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Monobenzone Cream CAS 103-16-2

Molecular Formula: C13H12O2

Formula Weight: 200.23

ZSpharmac: Monobenzone Cream Supplier

Product Name: Monobenzone Cream
CAS No: 103-16-2
Purity: 99%

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Basic Info

Product Name:Monobenzone Cream
Other Names:Monobenzone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White to Beige Powder
EINECS No.:203-083-3
Storage:Store Below +30°C.
Provide:Monobenzone Cream MSDS;
Monobenzone Cream COA

What is Monobenzone Cream?

Monobenzone is a topical depigmentation agent utilized to deal with hyperpigmentation such as various coloring areas, age locations, melanoma, etc, with impressive end results. Monobenzone Cream can degenerate melanin in the skin, stop the advancement of melanin in the skin, and bring back the skin to a healthy and balanced color without destroying melanocytes. It is very lightly harmful and also is usually made into lotion or liniment. It has been taped in the USA Pharmacopoeia. Manufacturing. Today, there is no medication for the therapy of areas in our country, and also the cosmetics utilized for the treatment of places have little impact, and also some cosmetics add a huge quantity of dangerous substances such as hydroquinone as well as metal mercury to achieve the impact of eliminating areas and bleaching. Creating monobenzone into freckle-removing medicines or cosmetics has good impact as well as low poisoning, which can satisfy the urgent needs of a great deal of yellow individuals struggling with freckles, and will certainly rate by domestic and also foreign markets.

Monobenzone Cream Property

Melting point 119-120 °C (lit.)
Boiling point 297.96°C (rough estimate)
density 1,26 g/cm3
refractive index 1.5906 (estimate)
storage temp. Store below +30°C.
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Powder, Crystals, and/or Chunks
color Off-white to beige to brown
Water Solubility slightly soluble


Application of Monobenzone Cream

Monobenzone Cream is a topical depigmentation representative used to deal with hyperpigmentation, such as various pigmentation areas, age spots, melanoma, and so on, with noticeable results. It can decay melanin in the skin, avoid the formation of melanin in the skin, and bring back the skin to a healthy and balanced shade without ruining the melanocytes.

On top of that, recent researches have actually shown that monobenzone integrated with imiquimod is more reliable in C57BL6 computer mice than monobenzone or imiquimod alone. Thirty 4-week-old C57BL6 mice were divided right into 3 teams: A, B, and C, as well as were provided 40% monobenzone integrated with 5% imiquimod in group A, 40% monobenzone in team B, as well as 40% monobenzone in team C. 5% imiquimod was related to the reduced rear of the computer mice, and also each team was applied daily for 60 successive days. Another 5 C57BL6 computer mice were taken as the unfavorable control group with no therapy. Outcomes: Depigmentation took place at the application website after 2 weeks of application in groups An and also B, as well as there was no substantial difference during decolorization between both groups (t=1.23, P > 0.05), but after 2 months, the two groups showed no substantial difference. There was a statistically substantial distinction in the depigmentation score of the application website in the team A (t=2.43, P<0.05); the depigmentation of the non-application site in the team A was considerably various from that in the group B (t=2.45, P<0.05). <0.05); in group C, just a percentage of depigmentation happened in the drug-applied website of one computer mouse. In the negative control group, no depigmentation and exfoliation were seen.

Monobenzone Lotion is effective in treating or avoiding herpes virus infection. The CC50 of monobenzone on HONE-1 cells was 1000 μmol/ L. Monobenzone Cream can dose-dependently prevent the duplication of EBV lytic phase, and the IC50 for EBV lytic stage DNA replication is 0.63 micromol/L. The CC50 of monobenzone on Vero cells is 652.4 μmol/ L. Monobenzone prevents HSV-1 replication with an IC50 of 0.81 μmol/ L. Monobenzone prevented HSV-2 duplication with an IC50 of 1.92 μmol/ L. The CC50 of monobenzone on HFF cells was 550 μmol/ L. Monobenzone inhibits HCMV duplication with an IC50 of 4.97 micromol/L.

Quality Control of Monobenzone Cream

1. Properties: This product is milky white or yellowish, uniform and delicate O/W cream. It meets the requirements for ointment in the 2005 edition of “Chinese Pharmacopoeia”.

2. Identification: Take an appropriate amount of this product, equivalent to 500 mg of monobenzone, into a centrifuge bottle, add 100 ml of water, shake until the cream is completely dispersed, centrifuge, gently pour out the substances floating on the surface, and wash the filter residue with water , centrifuged again, and decanted the aqueous layer. Transfer the residue to a separatory funnel, add chloroform to adjust the volume to about 100 ml, shake, separate the chloroform layer, and filter with cotton gauze. Transfer the filtrate to a 150 ml flask, evaporate and recover chloroform in a ventilated place, add 5 ml of pyridine and 3 ml of anhydrous acetic acid to the dry residue, reflux the flask for 10 min, cool, then add 100 ml of water and 6 ml of acetone , Seal the flask, and cool it in the refrigerator for 1 h. Separate the precipitate in a glass crucible, wash the precipitate with water until there is no residual pyrimidine smell, and dry the precipitate with phosphorus pentoxide for 16 h in a vacuum desiccator. Determination of the melting point of the precipitate should be 110 ~ 113 ℃ (acetate of monobenzone).

3. Inspection: It should comply with the relevant provisions of the “Chinese Pharmacopoeia” 2005 edition cream.

4. Content determination: chromatographic conditions EclipseXDB-C18 (150 mm × 4.6 mm, 5 μm) chromatographic column, column temperature 30 ° C, detection wavelength 292 nm, mobile phase: acetonitrile: water = 60: 40, flow rate 1.0ml/min , injection volume 10 μl

5. Sample stability and irritation test

1) Illumination test: put this product in a colorless glass container, put it under (4500 ± 500) Lx strong light, and take samples at 0, 1, 5 days to check the properties, melting time limit, content and other indicators. Results The color of each indicator of the sample was slightly darker and the content was slightly lower than that of 0 d, which indicated that the product was sensitive to light and should be stored away from light.

2) Accelerated test: Take 3 batches of cream and place them at (30 ± 2) ℃ and relative humidity (60 ± 5)% for 10 days, and examine their properties, contents, etc. at 0, 1, 5 and 10 days respectively. There was no significant change in any of the indicators compared with 0 d.

Irritation test: Take 10 healthy adult mice, male or female, body weight (20 ± 3) g, divide them into administration group and blank control group (blank matrix), shave off the back hair, and apply the ointment on the back of the mice After 24 hours, observe the local skin reaction. The results showed no redness and swelling on the back, and there was no significant difference between the two groups.

Since the cream contains 20% Monobenzone Cream, since Monobenzone Cream is a fat-soluble drug, the amount of other components in the oil phase should be appropriately reduced. The saponification product of stearic acid and triethanolamine is an O/W emulsifier, stearyl alcohol is used as an auxiliary emulsifier and lubricant, which can emulsify and absorb more water, glycerin is used as a humectant, and laurocapram is a colorless and odorless Liquid, with a greasy feeling in contact with the skin, non-irritating, non-toxic, can make the cream soft and easy to spread, and can also significantly enhance the speed of the drug passing through the stratum corneum of the skin and increase the concentration of the drug in the skin, so as to better exert its therapeutic effect It is a good penetration enhancer. The oil-in-water cream base is adopted, the preparation process is simple, the design is reasonable, the stability is good, no irritation, the clinical curative effect is good, and it is worthy of clinical popularization and application.

Preparation of Monobenzone Cream

Under microwave irradiation, Monobenzone Cream was manufactured with hydroquinone, salt hydroxide in addition to benzyl chloride as sources together with also N,N-dimethylformamide (DMF) as solvent. The effects of molar percent of stimulants, microwave radiation power and also radiation time on the return of monobenzone were looked into by particular facet experiment. The experimental outcome disclose that: when n (benzyl chloride): n (hydroquinone): n (salt hydroxide) = 1: 1.4: 1.4, DMF15mL, microwave radiation power of 320W, radiation time of 60s, Monobenzone Lotion The return is 63.79%.

Add 2.63 g (0.028 mol) of hydroquinone to a 100mL Erlenmeyer flask, consider 1.12 g (0.028 mol) of salt hydroxide, add 8mL of water, as well as add dropwise to the container filled with hydroquinone after the salt hydroxide is liquified. Shake well in the Erlenmeyer flask, then add 15mL of DMF and 2.52 g (0.02 mol) of benzyl chloride, and respond with radiation for 60s under the problem of microwave radiation power of 320W. Trendy to room temperature after the response. Adjust to alkaline with 10% salt hydroxide initially, then filter with suction, wash the filter cake with 10% salt hydroxide till the filtrate is anemic (the filter cake is hydroquinone bisbenzyl ether, which can be reused). The filtrate was acidified with hydrochloric acid to completely precipitate monobenzone, and also after suction purification and ice water washing, recrystallization with alcohol as well as water, and also decolorization with triggered carbon, 2.55 g of white solid was acquired with a return of 63.79%.

About Products:
If you need Monobenzone Cream, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Monobenzone Cream manufacturer and supplier, ZSpharmac will provide Monobenzone Cream raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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