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Methyl Thioglycolate CAS 2365-48-2

Molecular Formula: C3H6O2S

Formula Weight: 106.14

ZSpharmac: Methyl Thioglycolate Supplement

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Product Name: Methyl Thioglycolate
CAS No: 2365-48-2
Purity: 99%

Basic Info

Product Name:Methyl Thioglycolate
Other Names:Methyl thioglycolate, 99%
CAS:2365-48-2
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Clear Colorless Liquid
EINECS No.:219-121-7
Storage:Store Below +30°C.
Provide:Methyl Thioglycolate MSDS;
Methyl Thioglycolate COA

What is Methyl Thioglycolate?

Methyl thioglycolate is a colorless transparent oily liquid, soluble in water, with the smell of allicin. It is an important intermediate for the synthesis of medicines, pesticides, food flavors and tobacco flavors, and can be used as an organotin heat stabilizer and a molecular weight regulator for macromolecules. Polymethyl thioglycolate can also be used as a low temperature curing agent for epoxy resins, optical lenses and manufacturing adhesives. The current production and synthesis method of methyl thioglycolate mainly uses thioglycolic acid and methanol as raw materials, and uses sulfuric acid as a catalyst for batch synthesis. This process has many problems such as low yield, long reaction time and serious equipment corrosion.

Methyl Thioglycolate Properties:

Melting point -24 °C
Boiling point 42-43 °C/10 mmHg (lit.)
density 1.187 g/mL at 25 °C (lit.)
refractive index n20/D 1.466(lit.)
Fp 86 °F
storage temp. Store below +30°C.
solubility 40g/l
pka8.04±0.10(Predicted)
form Liquid
color Clear colorless
Water Solubility 40 g/L (20 ºC)

 

Application of Methyl Thioglycolate in Organic Synthesis

1. Preparation of Drug Articaine Hydrochloride
36-39mol methyl thioglycolate and 2-5L (37-40mol) 2-methacrylonitrile were reacted in a mixed solution of 11-14L sodium methoxide and methanol (prepared from metal sodium 0.8-1.1kg), after the reaction was over Adjust pH value with concentrated hydrochloric acid to be 7 and add dropwise 30% hydrogen peroxide 4-7L (4-7mol), then add concentrated hydrochloric acid 3.5L dropwise to the reaction system, concentrate under reduced pressure to obtain intermediate compound B; 3-5kg (18-21mol) Intermediate compound B was dissolved in 25L dichloromethane containing 4-6L (55-58mol) pyridine, and α-chloropropionyl chloride 3-5L (37-40mol) was added dropwise. After the reaction, the reaction mixture was After washing, drying and concentration under reduced pressure, intermediate compound C was obtained. 2-4kg (10-13mol) of intermediate compound C was dissolved in 3-6L dimethyl sulfoxide and added dropwise to the solution containing 1-3L (24-279mol) n-propylamine and In the solution of 21-40L dimethyl sulfoxide, after the reaction is completed, mix with ice water, extract with ethyl acetate, dry, and concentrate under reduced pressure to obtain an oily substance, then dissolve the oily substance with acetone, and adjust the pH value with concentrated hydrochloric acid. 5-6, crystallize, filter, and dry to obtain crude articaine hydrochloride.

2. Hair care and depilatory in tanning
Methyl thioglycolate can effectively attack the connective tissue connected to the hair root, more effective hair removal, and keep the hair intact in the liming solution. The steps of tanning for hair protection and depilation are as follows:
(1) Soaking in water: Weigh 100 parts by weight of raw hides and put them in a rotating drum, add 200 parts by weight of clear water, 0.15 parts by weight of water immersion aids, and 0.2 parts by weight of preservatives, turn at 28°C for 4 hours; add 0.2 parts of soda ash, Continue to rotate for 6 hours; drum out and wipe off the moisture on the surface of the skin;
(2) Hair protection and depilation: take 100 parts by weight of the above-mentioned treated rawhide in a drum, add 100 parts by weight of water, 0.1 part by weight of a hair-preserving and depilatory agent, rotate at 28°C for 15 minutes, stop for 15 minutes, repeat 5 times; add 0.1 parts by weight of sodium sulfide and turn for 4 hours, separate and remove hair;
(3) Lime: Continue to add 100 parts by weight of water, 2.0 parts by weight of hydrated lime, 1.0 parts by weight of liming aids, 0.2 parts by weight of preservatives, turn at 28°C for 60 minutes, stop and soak for 60 minutes, and then continue to turn 10 minutes, stop and soak for 60 minutes, a total of 8 hours; drum;
(4) Washing: Weigh 100 parts by weight of the above-mentioned treated ash skin into a drum, add 100 parts by weight of water, 0.2 parts by weight of water washing aid, rotate at 28°C for 30-60 minutes, and eject the drum. The soaking aid is sodium lauryl sulfate with a weight ratio of 1:0.5: nonylphenol polyoxyethylene; polyoxypropylene ether; the hair-preserving and depilatory agent is methyl thioglycolate; the liming aid is chitosan; The agent is dodecyl polyoxyethylene phosphate.

3. Preparation of non-steroidal anti-inflammatory drug intermediates
After chlorination, acrylonitrile reacts with methyl thioglycolate under the protection of N2 atmosphere in sodium methoxide to obtain 2-carboxymethyl-3-aminothiophene, the amino group is replaced by a sulfonyl chloride group and then chlorinated, and reacts with methylamine to obtain 5-carboxymethyl-3-aminothiophene. Methyl chloro-2-carboxylate-3-methylaminosulfonylthiophene. Methyl 5-chloro-2-carboxylate-3-methylaminosulfonylthiophene (MCMTC) is an important intermediate of non-steroidal anti-inflammatory drugs, which can synthesize lornoxicam, tenoxicam and other anti-inflammatory drugs. Blood lipids and drugs for the treatment of rheumatism.

The Synthetic Method of Methyl Thioglycolate

Methyl Thioglycolate SUMMARY OF THE INVENTION

The technical problem to be solved by the present invention is to provide a method for producing methyl mercaptoacetate which has low requirements on the purity of the main raw material thioacetic acid and is easy to purify. In order to solve the above-mentioned technical problems, the technical scheme of the present invention is: a method for producing methyl thioacetate is to combine thioacetic acid with a purity of 70.0%~96.0% and methanol with a purity of 95.0%~99.9% by 1:1.3 The molar ratio of ~ 4.0 is added to the reaction device, then the activator is added, and the reaction is carried out by stirring and heating. After the reaction is completed, the reaction product is subjected to liquid separation to obtain methyl thioacetate, which can be equipped with a thermometer and a condenser. , liquid separation device, closed electromagnetic stirrer reaction device. The activator is a methanol solution of p-toluenesulfonic acid with a mass concentration of 20% to 30%, and the dosage is 0.5% to 1.0% of the total mass of the feed. The methanol solution of p-toluenesulfonic acid is prepared by using methanol of p-toluenesulfonic acid. A methanol solution of p-toluenesulfonic acid with a mass concentration of 20% to 30%.

The reaction is to first add 60% of the total activator of the activator and then stir and heat, and then reflux at 45 to 55 ° C for 3 to 5 hours, and then add 40% of the total activator to continue stirring and heating. Reflux reaction at 55-65°C for 3-5 hours. The mercaptoacetic acid is 80%-85% pure thioglycolate, and the methanol is 99.5%-99.9% industrial anhydrous methanol. The liquid-separating distillation includes separating the ester layer located in the lower layer of the reaction product with a liquid-separating device, performing vacuum distillation on the ester layer, and separating the front distillate, methyl thioglycolate and the bottom of the still. Among them, the fore distillate accounts for 9.5% of the mass of the ester layer, and after standing, the water accounting for 20% of the mass content of the fore distillate can be separated, and the crude methyl mercaptoacetate (purity of 85% ~ 80% of the mass content of the fore distillate) 95%); Methyl mercaptoacetate accounts for 81% of the quality of the ester layer (purity ≥ 98.5); The residual amount at the bottom of the kettle accounts for 9.5% of the quality of the ester layer, wherein, the methyl mercaptoacetate mass content is 10.0%, not The mass content of the reacted thioacetic acid is 80.0%, and the residue at the bottom of the kettle can continue to carry out the next esterification reaction. The total average recovery rate of mercaptoacetic acid in the bottom residue liquid is ≥85%. Due to the adoption of the above technical solution, the requirement for the purity of the main raw material mercaptoacetic acid is reduced, the main raw material mercaptoacetic acid used does not need to be purified, and the cost is effectively reduced. ≥85%.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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