Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical

Mystiric Acid CAS 544-63-8

Molecular Formula: C14H28O2

Formula Weight: 228.37

ZSpharmac: ZSpharmac Supplement

Share on facebook
Facebook
Share on twitter
Twitter
Share on linkedin
LinkedIn
Share on pinterest
Pinterest
Share on whatsapp
WhatsApp
Share on email
Email
Product Name: Mystiric Acid
CAS No: 544-63-8
Purity: 99%

Basic Info

Product Name:Mystiric Acid
Other Names:Myristic Acid, 99%
CAS:544-63-8
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Plant Extracts
Appearance:White Flakes, Powder, Chunks or Crystalline Mass
EINECS No.:208-875-2
Storage:Room Temp
Provide:Mystiric Acid MSDS;
Mystiric Acid COA

What is Mystiric Acid?

Mystiric Acid is also called tetradecanoic acid. Crystallized from methanol is a white crystalline or lobular waxy solid. Naturally found in fish oil, coconut oil, babassu oil and cottonseed oil. The relative molecular mass is 228.36. The relative density is 0.8584 (60°C), 0.8394 (90°C). Melting point 58.5 ℃. The boiling point is 326.2°C, 250.5°C (13.332×103Pa), 199°C (2.133×103Pa), 196.5°C (2.000×103Pa), 184°C (0.533×103Pa), 149.3°C (0.133×103Pa). Refractive index 1.4274 (70°C). Insoluble in water, soluble in ethanol, methanol, acetone, ether, petroleum ether, benzene, chloroform, glacial acetic acid. Mice were injected intravenously (43±2.6) mg/kg.

Mystiric Acid Properties:

Melting point 52-54 °C(lit.)
Boiling point 250 °C100 mm Hg(lit.)
density 0.862
vapor pressure <0.01 hPa (20 °C)
refractive index nD60 1.4305; nD70 1.4273
FEMA 2764 | MYRISTIC ACID
Fp >230 °F
storage temp. room temp
solubility 1.07mg/l
pka4.78±0.10(Predicted)
form Flakes, Powder, Chunks or Crystalline Mass
color White
Water Solubility <0.1 g/100 mL at 18 ºC

 

Myristic Acid Application

Application 1.
CN201410495119.0 reports an anti-acne and itching-relieving facial cleanser and also a prep work method thereof.In today creation, isopropyl myristate, avocado oil, Mystiric Acid, cetearyl alcohol, sodium chloride, mint, grapefruit peel powder, agar and also water are logically intensified, as well as the obtained face cleanser has excellent cleansing efficiency. After cleaning the face, the skin is rejuvenating as well as fragile, and also there is no feeling of tightness; the ended up product of the innovation can efficiently remove face acne, and likewise has the result of eliminating itching, the elimination rate of face acne can be as high as 80%, and also no acne marks are left after elimination.

Application 2.
Wang Qianqian et al. used the metathesis response of calcium nitrate as well as sodium carbonate to prepare calcium carbonate, as well as the crystal structure and also surface buildings of calcium carbonate were controlled by including Mystiric Acid. The impact of Mystiric Acid on the crystal structure of calcium carbonate. The outcomes revealed that after including Mystiric Acid, the crystal structure of calcium carbonate changed from vaterite to calcite, as well as the morphology transformed from round to uneven cuboid; the surface area of calcium carbonate was all activated, from hydrophilic to hydrophobic., After the surface is hydrophobic, the level of cluster of calcium carbonate is dramatically lowered; the carboxyl anion of Mystiric Acid and calcium ions undergo chemical binding reaction, which enhances the stability of calcium carbonate structure. To conclude, the enhancement of Mystiric Acid offers a simple idea for the crystal type regulation and surface area alteration of calcium carbonate.

Extraction Method of Myristic Acid

A method for extracting Mystiric Acid from Coccococcal algae comprises the following steps: extraction with ethyl acetate; chromatography with a reverse-phase silica gel column; chromatography with a sephadex LH-20 gel column; Chromatography with phase silica gel column; Chromatography with normal-phase silica gel column; Extraction of Mystiric Acid from Coccococcolocystis by the method of PTLC preparation.

Specifically include the following steps:

Step 1, preparing the ethyl acetate phase extract of Coccococcides algae: performing extraction treatment with ethyl acetate as the extractant, combining the extracts, and concentrating under reduced pressure to obtain the ethyl acetate phase extract of Coccococcus chinensis;

Cytococcus algae grew to a stable stage, harvested, and freeze-dried to obtain 19.3740g of algal powder of Coccococcus chinensis, leaching with 75% ethanol to obtain 5.1247g of ethanol extract, adding equal volumes of ethyl acetate and water, and repeatedly extracting , the ethyl acetate phase was collected, combined, and concentrated to dryness under reduced pressure to obtain 4.2357 g of the ethyl acetate phase extract of Coccoccololithiasis;

Step 2. The primary crude product of Mystiric Acid is prepared by reversed-phase silica gel column chromatography: the obtained ethyl acetate phase extract of Coccoccus marinae is chromatographed with a reversed-phase silica gel column, collected, detected, combined, and concentrated to dryness under reduced pressure, Obtain a crude product of Mystiric Acid;

After dissolving 4.2357g of the ethyl acetate phase extract of Coccoccus chinensis with an appropriate amount of analytically pure methanol, reverse-phase silica gel (180g) column chromatography was carried out; followed by water, a methanol solution with a mass fraction of 25%, a mass fraction of 50% Methanol solution with a mass fraction of 75% methanol solution, methanol elution, 1.5L per gradient, flow rate controlled at 30mL/min, 1 tube per 200mL was collected, rotary evaporated, the effluent was initially analyzed by TLC, and the palm The acid high-concentration stream is segmented, and concentrated to dryness under reduced pressure to obtain a crude product of Mystiric Acid;

Step 3. Preparation of secondary crude Mystiric Acid by SephadexLH-20 chromatography on Sephadex column: The obtained ethyl acetate phase extract of Coccococcus marinae is subjected to chromatographic treatment with SephadexLH-20 on Sephadex column, Collect, detect, merge, concentrate under reduced pressure to dryness, obtain secondary crude product of Mystiric Acid;

After dissolving the crude Mystiric Acid with an appropriate amount of methanol, it was placed on a Sephadex LH-20 Sephadex column, eluted with methanol as an eluent, the flow rate was controlled at 8S/drop, and each fraction was collected using an automatic collector, every 30min. In one tube, the effluent was initially analyzed by TLC, and the fractions from tubes 21 to 25 were combined and concentrated to dryness under reduced pressure to obtain secondary crude Mystiric Acid;

Step 4. The primary product of Mystiric Acid is prepared by reversed-phase silica gel column chromatography: the obtained secondary crude product of Mystiric Acid is subjected to chromatography treatment with a reversed-phase silica gel column, collected, detected, combined, and concentrated to dryness under reduced pressure to obtain nutmeg Acid once fine;

The secondary crude Mystiric Acid was subjected to RPC18 reversed-phase silica gel column chromatography with a mass fraction of 60%, 70%, 80%, 90%, and 100% of the acetone-water system gradient, each gradient elution was 200 mL, and the flow rate was controlled. 10mL/min, rotary steam, preliminary analysis of the effluent by TLC, combined Mystiric Acid high-concentration flow segments, concentrated to dryness under reduced pressure, to obtain a Mystiric Acid fine product;

Step 5, normal phase silica gel column chromatography to prepare Mystiric Acid secondary quality product: the obtained primary myristic acid quality product is subjected to chromatographic treatment with normal phase silica gel column, collected, detected, combined and concentrated to dryness under reduced pressure to obtain nutmeg Acid secondary boutique;

The primary product of Mystiric Acid was subjected to normal-phase silica gel column chromatography, and the sample was mixed with silica gel powder. The silica gel was saturated with n-hexane and then loaded into the column. The volume ratio is 50:1, 2 drops of glacial acetic acid are added, the fractions are collected, 63-67 tubes are combined, and concentrated to dryness under reduced pressure to obtain the secondary quality Mystiric Acid;

Step 6. Preparation of pure Mystiric Acid by PTLC: perform PTLC on the obtained secondary quality Mystiric Acid, spotting, unfolding, scraping, sample recovery, and storing at -20°C to obtain pure myristic acid;

The Mystiric Acid secondary quality product is passed through PTLC, and finally myristic acid is obtained: using a high-efficiency thin-layer chromatography plate, develop it in a developing agent with a volume ratio of petroleum ether: ethyl acetate=15: 1, and the front and rear ends are colored. , scrape the middle part with a blade, combine, dissolve in methanol, centrifuge at high speed, collect the supernatant, and concentrate under reduced pressure to dryness to finally obtain Mystiric Acid.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Mystiric Acid Quotation