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Methyl Phenol CAS 108-95-2

Molecular Formula: C6H6O

Formula Weight: 94.11

ZSpharmac: Methyl Phenol Supplement

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Product Name: Methyl Phenol
CAS No: 108-95-2
Purity: 99%

Basic Info

Product Name:Methyl Phenol
Other Names:Phenol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Faintly Yellow Liquid
EINECS No.:203-632-7
Storage:Warehouse Ventilation Low Temperature Drying 2-8 ° C
Provide:Methyl Phenol MSDS;
Methyl Phenol COA

What is Methyl Phenol?

Methyl Phenol is one of the main components of coal tar. In 1834, Runge discovered Methyl Phenol from coal tar. In 1841, Laurent first obtained crystalline Methyl Phenol. Methyl Phenol is a product in which one hydrogen atom on the benzene ring is replaced by a hydroxyl group. Methyl Phenol exist in nature in free form or as derivatives (more in the form of derivatives). Pure products are white or colorless crystals that are easily deliquescent. In the air or in contact with unclean substances, it gradually turns into reddish crystals. It has a special smell, is poisonous and is highly corrosive. The reactivity of Methyl Phenol is mainly the reaction of hydroxyl and aromatic rings. The hydrogen of the hydroxyl group is easily dissociated into hydrogen ions, so it is acidic and reacts with sodium hydroxide to generate sodium phenolate; but the acidity of Methyl Phenol is lower than that of carboxylic acid and carbonic acid, so sodium phenolate frees Methyl Phenol in aqueous carbonate solution; Methyl Phenol is easily It is oxidized to form benzoquinone (pink), which is further oxidized to form a brown polymer; it can be reduced to benzene when it interacts with metal zinc; it can be reduced to cyclohexanol by hydrogenation under the action of nickel catalyst; the hydroxyl group can also generate ether Or ester; the reaction on the aromatic ring of Methyl Phenol is mainly manifested as electrophilic substitution reaction, such as halogenation, nitration, sulfonation, alkylation, acylation, carboxylation and coupling reaction with diazonium salt, these electrophilic reactions are mainly The ortho and para positions of the hydroxyl group occur; the aromatic ring has high reactivity to the carbonyl group of ketone and aldehyde, such as reacting with acetone to generate bisphenol A; under the catalysis of acid and alkali, phenol and formaldehyde can generate phenolic polymerization thing. Methyl Phenol is an edible spice that is temporarily allowed to be used in my country’s GB2760-1996 regulations.

Methyl Phenol Properties:

Melting point 40-42 °C(lit.)
Boiling point 182 °C(lit.)
density 1.071 g/mL at 25 °C(lit.)
vapor density 3.24 (vs air)
vapor pressure 0.09 psi ( 55 °C)
refractive index n20/D 1.53
Fp 175 °F
storage temp. 2-8°C
solubility H2O: 50 mg/mL at 20 °C, clear, colorless
pka9.89(at 20℃)
form liquid
color faintly yellow
Specific Gravity1.071
OdorSweet, medicinal odor detectable at 0.06 ppm
PH6.47(1 mM solution);5.99(10 mM solution);5.49(100 mM solution);
Odor Threshold0.0056ppm
explosive limit1.3-9.5%(V)
Water Solubility 8 g/100 mL


Methyl Phenol Uses

  1. Methyl Phenol is an important organic chemical raw material, which can be used to prepare phenolic resin, caprolactam, bisphenol A, salicylic acid, picric acid, pentachlorophenol, 2,4-D, adipic acid, phenolphthalein N-acetoethoxy Aniline and other chemical products and intermediates have important uses in chemical raw materials, alkylphenols, synthetic fibers, plastics, synthetic rubbers, medicines, pesticides, fragrances, dyes, coatings and oil refining industries. Furthermore, phenol can additionally be made use of as a solvent, experimental reagent and also anti-bacterial. From 1997 to 2002, the demand for phenol in major regions such as the United States, Western Europe and Japan maintained an average annual growth rate of 4.2%.
  2. Methyl Phenol is an important raw material for the production of pesticides. It can produce insecticides carbosulfur, cyclophosphine, vegetable and fruit phosphorus, fungicides prochloraz, triazolone, difenoconazole, herbicides 2,4-D, 2 , 4-D-butyl ester and rodenticides diaphanous, bromine diaphanous. In addition, phenol is alkylated to produce alkylphenols such as nonylphenol, dinonylphenol, sec-octylphenol, and polyarylphenols such as 2-methylbenzylphenol, 2,2-dimethylbenzyl Base Methyl Phenol, etc., are important intermediates of surfactants.
  3. he colorimetric determination of nitrate and nitrite of Methyl Phenol in sulfuric acid solution. Indirect determination of potassium. Used to bind excess free halogen. Determination of oxides of alkaline earth metals. Determination of ammonia, hypochlorite, 1-hydroxy acid.As a solvent for identifying the molecular weight of refractory substances. Microstaining, and so on.
  4. Methyl Phenol GB 2760–1996 stipulates that it is temporarily allowed to use the edible spice.

Preparation of Methyl Phenol

Its preparation methods are as follows.
Sulfonated alkali fusion method The old industrial production method of Methyl Phenol is the sulfonated alkali fusion method. Using concentrated sulfuric acid or sulfur trioxide as a sulfonating agent, benzene is subjected to gas-phase sulfonation and converted into benzenesulfonic acid, and then neutralized with sodium sulfite, and then Make sodium benzenesulfonate react with molten caustic soda to generate sodium phenate and Na2SO3 dissolved in water, separate by crystallization, and acidify the separated sodium phenate solution by immersion with sulfur dioxide or dilute sulfuric acid to obtain a crude product, which is distilled under reduced pressure to obtain a crude product. Get the finished product. The propylene separated from the cracked gas by the cumene method is subjected to an alkylation reaction with benzene at a normal pressure of 80 to 90 °C in the presence of an aluminum trichloride catalyst, and cumene is obtained by distillation and separation. Under the pressure of 100~120℃ and 300~400kPa, it is directly oxidized into cumene hydrogen peroxide, the oxidizing liquid is concentrated to about 80%, and the cumene hydrogen peroxide is split into phenol and acetone with sulfuric acid under normal pressure at 60℃. Refined to obtain acetone and Methyl Phenol, respectively. The method has low cost and less three wastes. The raw materials come from propylene and petroleum benzene in petroleum gas, and Methyl Phenol and acetone can be obtained at the same time, both of which are widely used chemical raw materials. The intermediate product, cumene hydroperoxide, can be isolated as an initiator for the rubber industry, and the intermediate cumene can be used as a raw material for the production of the intermediate p-cumylaniline of the herbicide isoproturon. This method is suitable for large-scale continuous production, and most of the Methyl Phenol production in the world currently adopts this method.

Production Method of Methyl Phenol

Methyl Phenol was first recovered from coal tar, as well as a lot of it is presently manufactured. By the mid-1960s, the technological route of generating phenol as well as acetone by the cumene method has been created, and it has created to make up half of the globe’s phenol output. Presently, the phenol produced by this process has actually represented more than 90% of the globe’s Methyl Phenol output. Various other production procedures include toluene chlorination, chlorobenzene, as well as sulfonation.There are two kinds of production methods in my country: cumene method and sulfonation method. Since the sulfonation method consumes a large amount of sulfuric acid and caustic soda, my country will also retain only a few sulfonation method units, and gradually produce mainly cumene method. 1. Sulfonation method Using benzene as raw material, sulfonated with sulfuric acid to generate benzenesulfonic acid, neutralized with sulfurous acid, alkali-fused with caustic soda, and obtained through steps such as sulfonation and vacuum distillation. Raw material consumption quota: pure benzene 1004kg/t, sulfuric acid (98%) 1284kg/t, sodium sulfite 1622kg/t, caustic soda (100% discount) 1200kg/t. 2. Cumene method Propylene and benzene generate cumene under the action of aluminum trichloride catalyst, cumene is oxidized to generate cumene hydroperoxide, and then decomposed with sulfuric acid or resin. At the same time, phenol and acetone are obtained. About 0.6t of acetone is co-produced per ton of phenol. Raw material consumption quota: benzene 1150kg/t, propylene 600kg/t. 3. Chlorobenzene hydrolysis method Chlorobenzene is catalytically hydrolyzed with caustic soda aqueous solution under high temperature and high pressure to generate sodium benzene, and then neutralized with acid to obtain phenol. 4. Refining method of crude phenol It is obtained by refining crude phenol from coal tar. 5. In the presence of a solid molybdenum catalyst, lassifa benzene is subjected to chlorine oxidation reaction at high temperature to generate chlorobenzene and water, and chlorobenzene is catalytically hydrolyzed to obtain phenol and hydrogen chloride, and the hydrogen chloride is recycled.

Methyl Phenol Disinfectant and Antiseptic

Methyl Phenol can denature proteins, so it has bactericidal effect. It has strong antibacterial activity against many microorganisms, such as gram-positive bacteria, gram-negative bacteria, mycobacteria, some fungi and viruses, and is resistant to Mycobacterium tuberculosis, spores and acid. The killing power of bacteria is poor. Phenol has the strongest activity in acidic solution; increasing temperature can also improve its antibacterial activity; the presence of organic matter will make its activity disappear. Diluted solution of Methyl Phenol can be used as a disinfectant and antiseptic, and has been used in surgery. In the 19th century, although the British doctor Lister had superb surgical techniques, he could not solve the problem of death of patients due to infection after surgery, and the mortality rate was 5%. He managed to find a drug to kill the microbes that infect the wound. Once he found that a cleaner used carbolic acid to eliminate the odor of the sewer, which inspired him to use carbolic acid dilute solution for surgery for the first time. The patients treated in this way did not experience any accidents such as infection. The incident shocked the world. In 1876, he completed a dissertation on disinfection, and only 10 years after it was published, the disinfection method was fully applied all over the world. Methyl Phenol is mainly used as an antibacterial preservative in injection and topical preparation products. The effective concentration is 0.1% to 0.5%, which can inhibit the growth of general bacteria. Cocci require a concentration of 3%, and to kill mold requires a concentration of more than 1.3%. Spores and viruses are very resistant to this product, so it is generally ineffective. Usually 1% to 5% concentration is used for disinfection of houses, poultry (livestock) houses, venues and other environments, and 3% to 5% concentration is used for utensils and equipment disinfection. The application method is spraying or soaking. The utensils and instruments should be soaked and disinfected for more than 30 to 40 minutes, but the troughs and drinking fountains can be used after soaking and disinfecting with normal water. Phenol is highly corrosive and toxic, mainly acting on the central nervous system, and the lethal dose for adults is about 1g. It has irritating, anesthetic and necrotic effects on skin and mucous membranes. Phenol is toxic by skin contact, swallowing or inhalation; mistakenly ingesting a small amount of Methyl Phenol can cause nausea, vomiting, shock, coma, and even death due to respiratory failure. The amount of phenol used as a preservative is small, so there are fewer adverse reactions. Since phenol is corrosive and irritating to tissues, it has been replaced by more effective and less toxic phenol derivatives, but the carbolic acid coefficient can still be used to express the bactericidal strength. For example, the carbolic acid coefficient of Methyl Phenol is 1, and when the carbolic acid coefficient of cresol to typhoid bacteria is 2, it means that the bactericidal ability of cresol is twice that of Methyl Phenol.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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