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Methyl-β-Cyclodextrin CAS 128446-36-6

Molecular Formula: C54H94O35

Formula Weight: 1303.3

ZSpharmac: Methyl-β-Cyclodextrin Cosmetic Raw Material Suppliers

Product Name: Methyl-β-Cyclodextrin
CAS No: 128446-36-6
Purity: 99%

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Basic Info

Product Name:Methyl-β-Cyclodextrin
Other Names:Beta-Cyclodextrin Methyl Ethers
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Powder
EINECS No.:1308068-626-2
Storage:Room Temp
Provide:Methyl-β-Cyclodextrin MSDS;
Methyl-β-Cyclodextrin COA

What is Methyl-β-Cyclodextrin?

Methyl-beta-cyclodextrin (MβCD) is a derivative of cyclodextrin (CD) and a member of the cyclodextrin family. Cyclodextrin itself is a cyclic oligosaccharide formed by α-D-glucose units connected by α-1,4-glycosidic bonds. Common cyclodextrins include α-CD (composed of 6 glucose units), β-CD (composed of 7 glucose units) and γ-CD (composed of 8 glucose units). Methyl-beta-cyclodextrin is a modified product obtained by introducing methyl groups at certain hydroxyl positions of β-cyclodextrin.

Methyl-β-Cyclodextrin Property

Melting point 180-182 °C(lit.)
alpha +159°(25℃, c=1, H2O)
Fp 187 °C
storage temp. room temp
solubility H2O: soluble50mg/mL
form powder
color White to off-white
optical activity[α]25/D +159°, c = 1 in H2O
Water Solubility Soluble in water


Methyl-β-Cyclodextrin Uses

1. Pharmaceutical industry
Solubilizer: Methyl beta-cyclodextrin can form inclusion complexes with a variety of poorly soluble drugs, improve the water solubility of drugs, and thus enhance the bioavailability of drugs. This allows drugs that are originally poorly absorbed orally to be effectively delivered, reducing the dosage and improving the efficacy.
Drug stabilizer: Through inclusion complexation, methyl beta-cyclodextrin can protect drug molecules from environmental factors (such as light and oxidation) and enhance the stability of drugs.
Drug sustained and controlled release: Regulate the release rate of drugs, achieve timed and localized release of drugs, reduce toxic side effects, and improve therapeutic effects.

2. Biomedical research
Cell biology: Used to remove cholesterol from cell membranes and study the effects of cholesterol on cell functions, such as cell signaling and membrane fluidity.
Gene transfection: As an auxiliary component of transfection reagents, it helps DNA or RNA molecules penetrate cell membranes and improve transfection efficiency.
Apoptosis research: By regulating cholesterol levels, it affects the apoptosis pathway and is used as a tool to study the mechanism of cell death.

3. Food Industry
Stabilizers and emulsifiers: Improve the stability of oil and water phases in food, prevent stratification, and extend the shelf life of food.
Flavor enhancement: Improve the taste and flavor of food by encapsulating odor molecules or enhancing the solubility of flavor molecules.

4. Environmental Science
Pollution Removal: By using its strong encapsulation effect on hydrophobic organic pollutants, methyl beta-cyclodextrin can be used for water purification, removal of oil stains, pesticide residues, etc.

5. Cosmetics and Personal Care
Active Ingredient Delivery: As a carrier, it helps active ingredients to better penetrate the skin and enhance the efficacy of skin care products.
Formula Stability: Improve the stability of unstable ingredients in the formula, prevent oxidation or decomposition, and extend the shelf life of the product.

6. Analytical Chemistry
Sample Pretreatment: As an extractant, it is used to enrich and purify trace analytes and improve detection sensitivity.

7. Materials Science
Nanomaterial Synthesis: As a template or stabilizer, it participates in the preparation of materials such as nanoparticles and nanocapsules, and regulates the morphology and properties of materials.

Outstanding Application of Methyl Beta-Cyclodextrin In Cosmetics

1. Enhanced delivery of active ingredients
Methyl beta-cyclodextrin can form inclusion complexes with active ingredients in cosmetics, especially those that are hydrophobic or poorly soluble. This inclusion complex not only improves the solubility and stability of these ingredients in aqueous formulas, but also promotes their permeability through the skin, thereby enhancing the bioavailability of active substances and making skin care products more effective.

2. Skin feel and formula optimization
Due to its ability to improve the water solubility of hydrophobic ingredients, methyl beta-cyclodextrin helps reduce the greasy feel in the formula and makes cosmetics feel more refreshing to use. This is especially important for products such as lotions, essences, and creams, which can enhance the consumer experience.

3. Fragrance control and stability
In perfume and fragrance products, methyl beta-cyclodextrin can encapsulate volatile fragrance molecules, prolong the durability and stability of the fragrance, and improve the safety of the product.

4. Anti-pollution and anti-oxidation
The inclusion complex of methyl beta-cyclodextrin can be used to remove tiny pollutants on the skin surface, such as heavy metal ions and organic pollutants, and reduce their damage to the skin. In addition, it can also enhance the antioxidant capacity of cosmetics by encapsulating and stabilizing easily oxidized ingredients, such as vitamin C.

5. Gentle exfoliation and cleansing
In cleansing products, methyl beta-cyclodextrin can gently remove excess oil and dead skin cells on the skin surface without damaging the skin’s natural barrier, and is suitable for sensitive skin.

6. Formula stabilizer
In cosmetic formulas, methyl beta-cyclodextrin can also act as a stabilizer to prevent adverse interactions between active ingredients, or prevent ingredients from degrading due to temperature changes, light and other factors, thereby extending the shelf life of the product.

Contact Us

As a company specializing in the production and supply of Methyl beta-cyclodextrin raw materials, we are committed to providing customers with high-quality products and preferential prices. We have rich experience and technology to ensure the quality and stable supply of our products. No matter where you are, we can provide you with the Methyl beta-cyclodextrin raw materials you need to support your production and research and development.

We always adhere to the principle of honest management, strictly control product quality, and serve every customer with a customer-first attitude. Over the years, we have established good cooperative relations with domestic and foreign customers and won their trust and praise.

If you have any needs or are interested in our products, please contact our service staff directly, and we will wholeheartedly provide you with the best service and products. Looking forward to cooperating with you and developing together!

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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