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Methyl Phenylacetate CAS 101-41-7

Molecular Formula: C9H10O2

Formula Weight: 150.17

ZSpharmac: Methyl Phenylacetate Raw Material Supplier

Product Name: Methyl Phenylacetate
CAS No: 101-41-7
Purity: 99%

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Basic Info

Product Name:Methyl Phenylacetate
Other Names:Phenylacetic Acid Phenylacetate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colourless Neat
EINECS No.:202-940-9
Storage:Store Below +30°C.
Provide:Methyl Phenylacetate MSDS;
Methyl Phenylacetate COA

What is Methyl Phenylacetate?

Methyl phenylacetate, whose English name is Methyl phenylacetate, is a clear liquid under normal temperature as well as pressure, with a honey-like scent. It is soluble in a lot of natural solvents, however insoluble in water. Methyl phenylacetate is commonly utilized as an intermediate in organic synthesis and also pharmaceutical chemistry. In great chemical manufacturing, this substance can be used as a fragrance, as well as is usually utilized to prepare flower flavors, such as rose, climbed as well as various other tastes.

Methyl Phenylacetate Property

Melting point 

107-115 °C

Boiling point 

218 °C (lit.)


1.066 g/mL at 20 °C (lit.)

vapor pressure 

16.9-75Pa at 20℃

refractive index 

n20/D 1.503(lit.)


195 °F

storage temp. 

Store below +30°C.


Chloroform (Slightly), Methanol (Slightly)






at 10.00 % in dipropylene glycol. sweet floral honey spice waxy almond

Odor Type


Water Solubility 

Miscible with water.

Methyl Phenylacetate Uses

  1. Methyl phenylacetate is made use of as a reagent in the synthesis of different organic responses, among which is the synthesis of methyl phenylacetate; a lichen metabolite with anti-inflammatory residential properties.
  2. Methyl phenylacetate is used as a flavor to prepare honey, chocolate, cigarette and other flavors.
  3. Methyl phenylacetate has a honey-like sweet taste and a slightly musky aroma. It is commonly made use of to prepare flower tastes, such as rose, briar and other tastes, along with tobacco and also soap. This item is additionally utilized in natural synthesis and the manufacture of drugs atropine and also anisodamine (artificial approach).

Methyl Phenylacetate Application

Methyl phenylacetate has a strong ester fragrance and can be made use of as a flavoring representative as well as is widely used in the manufacturing and also preparation of food and cosmetics. As an organic synthesis reagent, methyl phenylacetate can be used to construct a selection of anti-inflammatory bioactive molecules as well as drug molecules. For example, it is an essential artificial intermediate for atropine. Atropine is generally utilized to relieve smooth muscle spasm. Large amounts can eliminate small discomfort. Vasospasm enhances microcirculation, inhibits gland secretion, relieves the inhibition of the heart by the vagus nerve, increases the heartbeat, dilates the students, increases intraocular stress, excites the respiratory system center, and eases breathing inhibition.


Methyl phenylacetate (285 μL, 1.97 mmol, 1 equiv) and also ethanolamine (120 μL, 1.97 mmol, 1.00 equiv) were sequentially included through a syringe to the tetrahydrofuran option (1.95 mL) of the azacarbene stimulant IMes (30 mg, 98 μmol, 0.05 equiv). )middle. TLC checks the reaction combination, as well as the response basic materials will be totally transformed after regarding 8 hours. The response mixture was directly vaporized under lowered stress on a rotary evaporator to eliminate volatiles, and also the resulting residue was cleansed by silica gel column chromatography (10% MeOH in CHCl) to get the matching amide product as a white powder (355 mg, 100 %).

Methyl Phenylacetate Production Method

It is acquired by hydrolysis and esterification of phenylacetonitrile. Put methanol into a completely dry glass-lined reaction pot, mix as well as cool to below 30 ° C, add sulfuric acid dropwise, raise the temperature to 90 ° C after the addition, start adding phenylacetonitrile dropwise, control the temperature at about 95 ° C, and coating adding in 1.5 hours. After reacting at 95-100 ° C for 6 hours, cool down to listed below 40 ° C and also add water equivalent to about 0.6 times of the response solution to water down. Delegate separate the acid water, add saturated sodium carbonate option to reduce the effects of and also wash, and also discard the water layer. Use anhydrous calcium chloride to dehydrate as well as fractionate under minimized pressure to acquire methyl phenylacetate with a yield of 80%. An additional prep work technique is to pass benzyl chloride, anhydrous methanol and also water via hydrogen chloride under reflux until saturated, leave it for 2-3 hrs, and also warm it for 1 hr to produce this item.

About Products:
If you need Methyl Phenylacetate, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
Our company, as an experienced Methyl Phenylacetate manufacturer and supplier, ZSpharmac will provide Methyl Phenylacetate raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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