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N-Acetylneuraminic acid CAS 131-48-6

Molecular Formula: C11H19NO9

Formula Weight: 309.27

ZSpharmac: N-Acetylneuraminic acid Supplier

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Product Name: N-Acetylneuraminic acid
CAS No: 131-48-6
Purity: 99%

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Basic Info

Product Name:N-Acetylneuraminic acid
Other Names:Sialic Acid
CAS:131-48-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Synthetic, Crystalline
EINECS No.:205-023-1
Storage:-20°C
Provide:N-Acetylneuraminic acid MSDS;
N-Acetylneuraminic acid COA

What is N-Acetylneuraminic acid?

N-acetylneuraminic acid is one of the most extensively distributed sialic acid (N-acylneuraminic acid) in nature, primarily composed of glycoproteins, glycolipids or bacterial capsular compounds in pet cell membrane layers or secretions. In glycoproteins or glycolipids, the ketone team at the 2-position kinds a glycosidic bond to make sure that it lies at the non-reducing end of the sugar side chain, as well as its adverse charge or special chemical structure makes it have different physiological specificities. In nature, from viruses to animals, the enzyme (neuraminidase) that hydrolyzes and removes the terminal N-acetylneuraminic acid is very widely distributed. By processing the change in the physiological activity of this enzyme, the terminal acidic sugar has been clarified. The role of residues. For example, this sugar residue constitutes the binding site of the influenza virus on the erythrocyte membrane and plays a major role in the mutual recognition mechanism of plasma glycoproteins and liver cells or in the recognition mechanism of lymphocytes to the circulation pathway. Although the biosynthetic pathway is somewhat different in animals and bacteria, they all go through N-acetylmannosamine or its 6-phosphate, which is catalyzed by specific pyrophosphatase and reacts with CTP to generate CMP-N-acetylneuraminic acid Afterwards, sugar chains are incorporated by a glycosylation reaction.

N-Acetylneuraminic acid Property

Melting point 184-186 °C
alpha -32 º (c=2,water)
Boiling point 449.56°C (rough estimate)
density 1.3580 (rough estimate)
refractive index -32 ° (C=1, H2O)
storage temp. -20°C
solubility 50 g/L (20°C)
pka2.41±0.54(Predicted)
form synthetic, crystalline
color White to Off-White
Water Solubility 50 g/L (20 ºC)

 

N-Acetylneuraminic Acid Efficacy

1. Enhance infant’s intelligence and also memory
N-Acetylneuraminic Acid is a vital element of brain gangliosides. The material of sialic acid in the afferent neuron membrane is 20 times that of other cells. Because the transmission of mind details as well as the conduction of nerve impulses have to be recognized through synapses, as well as sialic acid is a mind nutrient that acts upon brain cell membranes as well as synapses, so sialic acid can promote The advancement of memory and also knowledge. Research studies have actually located that enhancing the content of sialic acid in the breastfeeding diet will raise the web content of sialic acid in the infant’s mind, and the expression level of genetics related to finding out will certainly additionally raise, therefore improving its learning as well as memory capabilities. In infants, the web content of sialic acid is only 25% of that in breast milk. Considering That N-Acetylneuraminic Acid is synthesized in the liver, in very early youth development, the brain creates quickly, while the liver develops extremely gradually. The sialic acid synthesized by the liver It is tough to meet the requirements of brain advancement, therefore, infants specifically require to supplement sialic acid. Infants fed by mommies who consumed bird’s nest throughout breastfeeding were smarter than other infants of the same age.

2. Anti-senile dementia
N-Acetylneuraminic Acid has safety as well as stabilizing impacts on afferent neuron. After the protease situated on the surface of afferent neuron membrane is combined with sialic acid, it can not be deteriorated by extracellular protease. In some neurological diseases, such as very early senile dementia and also schizophrenia, the web content of sialic acid in the blood or mind will reduce, and also after healing from drug therapy, the content of N-Acetylneuraminic Acid will certainly go back to typical, which reveals that sialic acid is associated with the growth of nerve cells. metabolic procedure.

3. Anti-recognition
Between molecules as well as cells, in between cells and also cells, and in between cells as well as the outside world, the N-Acetylneuraminic Acid at the end of the sugar chain can work as an acknowledgment site or mask the acknowledgment website. The sialic acid connected to the end of the glycosides through glycosidic bonds can efficiently avoid some important antigenic sites as well as recognition marks on the cell surface, thereby safeguarding these saccharides from being acknowledged as well as weakened by the surrounding body immune system.

4. Antibacterial, antiviral, antitumor
Due to the special framework of the 9-carbon amino sugar of the N-Acetylneuraminic Acid particle, there is no enzyme that deteriorates this material in the digestive tract system. Consequently, the polypeptide conjugate developed by it will certainly not be deteriorated by the enzymes in the digestive tract when it passes through the gastrointestinal system, and after that right into the intestine. In the digestive system, details sialic acid-polypeptide conjugates can develop competitive binding with pathogenic bacteria, toxic substances, and virions going into the digestive tract, therefore preventing digestive tract toxic substances, pathogenic germs, as well as virions from binding to intestinal tract mucosal cells. It can be seen that adding sialic acid to food can boost the anti-bacterial, detoxing and antiviral capacities of the intestine.

5. Hinder leukocyte attachment and anti-inflammation
When cells is inflamed or harmed, white blood cells collect around the swollen cells to apply anti-bacterial and anti-inflammatory results. In the 1990s, scientists in the United States discovered that the gathering of leukocytes is related to the process of cell attachment, as well as the process of cell adhesion is related to E-selection (E-Selection) of epidermal cells including sialyl tetrasaccharide nuclei externally of leukocytes. When swelling occurs, endothelial cells are stimulated by cytokines to generate E-selection, which can acknowledge tetrasaccharides externally of leukocytes and combine with them, making leukocytes abide by the vascular endothelium, and then reach the inflammatory tissue via the vascular endothelium. Therefore, synthesizing some sialic acid by-products with less complex frameworks and also even more effective than tetrasaccharides as sticky drugs to treat swelling will become a research hotspot.

6. Improve human immunity
N-Acetylneuraminic Acid will certainly not be weakened by digestive enzymes in the digestion system, and also can go into the intestinal system to stop pathogenic microbes from adsorbing on intestinal cells, and also contribute in withstanding numerous pathogenic bacteria. Free sialic acid in body fluids can protect against the adsorption of chilly viruses on the cell surface, as well as based upon this system, anti-cold drugs based upon sialic acid derivatives have actually been developed.

7. Boost intestinal tract absorption of nutrients
N-Acetylneuraminic Acid has a solid adverse charge as well as is usually located at the end of the glycoprotein or glycolipid externally of the cell membrane, which is the main resource of adverse charge on the cell membrane. The unfavorable charge of sialic acid makes red cell and also other cells drive away each other, staying clear of meaningless cell interactions in the blood flow. According to the concept that the contrary sex brings in each other, the favorably billed minerals as well as some vitamins (such as vitamin B12 consisted of in food and trace quantities) that go into the intestinal tract are quickly incorporated with sialic acid with a solid negative cost. As a result, sialic acid can improve the absorption capacity of the intestines for minerals and also vitamins, as well as supplementing sialic acid can enhance the body’s absorption of nutrients.

With the raising understanding and also expedition of the organic functions of N-Acetylneuraminic Acid, the exploration of biologically active substances led by sialic acid has come to be a new research study area. Sialic acid and its by-products are commonly utilized in food and health items. and medical applications are progressively extensive. It can be seen that sialic acid has a high health worth to the human body. In view of this, bird’s nest is considered as the front runner food for health care by increasingly more individuals.

Absorption and Metabolism of N-Acetylneuraminic Acid

N-Acetylneuraminic Acid is an essential nutrient for the cognitive development of the human brain. It does not exist in plants. It exists in large quantities in vertebrates and higher invertebrates, such as mutton, pork and beef. Eggs are rich in sialic acid, and breast milk is rich in sialic acid. The content of sialic acid is much higher than that of cow’s milk, while the content of poultry and fish is very small. Little is known about the mechanism of sialic acid digestion and absorption, and the current latest research data only stays in mammals. Figure 1 is a schematic diagram of the metabolism of exogenous sialic acid into Neu-5AC in mammals. Many cells in the human body, such as blood cells, fibroblasts, neurons, etc., can absorb exogenous free N-Acetylneuraminic Acid into the cells through pinocytosis, endocytosis and lysosome transport, and the absorbed N-Acetylneuraminic Acid Acid is released or hydrolyzed by intracellular sialidase, then transported into the cytosol, activated in the nucleus, and converted into cytidine monophosphospate-Sialic acid (CMP-SA), in the Golgi Glycosides are formed in the body.


The research on the metabolism of N-Acetylneuraminic Acid is obtained from mammals in imitation of human physiological conditions. From the perspective of metabolic time, because different sialic acids have different pathways, the metabolic time is different. The Neu- The SA biosynthetic enzymes of 5GC and Neu-5AC were not different, and the metabolic pathways were quite different. When mice ingest free Neu-5GC, they can quickly enter the blood circulation and excrete through urine, but there is almost no retention in the intestines and liver. If they ingest sialic acid bound to glycoproteins, the metabolic pathway is quite special. It is widely distributed in the intestinal tract, liver and blood, and is stable for several hours, and its metabolites can be seen in the urine after 48 hours.

About Products:
If you need N-Acetylneuraminic Acid as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced N-Acetylneuraminic Acid manufacturer and supplier, ZSpharmac will provide N-Acetylneuraminic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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