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Methanol Bp CAS 67-56-1

Molecular Formula: CH4O

Formula Weight: 32.04

ZSpharmac: Methanol Bp Supplement

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Product Name: Methanol Bp
CAS No: 67-56-1
Purity: 99%

Basic Info

Product Name:Methanol Bp
Other Names:Methyl Alcohol
CAS:67-56-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:White Liquid Free From Particulates
EINECS No.:262-390-0
Storage:2-8°C
Provide:Methanol Bp MSDS;
Methanol Bp COA

What is Methanol Bp?

Methanol Bp, also known as “wood alcohol”, is an organic compound and the simplest saturated monohydric alcohol. Appearance is colorless, transparent, flammable, volatile toxic liquid. Drinking 5 to 10 ml by mistake can cause blindness, and a large amount of drinking can lead to death. Methanol is non-corrosive to metals at room temperature (except lead and aluminum), and has a slight alcohol odor. Relative density 0.792 (20/4°C), melting point -97.8°C, boiling point 64.5°C, flash point 12.22°C, auto-ignition point 463.89°C, vapor density 1.11, vapor pressure 13.33KPa (100mmHg21.2°C), explosion limit of vapor and air mixture 6-36.5% (volume ratio), miscible with water, ethanol, ether, benzene, ketone, halogenated hydrocarbons and many other organic solvents. Typically used as a solvent, antifreeze, fuel or neutralizer.

Methanol Bp Properties:

Melting point -98 °C(lit.)
Boiling point 65.4 °C(lit.)
density 0.791 g/mL at 25 °C
vapor density 1.11 (vs air)
vapor pressure 410 mm Hg ( 50 °C)
refractive index n20/D 1.329(lit.)
Fp 52 °F
storage temp. 2-8°C
solubility benzene: miscible(lit.)
pka15.2(at 25℃)
form Liquid Free From Particulates
color <10(APHA)
Specific Gravity0.793 (20/20℃)
Relative polarity0.762
OdorFaint alcohol odor detectable at 4 to 6000 ppm (mean = 160 ppm)
Odor Threshold33ppm
explosive limit5.5-44%(V)
Water Solubility miscible

 

Methanol Bp Uses

  1. Methanol Bp extraction solvent. GB 2760-96 is listed as food processing aids.
  2. Methanol Bp is used as analytical reagent and chromatographic reagent, and is also used in organic synthesis.
  3. Methanol Bp is mainly used to prepare formaldehyde and used as methylating agent and solvent in organic synthesis. It is the raw material of methyl tert-butyl ether and can also be used as automobile fuel.
  4. Methanol Bp is used for the separation of calcium sulfate and magnesium sulfate, the separation of strontium bromide and barium bromide, and the reagent for the determination of boron.
  5. Methanol Bp is one of the basic organic raw materials. Mainly used in the manufacture of formaldehyde, acetic acid, methyl chloride, methylamine and dimethyl sulfate and other organic products. It is also a resources for pesticides (pesticides, acaricides), medicines (sulfonamides, synthomycin, and so on), as well as one of the raw products for the synthesis of dimethyl terephthalate, methyl methacrylate and also methyl acrylate.It is also an important solvent and can also be mixed with gasoline as an alternative fuel. Since the 1980s, methanol has been used in the production of gasoline octane number additive methyl tert-butyl ether, methanol gasoline, methanol fuel, and methanol protein。
  6. Methanol Bp is used as basic organic raw material, solvent and antifreeze. Mainly used in the system of formaldehyde, essence, dyes, medicine, gunpowder, antifreeze, etc.
  7. Methanol Bp is used to prepare Karl Fischer reagent for the determination of trace moisture in alcohols, saturated hydrocarbons, benzene, chloroform and pyridine.
  8. Methanol Bp is used to separate calcium sulfate and magnesium sulfate. It is mixed with isobutanol to separate bromide of strontium and barium. Inspection and determination of boron. Solvent. Methylating agent for organic synthesis. Leaching agent. Extracting agent. Cleaning agent. agent.

Rational Properties of Methanol Bp

Methanol was first separated from the distillate of dry distillation wood, so it is also called wood alcohol or lignin. Most of methanol exists in nature in the form of ester or ether, and only some leaves or fruits contain a small amount of free methanol. Methanol is a flammable, colorless and toxic liquid; the pure product has a slight ethanol odor, and the crude product is pungent and unpleasant; soluble in water, ethanol, ether, acetone, benzene and other organic solvents, and less miscible with saturated hydrocarbons; with water Azeotropes cannot be formed. Methanol is flammable and explosive. During storage and transportation, sunlight exposure, leakage, impact and rolling should be prevented. The storage temperature should not exceed 30℃, and it should not be stored and transported together with oxidants. Operators should have personal protective equipment, pay special attention to eye protection.

Clinical Manifestations of Methanol Bp

The main damaged target organs after acute methanol poisoning are the central nervous system, optic nerve and retina. The incubation period of inhalation poisoning is generally 1 to 72 hours, and there are also 96 hours; oral poisoning is mostly 8 to 36 hours; if ethanol is ingested at the same time, the incubation period is longer. Clinical features Irritation symptoms: Inhalation of methanol vapor can cause eye and respiratory mucosal irritation.Central nervous system symptoms: Patients typically have dizziness, headache, dizziness, tiredness, surprising gait, sleep problems, uncaring expression, and cloudy awareness. In serious instances, confusion, coma, and epilepsy-like convulsions might happen. Extreme dental poisoning may have signs and symptoms of extrapyramidal damages or Parkinson’s syndrome. In proportion infarct necrosis of the lentiform nucleus and subcortical main white matter was found on head CT evaluation.hallucinations, depression and other symptoms. Ocular symptoms: initially manifested as dark shadows, flashes, blurred vision, eye pain, photophobia, diplopia, etc. In severe cases, visual acuity drops sharply, which can cause permanent blindness in both eyes. Examination showed pupil dilation or constriction, slow response to light or disappearance, papilledema, peripheral retinal congestion, hemorrhage, edema, and optic atrophy in the late stage. Acidosis: reduced carbon dioxide binding capacity, severe cyanosis, deep and fast breathing Kussmaul breathing. Digestive system and other symptoms: The patient has nausea, vomiting, epigastric pain, etc., which can be complicated by liver damage. Oral poisoning can be complicated by acute pancreatitis. A couple of situations were accompanied by tachycardia, myocarditis, S-T segment and T wave changes, and also acute renal failure. Severe acute methanol poisoning has severe headache, nausea, vomiting, sharp loss of vision, and even blindness, hazy consciousness, delirium, convulsions and coma. Eventually, it can die from respiratory failure. According to the history of methanol exposure, the clinical manifestations mainly include central nervous system damage, eye damage and metabolic acidosis in a short period of time. Referring to the on-site hygiene investigation, other diseases with similar manifestations are excluded, and the diagnosis is not difficult after comprehensive analysis. If necessary, blood and urine methanol can be measured. Early poisoning should be differentiated from colds, neurasthenia, and acute gastroenteritis. In addition, it should be differentiated from acute poisoning of methyl chloride, ethylene glycol and other causes of encephalopathy and optic nerve damage. The occupational history must be inquired in detail, on-site hygienic investigation, close observation of the progression of the disease, combined with laboratory tests, can lead to a correct diagnosis.

Introduction to Methanol Bp Toxicology

Human (male) oral LDLo: 6422mg/kg; TDLo: 3429mg/kg. Female oral TDLo: 4mg/kg. It is also reported that human oral LDLo: 428mg/kg, 143mg/kg; inhaled TCLo: 86000mg/m3, 300ppm. Rat oral LD50: 5628mg/kg; inhalation LC50: 64000ppm/4H. Mice oral LD50: 7300mg/kg; inhalation LCLo: 50gm/m3/2H. Rabbit percutaneous LD50: 15800mg/kg. After the methanol is absorbed into the body, it can be rapidly distributed in various tissues of the body. Among them, the content in cerebrospinal fluid, blood, bile and urine is the highest, the content in aqueous humor and vitreous humor is also high, and the content in bone marrow and adipose tissue is the lowest. Methanol is metabolized in the liver, oxidized to formaldehyde by alcohol dehydrogenase, and then oxidized to formic acid. This product oxidizes slowly in the body, only 1/7 of that of ethanol, and the excretion is also slow, so it has obvious accumulation effect. The unoxidized methanol is excreted from the body through the respiratory tract and kidney, and part of it is slowly excreted through the gastrointestinal tract. It is speculated that the concentration of methanol in the air is 39.3-65.5g/m^3, and it can be poisoned for 30-60 minutes. Oral administration of 5-10ml can cause severe poisoning; oral administration of 15ml at a time, or 124-164ml in divided doses within 2 days, can cause blindness. There are reports that a single oral 30ml can be fatal. Methanol mainly acts on the nervous system, has obvious anesthetic effect, and can cause cerebral edema. The anesthetic concentration of methanol is close to LC, so it is more dangerous. It has a special selective effect on the optic nerve and retina, which can easily cause optic nerve atrophy, resulting in blindness in both eyes. Methanol vapor has a strong irritating effect on the mucous membranes of the respiratory tract. The toxicity of methanol is related to the accumulation of its metabolites formaldehyde and formic acid. Previously, it was believed that the toxicity was mainly caused by formaldehyde. Formaldehyde could inhibit the oxidative phosphorylation process of the retina, so that ATP could not be synthesized in the membrane, the cells would degenerate, and finally cause optic atrophy.Methanol inhibits certain oxidase systems in the body, inhibits the aerobic decomposition of sugars, causes the accumulation of lactic acid and other organic acids and the accumulation of formic acid, and causes acidosis. It is generally believed that the toxicity of methanol is caused by itself and its metabolites. DLH:+6000ppm

Methanol Bp Poisoning Treatment Method

The patient should be removed from the scene immediately and the contaminated clothing removed. Oral lavage with 1% sodium bicarbonate, magnesium sulfate catharsis. Removes the absorbed methanol from the body. Dialysis therapy: For severe poisoning, hemodialysis or peritoneal dialysis should be performed as soon as possible to relieve the symptoms of poisoning, save the patient’s life, and reduce sequelae. The indications for hemodialysis therapy are: ① blood methanol> 15.6mmol/L; or formic acid> 4.34 mmol/L; ② severe metabolic acidosis; ③ severe visual impairment or papillary retinal edema. Antidote: Ethanol is an antidote for methanol poisoning. The application of ethanol can prevent methanol oxidation and promote methanol discharge. With 10% glucose solution made into 5% ethanol solution, intravenous drip slowly. There is not much domestic clinical experience. Correct acidosis: According to blood gas analysis or carbon dioxide binding capacity measurement and clinical manifestations, give sodium bicarbonate solution or sodium lactate solution as soon as possible. Supportive and symptomatic treatment: Actively prevent and treat cerebral edema, reduce intracranial pressure, improve fundus blood circulation, and prevent optic neuropathy according to the condition. Maintain respiratory and circulatory function and maintain electrolyte balance. Give plenty of B vitamins. It has been suggested to treat methanol poisoning with formate and 4-methylpyrazole (4MP), which has been confirmed in monkey experimental studies and has not been used clinically so far.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vision
Become the most trusted chemical supplier in the world
Our Business Philosophy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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