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Naringin CAS 10236-47-2

Molecular Formula: C27H32O14

Formula Weight: 580.53

ZSpharmac: Naringin Supplier

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Product Name: Naringin
CAS No: 10236-47-2
Purity: 99%

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Basic Info

Product Name:Naringin
Other Names:Nanoliposomal Naringin
CAS:10236-47-2
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White Crystalline
EINECS No.:233-566-4
Storage:2-8°C
Provide:Naringin MSDS;
Naringin COA

What is Naringin?

Naringin is a flavonoid compound. Since there is no conjugation between ring A and ring B, there is a strong ultraviolet absorption peak at 282nm, which enables naringin to display various biological activities and pharmacological effects, and naringin can significantly improve local microcirculation and nutrient supply , effectively resists dark circles, revealing bright eyes. And studies have shown that naringin has an inhibitory effect on the proliferation and migration of melanocytes, so as to fight against pigmented dark circles caused by pigmentation.
The extracted in addition to cleansed naringin is a white to light yellow crystalline powder with an actually bitter choice. After hydrolysis and also in addition hydrogenation, naringin dihydrochalcone, which is 150 times sweeter than sucrose, is gotten. The solubility of naringin alike temperature degree water is simply 0.1%, as well as similarly the solubility can be boosted to 10% at 75 ° C. It is conveniently soluble in methanol, ethanol, acetone, cozy acetic acid, damages antacids solution, as well as likewise formamide, as well as also insoluble in oil ether, benzene, as well as additionally ether. in addition to non-polar solvents such as chloroform.

Naringin Property

Melting point 

166 °C

alpha 

-91 º (c=1, C2H5OH)

Boiling point 

559.35°C (rough estimate)

density 

1.3285 (rough estimate)

vapor pressure 

2.25Pa at 20℃

refractive index 

-84 ° (C=2, EtOH)

storage temp. 

2-8°C

solubility 

DMSO : 1 mg/mL (1.72 mM; Need ultrasonic)H2O : 1 mg/mL (1.72 mM; ultrasonic and warming and heat to 80°C)

form 

crystalline

pka

7.17±0.40(Predicted)

color 

off-white

optical activity

[α]20/D 80±10°, c = 1% in ethanol

Water Solubility 

Soluble in water, alcohol, acetone and warm acetic acid.

 

Efficacy and Function of Naringin

1. Anti-bacterial, antiviral
Naringin and also hesperetin can prevent the growth of Staphylococcus aureus, Escherichia coli, Shigella along with typhoid bacillus in examination tubes, naringin can avoid yeast in addition to fungis, and also prevent virus-infected computer mice Security results. Naringin and hesperidin in grapefruit appear like other flavonoids as well as additionally have anti-inflammatory domestic or business homes.

2. Lower blood glucose
In fresh grapefruit juice, it has insulin-like components, which can lower blood glucose degree, as well as also is an outstanding food therapy for individuals with diabetes as well as weight problems.

3. Antispasmodic and additionally enhances the result of vitamin C
The naringenin contained in grapefruit has noticeable antispasmodic effect. And also pomelo peel off in addition to hesperidin can improve the blood cell gathering in the conjunctival vessels of the eyes and the decrease of capillary resistance in computer mice brought on by lack of vitamin C.

4. Expectorant as well as antitussive
The external peel of pomelo is the commonly made use of standard Chinese medication orange red. The limonene in addition to pyrene had in it can make the breathing secretions a whole lot even more as well as likewise thinner after breathing, which is conducive to the discharge of spit, as well as also has an outstanding expectorant and antitussive result.

Naringin can prevent the problems of oxidative anxiousness to the body’s internal body organs, consequently enhancing the body’s resistance as well as enhancing the body’s resistance to ailment. The antioxidant function of naringin has a great deal to do with its two energised phenolic hydroxyl groups. Phenolic hydroxyl groups can raise the levels of superoxide dismutase (TURF), glutathione peroxidase (GPx) as well as catalase (ANIMAL FELINE) by integrating with absolutely free radicals, energised oxygen molecules in addition to certain transition steel ions in the body. along with different other tasks, play an antioxidant feature.

Antitussive Effect of Naringin

Research studies on the antitussive activity website of naringin show that intravenous shot of naringin has no effect on cough generated by electric stimulation of remarkable laryngeal nerve in test subject, and also intraventricular shot of naringin has no substantial result on cough caused by electrical stimulation of airway nerve in guinea pigs, indicating that the antitussive part of naringin is not in the central, and also its antitussive mode should be outer antitussive.

The results of further antitussive target research study revealed that there was no substantial distinction in the inhibitory effect of naringin on coughing caused by electric excitement of the vagus nerve of capsaicin-desensitized test subject and non-desensitized test subject, suggesting that the depletion of C fiber neuropeptides has a result on naringin. The antitussive impact of naringin has no obvious effect, suggesting that the antitussive impact of naringin is not dependent on the launch of C fiber neuropeptide; ATP-K+ ion channel details blocker glibenclamide has no result on naringin in hindering capsaicin-induced guinea pig The result of coughing has no significant effect, recommending that naringin does not play an antitussive result by opening up the ATP-K+ ion channel; Coughing has a significant repressive impact, recommending that the antitussive effect of naringin is associated with the inhibition of quick adaptation receptors (RARs).

In addition, naringin can considerably minimize the air passage hyperresponsiveness as well as cough sensitivity to capsaicin in test subject with persistent bronchitis caused by chronic smoke (8 weeks), and substantially prevent the secretion of lung inflammatory aspects and Increase the antioxidant degree in the lungs; and also its result on preventing the increased coughing level of sensitivity brought on by chronic smoke (8 weeks) is not weaker than that of levodropropizine as well as mogisteine, which are typically used in professional outer antitussives. More device research studies showed that naringin inhibited the rise of cough sensitivity in test subject with persistent bronchitis caused by chronic smoke, which was due to its restraint of smoke-induced rises in lung cells SP web content and NK-1 receptor expression, restraint of lung tissue NEP It is related to the reduction of enzyme task, and afterwards the reduction of respiratory tract neurogenic inflammation caused by chronic smoke.

The above research study results recommend that naringin and also its primary metabolite naringenin not just have excellent repressive effect on experimental coughing under physiological state, however additionally have significant antitussive effect on coughing under pathological state such as chronic airway inflammation; On top of that, it additionally has a substantial inhibitory result on coughing induced by air passage neurogenic inflammation.

Naringin has the following features:
① Naringin can act on several targets, not just has antitussive effect, but also has phlegm-reducing impact, and can likewise stand up to breathing inflammation. It is a multi-target medication for the therapy of respiratory system diseases;

② Naringin has a considerable peripheral antitussive result, as well as its antitussive result is not weak than that of levodropropizine and also mogisteine, which are generally made use of in clinical technique; Coughing brought on by inflammation has a considerable repressive impact, and can prevent air passage hyperresponsiveness, respiratory tract immune inflammation, and also neurogenic swelling, recommending that naringin can be utilized not just for the treatment of intense coughing, but also for neurogenic inflammation-mediated cough as well as hypersensitivity coughing of chronic bronchitis as well as other illness; and also the antitussive system of naringin is clear, which is generally pertaining to the restraint of quickly suitable receptors (RARs);.

③ Naringin has a substantial expectorant effect. It can not just water down spit by promoting the secretion of serous fluid, yet also promote the transportation function of air passage cilia to advertise the discharge of spit. It can additionally inhibit the proliferation as well as improvement of cup cells. As well as lower the generation as well as secretion of mucin (MUC5AC) to minimize the thickness of sputum, contribute in numerous web links, and ultimately achieve the purpose of expectoration, which is beneficial to the therapy of persistent breathing diseases with pathological qualities of mucin hypersecretion;.

④ Naringin can not only inhibit the incident of respiratory tract inflammation, but likewise advertise the regression of swelling to enhance the healing capacity of breathing system inflammatory illness;.

⑤ Naringin has great security.

Biological Functions of Naringin

Enhance meat high quality
Including naringin to livestock as well as chicken feed can enhance the antioxidant capacity of meat, lengthen the storage period of meat and also improve the shade of meat, making pet meat extra preferred with consumers.

Enhance the body’s resistance
Naringin can hinder the damages of oxidative anxiety to the body’s internal body organs, thereby enhancing the body’s resistance and also boosting the body’s resistance to illness. The antioxidant function of naringin has a great deal to do with its 2 active phenolic hydroxyl teams. Phenolic hydroxyl groups can boost the degrees of superoxide dismutase (TURF), glutathione peroxidase (GPx) and catalase (CAT) by integrating with totally free radicals, active oxygen particles and particular transition steel ions in the body. as well as various other activities, play an antioxidant role.

Some researches in recent times have shown that naringin can improve the immune action of animals and poultry under warmth stress and anxiety atmosphere as well as minimize warmth stress and anxiety reaction. Alhidary et al. administered 1 g and 2 g of naringin weekly to 4-month-old Awasi sheep under high temperature conditions (ordinary room temperature: 38.3 ° C). After 60 days, the plasma healthy protein concentration of the lamb in the 1 g treatment group was comparable to that in the control team. Ratio of naringin increased considerably, and had higher day-to-day gain (increase of 5.2%) and also greater feed conversion effectiveness (boost of 17.1%); in a follow-up trial, the oral dosage of naringin was boosted to 7 g per week as well as 14 g, it was located that the overall focus of main antibodies in product of lamb was significantly boosted, the development rate was even more raised, as well as the activities of SOD and also GPx in plasma likewise boosted to differing levels.

About Products:
If you need Naringin, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Naringin manufacturer and supplier, ZSpharmac will provide Naringin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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