Synthesis of Benzoic Acid and also Methanol
Artificial methyl benzoate is to be raw material with benzoic acid as well as methyl alcohol, acquires methyl benzoate via the catalysis of acid stimulant, and also response equation is as received (1-1). This reaction belongs to the category of esterification response in natural synthesis. As a result, in the endothermic reaction procedure of its reversible equilibrium, the reaction price is significantly impacted by the temperature level and the catalytic effect of the driver, and the reaction temperature is restricted by methanol, generally just 70 ~ 90 ° C, so that the water generated by the response It exists in the system and also can not be gotten rid of. In order to raise its reaction price, people have actually likewise created a series of catalytic reaction modern technologies, along with chemical catalysis, there are physical catalysis and biocatalysis.
Chemical catalysis
The chemical catalysis approach is mainly to study the impact of numerous drivers on the catalytic effect of the reaction. In recent times, scientists have mostly targeted at establishing more effective and environmentally friendly drivers. Currently, there are mainly 5 kinds of stimulants, as displayed in Table 1-2.
The reason that the efficient rate of methyl benzoate can not remain to improve mostly is: temperature level of reaction is reduced, is normally all less than the boiling point temperature of water, and under this problem, the water that creates can not be efficiently removed, as well as esterification is relatively easy to fix For that reason, the reaction that generates water will seriously limit the progress of the response, as well as the addition of the driver just minimizes the activation energy of the response, thereby enhancing the price of the reaction, and it is not likely to realize the full esterification of p-benzoic acid.
Physical catalysis
The techniques of physical catalysis are mostly reported in the literature as ultrasonic catalysis and microwave catalysis. Research studies have shown that although microwave radiation can increase the price of esterification, it still can not totally replace the catalytic impact of the driver. Using conventional acid drivers is still an excellent way to boost the reaction rate.
Biocatalysis
Making use of biological enzymes as stimulants has the advantages of high reactivity and mild response problems. Specifically in food processing, enzymes can be utilized to ferment esters. Utilized in the pharmaceutical industry, it can manufacture prescription antibiotics and also fat esters, and so on. Nonetheless, such catalysts are prone to deactivation and inadequate universality. The result of this method artificial methyl benzoate is very low, is primarily relevant to fine chemical sectors such as food, flavors, is not suitable for massive industrial manufacturing.
Synthesis technique of acetophenone and dimethyl carbonate
Dimethyl carbonate includes active teams carbonyl, methoxy, etc, to make sure that it can react chemically with acids, esters, alcohols, and so on, and afterwards produce different great organic chemicals. Wu et al. reported that strong base catalyzed dicarbonate The reaction of methyl ester with acetophenone to prepare methyl benzoate.
Synthesis of Benzyl Alcohol and also Methanol
At present, along with acid-catalyzed esterification to synthesize esters as well as transesterification to manufacture esters, according to the various reactants in the response, individuals also study the oxidative synthesis of alcohol-aldehyde synthesis, alcohol-acid synthesis and alcohol-alcohol synthesis.
