The main damaged target organs after acute methanol poisoning are the central nervous system, optic nerve and retina. The incubation period of inhalation poisoning is generally 1 to 72 hours, and there are also 96 hours; oral poisoning is mostly 8 to 36 hours; if ethanol is ingested at the same time, the incubation period is longer. Clinical features Irritation symptoms: Inhalation of methanol vapor can cause eye and respiratory mucosal irritation.Central nervous system symptoms: Patients typically have dizziness, headache, dizziness, tiredness, surprising gait, sleep problems, uncaring expression, and cloudy awareness. In serious instances, confusion, coma, and epilepsy-like convulsions might happen. Extreme dental poisoning may have signs and symptoms of extrapyramidal damages or Parkinson’s syndrome. In proportion infarct necrosis of the lentiform nucleus and subcortical main white matter was found on head CT evaluation.hallucinations, depression and other symptoms. Ocular symptoms: initially manifested as dark shadows, flashes, blurred vision, eye pain, photophobia, diplopia, etc. In severe cases, visual acuity drops sharply, which can cause permanent blindness in both eyes. Examination showed pupil dilation or constriction, slow response to light or disappearance, papilledema, peripheral retinal congestion, hemorrhage, edema, and optic atrophy in the late stage. Acidosis: reduced carbon dioxide binding capacity, severe cyanosis, deep and fast breathing Kussmaul breathing. Digestive system and other symptoms: The patient has nausea, vomiting, epigastric pain, etc., which can be complicated by liver damage. Oral poisoning can be complicated by acute pancreatitis. A couple of situations were accompanied by tachycardia, myocarditis, S-T segment and T wave changes, and also acute renal failure. Severe acute methanol poisoning has severe headache, nausea, vomiting, sharp loss of vision, and even blindness, hazy consciousness, delirium, convulsions and coma. Eventually, it can die from respiratory failure. According to the history of methanol exposure, the clinical manifestations mainly include central nervous system damage, eye damage and metabolic acidosis in a short period of time. Referring to the on-site hygiene investigation, other diseases with similar manifestations are excluded, and the diagnosis is not difficult after comprehensive analysis. If necessary, blood and urine methanol can be measured. Early poisoning should be differentiated from colds, neurasthenia, and acute gastroenteritis. In addition, it should be differentiated from acute poisoning of methyl chloride, ethylene glycol and other causes of encephalopathy and optic nerve damage. The occupational history must be inquired in detail, on-site hygienic investigation, close observation of the progression of the disease, combined with laboratory tests, can lead to a correct diagnosis.