Zhishang Chemical

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Zhishang Chemical

Musk Ketone CAS 81-14-1

Molecular Formula: C14H18N2O5

Formula Weight: 294.3

ZSpharmac: Musk Ketone Supplier

Product Name: Musk Ketone
CAS No: 81-14-1
Purity: 99%

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Basic Info

Product Name:Musk Ketone
Other Names:Ketone Moschus
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Yellow Powder
EINECS No.:201-328-9
Provide:Musk Ketone MSDS;
Musk Ketone COA

What is Musk Ketone?

Musk Ketone dates back to 1888, when German drug store Albert Baur inadvertently developed it while trying to find a better means to produce the explosive TNT. In the perfume market, Musk Ketone is known as a fixative due to the fact that it can maintain volatility as well as enhance the perseverance of fragrance aroma.

Musk Ketone Property

Melting point 134-137 °C
Boiling point 436.08°C (rough estimate)
density 1.2051 (rough estimate)
vapor pressure 0.001Pa at 25℃
refractive index 1.5110 (estimate)
Fp 2 °C
storage temp. 2-8°C
Water Solubility Insoluble (<0.1 g/100 mL at 20 ºC)


Musk Ketone Uses

  1. Musk Ketone is just one of the critical best nitro musks and also is a terrific fixative. It is widely used in scent formulations, as well as can be utilized in those who need musk fragrance, especially in sweet, asian as well as heavy fragrance scents. When shown to methyl ionone, cinnamon alcohol, benzyl salicylate, etc, it can create powdery scent. It can be used in soap significance in an ideal quantity, and the dose is typically 1%-5%.
  2. Musk Ketone is one of the very best fixatives offered in a wide range of fragrance solutions. Yet the price is pricey, and it can only be made use of in premium fragrance, face powder as well as cream significance, as well as the dose is generally 0.2%-1.5%.
  3. Musk Ketone has a scent similar to all-natural musk. The aroma is sensational as well as sensible. Used as a fixative for aesthetic scents and also seasonal fragrances.

Production Method of Musk Ketone

From m-xylene by tert-butylation, acetylation and nitration reactions in the system. When isobutanol is used as the alkylating agent for tert-butylation, the reaction temperature is 50-54°C. It is technically reasonable to use isobutene for alkylation. In this case, aluminum trichloride is used as a catalyst, and the generated 1,3-dimethyl-5-tert-butylbenzene is purified by vacuum distillation (boiling point 85-90℃/0.0016-0.0019MPa). Acetylation uses aluminum trichloride as a catalyst, and the reaction temperature is 58-60°C. Iron trichloride or zinc chloride can also be used, and the reaction temperature is 90-95°C. During the nitration reaction, first cool the nitric acid to -8-10°C, then add 2,6-dimethyl-4-tert-butyl acetophenone, and react at -5-8°C. The nitrated product was washed with water, and the resulting crude product was recrystallized from ethanol.

Ecological Information of Musk Ketone

Production of Musk Ketone can lead to its release into the environment through various waste streams; its use as a fragrance in cosmetics and as a fragrance in some detergents, fabric softeners, household cleaning products and other fragranced products can lead to its direct release to the environment. If released to air, a vapor pressure of 3.0X10-7 mmHg at 25 °C indicates that Musk Ketone will exist in both the vapor and particle phases in the atmosphere. Vapor-phase muscone degrades free radicals by reacting with photochemically generated hydroxyl groups in the atmosphere; the half-life of this reaction in air is estimated to be 25 days. The particulate phase Musk Ketone will be removed from the atmosphere through wet and dry deposition. Muscone contains a chromophore that absorbs at >290 nm and thus may be susceptible to photolysis by direct sunlight. If released into soil, the Musk Ketone is not expected to flow based on an estimated Koc of 8700. Based on an estimated Henry’s law constant of 2.5X10-7 atm- volatilization from moist soil surfaces may be an important, relatively slow fate process m3/mol. In addition, soil sorption is expected to attenuate volatilization. Based on its vapor pressure, Musk Ketone is not expected to volatilize from dry soil surfaces. Using Japan MITI test, water. If released into water, Musk Ketone is expected to adsorb to suspended solids and sediment based on the estimated Koc. Volatilization from the surface is not expected to be an important fate process based on the estimated Henry’s law constant for this compound. The estimated volatilization half-lives were 170 days and >1 year for the model river and model lake, respectively. A BCF of 1380 indicates a very high bioconcentration in aquatic life. Hydrolysis is not expected to be an important environmental fate process because the compound lacks functional groups that hydrolyze under ambient conditions (pH 5 to 9). Occupational exposure to muscone may occur through inhalation and dermal exposure to this compound in workplaces where muscone is produced or used. Surveillance data indicate that the general population may be exposed to Musk Ketone through inhalation. Skin absorption may play a role in the application of musk-containing perfumes and cosmetics to the skin or from textiles that contain musk-scented residues from laundry detergents. Exposure may also occur through ingestion of contaminated food.

Effects of Musk Ketone on Mouse Hepatic Cytochrome P450 Enzymes

Nitroaromatic musks, containing Musk Ketone (MK; 2,6-Dimethyl-3,5-dinitro-4-tert-butylacetophenone), are made use of as scent energetic components in house products, cosmetics, as well as additionally toiletries chemicals. Muscarinic xylene (MX; 1,3,5-trinitro-2-t-butylxylene), one more nitromusk, is not genotoxic nevertheless has actually been reported to create liver developments in computer system mice in consistent bioassays. On top of that, MX has in fact been revealed to trigger along with inhibit the cytochrome P450 2B (CYP2B) isoenzyme in computer mouse liver. The capacity of MX to stop CYP2B enzymatic job has actually been credited to the inactivation of the enzyme by specific amine metabolites. MK is structurally equivalent to MX, yet lacks the nitro replacement that is lowered to an inactive amine metabolite. For that reason, we assumed that MK would absolutely cause however not inhibit CYP2B isozymes. To examine this theory, 2 collections of experiments were done to assess the result of MK on computer mouse liver cytochrome P450 enzymes. To assess the capacity of MK to create cytochrome P450, computer system mice were dosed daily by dental gavage with dosages differing from 5 to 500 mg/kg MK for 7 days. This treatment triggered pleiotropic responses in the liver of computer system mice, consisting of boosted liver weight, improved microsomal complete healthy and balanced protein, as well as likewise centrilobular hepatocyte hypertrophy. At the highest dosage checked, MK developed a 28-fold rise in CYP2B enzyme task as well as also a small (around 2-fold) boost in cytochrome P450 1A as well as 3A (CYP1A as well as likewise CYP3A) enzyme task contrasted to control levels. Healthy and balanced healthy protein as well as additionally mRNA analysis confirmed the family member induction levels of CYP2B, CYP1A, along with CYP3A. In addition to that, MK created CYP2B with a no-observed-effect level (NOEL) of 20 mg/kg. To examine the capacity of MK to hinder phenobarbital-induced CYP2B task, computer mice were administered 500 ppm phenobarbital (PB) in drinking water for 5 days to cause CYP2B isozymes, abided by a solitary equimolar (0.67 mmol/kg) with dental gavage dosages of MK (198 mg/kg) or MX (200 mg/kg), microsomes were prepared 18 hrs later on. While MX hindered more than 90% of PB-induced CYP2B job in microsomes, MK created just a tiny (about 20%) decrease in PB-induced CYP2B chemical task. These end results suggest that like MX. MK is a PB-type inducer of computer system mouse liver CYP2B isozymes, yet unlike MX, MK does not effectively stop PB-induced CYP2B chemical task. This was adhered to by a singular equimolar (0.67 mmol/kg) oral gavage dose of MK (198 mg/kg) or MX (200 mg/kg), as well as microsomes were prepared 18 humans resources later. While MX inhibited greater than 90% of PB-induced CYP2B task in microsomes, MK triggered simply a small (around 20%) decrease in PB-induced CYP2B enzymatic job. These outcomes suggest that like MX. MK is a PB-type inducer of computer system mouse liver CYP2B isozymes, yet unlike MX, MK does not correctly prevent PB-induced CYP2B chemical job. This was followed by a solitary equimolar (0.67 mmol/kg) oral gavage dose of MK (198 mg/kg) or MX (200 mg/kg), as well as microsomes were prepared 18 hours later. While MX prevented above 90% of PB-induced CYP2B task in microsomes, MK caused simply a little (roughly 20%) decrease in PB-induced CYP2B chemical activity. These outcomes suggest that like MX. MK is a PB-type inducer of computer mouse liver CYP2B isozymes, yet unlike MX, MK does not efficiently avoid PB-induced CYP2B chemical task.

About Products:
If you need Musk Ketone, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Musk Ketone manufacturer and supplier, ZSpharmac will provide Musk Ketone raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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