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Metil Paraben CAS 99-76-3

Molecular Formula: C8H8O3

Formula Weight: 152.15

ZSpharmac: Metil Paraben Supplier

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Product Name: Metil Paraben
CAS No: 99-76-3
Purity: 99%

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Basic Info

Product Name:Metil Paraben
Other Names:Methylparaben
CAS:99-76-3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Almost White Crystalline Powder
EINECS No.:202-785-7
Storage:Room Temp
Provide:Metil Paraben MSDS;
Metil Paraben COA

Metil Paraben Content Analysis

Technique 1 is figured out according to the web content evaluation method in “Butyl p-Hydroxybenzoate (07002 )”. Each mL of sodium hydroxide amounts 152.2 mg of this item (C8H8O3).
Method 2 Take 0.1 g (exact to 1 mg) of the sample that has actually been dried out on silica gel for 5 h ahead of time, and move it right into a 300 ml flask with a glass stopper. Include 10ml of 1mol/L salt hydroxide as well as heat on a water bathroom for 15min. After cooling down, include 0.1 mol/L potassium bromate 50.00 ml, potassium bromide 5.0 g as well as 1mol/L hydrochloric acid 30ml. Position it in a dark area for 15 mins after securing. Add 1 g of potassium iodide, shake the flask strongly, titrate with 0.1 mol/L sodium thiosulfate, and also utilize starch test solution (TS-235) as indicator. Each ml of 0.1 mol/L potassium bromate amounts 25.36 mg of this item (C8H8O3).

Metil Paraben Property

Melting point 

125-128 °C (lit.)

Boiling point 

298.6 °C

density 

1,46g/cm

vapor pressure 

0.000005 hPa (20 °C)

refractive index 

1.4447 (estimate)

Fp 

280°C

storage temp. 

room temp

solubility 

ethanol: soluble0.1M, clear, colorless

pka

pKa 8.15(H2O,t =20.0) (Uncertain)

form 

Crystalline Powder

color 

White to almost white

PH

5.8 (H2O, 20°C) (saturated solution)

Water Solubility 

Slightly soluble in water.

 

Application of Metil Paraben

  1. Technique 1 is figured out according to the web content evaluation method in “Butyl p-Hydroxybenzoate (07002 )”. Each mL of sodium hydroxide amounts 152.2 mg of this item (C8H8O3).
  2. Method 2 Take 0.1 g (exact to 1 mg) of the sample that has actually been dried out on silica gel for 5 h ahead of time, and move it right into a 300 ml flask with a glass stopper. Include 10ml of 1mol/L salt hydroxide as well as heat on a water bathroom for 15min. After cooling down, include 0.1 mol/L potassium bromate 50.00 ml, potassium bromide 5.0 g as well as 1mol/L hydrochloric acid 30ml. Position it in a dark area for 15 mins after securing. Add 1 g of potassium iodide, shake the flask strongly, titrate with 0.1 mol/L sodium thiosulfate, and also utilize starch test solution (TS-235) as indicator. Each ml of 0.1 mol/L potassium bromate amounts 25.36 mg of this item (C8H8O3).

Cosmetic Preservatives-Metil Paraben

The most common paraben preservatives in cosmetics, the paraben x esters that are very common in the cosmetics we use are paraben preservatives. Since cosmetics are all chemically synthesized products, in order to avoid bacterial reproduction, Oxidative deterioration, so it is understandable to add preservatives to cosmetics, but in order to prolong the shelf life of their own products, they add excessive preservatives in private, but when they encounter inspections, those products that meet the regulations are taken out.

Paraben ester preservatives are one of the most widely used preservatives at present, but their dosage is relatively large. With the growth of carbon chain, their water-soluble phase gradually becomes poor, which affects their distribution rate in the water phase. Its anti-mildew effect is more prominent. Metil Paraben has the best water solubility and can often be added directly to the water phase; while ethyl, propyl, butyl and isobutyl paraben tend to dissolve in the oil phase.

Metil Paraben is a preservative suitable for acidic systems. It has the highest antibacterial activity of 77% at pH 5, 63% at pH 7, and close to 50% at pH 8.5. Therefore, the activity of parabens in the system can be improved mainly by lowering the pH value of the system, usually 7.0-6.5 or lower, although sometimes they can also maintain their efficacy in a system with a slightly higher pH value.

Metil Paraben affects multiple molecular pathways in cells

1. Accelerate pigmentation and dull skin;

2. Paraben esters are endocrine disrupting substances, which will affect the normal secretion of androgen in the body, increase the level of estrogen, and reduce the level of sperm in the human body;

3. Pregnant women will cause genital deformities in newborns.

Ecological Information of Metil Paraben

The production and additionally use of Metil Paraben as a yeast as well as mold inhibitor, a shipment agent for eye decreases, a chemical for food, beverages and also cosmetics, and also a preservative for topical medicines may result in its release right into the atmosphere using different waste streams. If introduced to air, the approximated vapor pressure at 25 ° C is 2.4X10-4 mm Hg, suggesting that methylparaben will absolutely exist in the atmosphere in both the vapor and likewise particle stages. Metil Paraben in the gas stage breaks down cost-free radicals in the ambience by responding with photochemically created hydroxyl teams; the half-life of this response in air is approximated to be ultimately. Particle methylparaben will be removed from the ambience by wet as well as completely dry deposition. Methylparaben consists of a chromophore that soaks up at > 290 nm and additionally therefore might be vulnerable to photolysis by straight sunshine. If launched to soil, methylparaben is anticipated to be extremely mobile based upon an estimated Koc of 87. Methylparaben has a pKa of 8.5, recommending that this compound will be partly present in the setting as an anion, which normally does not adsorb a whole lot a lot more highly to dirt. Dirts and also clays include even more natural carbon than their neutral equivalents. Volatilization from wet dirt surfaces is not prepared for to be a considerable fate procedure based upon an approximated Henry’s Regulations constant of 2.3X10-9 atm-cu m/mole. Based on its vapor stress and anxiety, Metil Paraben is not anticipated to vaporize from totally dry dust surfaces. Utilizing the Zahn-Wellens exam, 100% biodegradation was observed within 6 days after a 2-day acclimatization duration, suggesting that biodegradation may be an important eco-friendly fate treatment in dirt and additionally water. If introduced to water, methylparaben is not expected to adsorb to postpone solids in addition to debris based on the approximated Koc. Volatilization from the surface area is not expected to be a critical fate process based upon the estimated Henry’s law constant for this compound. An approximated BCF of 9 recommends a minimized bioconcentration possibility in water organisms. Although hydrolysis of methylparaben may occur at raised temperatures, it is not expected to be a considerable fate process under ambient troubles. Occupational direct exposure to methylparaben might take place through breathing and also dermal direct exposure to this substance in workplaces where methylparaben is produced or made use of. Security and likewise usage information recommend that the fundamental populace might be exposed with facial contact with items including this substance, intake of specific foods, breathing as well as likewise straight exposure to house dust, as well as intake of clinical things.

About Products:
If you need Metil Paraben, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Metil Paraben manufacturer and supplier, ZSpharmac will provide Metil Paraben raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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