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Melotin CAS 73-31-4

Molecular Formula: C13H16N2O2

Formula Weight: 232.28

ZSpharmac: Melotin Supplier

Product Name: Melotin
CAS No: 73-31-4
Purity: 99%

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Basic Info

Product Name:Melotin
Other Names:Melatonine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to off-White Powder
EINECS No.:200-797-7
Provide:Melotin MSDS;
Melotin COA

What is Melotin?

Melotin is an indispensable all-natural hormonal agent in the human body, which regulates and affects the secretion of various other different hormonal agents. When melatonin in the body decreases, numerous features of the body will certainly be influenced, and numerous diseases will certainly follow. Researches have revealed that the secretion of melatonin in the body starts to reduce after midlife, as well as its secretion is minimal in old age. Taking adequate melatonin as early as possible can boost the feature of the endocrine system, improve resistance, boost anti-stress and anti-oxidation functions, boost sleep, decrease the aging speed of the human body, and decrease the degeneration of sex-related body organs; melatonin can likewise help stop and also deal with cancer, It is especially helpful for regular sleeping disorders.

Pineal gland, also referred to as melatonin, is a hormonal agent produced by pineal cells. Its chemical structure is 5-methoxy-N-acetyltryptamine. Its physical function is to prevent the gonad, thyroid, and adrenal glands., parathyroid gland and pituitary function, inhibit youngsters’s precocious adolescence, decrease pituitary melanin-stimulating secretion; as well as have main nervous system impacts, which can boost the convulsion limit and cause sleepiness. After the pineal gland was eliminated, the experimental animals showed hyperplasia and also hypertrophy of the abovementioned glands, especially in premature rats with bright gonads as well as sex body organs, increased secretion of LH and also FSH from the pituitary gland, and raised secretion of thyroid and also adrenal cortex hormones. Pineal gland has the result of minimizing pituitary MSH and also whitening the skin. This element acts on the central nerve system, revealing slow rhythm on the human EEG, raising the convulsion limit, and also drowsiness, yet does not affect their behavior and personality. Electrogram adjustments.

Melotin Property

Melting point 116.5-118 °C (lit.)
Boiling point 374.44°C (rough estimate)
density 1.1099 (rough estimate)
refractive index 1.6450 (estimate)
Fp 9℃
storage temp. -20°C
solubility Soluble in ethanol to at least 50mg/ml
form Powder
color white to off-white


Melotin Uses

Melotin is a hormonal agent produced by the pineal gland. Melatonin is a very saved, non-receptor cost-free radical scavenger and also broad-spectrum antioxidant. Melatonin helps shield versus ischemia-reperfusion injury in the liver, brain, heart muscular tissue, gut, as well as kidneys.

Melotin can be extensively used in health food, medicine, different cosmetics, beneficial care items. Functions: 1. Melatonin as well as blemish removal, all-natural bleaching: melatonin can lighten the skin. It can control human endocrine, eliminate dark spots, age places, chloasma, pregnancy areas as well as pigmentation brought on by sun radiation, whiten, moisturize and also restore youthful look to the skin. 2. Efficiently boost rest: Ideal supplementation of melatonin can properly improve sleep high quality. 3. Extend life: Melotin is one of the most vital high-efficiency endogenous anti-oxidant in the mind, which has a safety effect on the brain. For that reason, melatonin is a vital anti-aging hormone.4. Preserve as well as boost sex-related function: Supplementing melatonin can boost the sexual feature of middle-aged and senior people that are sickly and energy-decreasing, causing loss of sex drive.

Synthesis and Biosynthesis of Melotin


As mentioned above, the secretion of Melotin is controlled by light. When the retina perceives the brightness of blue light in the environment, it transmits the light-dark signal to the pineal gland, making it produce Melotin in the dark. Pineal cells use L-tryptophan (L-tryptophan) as a raw material to obtain 5-hydroxytryptophan under the action of tryptophan hydroxylase, and then convert it into 5-hydroxytryptophan (serotonin) through the action of decarboxylase ), and then react with acetyl-CoA under the catalysis of N-acetyltransferase to convert into N-acetyl-5-hydroxytryptamine, and finally melatonin can be obtained under the action of methyltransferase.


Some physiological and pharmacological activities of melotin have been successfully applied in medicine and health food, and the large market demand makes it necessary to explore the chemical synthesis of melatonin. It is worth mentioning that the synthesis process of melatonin is mature and of high purity, and has become the main source of melatonin at present. There are too many methods reported in the literature, and only representative synthetic routes are introduced here. Using 5-methoxyindole as the starting material, Melotin can be obtained in a very considerable yield through four steps of oxalylation, amination, reduction and acetylation; another classic method is to use Fischer indole synthesis The method uses 4-methoxyphenylhydrazine and 4-chlorobutanal as raw materials to obtain 5-methoxytryptamine through condensation, and finally only needs acetylation to obtain melatonin.

Physiological Effects of Melotin

① Effects on the brain: Melotin ingested by the mind is focused in the midbrain as well as hypothalamus, which improves the task of mind pyridoxal kinase, consequently advertising the decarboxylation of glutamic acid to create γ-aminobutyric acid, in addition to the decarboxylation of 5-hydroxytryptophan to create 5- Serotonin, the boost in the web material of these 2 repressive natural chemicals, has a controling in addition to relaxing influence on the central nerves.
② Results on the hypothalamus and additionally pituitary gland: In addition to AVT, the polypeptide compounds produced by the pineal gland consist of thyrotropin-releasing hormone (TRH) and additionally luteinizing hormone-releasing hormonal agent (LRH), which correspond as those generated by the hypothalamus. After shot of Melotin, gonadotropin (GnH) (FSH, LH) and melanocyte stimulating hormone representative (MSH) can be decreased, while development hormone (GH) can be elevated. Removal of the pineal gland triggers pituitary hypertrophy, improved secretion of pituitary GnH (FSH, LH), ACTH, and lowered prolactin (PRL) as well as additionally antidiuretic hormonal agent (ADH).
③ Partnership with gonads: Pineal gland has a repressive outcome on the reproductive system. Medically, pineal principal cell tumors can lead to postponed teenage years, while pineal teratomas, due to the exemption of principal cells, can be made complex by intense adolescence. Environmental light as well as additionally thoughtful nerves can affect the reproductive system feature by taking care of the synthesis as well as launch of melatonin in the pineal gland.
④ Collaboration with thyroid gland: When melatonin is used, the secretion of thyroid hormone representatives lowers, possibly by preventing the launch of TRH in the hypothalamus and also the secretion of thyroid-stimulating hormonal agent (TSH) in the pituitary, thus avoiding thyroid feature.
⑤ Connection with the adrenal cortex: Melotin has a strong inhibitory outcome on the adrenal cortex. When healthy and balanced as well as well balanced individuals are injected with pineal gland remove, the secretion of aldosterone is minimized, and the discharging of 17 ketone steroids is decreased.
⑥ Connection with pancreatic islands: Pineal gland can cause reduced blood glucose and additionally rise glucose resistance. To sum up, the pineal gland can help the pituitary gland to handle endocrine functions, and additionally it plays an essential duty in maintaining a fairly continuous interior environment as well as controlling some endocrine attributes, especially the gonads.

About Products:
If you need Melotin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Melotin manufacturer and supplier, ZSpharmac will provide Melotin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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