Zhishang Chemical

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Zhishang Chemical

N-Acetylneuraminic Acid CAS 131-48-6

Molecular Formula: C11H19NO9

Formula Weight: 309.27

ZSpharmac: N-Acetylneuraminic Acid Supplement

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Product Name: N-Acetylneuraminic Acid
CAS No: 131-48-6
Purity: 99%

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Basic Info

Product Name:N-Acetylneuraminic Acid
Other Names:N-Acetylneuraminic acid
CAS:131-48-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Synthetic, Crystalline
EINECS No.:205-023-1
Storage:-20°C
Provide:N-Acetylneuraminic Acid MSDS;
N-Acetylneuraminic Acid COA

What is N-Acetylneuraminic Acid?

N-Acetylneuraminic Acid is the most commonly distributed sialic acid (N-acylneuraminic acid) in nature, primarily composed of glycoproteins, glycolipids or microbial capsular substances in pet cell membrane layers or secretion liquids. In glycoproteins or glycolipids, the keto group at the 2-position types a glycosidic bond as well as is located at the non-reducing end of the sugar side chain, and also its adverse cost or unique chemical framework makes it have different physical specificities. In nature, an enzyme (neuraminidase) that hydrolyzes as well as gets rid of terminal N-Acetylneuraminic Acid is widely dispersed from viruses to animals. By refining this enzyme, the physical activity modifications, as well as this incurable acid sugar residue has been determined. effect. For example, this sugar residue constitutes the binding website of the influenza infection on the erythrocyte membrane and also plays a major role in the common recognition of plasma glycoproteins with hepatocytes or the recognition system by lymphocytes of circulatory pathways. Although the biosynthetic paths are rather various in pets and germs, they all go through N-acetylmannosamine or its 6-phosphate ester, which is militarized by a specific pyrophosphatase as well as responds with CTP to produce CMP-N-Acetylneuraminic Acid. Unification of sugar chains by transglycosylation responses.

N-Acetylneuraminic Acid Chemical Properties

Melting point 184-186 °C
alpha -32 º (c=2,water)
Boiling point 449.56°C (rough estimate)
density 1.3580 (rough estimate)
refractive index -32 ° (C=1, H2O)
storage temp. -20°C
solubility 50 g/L (20°C)
pka2.41±0.54(Predicted)
form synthetic, crystalline
color White to Off-White
Water Solubility 50 g/L (20 ºC)

 

Effects of N-Acetylneuraminic Acid

N-Acetylneuraminic Acid is a vital part of mind gangliosides. The content of sialic acid in afferent neuron membrane layers is 20 times that of other cells. Given that brain information transmission and also nerve impulse transmission have to be attained via synapses, N-Acetylneuraminic Acid is a mind nutrient that acts on brain cell membranes as well as synapses, so sialic acid Can promote the advancement of memory and also intelligence. Researches have found that enhancing the material of sialic acid in the nursing diet will certainly enhance the web content of sialic acid in the infant’s mind, and the expression degrees of learning-related genes will certainly additionally raise, consequently improving their discovering and also memory capabilities. In infants, the content of N-Acetylneuraminic Acid is just 25% of that in breast milk. Since sialic acid is synthesized in the liver, in the early stages of child development, the mind creates quickly, while the liver creates gradually, as well as the sialic acid manufactured by the liver is It is hard to satisfy the requirements of mind development, therefore, babies specifically need to supplement sialic acid. Infants fed by moms that consume bird’s nest while breastfeeding are smarter than other babies of the same age.

N-Acetylneuraminic Acid has protective and also maintaining results on afferent neuron. The protease located on the surface of afferent neuron membrane layer can not be degraded by extracellular protease after integrating with sialic acid. The material of sialic acid in the blood or brain of people with some neurological illness, such as Alzheimer’s illness as well as schizophrenia, will certainly lower. After healing from drug therapy, the web content of sialic acid will go back to regular, which shows that sialic acid is associated with the metabolic procedure of nerve cells.

Between molecules and also cells, cells as well as cells, and cells and the outdoors, N-Acetylneuraminic Acid at the end of the sugar chain can serve as an acknowledgment website or mask the acknowledgment site. The sialic acid linked to the end of glycoconjugates with glycosidic bonds can properly stop some crucial antigenic sites on the cell surface from being recognized as well as classified, therefore protecting these glycoconjugates from being recognized and also degraded by the surrounding body immune system.

Due to the unique framework of the 9-carbon amino sugar of the N-Acetylneuraminic Acid molecule, there is no enzyme to break down the compound in the digestive tract system. As a result, the peptide conjugate formed by it will certainly not be weakened by the enzymes in the digestion system when it passes through the gastrointestinal system. into the gut. In the gut, details sialic acid polypeptide conjugates can develop affordable binding with pathogenic bacteria, toxins and virions getting in the intestine, therefore protecting against the binding of intestinal toxins, pathogenic germs as well as virions to digestive mucosal cells. It can be seen that adding sialic acid to food can boost the anti-bacterial, detoxification and antiviral capabilities of the intestinal system.

When tissue is inflamed or damaged, white blood cells gather around the irritated cells to play an antibacterial as well as anti-inflammatory effect. In the 1920s and 1990s, researchers in the United States found that the gathering of leukocytes was connected to the cell adhesion process, as well as the cell bond procedure was connected to the E-Selection of an N-Acetylneuraminic Acid-containing tetrasaccharide core externally of leukocytes. When swelling takes place, endothelial cells are stimulated by cytokines to create E-selection, which can recognize tetrasaccharides externally of leukocytes as well as integrate with them to make leukocytes stick to the vascular endothelium, and after that get to the inflammatory cells with the vascular endothelium. As a result, the synthesis of some sialic acid derivatives with simpler structures as well as more reliable than tetrasaccharides as attachment medicines to treat inflammation will come to be a study hotspot.

N-Acetylneuraminic Acid is not weakened by gastrointestinal enzymes in the gastrointestinal system, as well as can go into the digestive tract to avoid pathogenic bacteria from adsorbing to intestinal tract cells, and also play a role in resisting a variety of pathogenic germs. Free sialic acid in body fluids can avoid the adsorption of chilly virus on the cell surface area, and based on this device, anti-cold drugs based on sialic acid by-products have been created.

N-Acetylneuraminic Acid has a solid unfavorable fee as well as is normally situated at the end of the glycoprot

ein or glycolipid on the surface of the cell membrane layer, and also is the major source of the negative cost of the cell membrane. The negative fee of sialic acid makes red cell and also other cells ward off each other, preventing meaningless cell interactions in the blood flow. According to the principle of mutual attraction of opposite sexes, positively billed minerals and some vitamins (such as vitamin B12 contained in food and its trace quantities) getting in the intestinal tract are quickly integrated with highly negatively billed sialic acid. Therefore, sialic acid can enhance the digestive absorption of minerals and also vitamins, and supplementation of sialic acid can enhance the body’s absorption of nutrients.

With the increasing understanding and also expedition of the organic features of N-Acetylneuraminic Acid, the exploration of naturally active substances with sialic acid as the lead has actually come to be a new research field. Sialic acid and also its by-products are made use of in food, healthcare items as well as medical applications are increasingly widespread. It can be seen that sialic acid has a high healthcare worth to the human body. In view of this, bird’s nest is pertained to by increasingly more individuals as the first choice for health care.

The Role of Sialidase and N-Acetylneuraminic Acid Catabolism in Crocodiles

The payment of N-Acetylneuraminic Acid scavenging to the nourishment of Mycoplasma crocodilians was explored. Wild-type growth was considerably faster (P<0.01) than those that fell short to launch (extracellular NanI-mutant) or catabolize (NanA-mutant) from glycoconjugates in serum-only supplemented very little SP-4 medium N-Acetylneuraminic Acid, yet development of sialidase-negative mutants might not be restored to wild-type prices by just adding unconjugated sialic acid to the medium. In a 1:1 growth competition assay, wild-type sialidase-negative mutants were recuperated more than 99-fold after co-culture on lung fibroblasts in serum-free RPMI 1640 tool, despite the enhancement of sugar. The advantage of scavenging nutrients by this mechanism in a complex glycan-rich environment might aid to balance the expected discerning downside of the pathogenic role of mycoplasma sialidase in infected hosts.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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