Methyl Hesperidin CAS 11013-97-1

Molecular Formula: C29H36O15

Formula Weight: 624.59

ZSpharmac: Methyl Hesperidin Supplier

Product Name: Methyl Hesperidin

CAS No: 11013-97-1

Purity: 99%

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Basic Info

Product Name:	Methyl Hesperidin
Other Names:	Methyl Chalcone
CAS:	11013-97-1
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	Yellow Solid
EINECS No.:	600-945-4
Storage:	Refrigerator
Provide:	Methyl Hesperidin MSDS； Methyl Hesperidin COA

What is Methyl Hesperidin?

Methyl hesperidin is a type of flavonoid compound developed by hesperidin via formazan, which can boost the coronary circulation of separated rabbit heart, increase the cardiac outcome of dogs, reduce myocardial oxygen usage, as well as unwind isolated bunny aortic strips. Minimize the vascular resistance of the dog’s reduced limbs, significantly reduce blood pressure and coronary, renal, and also cerebrovascular resistance, as well as boost coronary and kidney blood flow.The combination of methyl hesperidin and VitC can prevent and treat high blood pressure and brain blood. In recent years, orange vitamin C granules have been developed; as early as the 1960s, it has become the main raw material of “Maidong”, and it is compatible with other medicines to strengthen blood vessels. Widely used in clinical. At present, methyl hesperidin is derived from the methylation of hesperidin (hesperidin R), and the traditional process is to dissolve hesperidin in sodium hydroxide solution by the liquid alkali method (sodium hydroxide method), and then Add methylation reagent – dimethyl sulfate for methylation reaction to obtain methyl hesperidin, the yield of this method is only 70.0%.

Methyl Hesperidin Property

Melting point	>124°C (Subl.)
Boiling point	583.81°C (rough estimate)
density	1.3090 (rough estimate)
refractive index	1.5940 (estimate)
storage temp.	Refrigerator
solubility	DMSO (Slightly), Pyridine (Slightly), Water (Slightly)
form	Solid
color	Yellow

Methyl Hesperidin Uses

Methyl hesperidin is used for content determination/identification/pharmacological experiments, etc.
Methyl hesperidin is used to increase the resistance of capillaries, normalize capillary permeability.

Application of Methyl Hesperidin

Methyl hesperidin is a mixture of various similar substances produced by the methylation reaction of hesperidin, but the main component is 3-methyl hesperidin, which is easily soluble in water and belongs to the vitamin P class of drugs, with antiviral and antiviral properties. Antibacterial effect, can also enhance the role of vitamin C; can inhibit the role of tyrosinase, used for the treatment of dark spots, freckles and other skin diseases, has the effect of whitening the skin; can strengthen capillary resistance, maintain normal permeability of blood vessels, Make capillaries elastic and tough, prevent and treat capillary bleeding, gingival bleeding, etc.; in addition, methyl hesperidin can be used for nosebleeds, retinal hemorrhages, gastrointestinal bleeding, and prevention and treatment of bleeding before or after surgery: for ” The raw materials of “Maitong”, “Xinmaining” and “Orange Vitamin C” preparations are also used in whitening and spot-removing products and food additives.

Preparation Method and Pharmacokinetics of Methyl Hesperidin

Preparation Method:

Accurately weigh 40g of dermoside and add it to a 500mL three-neck flask, add 200mL of water, start stirring, and stir to form a suspension, then add 10g of calcium hydroxide, then slowly add 15mL of dimethyl sulfate dropwise, and the reaction temperature is controlled at 30 After reacting at ℃ for 6 hours, extract twice with n-butanol, combine the organic phases, wash once with water and once with saturated brine, recover n-butanol under reduced pressure to obtain crude methyl hesperidin. Add 240 mL of ethanol (95%) to the crude product, heat to 60°C to dissolve, filter while hot, cool and crystallize the filtrate at room temperature for 2 days, filter with suction, and dry at 80°C to obtain an orange-yellow crystalline powder, namely methyl hesperidin 30.0 g, the yield is 75.0%.

Pharmacokinetics:

The half-life of methyl hesperidin is extremely short. In order to quickly eliminate methyl hesperidin and maintain the desired effective concentration in the near future, the administration method is preferably infusion. The short maintenance of the pharmacological effect of the drug may be related to the fast metabolism of the drug.

The apparent volume of distribution of methyl hesperidin is small, about 0.51, almost all of which are distributed in the blood, and other tissues and cells are less, which is consistent with the one-compartment model for its kinetic characteristics.

Expression of Methyl Hesperidin in Cells Via Nrf2-ARE Pathway

Methyl Hesperidin is a combination of methylated derivatives of the citrus flavonoid hesperidin, used as a food or pharmaceutical additive. Dietary MHES can be hydrolyzed by gut microbiota to generate aglycones. As a result, we prepared hydrolyzed methylhesperidin (h-MHES) as well as examined its pharmacological task in human epidermal keratinocytes. h-MHES promotes nuclear translocation of nuclear aspect erythroid 2-related factor 2 (Nrf2) and also cytoprotective genes such as heme oxygenase-1 (HO-1) and also glutamate cysteine ligase catalytic subunit (GCLC)) expression. h-MHES also raised intracellular glutathione levels and also minimized UVB-induced responsive oxygen species. Furthermore, h-MHES boosted the phosphorylation of p38 mitogen-activated protein kinase (MAPK), as well as p38 MAPK prevention considerably undermined h-MHES-induced expression of HO-1 and also GCLC. In addition, when we purified elements of h-MHES, we determined two methoxychalcones as novel Nrf2 activators. Our research study reveals that h-MHES can cause cytoprotective gene expression and also lower oxidative stress via the Nrf2-ARE pathway in keratinocytes, recommending that MHES may assist subdue UVB-induced skin damage in vivo.

About That Product:
If you need Methyl Hesperidin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Methyl Hesperidin, ZSpharmac will provide Methyl Hesperidin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.