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Zhishang Chemical

Methyl 2-Octynoate CAS 111-12-6

Molecular Formula: C9H14O2

Formula Weight: 154.21

ZSpharmac: Methyl 2-Octynoate Supplier

Product Name: Methyl 2-Octynoate
CAS No: 111-12-6
Purity: 99%

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Basic Info

Product Name:Methyl 2-Octynoate
Other Names:Methyl 2-Octynoate, 98%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colourless Neat
EINECS No.:203-836-6
Provide:Methyl 2-Octynoate MSDS;
Methyl 2-Octynoate COA

What is Methyl 2-Octynoate?

The 2-alkynoates mainly include methyl heptyne carboxylate and Methyl 2-Octynoate, which have industrial applications. They are mainly used in high-end daily chemical flavors, and can also be added to food flavors. It has a sharp, fresh fragrance, diluted with violet leaf and mimosa-like aromas. These two spices are mainly used in daily chemical essences, and can be used together with other spices in essences such as gardenia, tuberose, violet, osmanthus, and rose.

Methyl 2-Octynoate is a 2-alkynoate compound with similar functions. At present, there are not many reports on the preparation methods of such compounds. The main methods are as follows: 1) Alkyne compound and strong base form sodium alkyne compound, sodium alkyne reacts with carbon dioxide to obtain alkyne acid, and then esterifies to obtain the desired ester ; 2) Alkynes and methyl chloroformate are directly prepared under alkaline conditions; 3) Alkynes, carbon monoxide and oxidants are prepared in the presence of catalysts. These methods all involve the synthesis of intermediate alkynes. Octyne and heptyne are not commercially available at present, and their preparation is relatively difficult. In addition, the reagents used in these methods, such as sodium amide and methyl chloroformate, are relatively dangerous, or the catalysts are expensive and the reaction conditions are harsh, so it is difficult to industrialize.

Methyl 2-Octynoate Property

Boiling point 

217-220 °C(lit.)


0.92 g/mL at 25 °C(lit.)

vapor pressure 

10.6-13.9Pa at 20-25℃

refractive index 

n20/D 1.446(lit.)


192 °F

storage temp. 



Chloroform (Slightly), Methanol (Slightly)




Clear Colourless


Preparation Method of Methyl 2-Octynoate

Methyl 2-octynoate was prepared as follows:

Step 1: Synthesis of methyl 2,3-dibromononanoate: add 100g (0.64mol) methyl 2-nonenoate and 150ml dichloromethane to a 500ml three-neck flask, add 108g (0.67mol) dropwise at 0°C Add bromine within 1 hour, continue to stir for 2 hours after the dropwise addition, and recover dichloromethane under reduced pressure to obtain the intermediate 2,3-dibromononanoic acid methyl ester.

Step 2: Add 2,3-dibromononanoic acid methyl ester obtained in step 1 to 200ml of ether, slowly add 56g (1.41mol) of potassium hydroxide at 30°C, finish adding within 1 hour, and continue at this temperature Stir for 5 hours, add water to quench the reaction after the reaction is complete, separate the liquids, recover the solvent from the organic phase to obtain the crude product, and rectify under reduced pressure to obtain the finished product 2-octynecarboxylate methyl ester with a yield of 26%.

Determination of the Safety of Methyl 2-Octynoate

In the here and now work, a method for the qualitative along with quantitative analysis of 24 unforeseeable substances kept in mind by the European Union as thought allergens in aesthetic things is reported. The checklist consists of benzyl alcohol, limonene, linalool, methyl 2-octynoate, beta-citronellol, geraniol, citral (both isomers), 7-hydroxycitronellal, anisyl alcohol, Cinnamaldehyde, cinnamyl alcohol, eugenol, isoeugenol (both isomers), coumarin, α-isomethylionone, lilyaldehyde, α-amyl cinnamaldehyde, lyral, α-amyl cinnamyl alcohol, farnesol (3 isomers), alpha-hexylcinnamaldehyde, benzyl cinnamate, benzyl benzoate as well as benzyl salicylate.The viability of a headspace (HS) autosampler for use with a gas chromatograph (GC) furnished with a programmable temperature evaporator (PTV) as well as a quadrupole mass spectrometry (qMS) detector was explored. By utilizing a headspace sampler, example prep work is reduced to introducing the sample right into the vial. This lowers analysis time as well as speculative mistake connected with this action of the analysis procedure. Two various injection strategies were made use of: solvent air vent injection and thermal split shot. The initial supplies a method to raise level of sensitivity while keeping a basic headspace instrumentation and also is recommended for substances at trace levels. Utilize a lining filled with Tenax-TA to preserve substances of passion throughout airing vent. The signals acquired when injecting using thermal splitting up enabled the metrology of all substances according to the threshold values of the European Aesthetic Instruction. Utilizes 1D gas chromatography paired to a traditional quadrupole mass detector and also sufficiently divides 24 analytes in a run time of approximately 12 minutes. Matrix results were overcome making use of a standard enhancement treatment as a quantification strategy. It should be stressed that the method has excellent accuracy and also accuracy. Additionally, it is quick, straightforward and also – judging by the results – really suitable for the resolution of suspected allergens in various cosmetic items.

About Products:
If you need Methyl 2-Octynoate as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Methyl 2-Octynoate manufacturer and supplier, ZSpharmac will provide Methyl 2-Octynoate raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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