(1) Butyllithium is very easy to spontaneously ignite when exposed to air. When measuring, the tip of the needle will emit sparks in the air;
(2) The whole process must be protected with inert gas, and special attention must be paid to safety;
(3) When butyllithium catches fire , must be extinguished with sand. Usually, it is necessary to have sand and soil for fire fighting within reach;
(4) When preparing and using butyllithium, it is best not to operate alone, so as not to be unable to handle it alone in case of an accident;
(5) n-butyllithium It is a reagent with particularly strong nucleophilicity and can initiate anionic polymerization. Plastic or rubber containers should be avoided and stored at low temperature in the dark;
(6) The reaction system and solvent using butyllithium should be strictly anhydrous and free of water;
(7) Do not touch or drop butyllithium on flammable substances (such as the acetone cold bath in Dewarpin);
(8) The needle may be blocked in the process of taking butyllithium ( When the air humidity is high, the solids in front of the needle or the rubber shavings of the anti-mouth plug are stuffed into the needle hole), you must be calm, and promptly tell the person accompanying you to handle it properly;
(9) Once butyl lithium drips onto the table Or on the ground, don’t be nervous, immediately cover with asbestos cloth or sand. Do not drip into clothes or solvents;
(10) When the dosage is large, it is recommended to use a dry and clean stainless steel tube directly, and slowly add butyllithium dropwise to the reaction through the slight positive pressure of a suitable inert gas that can control the flow rate. In the system, the measure to be interrupted at any time is to timely pump the stainless steel conduit from below the liquid level of butyllithium to above the liquid level;
(11) The addition rate of butyllithium should be strictly controlled. The outer wall of the part exposed to the dry ice-acetone bath above the surface will form a thick frost, and it is basically impossible to clearly observe the speed of the reaction in the reaction bottle.
