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Methionine Dl CAS 63-68-3

Molecular Formula: C5H11NO2S

Formula Weight: 149.21

ZSpharmac: Methionine Dl Supplier

Product Name: Methionine Dl
CAS No: 63-68-3
Purity: 99%

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Basic Info

Product Name:Methionine Dl
Other Names:L-Methionine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Solid
EINECS No.:200-562-9
Provide:Methionine Dl MSDS;
Methionine Dl COA

What is Methionine Dl?

Methionine is a sulfur-containing non-polar aliphatic amino acid, similarly described as methionine, which is just one of the needed amino acids for human body, abbreviated as Met along with M. Glycogenic needed amino acids. It was separated from casein in 1922. It is the only amino acid containing a thioether framework. There are l-body as well as likewise dl-body. Natural products are l-body. The family member molecular mass is 149.21. Has an unique smell. A little wonderful. Steady to air as well as heat. L-methionine can be hydrolyzed or created by fermentation from several healthy proteins. Methionine D1 is synthesized through the adhering to responses by chemical techniques, as well as the pertinent reaction equations are as complies with:


Methionine Dl is a vital amino acid for the nourishment of humans and also animals. It is frequently made use of to prepare substance amino acid infusions, and is also a drug for treating severe hepatitis and liver cirrhosis, and an antidote for medicines. Methionine Dl is widely made use of in compound feed for livestock, pigs as well as poultries. Its metabolic process is linked to cysteine. Formylated methionine in prokaryotes is the beginning amino acid for healthy protein biosynthesis. It can likewise be exchanged s-adenosylmethionine by ATP activation, and join the synthesis of creatine and also choline as a methyl donor.

Young mice lacking methionine can not expand normally. The main physiological function of methionine is to supply methyl groups. It participates in the biochemical reaction of methyl transfer in the body by providing a methyl team (-CH3). It is needed to supply a methyl team during the synthesis of choline as well as creatine. Lysine, histidine as well as Arginine additionally needs it to provide methyl teams for methylation, and also free carboxyl groups on healthy protein particles likewise require it to provide methyl groups for methylation. Foods rich in methionine are mainly meat, fish, chicken, and eggs, as well as mixed with beans and cereals can play a complementary role in healthy protein.

Methionine Dl Property

Melting point 284 °C (dec.)(lit.)
alpha 23.25 º (c=2, 6N HCl)
Boiling point 393.91°C (estimate)
density 1,34g/cm
refractive index 1.5216 (estimate)
storage temp. 20-25°C
solubility 1 M HCl: 0.5 M at 20 °C, clear, colorless
pka2.13(at 25℃)
form Solid
color White
PH5-7 (10g/l, H2O, 20℃)
optical activity[α]20/D +23.7±0.5°, c = 5% in 5 M HCl
Water Solubility Soluble


Application of Methionine Dl

1. Application in the pharmaceutical sector
Methionine Dl is a necessary amino acid, which has essential dietary value for the body. Methionine can maintain the development and also development of the body as well as nitrogen balance. In the process of animal metabolic process, it has a certain impact on the synthesis of choline as well as liver fat from adrenaline. Methionine Dl can promote fat metabolic rate in the liver. It is scientifically made use of for chronic hepatitis, cirrhosis, fat Avoidance and also therapy of liver etc. It can additionally be made use of as an adjuvant treatment for poisoning by sulfonamides, arsenic or benzene, etc. It can additionally be made use of as a choleretic to adjust the pH worth of pee as well as reduce fat buildup. Methionine is an essential component of clinical amino acid mixture, and is just one of the major elements of 11, 14, 17, 18 and 20 amino acid mixtures.

2. Application in feed sector
Methionine Dl is one of the most vital amino acids required for livestock and also chicken to synthesize animal protein. It is a fortifier for healthy protein feed and a nutritional additive to offset the balance of amino acids. Because methionine can not be manufactured in pets, it needs to be consumed from food, so it is included the feed, it can promote the growth of poultry and also animals, boost the quantity of lean meat and accomplish the effect of reducing the feeding cycle and efficiently improve the use rate of protein. When animals as well as chicken do not have methionine, they will reveal stunting, weight loss, damages to liver and also kidney functions, muscle degeneration and also degeneration of hair high quality. Including 1 kg of methionine to pet feed is equivalent to the dietary worth of 50 kg of fish meal, and the general amount is 0.05% to 0.2%. The quantity of methionine included the compound feed for chicken is 0.5-2.5 kg/ t, and also the quantity of methionine in the substance feed for pigs is 0.5-1.0 kg/ t. % to 0.25% methionine can enhance the weight of broilers by 11.8% to 15.9%. Adding methionine and also mibolone to ruminant diets can increase lamb wool production by 25% as well as milk production The yield boosted by more than 42%, the meat yield × boosted by 12%, and also the feed was saved by 10%. DL-methionine, hydroxymethionine, hydroxymethionine calcium salt and also N-hydroxymethylmethionine are used as feed additives, all of which can be manufactured by chemical techniques. Furthermore, methionine steel salts can increase the focus of metal ions including Zn, Cr, Mn, Fe in pets. biological usage.

3. Various other applications
In regards to clinical cosmetology, Japan first created the amino acid beauty food – Amino Acid Estai. It has been proved by study that the charm result mainly originates from 9 kinds of essential amino acids in addition to glutamic acid, proline and arginine. Some promote healthy protein synthesis, some promote the synthesis of collagen, keratin as well as other proteins that compose the skin, some promote the secretion of development hormone, which is helpful for skin health and wellness, as well as some improve sleep top quality and also human immune feature, and also boost total skin health. Nourishment, physical conditioning, sleep, as well as a person’s capacity to reply to emphasize all contribute to the formation of healthy and balanced skin.

In addition, Methionine Dl is an excellent antioxidant, due to the fact that the sulfur atom contained in the methionine particle can feed on free radicals. Methionine is needed for the synthesis of nucleic acid collagen protein in body cells, and it is additionally advantageous for ladies who take birth control pills to take methionine. On top of that, Methionine Dl is likewise commonly utilized in food, biochemical research, photographic modern technology, cosmetics and other fields.

Physiological Functions of Methionine Dl

1. Enhance immune feature
1) Non-specific immunity: Research studies have reported that the absence of critical Methionine Dl will certainly reduce the phagocytic feature of outer lymphocytes in griddles. The phagocytosis activity of lymphocytes as well as serum lysozyme activity showed a pattern of very first raising and after that lowering with the boost of LMA enhancement level, which indicated that including LMA to diet plan might boost broiler feed utilization performance and non-specific immune feature.

2) Specific resistance: Humoral immunity A lot of researches have actually revealed that the degree of Methionine Dl in the diet regimen can impact the humoral immunity of pets. 6 various degrees of methionine were included in the diet with 21% crude protein to feed griddle hens aged 0-21 days. It was found that when the methionine degree was 0.60%, the antibody titer of lamb red cell increased, however when the methionine degree was 0.60%. 0.70% does not influence the product antibody titer after inoculation. Correct addition of methionine to cellular resistance chicken diets can promote the proliferation as well as makeover of outer blood, thymus as well as spleen T lymphocytes, while the lack of methionine can decrease the expansion and also transformation of T lymphocytes.

2. Improve antioxidant ability
Studies have found that Methionine Dl is just one of the essential nutrients, as well as metabolites such as glutathione (GSH), cysteine, and also sulfate can be created via the transsulfuration path. These sulfur-containing amino acids and GSH are antioxidant compounds. Antioxidant compounds such as GSH can remove H2O2 as well as lipid peroxyl free radicals in the body.

3. Enhance reproductive performance
Methionine Dl can enhance the fertilizing rate of reproducing eggs and also the hatching price of fertilized eggs, and the chicks will be solid as well as neat after hatching. Researches have shown that methionine is associated with the procedure of sperm formation, and also diets with reduced methionine degrees can considerably reduce sperm thickness as well as reliable sperm matter.

4. Detoxification function
Methionine Dl is an important amino acid for animals, which can utilize its methyl team to methylate harmful materials or drugs to detoxify. Research studies have actually discovered that methionine can incorporate with the mycotoxins in the diet to greatly lower the toxicity, so it has the function of illness avoidance and also healthcare for pets.

Production Method of Methionine Dl

For dehydration, feed glycerin, potassium bisulfate, and potassium sulfate at a ratio of 1:0.5:0.026. Put 1/7 of the amount of glycerin and all the potassium bisulfate and potassium sulfate into the reaction tank. After the temperature rises to 190°C, add the rest of glycerin dropwise. Control the reaction temperature at 180-220°C. Aldehyde gas is collected in a storage tank through a condenser to obtain crude acrolein. Add 10% NaHCO3 solution to the crude product to adjust the pH to 6, carry out fractional distillation, and collect fractions at 50-75°C to obtain crude acrolein. The addition is based on acrolein, methylisothiourea sulfate, sodium hydroxide, copper acetate, and formic acid in a ratio of 1:2.45:3.8:0.01:0.024.
For cyclization, first put methylisothiourea sulfate into the methyl mercaptan generating tank, add NaOH solution dropwise, and heat at the same time to control the temperature not to exceed 95°C. The generated methyl mercaptan first enters the buffer tank, and then enters the 50% The washing tank of sulfuric acid solution and another flushing tank, finally enter the addition tank filled with acrolein, formic acid and copper acetate in advance, heat and stir to keep the reaction temperature at 35-41°C. When the reaction is approaching the end point, the reactant is light yellow and mixed with flocs, and its relative density is measured from time to time. When the relative density is 1.066-1.074 (20°C), it indicates that the reaction has reached the end point. In 3-methylthiopropanal.
Feed according to the ratio of 3-methylthiopropanal, sodium cyanide, and ammonium bicarbonate at a ratio of 1:0.52:1.75. Ammonium bicarbonate was dissolved in water 4 times its weight and sodium cyanide was dissolved in water 3 times its weight respectively, and then they were put into the reaction tank, and 3-methylthiopropionaldehyde was slowly added dropwise under stirring, and kept warm for 75 React at -80°C for 3 hours to obtain ureide.
Hydrolyze 1.1 parts of lime to make lime milk, take another 0.424 parts of sodium hydroxide solution into the reaction tank, add 1 part of urea, heat up for alkali hydrolysis and discharge ammonia for 1 hour, keep warm at 165 ° C, pressure 0.5 MPa, react 1h, DL-methionine sodium salt was obtained. Neutralize and decolorize the above DL-methionine sodium salt with HCl to adjust the pH to 5-6, boil with 1% activated carbon for 45 minutes, filter while hot to remove the residue, collect the filtrate, cool and crystallize, filter to collect the crystals, and dry at 100°C to obtain the crude Methionine Dl.
For refining, feed the crude product, distilled water, activated carbon, and EDTA in a ratio of 1:7:0.04:0.0007, put them into the refining tank, stir, decolorize for 1.5 hours, filter to remove slag, collect the filtrate, cool and place for 15-20 hours to crystallize, The crystals were collected by filtration and dried to obtain the finished product of Methionine Dl.

About Products:
If you need Methionine Dl, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Methionine Dl manufacturer and supplier, ZSpharmac will provide Methionine Dl raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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