Zhishang Chemical

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Zhishang Chemical

Methyl 3-Phenylpropanoate CAS 103-25-3

Molecular Formula: C10H12O2

Formula Weight: 164.2

ZSpharmac: Methyl 3-Phenylpropanoate Supplier

Product Name: Methyl 3-Phenylpropanoate
CAS No: 103-25-3
Purity: 99%

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Basic Info

Product Name:Methyl 3-Phenylpropanoate
Other Names:3-Phenylpropionic Acid Methyl Ester
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colourless to Pale Yellow Oil
EINECS No.:203-092-2
Storage:Sealed in dry,Room Temperature
Provide:Methyl 3-Phenylpropanoate MSDS;
Methyl 3-Phenylpropanoate COA

What is Methyl 3-Phenylpropanoate?

Methyl 3-Phenylpropanoate is also called methyl phenylpropanoate, methyl hydrogenated cinnamate. Esters and derivatives of esters have important uses in medicine, chemicals, fuels, etc., such as synthetic perfumes, flavoring agents, detergents, and surfactants.

Methyl 3-Phenylpropanoate Property

Melting point 142-145 °C
Boiling point 91-92 °C4 mm Hg(lit.)
density 1.043 g/mL at 25 °C(lit.)
refractive index n20/D 1.502(lit.)
Fp 212 °F
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Oil
color Colourless to Pale Yellow
Water Solubility Soluble in chloroform. Insoluble in water.


Methyl 3-Phenylpropanoate Uses

Methyl 3-Phenylpropanoate is used as a pharmaceutical intermediate and also used in organic synthesis.

Preparation of Methyl 3-Phenylpropanoate

Method 1: Add 4mL of methanol, 0.3mmol of styrene, and 0.1g of 0.15wt% Ru/CeO2 catalyst to a 50mL Teflon-lined reactor, add a magnet, fill it with 0.5MPa CO, seal it, and The reaction was stirred at 180° C. for 12 hours. After the reaction, the product was characterized by mass spectrometry and quantified by gas chromatography. The product looks like this:

Method 2. Methylation reactions are not only related to biological processes, but also play an important role in the functionalization of bioactive molecules in synthetic chemistry. Traditional methylating reagents include methyl iodide, dimethyl sulfate, methyl p-toluenesulfonate, and diazomethane. Although these methylating reagents are efficient, they are usually unstable, dangerous or highly toxic. CN201811224832.6 reported that methyl trifluoroacetate was used as a green and environmentally friendly reagent to react in the presence of a base to obtain the corresponding methylated product.

Preparation of Methyl 3-Phenylpropanoate

Add phenylpropionic acid (100 mg, 0.67 mmol), DMF (4 mL), potassium tert-butoxide (224 mg, 2.0 mmol, 3eq.) into the reaction flask in turn, stir at room temperature for 5 minutes, and wait until the potassium tert-butoxide is uniform After dispersion, methyl trifluoroacetate (0.27mL, 2.7mmol, 4 eq.) was slowly injected into the reaction bottle. After 4 hours of reaction, TLC spotting showed that the raw material point disappeared, and the stirring was stopped. Extract twice with ethyl acetate and distilled water, then wash with saturated NaCl solution, combine the organic phases, dry the organic phases with anhydrous magnesium sulfate, filter to remove magnesium sulfate, remove the solvent by rotary evaporation, and purify by column chromatography to obtain colorless liquid styrene-acrylic acid Acid methyl ester (80 mg, 73% yield). HNMR (400 MHz, CDCl3) δ7.30 (d, = 7.0 Hz, 2H), 7.22 (d, = 7.8 Hz, 3H),3.70 (s, 3H), 2.98 (t, = 7.8 Hz, 2H), 2.66 (t, = 7.9 Hz, 2H); C NMR (100MHz, CDCl3) δ173.32, 140.54, 128.52, 128.29, 126.29, 51.58, 35.71, 30.97.

About Products:
If you need Methyl 3-Phenylpropanoate as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Methyl 3-Phenylpropanoate manufacturer and supplier, ZSpharmac will provide Methyl 3-Phenylpropanoate raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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