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Morpholine คือ CAS 110-91-8

Molecular Formula: C4H9NO

Formula Weight: 87.12

ZSpharmac: Morpholine คือ Supplement

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Product Name: Morpholine คือ
CAS No: 110-91-8
Purity: 99%

Basic Info

Product Name:Morpholine คือ
Other Names:Morpholine
CAS:110-91-8
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Colorless Alkaline Oily Liquid
EINECS No.:203-815-1
Storage:Store Below +30°C.
Provide:Morpholine คือ MSDS;
Morpholine คือ COA

What is Morpholine คือ?

Morpholine คือ, additionally known as 1,4-oxazacyclohexane, diethyleneimine oxide, is a colorless alkaline oily liquid with ammonia odor as well as hygroscopicity. The vapor as well as air form an eruptive mix with an explosion restriction of 1.8% to 15.2% (volume portion). Morpholine คือ is a second amine, and additionally has the residential or commercial properties of inorganic acid as well as organic acid at the same time, as well as can create salts and amides.
Morpholine คือ includes secondary amine teams and also has all the typical responsive features of additional amine teams. It can react with not natural acids to develop salts, and also react with organic acids to form salts or amides, which can be subjected to alkylation response, and also can likewise be reacted with ethylene oxide, ketone or Willgerodt response. Due to its one-of-a-kind chemical residential or commercial properties, morpholine has actually become one of the great petrochemical products with important industrial usage. It can be made use of to prepare NOBS, DTOS and also MDS and other rubber vulcanization accelerators, rust inhibitors, rust inhibitors, cleansing agents, descaling agents, pain relievers, anesthetics, sedatives, breathing and vascular stimulants, surfactants, optical whitening agents, fruit chemicals, textile printing and dyeing auxiliaries, and so on, in rubber, medication, pesticides, dyes, coverings and other markets It has a large range of uses. In medication, it is utilized to produce various essential medicines such as morpholine guanidine, virus spirit, ibuprofen, ketone, naproxen, dichloroaniline, and also sodium phenylacetate.
The manufacturing techniques of Morpholine คือ mainly include DEA method (diethanolamine technique) and also DEG method (diethylene glycol technique). A new sort of polymer monomer, morpholine acrylate, which has established swiftly abroad in recent years, is also worth noting. Acrylic morpholine is obtained by the reaction of acrylate and also morpholine. This item is a water-soluble monomer, and it is additionally water-soluble after polymerization, so it is used for the alteration of water-based polymers; additionally, it is likewise commonly used in the reaction of UV-curable materials Diluent; With the growing of application study, many new certain uses have been continually developed, coming to be an extremely swiftly developing polymer monomer.

Morpholine คือ Properties:

Melting point -7–5 °C (lit.)
Boiling point 126.0-130.0 °C 129 °C (lit.)
density 0.996 g/mL at 25 °C (lit.)
vapor density 3 (vs air)
vapor pressure 31 mm Hg ( 38 °C)
refractive index n20/D 1.454(lit.)
Fp 96 °F
storage temp. Store below +30°C.
solubility water: miscible
pka8.33(at 25℃)
form Liquid
color APHA: ≤15
Specific Gravity0.996
PH11.2 (H2O)(undiluted)
explosive limit1.4-15.2%(V)
Water Solubility MISCIBLE

 

Morpholine คือ Uses

  1. Morpholine คือ is used as raw material for medicine, rubber accelerator and optical brightener.
  2. Morpholine คือ is an intermediate of the fungicides dimethomorph and flumorph and the organophosphorus insecticide thiophos.
  3. Morpholine คือ is generally used in the manufacturing of rubber vulcanization accelerators, and also in the synthesis of surfactants, textile printing as well as dyeing accessories, medications, and also pesticides. Morpholine is likewise made use of as a stimulant for the polymerization of maleic butadiene, a corrosion prevention, and also an optical lightening agent. This product is also a solvent for dyes, resins, waxes, early glues, and casein. Today, the world’s morpholine manufacturing is 30,000-40,000 t/a.
  4. Morpholine คือ is the primary basic material of accelerator NOBS, used as logical reagent and solvent for material, wax, shellac, etc, utilized in the production of sodium sulfate, water glass and also ultramarine. It is likewise used in the manufacture of glass, paper, cleaning agent, soap, dyes, artificial fibers, leather, medication and porcelains.
  5. Morpholine คือ responds with inorganic acids to develop salts and also organic acids to form salts or amides. Alkylation reactions can be performed, likewise with ethylene oxide, ketones or Willgerodt responses.

Synthesis of Morpholine คือ

The synthesis of any Morpholine คือ ring involves intramolecular cyclization, which can be carried out under a variety of conditions. The cyclization step typically involves substituted 1,2-amino alcohols that undergo base-involved SN2 reactions or transition metal-catalyzed allyl substitutions. More diversity has been found in the synthesis of 1,2-amino alcohols, where epoxide, aziridine or ethanolamine derivatives are often used as starting synthetic building blocks. The most important recent breakthrough in morpholine synthesis is the stannamide route (SnAP) developed by Bode’s research group. It is a Cu(II) catalyzed cyclization by the reaction of SnAP reagent (2-((tributylstannyl)methoxy)ethan-1-amine or its derivatives) with aldehydes. This method is very attractive due to its wide range of substrates (aliphatic, aromatic and heteroaromatic aldehydes can be used) and generally good yields.
An important premise of modern drug screening is the need for screening libraries containing a large number of compounds with different structures. The construction of such screening libraries generally utilizes stable and mild reactions to synthesize a large number of derivatives from a single precursor. However, these widely used reactions, especially the ubiquitous Suzuki-Miyaura coupling, increase the unsaturation and planarity of the compounds under development, which does not match the trend of increasing saturation of drug molecules in the future. Therefore, sp3-sp3 or sp3-sp2 coupling reactions are highly sought after when applicable to unique frameworks such as morpholine. Perhaps the most influential aspect of morpholine functionalization is the photoredox amino α-position C-H arylation discovered by MacMillan’s group. This method forms C–C bonds in high yields between N-phenyl-protected morpholines and electron-deficient aryl or heteroaryl rings under mild conditions. The photoredox mechanism is that the photosensitive iridium catalyst participates in the one-electron transfer (SET) process of the aryl substituent and N-heterocycle, respectively, thereby enabling the coupling between the radicals formed by them. This provides an alternative synthetic approach for late-stage modification of important drugs.
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The Application of Morpholine in Medicine

1 Muscarinic acetylcholine receptor family (mAChRs) Peptic ulcers occur at the pylorus and duodenum of the stomach and are mucosal damage caused by the digestion of gastric juices. The occurrence of peptic ulcer is related to many factors, which can be divided into protective factors and damage factors. The former includes mucus, HCO3- and prostaglandins secreted by gastric mucous cells; the latter includes gastric acid, pepsin and Helicobacter pylori. Excessive secretion of gastric acid is the main cause of peptic ulcer, so drugs that inhibit gastric acid secretion have become the means of anti-peptic ulcer. Such drugs can be divided into receptor antagonists and proton pump (H+/K+-ATPase) inhibitors. In the article “Application of Benzimidazole in Drugs”, we mentioned proton pump inhibitors, which have the characteristics of strong selectivity and less side effects than histamine H2 receptor antagonists as receptor antagonists. Among morpholines, muscarinic acetylcholine receptors (mAChRs) antagonists, also known as M receptor antagonists, are used as anti-peptic ulcer drugs. In the process of gastric parietal cell acid secretion, M receptors, histamine H2 receptors and gastrin receptors are all involved and play a promoting role. In addition, M receptors are also involved in processes such as motor control, body temperature regulation, cardiovascular regulation and memory in the central nervous system. In the peripheral nervous system, they receive smooth muscle contraction, gland secretion, and the regulation of heart rate and myocardial contractility. Therefore, the indications of M receptor antagonists also include smooth muscle spasm, anesthesia, nausea and vomiting, and motion sickness.

2 Proteasome The proteasome is a multi-subunit macromolecular complex widely distributed in the cytoplasm and nucleus of eukaryotic cells. It has a variety of catalytic functions and can selectively degrade intracellular proteins. Proteasome inhibitors inhibit the activity of proteasome, thereby affecting the expression of cell growth-related proteins, cytokines and signaling molecules, interfering with the original process of cell proliferation, differentiation and apoptosis, and inhibiting the growth of tumor cells more obviously. Carfilzomib, a morpholine drug developed by Onyx Pharmaceuticals, was launched in 2012 for the treatment of multiple myeloma and is a second-generation irreversible proteasome inhibitor. In a clinical trial in combination with dexamethasone (NCT01568866), carfilzomib was associated with a lower rate of disease progression/mortality than the first-generation proteasome inhibitor bortezomib (36.9% vs. 52.3%), Median progression-free survival was longer (18.7 months vs. 9.4 months), with a more significant (one-sided p<0.001) efficacy.

3 Polymerase acidic protein (PA) On February 23, 2018, Baloxavir Marboxil, a morpholine drug developed by Shionogi, was approved by the Japan Pharmaceuticals and Medical Devices Agency (PMDA) for the treatment of influenza A and B virus infections. Baloxavir marboxil is a drug with a novel anti-influenza mechanism of action that is different from other antiviral drugs on the market. The drug is hydrolyzed into the active form against the influenza virus, baloxavir. Baloxavir marboxil is the world’s first approved polymerase acid endoproteinase inhibitor. Baloxavir is designed to inhibit the endonuclease activity of the polymerase acid (PA) protein, which is essential for influenza virus replication. few.

4 Squalene monooxygenase (SQLE) Long-term studies have found that inhibiting the biosynthesis of steroids is extremely important for the prevention and treatment of various skin diseases and deep infections caused by fungi. Inhibiting the synthesis of ergosterol in fungi can effectively inhibit the growth of fungi. Squalene cyclooxygenase is a cell membrane-bound enzyme that catalyzes the conversion of squalene to 2,3-epoxysqualene and is one of the rate-limiting enzymes in the sterol biosynthetic pathway. Therefore, researchers have developed a number of squalene oxidase inhibitors, which are used to disrupt the formation of fungal cell membranes, thereby killing or inhibiting fungi. Amorprofen, a morpholine drug, was originally a bactericidal drug used in agriculture, but it was later found to have good antibacterial activity against all pathogenic fungi other than non-colored filamentous fungi such as Aspergillus and Penicillium. The drug can be used to treat psoriasis, candidiasis of the skin, vitiligo, onychomycosis and other fungal infections. It not only cures skin fungal infections, but also spreads easily to the nails after being applied to the nails, and maintains a long-term antifungal effect, making it an ideal anti-superficial fungal drug.

5 Anaplastic lymphoma kinase (ALK) Anaplastic lymphoma kinase (ALK), named after its discovery in anaplastic large cell lymphoma (ALCL), is a receptor tyrosine kinase that belongs to the insulin receptor superfamily. Studies have found that ALK can be expressed not only in ALCL, but also in diffuse large B-cell lymphoma, non-small cell lung cancer, neuroblastoma, inflammatory myofibroblastic tumor and other tumors. Gene rearrangement, point mutation and amplification, so ALK gene has become a new target for anti-tumor therapy. The morpholine drug Alectinib hydrochloride, launched in 2014, is a tyrosine kinase inhibitor targeting anaplastic lymphoma kinase (ALK) and RET receptor tyrosine kinase, which can inhibit tumor cell proliferation and induce cell death. The drug is approved for the treatment of anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer. Compared with Crizotinib, the first ALK inhibitor, Alectinib hydrochloride was significantly more effective (p<0.0001), and in clinical trial NCT02075840, patients who took the drug had a longer median progression-free survival (25.7 months vs. 10.4 months).

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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