Zhishang Chemical

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Zhishang Chemical

Menthone Cas CAS 10458-14-7

Molecular Formula: C10H18O

Formula Weight: 154.25

ZSpharmac: Menthone Cas Supplement

Product Name: Menthone Cas
CAS No: 10458-14-7
Purity: 99%

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Basic Info

Product Name:Menthone Cas
Other Names:Menthone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless Liquid
EINECS No.:233-944-9
Storage:Sealed in Dry,Room Temperature
Provide:Menthone Cas MSDS;
Menthone Cas COA

What is Menthone Cas?

Menthone Cas is a monoterpenoid compound, which exists in the volatile oils of various plants such as mint, Nepeta, Scutellaria, and Agaricus, also known as 1-methyl-4-isopropylcyclohex-3-one, 2-isopropyl Base-5-methylcyclohexanone and p-3-ketone have cis and trans isomers. The trans form is called Menthone Cas, and the cis form is called isomenthone. Both cis and trans isomers are optical isomers. Several isomers are found in nature. Menthone Cas is colorless oily liquid with mint-like aroma, slightly soluble in water, soluble in ethanol and most organic solvents.

Menthone Cas Properties

Melting point 

-6 °C

Boiling point 

85-88 °C/12 mmHg (lit.)


0.896 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.450


69 °C

storage temp. 

Sealed in dry,Room Temperature




Clear colorless

optical activity

[α]/D -7.0±5°, neat

Water Solubility 

Slightly soluble in water



Menthone Cas Uses

Menthone Cas is used for spices, to prepare lavender, rose and other flavor essences for cosmetics; to prepare mint flavors for food, it is the edible flavor allowed by my country’s GB2760-1996 regulations; spices intermediates, synthesis of thymol and menthol ; It is also a pharmaceutical raw material.

CN200480031751.4 provides a fruit component-containing food with a sweetened base with mints, which has no heavy sweetness caused by the sweetened base, and provides a refreshing feeling during and after ingestion , and has high taste acceptability. In addition to the fruit component and the sweetened base, it also contains components (a) and (b):

(a) one or more cooling sensation substances selected from the group consisting of menthol, Menthone Cas, camphor, pulegol, isopulegol, hu Menthone Cas, eucalyptol, peppermint oil, pepper Peppermint oil, spearmint oil, eucalyptus oil, and isolates thereof; and (b) one or more cold-sensing substances selected from the group consisting of: 3-(1-menthalkoxy)-1 , 2-propanediol, N-ethyl-p-menthane-3-carboxamide, 3-(1-menthalkoxy)-2-methyl-1,2-propanediol, p-menthane-3,8-diol alcohol, 2-(1-menthalkoxy)-1-ethanol, 3-(1-menthalkoxy)-1-propanol, 4-(1-menthalkoxy)-1-butanol, cyclo formamide, acyclic formamide, N,2,3-trimethyl-2-isopropylbutanamide, menthyloxyalkanol (the alkyl group contains 2 to 6 carbons), menthyloxyalkyl Ethers (the alkyl group contains 1 to 6 carbons) and menthyl alkoxyalkanediols (the alkyl group contains 3 to 6 carbons). The inventors found that by adding a cooling-sensing substance such as menthol and a cooling-sensing substance such as 3-(1-menthalkoxy)-1,2-propanediol to a fruit juice-containing food containing a fruit component and a sweetening base, the production of A fruit juice-containing food product which has no residual heavy sweetness at the time of ingestion and after ingestion, provides a continuous refreshing feeling, has high taste acceptability, and suppresses even when stored under warm conditions for a long time Decreased feeling of freshness. The inventors have also found that these effects are not affected by the type of fruit juice-containing food.

Menthone Cas Pharmacology

Modern research shows that Menthone Cas has antiviral, anti-inflammatory, choleretic, and osmotic-promoting effects, and its thiosemicarbazone and semicarbazone derivatives also have anti-HIV-1 (IIIB) and HIV-2 (ROD) effects. Regarding the anti-inflammatory effect of Menthone Cas, it has been reported that it is related to the inhibition of the release of inflammatory factors in vitro.

Wang Feng et al. found through in vivo studies that Menthone Cas pretreatment has a protective effect on endotoxin-induced inflammation in model mice, and the effect is related to inhibiting the release of various inflammatory factors, thereby reducing inflammatory cell infiltration and inhibiting the pathological process of inflammatory response. The anti-inflammatory effect may be related to interfering with the activation of NLRP3 inflammasome by changing ion channels, reducing lysosomal damage or affecting NO release.

Menthone Cas Preparation

①Separate from peppermint oil.

② It can be prepared by using p-3-ene as raw material, reacting with formic acid, further reacting with potassium hydroxide, and finally acidifying with sulfuric acid [1].

③Using Hu Menthone Cas or piperonone as raw material and reducing it, it can be obtained [1].

④ It can be obtained by using l-menthol as raw material and oxidizing it with chromic acid [1].

Add 1.24 g (0.008 mol) of menthol and 20 mL of acetone to a 100 mL round-bottomed flask, and magnetically stir to dissolve. In a cold water bath, add 8ml of Jone’s reagent dropwise from a constant pressure dropping funnel while stirring, and green Cr2(SO4)3 precipitation can be seen during the dropwise addition. Add 25 mL of water and transfer to a separatory funnel, extract the organic phase with 10 mL of dichloromethane twice, wash the organic phase with 5 mL of water, combine the organic phases, evaporate the solvent on a hot water bath and dry with anhydrous sodium sulfate , that is, the crude product of L-Menthone Cas is obtained, and the yield is calculated.

During the whole process, the aqueous phase was poured into the prepared chromium waste liquid cup. The used glassware was washed three times with 5 mL of water each time and poured into the chrome waste cup. The collected chromium waste liquid (about 77mL) was added with 1.5 times the theoretical amount (about 3.2g) of sodium bisulfite and kept stirring for 5 minutes. It was observed that the waste liquid changed from orange to blue-green, indicating that the Cr6+ in the waste liquid was It has been fully reduced; adjust the pH value to 8 with 6mol/L KOH solution, let stand for 12h to completely precipitate Cr3+ into Cr(OH)3, filter with suction, and check whether the chromium concentration in the filtrate meets the emission standard by DPCI method.

Menthone Cas Environmental Fate

The production and also use Menthone Cas in perfume as well as flavor make-ups might cause its launch right into the setting through numerous waste streams. Menthone Cas takes place normally in numerous necessary oils, such as pepper mint, pepper mint, as well as geranium. If released right into air, the approximated vapour stress at 25 ° C is 0.28 mm Hg, which shows that menthone will exist only in vapour type in the ambient ambience. Gas-phase menthone is deteriorated in the environment by response with photochemically produced hydroxyl radicals; the half-life of this reaction in air is approximated to be 14 hours. If released into soil, Menthone Cas is anticipated to have high flexibility based on an estimated Koc of 120. Based on the estimated Henry’s Regulation constant of 1.6X10-4 atm-cu m/, volatilization from wet soil surface areas is expected to be an essential destiny process mole. Based on its vapour pressure, Menthone Cas is not anticipated to vaporize from completely dry dirt surface areas. Menthone is not expected to adsorb to put on hold solids and also debris in the water column if released to the approximated Koc. Based on the approximated Henry’s Legislation constant for this compound, volatilization from the water surface area is anticipated to be a vital fate procedure. The approximated volatilization half-lives for the design river as well as model lake are 0.5 and 8 days, respectively. Based on an approximated BCF worth of 15, the probability of bioconcentration is considered low. In offices where Menthone Cas is produced or used, inhalation and facial contact with this substance may lead to occupational direct exposure to menthone. The basic population may be subjected to Menthone Cas through skin contact with scents and also intake of products containing menthone.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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