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n-Butyllithium CAS 109-72-8

Molecular Formula: C4H9Li

Formula Weight: 64.06

Zhishang Chemical: n-Butyllithium

Product Name: n-Butyllithium
CAS No: 109-72-8
Purity: 99%

Basic Info

Product Name:n-Butyllithium
Other Names:n-ButyllithiuM
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic chemical raw materials
Appearance:yellow liquid
EINECS No.:203-698-7
Storage:Airtight, dry, low temperature (2-8℃)
Provide:n-Butyllithium MSDS;
SigmaAldrich COA

What is n-Butyllithium?

n-Butyllithium is a colorless or slightly yellow transparent liquid, stable at room temperature, and the lithium hydride is eliminated by heating. It decomposes in the presence of water, dissolves in hydrocarbons and ethers, forms complexes with ethers, amines and sulfides, and uses n-hexane as a solvent, with a density of 0.675g/ml. It is generally formulated into dilute solutions with molar concentrations ranging from 1.0M to 1.3M, and its mass percentage concentration is between 9% and 13%. It is widely used in drug intermediates, liquid crystal monomers, pesticides and organic catalytic reactions in the rubber industry.

n-Butyllithium Properties:

Melting point -95 °C
Boiling point 80 °C
density 0.68 g/mL at 20 °C
Fp 10 °F
storage temp. 2-8°C
solubility Miscible with diethyl ether and cyclohexane.
form liquid
color yellow
Specific Gravity0.695
OdorOdor of the solvent
Water Solubility vigorous reaction


n-Butyllithium Uses

  1. n-Butyllithium is widely used in organic synthesis and increases the carbon chain. It is a relatively basic laboratory product. 1. Metallization reaction: R-H+n-Butyl-Li→R-Li+Butane, the resulting substance alkyl lithium can react with various substances. 2. Directly carry out the metallation reaction: the aromatic compound connected to the substituent is reacted with n-butyllithium, and the metal lithium can be connected to the aromatic compound. 3. Nucleophilic addition and substitution reactions 4. Halogen-metal replacement
  2. The n-butyllithium solution is mainly used as an anionic polymerization initiator in the organic reaction synthesis of pharmaceutical intermediates, and is also used in synthetic rubber, flavor synthesis, liquid crystal materials and other industries and fields.
  3. n-Butyllithium (n-C4H9Li) is mainly used in organic reaction catalysts and is widely used in organic catalytic reactions in pharmaceutical intermediates, liquid crystal monomers, pesticides and rubber industries.
  4. n-Butyllithium solution is used as intermediate and linking agent for chemical products

Precautions for n-Butyllithium

(1) Butyllithium is very easy to spontaneously ignite when exposed to air. When measuring, the tip of the needle will emit sparks in the air;

(2) The whole process must be protected with inert gas, and special attention must be paid to safety;

(3) When butyllithium catches fire , must be extinguished with sand. Usually, it is necessary to have sand and soil for fire fighting within reach;

(4) When preparing and using butyllithium, it is best not to operate alone, so as not to be unable to handle it alone in case of an accident;

(5) n-butyllithium It is a reagent with particularly strong nucleophilicity and can initiate anionic polymerization. Plastic or rubber containers should be avoided and stored at low temperature in the dark;

(6) The reaction system and solvent using butyllithium should be strictly anhydrous and free of water;

(7) Do not touch or drop butyllithium on flammable substances (such as the acetone cold bath in Dewarpin);

(8) The needle may be blocked in the process of taking butyllithium ( When the air humidity is high, the solids in front of the needle or the rubber shavings of the anti-mouth plug are stuffed into the needle hole), you must be calm, and promptly tell the person accompanying you to handle it properly;

(9) Once butyl lithium drips onto the table Or on the ground, don’t be nervous, immediately cover with asbestos cloth or sand. Do not drip into clothes or solvents;

(10) When the dosage is large, it is recommended to use a dry and clean stainless steel tube directly, and slowly add butyllithium dropwise to the reaction through the slight positive pressure of a suitable inert gas that can control the flow rate. In the system, the measure to be interrupted at any time is to timely pump the stainless steel conduit from below the liquid level of butyllithium to above the liquid level;

(11) The addition rate of butyllithium should be strictly controlled. The outer wall of the part exposed to the dry ice-acetone bath above the surface will form a thick frost, and it is basically impossible to clearly observe the speed of the reaction in the reaction bottle.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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