Zhishang Chemical

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Zhishang Chemical

Methyl Guanosine CAS 118-00-3

Molecular Formula: C10H13N5O5

Formula Weight: 283.24

ZSpharmac: Methyl Guanosine Supplier

Product Name: Methyl Guanosine
CAS No: 118-00-3
Purity: 99%

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Basic Info

Product Name:Methyl Guanosine
Other Names:Guanosine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Light Yellow Powder
EINECS No.:204-227-8
Storage:Room Temp
Provide:Methyl Guanosine MSDS;
Methyl Guanosine COA

What is Methyl Guanosine?

The full name of Methyl Guanosine (Guanosine) is guanine nucleoside, also known as 9–β–D–ribofuranosyl guanine. Because of its taste and synergistic effect with sodium glutamate, it can improve the umami taste of MSG several times to dozens of times. At the same time, it is also an important raw material for nucleoside antiviral drugs such as ribavirin, acyclovir, acyclovir, ribavirin, and sodium guanosine triphosphate. Presently, the demand for Methyl Guanosine is boosting at an annual price of 10% to 20%, and also the marketplace possibility is very confident.

Methyl Guanosine Property

Melting point 250 °C (dec.) (lit.)
alpha -62 º (c=3, in 0.1 N NaOH)
Boiling point 425.8°C (rough estimate)
density 1.3790 (rough estimate)
refractive index -76 ° (C=1, 1mol/L NaOH)
storage temp. room temp
solubility 0.1 M NaOH: 0.1 g/mL, clear, slightly yellow
pkapK1:1.9(+1);pK2:9.25(0);pK3:12.33(OH) (25°C)
form Powder
color White to light yellow
optical activity[α]20/D -73±2°, c = 1.5% in 1 M NaOH
Water Solubility 0.75 g/L (25 ºC)


Methyl Guanosine Uses

  1. As an essential intermediate of food as well as pharmaceutical products, Methyl Guanosine can be utilized to manufacture food quality boosters – disodium 5′-guanylate, disodium nucleotides with preference, and also nucleoside antiviral medications such as ribavirin, Acyclovir, etc, are additionally the main basic materials for the manufacture of medications such as acyclovir (Acyclovir), ribavirin (ATC), and also guanosine triphosphate (GTP).
  2. Methyl Guanosine is primarily used as the primary resources for the manufacture of acyclovir, ribavirin, sodium guanosine triphosphate as well as various other medications.
  3. Methyl Guanosine is made use of as a forerunner of GMP, GDP, GTP as well as cGMP in cell society.
  4. Methyl Guanosine is used in solutions of bathroom items, cleaning items, fragrances, hair conditioners, lip balms, nail items, shampoos as well as skin care items.

Preparation of Methyl Guanosine

The production methods of Methyl Guanosine include chemical synthesis, cell autolysis and fermentation. Because the chemical synthesis method requires a large amount of organic solvents, there are problems such as raw material sources and environmental pollution, and it is rarely used in production; the autolysis method of bacteria is basically not used at present because its efficiency is too low; the production of Methyl Guanosine by fermentation method is due to its high yield, Due to the advantages of short cycle time and easy control, it has become an important method for industrial production of guanosine. Using Bacillus subtilis as the fermentation strain to prepare nucleosides has the advantages of high yield, less by-products in the product, and easy product separation and extraction. Therefore, Bacillus subtilis has become the most important production bacteria in the nucleoside fermentation industry.

In the 1960s, Japan carried out large-scale research on the production of Methyl Guanosine by fermentation, mainly focusing on traditional mutation breeding techniques to change the characteristics of the strain and increase the yield of Methyl Guanosine, up to 20g/L. Glycoside fermentation research is less. The research on guanine series compounds in my country began in the 1980s. With the sharp increase in the market demand for guanosine, more and more scientific research institutions have conducted comprehensive and in-depth research on the fermentation of Methyl Guanosine.

According to the survey, there is a big gap between the domestic Methyl Guanosine fermentation level and the world’s advanced level. The main reason is that the breeding technology is backward, the glycoside production level of the strain is not high; the fermentation cycle is long, the conversion rate and the comprehensive yield of extraction are low. Therefore, it is very necessary to develop high-yielding Methyl Guanosine engineering bacteria and efficient production processes.

A method for improving the yield of Methyl Guanosine produced by fermentation of Bacillus subtilis:

About Products:
If you need Methyl Guanosine as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Methyl Guanosine manufacturer and supplier, ZSpharmac will provide Methyl Guanosine raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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