eyes"--Nature Made Lutein

The main pigment parts of the retina:
Nature Made Lutein and also zeaxanthin make up the main elements of plant pigments such as veggies, fruits, as well as flowers, as well as are additionally the primary pigments in the macular area of the human eye. Human eyes contain a high amount of lutein, if the eyes lack this aspect, the eyes will certainly be blind.

Shield vision:
Nature Made Lutein is the major part of the macular pigment in the retina of the human eye and has a vital safety effect on the macula in the retina. When it wants, it is very easy to trigger macular deterioration and blurred vision, and then signs and symptoms such as vision degradation and myopia. Lutein can advertise the regeneration of rhodopsin in retinal cells, stop extreme nearsightedness and also retinal detachment, as well as soothe visual exhaustion, nearsightedness, amblyopia, strabismus, cataract, keratoconjunctival sicca, macular deterioration, retinal deterioration, etc. To enhance eyesight as well as protect vision. Especially ideal for pupils as well as vehicle drivers.

Safeguard eyes from light damage, delay eye aging as well as protect against pathological adjustments:
The optic nerve can not restore as well as is incredibly vulnerable to damage from harmful complimentary radicals. The antioxidant result of lutein can hinder the formation of hazardous complimentary radicals. The center of the macular area of the human eye– the fovea location is the most delicate part of the light, and additionally the most bountiful part of lutein. When ultraviolet rays and blue light go into the eyes, a lot of complimentary radicals will certainly be created, bring about cataracts, macular deterioration, and also cancer. Lutein can filter and also disintegrate ultraviolet as well as blue light to prevent the damages of ultraviolet and also blue light to the eyes, and also avoid vision degeneration and loss of sight caused by lutein shortage. Adolescents who are in the stage of eyeball growth coincide with the heaviest scholastic duration. The “light” damages brought on by inadequate consumption or too much intake of Nature Made Lutein is the basic factor for the occurrence of nearsightedness and amblyopia close to 60%. Supplementing lutein is equivalent to including a pair of “all-natural sunglasses” in the body, which will restore normal vision to a lot of teens with pseudomyopia as well as amblyopia

Impacts on retinal deterioration:
Retinitis pigmentosa (RP) is a persistent, dynamic, genetic, as well as dystrophic retinopathy. Evening blindness signs and symptoms often show up in youth. With the growth of the disease, the capability to adjust to the dark is weakened, photophobia, and vision silently decline., The field of vision diminishes, and ultimately it ends up being blind in the form of a tubular field of vision, which is called “cancer that is not cancer”. Retinitis pigmentosa mainly includes main retinitis pigmentosa, crystalline retinitis pigmentosa, punctate retinitis pigmentosa and amelanotic retinitis pigmentosa. The sore is generally the modern degeneration of the retinal neuroepithelium, specifically the rod cells responsible for vision in dark light, leading to night blindness, adhered to by the steady degeneration of the retinal layers from the outdoors to the within, accompanied by gliosis. The pigment epithelium additionally goes through degeneration and also hyperplasia, and also depigmentation or build-up can be seen, and also it migrates to the inner retinal layer. Hyaline deterioration as well as thickening of the retinal vascular wall, and also even full occlusion of the lumen. Choroidal blood vessels might have differing degrees of sclerosis, total or partial disappearance of veins, and also complete atrophy of the optic nerve. Supplementing lutein can boost the density of retinal pigment, improve the vision of RP clients, as well as improve the therapy rate.

Can successfully protect against retinopathy as well as pigment degeneration:
Diabetic retinopathy is a condition of retinal capillary circulation brought on by long-term hyperglycemia, blood circulation slowness, tissue hypoxia, capillary wall surface deterioration and also brittleness, and microvascular lumps, dots or spots appearing on the retina at the posterior pole of the fundus. Hemorrhage and cotton-like exudation reason vision loss. If it is not treated in time right now, the lesion will develop better. As a result of hypoxia, the retina of the eye creates new members vessels, which can trigger glasslike hemorrhage, reproductive retinopathy, grip retinal detachment, second glaucoma, and so on, resulting in blindness. Lutein can dramatically enhance the resistance of blood vessels, recover the lost balance of osmotic stress inside as well as outside blood vessels, lower the permeability of capillary, inhibit the leakage important in blood vessels, ensure the honesty of blood vessels in the eyes, as well as enable the eyes to get enough blood supply. At the same time, it can stop the damage triggered by the mix of complimentary radicals and also eye collagen, reinforce the retinal collagen structure, consequently boosting the treatment of numerous retinal conditions (such as: diabetic person retinopathy, retinitis pigmentation, hemorrhagic and also hypertensive retinopathy, macular deterioration, etc) rate, enhancement as well as restoration of vision loss arising from this.

Dramatically reduce the occurrence of cataracts:
Cataract is the main eye disease that creates blindness on the planet. The most up to date study shows that boosting the intake of Nature Made Lutein can accomplish the goal of birth price. It is believed that the mechanism is lower macular pigment thickness and also higher lens vision in middle-aged as well as elderly people. Density is very closely relevant, and higher lens aesthetic density is considered to be a clear function of cataract development.

Lutein stops macular deterioration:
Western medication primarily makes use of laser therapy, fibrinolytics, anti-platelet aggregation representatives, and also improvement of Nature Made Lutein items to treat macular deterioration. It has a certain scientific result. These can treat existing neovascularization and also control the disease, yet can not stop the development of new neovascularization, even more absorb blood stasis, recover vision, protect against reoccurrence of the condition, increase macular pigment thickness, Shield macula as well as promote macular growth.

Antioxidant result:
Nature Made Lutein has a strong antioxidant effect, can prevent the activity of active oxygen totally free radicals, and also protect against active oxygen cost-free radicals from destroying regular cells. Pertinent experiments have confirmed that active oxygen complimentary radicals can react with DNA, healthy proteins, and also lipids, compromise their physical functions, and cause persistent illness such as cancer cells, arteriosclerosis, and age-related jaundice. Physical or chemical quenching suspends singlet oxygen, thereby safeguarding the body from damage and improving the body’s resistance.

Delay arteriosclerosis impact:
Recent study results reveal that lutein has a delaying result on the very early process of arteriosclerosis. It is generally the partnership in between the modification of the intima density of the primary arteries and the material of lutein in the blood. The material of Nature Made Lutein in the blood is reduced, which can quickly cause the thickening of the arterial vessel wall. With the gradual rise of the web content of lutein, The propensity of arterial wall enlarging is reduced, and also arterial embolism is additionally considerably reduced. At the same time, lutein in arterial wall cells can additionally lower the oxidation of LDL cholesterol.

Preparation of Nature Made Lutein

Consider 600g of lutein extract and also 10g of 6% vitamin C liquid solution, add it to a 5000ml round bottom flask, dissolve 138g of logical grade KOH in 600g of 95% alcohol, and then include the ethanol option of KOH under mixing In a round bottom flask, after saponification reaction at 60 ° C for 3h, add 600g of pure water at 60 ° C to thin down, after that recoup the alcohol in a vacuum atmosphere with a stress of -0.08 Mpa and a temperature of 60 ° C to get 91% (quantity proportion) alcohol 389g, ultimately include 3000ml of 0.2 mol/l hydrochloric acid aqueous remedy at 60 ° C, mix for 60min, keep warm for 2h, centrifuge to divide the lutein crystals, wash the crystals with distilled water, and dry at -0.095 Mpa, at a drying temperature of 30 ° C, as well as vacuum-dried the crystals for 24h. 72.2 g of lutein crystals with a content of 885 g/kg were acquired. Mix 72.2 g of the above lutein crystals with 155 g of cyclodextrin, grind and also grate to acquire a finished lutein powder. The above-mentioned filtrate divided by centrifugation is counteracted as well as acidified by 4mol/l hydrochloric acid to a pH worth of 6-6.5, statically divided, as well as the collection web content is 612g of the upper layer oil (lutein resin) with a material of 18g/Kg. Reached 99.4%.

About Products:
If you need Nature Made Lutein, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Nature Made Lutein, ZSpharmac will provide Nature Made Lutein raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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