Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Search
Close this search box.

Methyl Cedryl Ether CAS 19870-74-7

Molecular Formula: C16H28O

Formula Weight: 236.39

ZSpharmac: Methyl Cedryl Ether Supplier

Facebook
Twitter
LinkedIn
Pinterest
WhatsApp
Email
Product Name: Methyl Cedryl Ether
CAS No: 19870-74-7
Purity: 99%

Navigation Bar

Basic Info

Product Name:Methyl Cedryl Ether
Other Names:Cedryl Methyl Ether
CAS:19870-74-7
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellowish Brown Liquid
EINECS No.:243-384-7
Storage:Sealed in dry,Room Temperature
Provide:Methyl Cedryl Ether MSDS;
Methyl Cedryl Ether COA

What is Diethanolamine Sigma?

Methyl cedryl ether is an essential scent raw material, which has the smell of ambergris and lotion, as well as is usually made from cedarwood oil. Methyl cedryl ether has a woody fragrance and a fragrance of ambergris. The appearance is liquid, the boiling point is 258 ° C, 96 ° C/130Pa. According to the details provided by RIFM, the acute poisoning data of methyl cedryl ether: oral LD50 > 5g/kg (rat), skin test LD50 > 5g/kg (bunny).

Methyl Cedryl Ether Property

Boiling point 259°C
density 0.976
refractive index 1.496
Fp >110°C
storage temp. Sealed in dry,Room Temperature

 

Preparation of Methyl Cedryl Ether

Method 1: CN201410265364.2 reported the use of fir oil as a raw material for the synthesis of methyl cedryl ether, and the separation of 3,6,8,8-tetramethyloctahydro-1H-3a,7-methylene from fir oil Reaction of azulen-6-ol with sodium benzyl gave 3,6,8,8-tetramethyloctahydro-1H-3a,7-methylene azulen-6-alcohol sodium, which was then reacted with dimethyl sulfate methylation reaction, that is, the production of methyl cedryl ether (10-methoxy-2,2,6,10-tetramethyltricyclo-[5,3,1,03,7] -undecane).
 
The beneficial effects of the present invention are:
 
The present invention adopts benzyl sodium to react with 3,6,8,8-tetramethyl octahydro-1H-3a,7-methylene azulen-6-ol, and benzyl sodium is converted into toluene after the reaction, which can be mixed with solvent toluene Distilled and separated together, the post-treatment is simpler, the reaction conditions are mild, the production process is safer, and it is suitable for industrial production. Compared with the active metal sodium or sodium hydride method, it has the characteristics of mild reaction conditions, high product yield and pure aroma.
 
In the rectification process of methyl cedryl ether, the present invention adopts superheated steam as the vaporization center of the material in the rectification tank, which can obviously improve the heat transfer effect of the material in the tank and improve the heat transfer efficiency of the material; The residence time at the bottom avoids bumping and coking of the materials in the kettle due to local overheating.
 
Two-stage gradient condensation is adopted, the cooling temperature of the first-stage condenser is controlled at 160-170°C, and the cooling temperature of the second-stage condenser is controlled at 50-60°C. Methyl cedryl ether is condensed in the first-stage condenser, while water vapor and low-boiling organic matter continue to pass through the first-stage condenser and enter the second-stage condenser to be condensed again. The rectification time of methyl cedryl ether can be shortened by nearly 1/3, and the aroma of methyl cedryl ether after rectification is pure, without burnt and miscellaneous smells, and is welcomed by perfumers. The market price per kilogram is higher than that of ordinary refined The price of similar products processed by distillation is about 20 yuan higher.
 
Compared with the technology of CN95100458.1, the present invention:
 
The shortcomings of CN95100458.1: the reaction of sodium metal or sodium hydride with cedryl alcohol to synthesize cedryl alcohol sodium, the reaction is violent, and side reactions are prone to occur, which brings difficulties to subsequent rectification and affects the aroma of methyl cedryl ether products; Using sodium amide cedryl alcohol reaction to synthesize sodium cedryl alcohol, ammonia gas will be produced in the sodium amide reaction, and the ammonia smell will be entrained in the reaction product, which will also affect the aroma and production operation environment of the methyl cedryl ether product. The present invention adopts benzyl sodium to react with 3,6,8,8-tetramethyl octahydro-1H-3a,7-methylene azulen-6-ol, and benzyl sodium is converted into toluene after the reaction, which can be mixed with solvent toluene They are distilled and separated together, and the post-processing is simple, which is more suitable for industrial production. Fig. 1 is the chemical reaction formula of the present invention.
 
 
Examples are as follows:
 
In a reactor with a stirring and reflux condenser, add 170ml of toluene and 137g of benzyl sodium, heat to reflux under stirring, add 3,6,8,8-tetramethyloctahydro-1H-3a dropwise, A solution of 223g of 7-methylene azulen-6-ol and 200ml of toluene, the temperature of the reaction system was controlled to reflux, and the dropwise addition time was 30min. After the dropwise addition, the reaction was refluxed for 1.5h, then cooled to room temperature, and the first step reaction was completed.
 
Continue to add 122g of dimethyl sulfate dropwise, and the dropwise addition is completed within 30min. After the dropwise addition, react at 70°C for 2.5h, wash the reaction mixture with 100ml of 10% sodium bicarbonate solution, let the layers stand, and separate the water layer , the oil layer was washed with 10% aqueous sodium chloride solution until neutral. Atmospheric pressure distillation recovers the solvent toluene first, and then carries out rectification. A superheated steam conduit is arranged at the bottom of the rectifying kettle 2, and a steam injection distributor 1 is installed at the end of the conduit, so that the superheated steam can be evenly rushed into the material, and plays the role of heat transfer, stirring, tumbling material and bubbling.
 
The rectifying tower 3 is equipped with a two-stage gradient condenser device, and the rectifying tower 3 is connected with the two-stage gradient condenser device through the distributor 4. The cooling temperature of the first-stage condenser 5 is controlled at 160-170°C, and the collected 160-170°C The fraction of /0.27kPa is 214 grams of methyl cedryl ether. Water vapor and low-boiling components pass through the first-stage condenser 5 and enter the second-stage condenser 6. The cooling temperature is controlled at 50-60°C. The condensed fractions then pass through the oil-water separator to obtain low-boiling components.
 
Method 2: Cedaryl alcohol and sodium amide are heated and reacted in a solvent to form cedryl alcohol sodium, and then reacted with methyl iodide to obtain methyl cedryl ether, and the fraction at 118-120°C/250Pa is collected by vacuum distillation to obtain the finished product. Greater than 96%, purity above 97%.
 
Examples are as follows:
 
In a 1000L autoclave, add 200L benzene, under stirring, add 35Kg sodium amide, close the autoclave, raise the temperature to 80°C and stir for 0.5 hours, then put the solution of 195Kg cedarwood alcohol and 250Kg benzene in the dissolving pot Put it into an autoclave, react at 80° C., and until the conversion rate reaches more than 99% by sampling analysis, the first step of reaction ends. The reaction mixture was cooled to 30°C, 162Kg of iodomethane was added, the temperature was slowly raised to 40°C with stirring, and the reaction was carried out for 1 hour. Then, the temperature was uniformly raised to 80°C within 2 hours, and the reaction was continued for 4 hours.
 
After the methylation reaction finishes, cool down, add 50Kg of 12% sodium hydroxide solution, after washing, add water to wash until neutral. Recover the solvent to obtain the crude product, and then rectify under reduced pressure to collect the distillate at 118-120°C/250Pa to obtain 204Kg of methyl cedryl ether product, the yield is 98%, the content of chromatographic analysis is more than 97%, and the refractive index nD201.4950-1.4970 , relative density d4200.9770 ~ 0.9790, with amber woody aroma.

About That Product:
If you need Methyl Cedryl Ether as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Methyl Cedryl Ether manufacturer and supplier, ZSpharmac will provide Methyl Cedryl Ether raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Methyl Cedryl Ether Quotation